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Hormonal Carcinogenesis IV pp 405–411Cite as

Effect of Dietary Genistein on Estradiol-induced Mammary Carcinogenesis in the ACI Rat

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Summary

We evaluated the possible effectiveness of genistein (GEN) as an inhibitor of mammary cancer in the ACI rat, a strain genetically susceptible to estrogen-induced mammary carcinogenesis. In this study, three-week old ACI rats were fed a phytoestrogen-free diet or a diet containing 250 ppm GEN. At nine weeks of age, the rats were implanted with 20 mg pellets containing either 2 mg 17β-estradiol (E2)/18 mg cholesterol or cholesterol alone. The appearance of palpable mammary tumors (MTs) was recorded. Our results show that E2-treated rats fed the GEN diet both prepubertally and as adults had the highest incidence of palpable MTs. E2-treated rats fed the GEN diet only prepubertally had delayed appearance of palpable MTs but the incidence quickly approached that of the rats fed GEN for the whole treatment period. Dietary GEN fed to adult E2-treated rats had the lowest incidence of MT. Rats implanted with the cholesterol pellet and fed either diet did not develop MTs.

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Author information

Authors and Affiliations

  1. Joint Graduate Program in Toxicology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA

    Valerie K. Turan & Paul E. Thomas

  2. Laboratory for Cancer Research, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA

    Paul E. Thomas

Authors
  1. Valerie K. Turan
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  2. Kenneth R. Reuhl
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  3. Paul E. Thomas
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Editor information

Editors and Affiliations

  1. Division of Etiology and Prevention of Hormonal Cancers, The University of Kansas Medical Center, 3901 Rainbow Boulevard, 2010 Breidenthal, Kansas City, KS, 66160-7417

    Jonathan J. Li (Profesor of Pharmacology, Toxicology and Therapeutics and Director) & Sara A. Li (Associate Research Professor of Pharmacology, Toxicology and Therapeutics) (Profesor of Pharmacology, Toxicology and Therapeutics and Director) &  (Associate Research Professor of Pharmacology, Toxicology and Therapeutics)

  2. Departmento de Patologia, Facultad de Medicina y Odontologia, Camino de Vera s/n, Valencia, 46071, Spain

    Antonio Llombart-Bosch (Director) (Director)

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© 2005 Springer Science+Business Media, Inc.

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Turan, V.K., Reuhl, K.R., Thomas, P.E. (2005). Effect of Dietary Genistein on Estradiol-induced Mammary Carcinogenesis in the ACI Rat. In: Li, J.J., Li, S.A., Llombart-Bosch, A. (eds) Hormonal Carcinogenesis IV. Springer, Boston, MA. https://doi.org/10.1007/0-387-23761-5_40

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  • DOI: https://doi.org/10.1007/0-387-23761-5_40

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-23783-1

  • Online ISBN: 978-0-387-23761-9

  • eBook Packages: MedicineMedicine (R0)

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