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The Mannose-Binding Lectin: An Infection Susceptibility Gene

  • R. Alan Ezekowitz
  • Lei Shi
  • Iain Fraser
  • Kazue Takahashi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 560)

Abstract

A critical but unanswered question is what defines each individual’s pre-morbid susceptibility to infection? w e propose that individuals must have an “immune haplotype” that shapes their response to infectious agents. Infection is a balance between the intrinsic virulence of the infectious agent and the host defenses. Recent viral outbreaks of SARS and influenza serve to illustrate this point as these viruses cause severe disease in certain individuals, yet there are others in whom the same infectious challenge results in minimal symptoms. On the other hand it might be that those self same people who are resistance to one particular viral infection might be susceptible to other infection challenges. Similar rules can apply to susceptibility to bacterial infections.

Keywords

Lipopolysaccharide Binding Protein Pattern Recognition Molecule Infectious Challenge Intrinsic Virulence Lectin Associate Serine Protease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • R. Alan Ezekowitz
    • 1
  • Lei Shi
    • 1
  • Iain Fraser
    • 1
  • Kazue Takahashi
    • 1
  1. 1.Laboratory of Developmental Immunology, Department of Pediatries, Harvard Medical SchoolMassachusetts General HospitalBoston

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