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The Lifecycle of Secretory Vesicles: Implications for Dendritic Transmitter Release

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Dendritic Neurotransmitter Release

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Abstract

In this brief review we have attempted to highlight the core principles and mechanism of regulated exocytosis and highlight some of the key questions and opportunities for analysis of the vesicle lifecycle in dendrites. Many questions remain: how are secretory vesicles targeted to dendrites? Does local vesicle biogenesis or recycling occur in dendrites? Do functionally distinct vesicle pools reside in the dendrite? Are secretory vesicles docked at active zones with distinct Ca2+ channels in dendrites? Are SVs and LDCVs differentially targeted and regulated in dendrites? How is vesicle priming and recycling controlled? We are entering a fascinating period in which many key molecular, biochemical, imaging, biophysical and bioinformatics tools can be assembled to allow functional analysis of dendritic release and forge the framework to understand the integrative function of dendritic retrograde signalling in health & disease.

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Authors and Affiliations

  1. Membrane Biology Group, School of Biomedical and Clinical Laboratory Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK

    Michael J. Shipston

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  1. David K. Apps
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  2. Michael A. Cousin
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  3. Rory R. Duncan
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  4. Ulrich K. Wiegand
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  5. Michael J. Shipston
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  1. Edinburgh University Medical School, Edinburgh, Scotland

    Mike Ludwig

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Apps, D.K., Cousin, M.A., Duncan, R.R., Wiegand, U.K., Shipston, M.J. (2005). The Lifecycle of Secretory Vesicles: Implications for Dendritic Transmitter Release. In: Ludwig, M. (eds) Dendritic Neurotransmitter Release. Springer, Boston, MA. https://doi.org/10.1007/0-387-23696-1_3

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