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The Interaction of Amyloid-β with ApoE

The form of beta amyloid is a partial determinant of the interaction with Apolipoprotein E
  • Donald B. Carter
Part of the Subcellular Biochemistry book series (SCBI, volume 38)

Abstract

Brain plaque deposition in the form of amyloid-beta (Aβ) peptide is a pathological hallmark of Alzheimer’s disease (AD). Apolipoprotein E (ApoE) is thought to be involved in plaque formation. Individuals afflicted with AD carrying the ApoE4 isoform have shown a greater number of Aβ plaques when compared to ApoE3 carriers, and inheritance of an ApoE4 allele increases the risk of AD when compared to ApoE2 and ApoE3 carriers. The role of ApoE in the pathogenesis of AD is not well understood but a hypothesis gaining widespread support is that ApoE is involved in deposition or clearance of Aβ by direct protein-to-protein interaction. We have established that various human Aβ conformations apparent during spontaneous aggregation confer differing degrees of binding to the three ApoE isoforms. When associated with lipid, ApoE4 bound preferentially to an intermediate aggregated form of Aβ and had higher avidity than did ApoE2 or ApoE3.

Key words

Apolipoprotein E (ApoE) amyloid-beta (Aβ) protofibrils cerebral spinal fluid (CSF) 

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Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Donald B. Carter
    • 1
  1. 1.CNS TherapeuticsPfizer CorporationKalamazooUSA

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