HIV and Associated Infections in the Intensive Care Unit: Perspectives from North America

  • Scott E. Evans
  • Andrew H. Limper
Part of the Perspective on Critical Care Infectious Diseases book series (CCID, volume 9)


Human Immunodeficiency Virus Intensive Care Unit Admission Progressive Multifocal Leukoencephalopathy Pneumocystis Pneumonia Human Immunodeficiency Virus Patient 
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  1. 1.
    Nakashima AK, Fleming PL. HIV/AIDS surveillance in the United States, 1981–2001. J Acquir Immune Defic Syndr 2003; 32Suppl 1:S68–85.PubMedGoogle Scholar
  2. 2.
    UNAIDS/WHO global AIDS statistics. AIDS Care 2003; 15:144.Google Scholar
  3. 3.
    Torres RA, Barr M. Impact of combination therapy for HIV infection on inpatient census. N Engl J Med 1997; 336:1531–1532.PubMedCrossRefGoogle Scholar
  4. 4.
    Nuesch R, Geigy N, Schaedler E, et al. Effect of highly active antiretroviral therapy on hospitalization characteristics of HIV-infected patients. Eur J Clin Microbiol Infect Dis 2002; 21:684–687.PubMedCrossRefGoogle Scholar
  5. 5.
    Ghani AC, Donnelly CA, Anderson RM. Patterns of antiretroviral use in the United States of America: analysis of three observational databases. HIV Med 2003; 4:24–32.PubMedCrossRefGoogle Scholar
  6. 6.
    Palella FJ, Jr., Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338:853–860.PubMedCrossRefGoogle Scholar
  7. 7.
    Afessa B, Green B. Clinical course, prognostic factors, and outcome prediction for HIV patients in the ICU. The PIP (Pulmonary complications, ICU support, and prognostic factors in hospitalized patients with HIV) study. Chest 2000; 118:138–145.PubMedCrossRefGoogle Scholar
  8. 8.
    De Palo VA, Millstein BH, Mayo PH, et al. Outcome of intensive care in patients with HIV infection. Chest 1995; 107:506–510.PubMedCrossRefGoogle Scholar
  9. 9.
    Rosen MJ, Clayton K, Schneider RF, et al. Intensive care of patients with HIV infection: utilization, critical illnesses, and outcomes. Pulmonary Complications of HIV Infection Study Group. Am J Respir Crit Care Med 1997; 155:67–71.PubMedGoogle Scholar
  10. 10.
    Wachter RM, Luce JM, Turner J, et al. Intensive care of patients with the acquired immunodeficiency syndrome. Outcome and changing patterns of utilization. Am Rev Respir Dis 1986; 134:891–896.PubMedGoogle Scholar
  11. 11.
    Wachter RM, Luce JM, Safrin S, et al. Cost and outcome of intensive care for patients with AIDS, Pneumocystis carinii pneumonia, and severe respiratory failure. Jama 1995; 273:230–235.PubMedCrossRefGoogle Scholar
  12. 12.
    Rosen MJ. Intensive care of patients with HIV infection. Semin Respir Infect 1999; 14:366–371.PubMedGoogle Scholar
  13. 13.
    Morris A, Creasman J, Turner J, et al. Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapy. Am J Respir Crit Care Med 2002; 166:262–267.PubMedCrossRefGoogle Scholar
  14. 14.
    Casalino E, Mendoza-Sassi G, Wolff M, et al. Predictors of short-and long-term survival in HIV-infected patients admitted to the ICU. Chest 1998; 113:421–429.PubMedCrossRefGoogle Scholar
  15. 15.
    Curtis JR, Bennett CL, Horner RD, et al. Variations in intensive care unit utilization for patients with human immunodeficiency virus-related Pneumocystis carinii pneumonia: importance of hospital characteristics and geographic location. Crit Care Med 1998; 26:668–675.PubMedCrossRefGoogle Scholar
  16. 16.
    Randall Curtis J, Yarnold PR, Schwartz DN, et al. Improvements in outcomes of acute respiratory failure for patients with human immunodeficiency virus-related Pneumocystis carinii pneumonia. Am J Respir Crit Care Med 2000; 162:393–398.PubMedGoogle Scholar
  17. 17.
    Ledergerber B, Egger M, Opravil M, et al. Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study. Lancet 1999; 353:863–868.PubMedCrossRefGoogle Scholar
  18. 18.
    Masur H. Critically Ill Immunosuppressed Host. In: Parrillo JE, Dellinger RP, eds. Critical Care Medicine: Principles of DIagnosis and Management in the Adult St. Louis: Mosby, 2001; 1089–1108Google Scholar
  19. 19.
    Dasgupta A, Okhuysen PC. Pharmacokinetic and other drug interactions in patients with AIDS. Ther Drug Monit 2001; 23:591–605.PubMedCrossRefGoogle Scholar
  20. 20.
    Soni N, Pozniak A. Continuing HIV therapy in the ICU. Crit Care 2001; 5:247–248.PubMedCrossRefGoogle Scholar
  21. 21.
    French M, Price P. Immune restoration disease in HIV patients: aberrant immune responses after antiretroviral therapy. J HIV Ther 2002; 7:46–51.PubMedGoogle Scholar
  22. 22.
    Wendel KA, Alwood KS, Gachuhi R, et al. Paradoxical worsening of tuberculosis in HIV-infected persons. Chest 2001; 120:193–197.PubMedCrossRefGoogle Scholar
  23. 23.
    Wislez M, Bergot E, Antoine M, et al. Acute respiratory failure following HAART introduction in patients treated for Pneumocystis carinii pneumonia. Am J Respir Crit Care Med 2001; 164:847–851.PubMedGoogle Scholar
  24. 24.
    Morris A, Wachter RM, Luce J, et al. Improved survival with highly active antiretroviral therapy in HIV-infected patients with severe Pneumocystis carinii pneumonia. Aids 2003; 17:73–80.PubMedCrossRefGoogle Scholar
  25. 25.
    Reilly JM, Cunnion RE, Anderson DW, et al. Frequency of myocarditis, left ventricular dysfunction and ventricular tachycardia in the acquired immune deficiency syndrome. Am J Cardiol 1988; 62:789–793.PubMedCrossRefGoogle Scholar
  26. 26.
    Berger JR, Sabet A. Infectious myelopathies. Semin Neurol 2002; 22:133–142.PubMedCrossRefGoogle Scholar
  27. 27.
    Ullrich R, Zeitz M, Heise W, et al. Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV): evidence for HIV-induced enteropathy. Ann Intern Med 1989; 111:15–21.PubMedGoogle Scholar
  28. 28.
    Call SA, Heudebert G, Saag M, et al. The changing etiology of chronic diarrhea in HIV-infected patients with CD4 cell counts less than 200 cells/mm3. Am J Gastroenterol 2000; 95:3142–3146.PubMedCrossRefGoogle Scholar
  29. 29.
    Bini EJ, Cohen J. Impact of protease inhibitors on the outcome of human immunodeficiency virus-infected patients with chronic diarrhea. Am J Gastroenterol 1999; 94:3553–3559.PubMedCrossRefGoogle Scholar
  30. 30.
    Nannini EC, Okhuysen PC. HIV1 and the gut in the era of highly active antiretroviral therapy. Curr Gastroenterol Rep 2002; 4:392–398.PubMedCrossRefGoogle Scholar
  31. 31.
    McArthur JC. Neurologic manifestations of AIDS. Medicine (Baltimore) 1987; 66:407–437.Google Scholar
  32. 32.
    Suffredini AF, Ognibene FP, Lack EE, et al. Nonspecific interstitial pneumonitis: a common cause of pulmonary disease in the acquired immunodeficiency syndrome. Ann Intern Med 1987; 107:7–13.PubMedGoogle Scholar
  33. 33.
    Beck JM, Rosen MJ, Peavy HH. Pulmonary complications of HIV infection. Report of the Fourth NHLBI Workshop. Am J Respir Crit Care Med 2001; 164:2120–2126.PubMedGoogle Scholar
  34. 34.
    Singh F, Rudikoff D. HIV-Associated Pruritus: Etiology and Management. Am J Clin Dermatol 2003; 4:177–188PubMedCrossRefGoogle Scholar
  35. 35.
    Koutsilieri E, Scheller C, Sopper S, et al. Psychiatric complications in human immunodeficiency virus infection. J Neurovirol 2002; 8Suppl 2:129–133.PubMedCrossRefGoogle Scholar
  36. 36.
    Ratner L. Human immunodeficiency virus-associated autoimmune thrombocytopenic purpura: a review. Am J Med 1989; 86:194–198.PubMedCrossRefGoogle Scholar
  37. 37.
    Little RF, Wilson WH. Update on the Pathogenesis, Diagnosis, and Therapy of AIDS-related Lymphoma. Curr Infect Dis Rep 2003; 5:176–184.PubMedCrossRefGoogle Scholar
  38. 38.
    Scadden DT. AIDS-related malignancies. Annu Rev Med 2003;54:285–303PubMedCrossRefGoogle Scholar
  39. 39.
    Masur H, Ognibene FP, Yarchoan R, et al. CD4 counts as predictors of opportunistic pneumonias in human immunodeficiency virus (HIV) infection. Ann Intern Med 1989; 111:223–231.PubMedGoogle Scholar
  40. 40.
    Jones JL, Hanson DL, Dworkin MS, et al. Surveillance for AIDS-defining opportunistic illnesses, 1992–1997. MMWR CDC Surveill Summ 1999; 48:1–22.PubMedGoogle Scholar
  41. 41.
    Wolff AJ, O’Donnell AE. Pulmonary manifestations of HIV infection in the era of highly active antiretroviral therapy. Chest 2001; 120:1888–1893.PubMedCrossRefGoogle Scholar
  42. 42.
    Montaner JS, Lawson LM, Levitt N, et al. Corticosteroids prevent early deterioration in patients with moderately severe Pneumocystis carinii pneumonia and the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1990; 113:14–20.PubMedGoogle Scholar
  43. 43.
    Consensus statement on the use of corticosteroids as adjunctive therapy for pneumocystis pneumonia in the acquired immunodeficiency syndrome. The National Institutes of Health-University of California Expert Panel for Corticosteroids as Adjunctive Therapy for Pneumocystis Pneumonia. N Engl J Med 1990; 323:1500–1504.Google Scholar
  44. 44.
    Limper AH, Offord KP, Smith TF, et al. Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis 1989; 140:1204–1209.PubMedGoogle Scholar
  45. 45.
    Wright TW, Gigliotti F, Finkelstein JN, et al. Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia. J Clin Invest 1999; 104:1307–1317.PubMedCrossRefGoogle Scholar
  46. 46.
    Kumar SD, Krieger BP. CD4 lymphocyte counts and mortality in AIDS patients requiring mechanical ventilator support due to Pneumocystis carinii pneumonia. Chest 1998; 113:430–433.PubMedCrossRefGoogle Scholar
  47. 47.
    Schein RM, Fischl MA, Pitchenik AE, et al. ICU survival of patients with the acquired immunodeficiency syndrome. Crit Care Med 1986; 14:1026–1027.PubMedGoogle Scholar
  48. 48.
    Confalonieri M, Calderini E, Terraciano S, et al. Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia. Intensive Care Med 2002; 28:1233–1238.PubMedCrossRefGoogle Scholar
  49. 49.
    Barnes PF, Bloch AB, Davidson PT, et al. Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med 1991; 324:1644–1650.PubMedGoogle Scholar
  50. 50.
    Daley CL, Small PM, Schecter GF, et al. An outbreak of tuberculosis with accelerated progression among persons infected with the human immunodeficiency virus. An analysis using restriction-fragment-length polymorphisms. N Engl J Med 1992; 326:231–235.PubMedCrossRefGoogle Scholar
  51. 51.
    Rosenberg AL, Seneff MG, Atiyeh L, et al. The importance of bacterial sepsis in intensive care unit patients with acquired immunodeficiency syndrome: implications for future care in the age of increasing antiretroviral resistance. Crit Care Med 2001; 29:548–556.PubMedCrossRefGoogle Scholar
  52. 52.
    Brown MC, Crede WB. Predictive ability of acute physiology and chronic health evaluation II scoring applied to human immunodeficiency virus-positive patients. Crit Care Med 1995; 23:848–853.PubMedCrossRefGoogle Scholar
  53. 53.
    Bonarek M, Morlat P, Chene G, et al. Prognostic score of short-term survival in HIV-infected patients admitted to medical intensive care units. Int J STD AIDS 2001; 12:239–244.PubMedCrossRefGoogle Scholar
  54. 54.
    Alves C, Nicolas JM, Miro JM, et al. Reappraisal of the aetiology and prognostic factors of severe acute respiratory failure in HIV patients. Eur Respir J 2001; 17:87–93.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Scott E. Evans
    • 1
  • Andrew H. Limper
    • 1
  1. 1.Division of PulmonaryCritical Care Medicine and Internal Medicine, Mayo Clinic and FoundationRochesterUSA

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