Lung Cancer pp 280-298 | Cite as

Molecular Events in Lung Cancer and Implications for Prevention and Therapy

  • Walter N. Hittelman
  • Jonathan M. Kurie
  • Stephen G. Swisher
Part of the M.D. Anderson Cancer Care Series book series (MDCCS)


Lung Cancer Small Cell Lung Cancer Lung Tumor Lung Cancer Risk Small Cell Lung Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Suggested Readings

  1. Fong KM, Sekido Y, Minna JD. Molecular pathogenesis of lung cancer. J Thorac Cardiovasc Surg 1999;118:1136–1152.CrossRefPubMedGoogle Scholar
  2. Gazdar AF, Minna JD. Targeted therapies for killing tumor cells. Proc Natl Acad Sci U S A 2001;98:10028–10030.CrossRefPubMedGoogle Scholar
  3. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57–70.CrossRefPubMedGoogle Scholar
  4. Hirsch FR, Franklin WA, Gazdar AF, et al. Early detection of lung cancer: clinical perspectives of recent advances in biology and radiology. Clin Cancer Res 2001;7:5–22.PubMedGoogle Scholar
  5. Hittelman WN. Genetic instability assessments in the lung cancerization field. In: Brambilla C, Brambilla E, eds. Lung Tumors: Fundamental Biology and Clinical Management. New York, NY: Marcel Dekker; 1999:255–267.Google Scholar
  6. Hittelman WN. Molecular cytogenetic evidence for multistep tumorigenesis: implications for risk assessment and early detection. In: Srivastava S, Hensen DE, Gazdar A, eds. Molecular Pathology of Early Cancer. Washington, DC: IOS Press; 1999:385–404.Google Scholar
  7. Hong WK, Spitz MR, Lippman SM. Cancer chemoprevention in the 21st century: genetics, risk modeling, and molecular targets. J Clin Oncol 2000;18(21 suppl):9S–18S.PubMedGoogle Scholar
  8. Khuri FR, Kurie JM. Antisense approaches enter the clinic. Clin Cancer Res 2000;6:1607–1610.PubMedGoogle Scholar
  9. Kim ES, Hong WK, Khuri FR. Prevention of lung cancer. The new millennium. Chest Surg Clin N Am 2000;10:663–690.PubMedGoogle Scholar
  10. Kurie JM. The biological basis for the use of retinoids in cancer prevention and treatment. Curr Opin Oncol 1999;11:497–502.CrossRefPubMedGoogle Scholar
  11. Kurie JM, Lippman SM, Hong WK. Chemoprevention trials: epithelial carcinogenesis and the biological basis of intervention. In: Bertino JR, ed. Encyclopedia of Cancer. Vol 1. San Diego, Calif: Academic Press; 1996;341–354.Google Scholar
  12. Lippman SM, Spitz MR. Lung cancer chemoprevention: an integrated approach. J Clin Oncol 2001;19(18 suppl):74S–82S.PubMedGoogle Scholar
  13. Mao L, Lee JS, Kurie JM, et al. Clonal genetic alterations in the lungs of current and former smokers. J Natl Cancer Inst 1997;89:857–862.CrossRefPubMedGoogle Scholar
  14. Saccomano G, Archer VE, Auerbach O, et al. Development of carcinoma of the lung as reflected in exfoliated cells. Cancer 1974;33:256–270.Google Scholar
  15. Spitz MR, Wei Q, Li G, et al. Genetic susceptibility to tobacco carcinogenesis. Cancer Invest 1999;17:645–659.PubMedCrossRefGoogle Scholar
  16. Swisher SG, Roth JA. Gene therapy in lung cancer. Curr Oncol Rep 2000;2:64–70.PubMedGoogle Scholar
  17. Swisher SG, Roth JA, Komaki R, et al. A phase II trial of adenoviral mediated p53 gene transfer (RPR/INGN 201) in conjunction with radiation therapy in patients with localized non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2000;19:461.Google Scholar
  18. Swisher SG, Roth JA, Nemunaitis J, et al. Adenovirus-mediated p53 gene transfer in advanced non-small-cell lung cancer. J Natl Cancer Inst 1999;91:763–771.CrossRefPubMedGoogle Scholar
  19. Tockman MS, Mulshine JL, Piantadosi S, et al. Prospective detection of preclinical lung cancer: results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression. Clin Cancer Res 1997;3(12 Pt 1):2237–2246.PubMedGoogle Scholar
  20. Tong L, Spitz MR, Fueger JJ, et al. Lung carcinoma in former smokers. Cancer 1996;78:1004–1010.CrossRefPubMedGoogle Scholar
  21. Wistuba II, Gazdar AF, Minna JD. Molecular genetics of small cell lung carcinoma. Semin Oncol 2001;28(2 suppl 4):3–13.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 2003

Authors and Affiliations

  • Walter N. Hittelman
  • Jonathan M. Kurie
  • Stephen G. Swisher

There are no affiliations available

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