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Clusterin and Alzheimer’s Disease

  • Miguel Calero
  • Agueda Rostagno
  • Blas Frangione
  • Jorge Ghiso
Part of the Subcellular Biochemistry book series (SCBI, volume 38)

Abstract

Clusterin (apolipoprotein J) is a ubiquitous multifunctional glycoprotein with the capability to interact with a broad spectrum of molecules, among them the Alzheimer’s Aβ peptide. Due to its colocalization with fibrillar deposits in systemic and cerebral amyloid disorders, clusterin is also considered an amyloid-associated protein. Although no genuine function has been attributed to this protein so far, it has been implicated in a wide variety of physiological and pathological processes, a role that may vary according to the protein maturation, sub-cellular localization, and the presence of certain tissue- or cell-specific factors. This review focuses on the importance of clusterin in health and disease conditions, with particular emphasis in its role in Aβ amyloidosis and other disorders of protein folding.

Key words

apolipoprotein J amyloid β cerebral amyloidosis neuroprotection neurotoxicity 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Miguel Calero
    • 1
    • 2
  • Agueda Rostagno
    • 2
  • Blas Frangione
    • 2
  • Jorge Ghiso
    • 2
  1. 1.Centro National de MicrobiologíaInstituto de Salud Carlos IIIMajadahonda, MadridSpain
  2. 2.Department of PathologyNew York University School of MedicineNew YorkUSA

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