The Mannose-Binding Lectin: An Infection Susceptibility Gene
A critical but unanswered question is what defines each individual’s pre-morbid susceptibility to infection? w e propose that individuals must have an “immune haplotype” that shapes their response to infectious agents. Infection is a balance between the intrinsic virulence of the infectious agent and the host defenses. Recent viral outbreaks of SARS and influenza serve to illustrate this point as these viruses cause severe disease in certain individuals, yet there are others in whom the same infectious challenge results in minimal symptoms. On the other hand it might be that those self same people who are resistance to one particular viral infection might be susceptible to other infection challenges. Similar rules can apply to susceptibility to bacterial infections.
KeywordsLipopolysaccharide Binding Protein Pattern Recognition Molecule Infectious Challenge Intrinsic Virulence Lectin Associate Serine Protease
Unable to display preview. Download preview PDF.
- 14.Tumer, M.W., and R.M. Hamvas. 2000. Mannose-binding lectin: structure, function, genetics and disease associations. Rev Immunogenet 2:305–322.Google Scholar
- 17.Thiel, S., T. Vorup-Jensen, C.M. Slover, W. Schwaeble, S.B. Laursen, K. Poulsen, A.C. Willis, P. Eggleton, S. Hansen, U. Holmskov, K.B. Reid, and J.C. Jensenius. 1997. A second serine protease associated with mannan-binding lectin that activates complement. Nature 386:506–510.PubMedCrossRefGoogle Scholar
- 19.Neth, O., D.L. Jack, M. Johnson, N.J. Klein, and M.W. Tumer. 2002. Enhancement of Complement Activation and Opsonophagocytosis by Complexes of Mannose-Binding Lectin with Mannose-Binding Lectin-Associated Serine Protease After Binding to Staphylococcus aureus. J Immunol 169:4430–4436.PubMedGoogle Scholar
- 22.Laursen, S.B., T.S. Dalgaard, S. Thiel, B.L. Lim, T.V. Jensen, H.R. Juul-Madsen, A. Takahashi, T. Hamana, M. Kawakami, and J.C. Jensenius. 1998. Cloning and sequencing of a cDNA encoding chicken mannan-binding lectin (MBL) and comparison with mammalian analogues. Immunology 93:421–430.PubMedCrossRefGoogle Scholar
- 31.Wright, A.E., and S.R. Douglas. 1904. Opsonins. Proc Roy Soc Ser 73:128–142.Google Scholar
- 33.Yang, K.K., B.G. Domer, U. Merkel, B. Ryffel, C. Schutt, D. Golenbock, M.W. Freeman, R.S. Jack, J. Fierer, M.A. Swancutt, and D. Heumann. 2002. Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol 169:4475–4480.PubMedGoogle Scholar
- 36.Summerfield, J.A., M. Sumiya, M. Levin, and M.W. Turner. 1997. Mannose-binding protein gene mutations are associated with childhood infection in a consecutive hospital series. Br Med J 314:1229–1232.Google Scholar