Summary and Conclusions
Several conclusions can be reached from the data presented. (1). Id-1 protein is an important biomarker for PCA. (2). The level of its expression is related to the malignancy of the PCA. (3). Id-1 expression levels in PCA tissue samples has the potential to be used as a prognostic marker since high Id-1 expression is related to poor prognosis; and low expression to good prognosis. (4). One of the possible pathways for Id-1 gene action is through the inactivation of the p16/Rb tumor suppressor pathway. (5). The activation of the MAPK signaling pathway is a cell proliferation pathways induced by Id-1. (6). Activation of the Id-1 gene may be an important step in the transition stage of PCA cells from androgen-dependent to androgen-independent state, the most malignant form of PCA.
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Wong, Y.C., Ling, M.T., Wang, X.H., Ouyang, X.S., Cheung, A.L.M., Chan, F.L. (2005). Id-1 Protein as a New Marker for PCA. In: Li, J.J., Li, S.A., Llombart-Bosch, A. (eds) Hormonal Carcinogenesis IV. Springer, Boston, MA. https://doi.org/10.1007/0-387-23761-5_16
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DOI: https://doi.org/10.1007/0-387-23761-5_16
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