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Adolescent Alcohol Drinking and Its Long-Range Consequences

Studies with Animal Models
  • William J. McBride
  • Richard L. Bell
  • Zachary A. Rodd
  • Wendy N. Strother
  • James M. Murphy
Part of the Recent Developments in Alcoholism book series (RDIA, volume 17)

Abstract

This chapter reviews findings, mainly obtained from the selectively bred alcohol-preferring (P) line of rats, on (a) the development of alcohol drinking during the peri-adolescent period, (b) neurobiological factors that may contribute to adolescent drinking, (c) interventions to prevent alcohol drinking during adolescence, and (d) some long-lasting consequences of adolescent alcohol drinking. The findings indicate that P rats readily initiate alcohol drinking during the early post-weaning, adolescent and peri-adolescent periods of development. The early age-of-onset of alcohol drinking in the P compared to the NP line is associated with (a) higher densities of serotonin-lA (5-HT1IA) receptors in cerebral cortical and hippocampal regions; (b) lower densities of dopamine (DA) D2 receptors in the ventral tegmental area (VTA); (c) higher functional activity in several limbic, cortical and hippocampal regions; and (d) sensitivity to the low-dose stimulating effect of ethanol. Conditioned taste aversion (CTA) training during adolescence produces long-term effects on preventing high alcohol drinking behavior of P rats. Alcohol drinking during peri-adolescence by P rats produces long-lasting effects that increase the acquisition of ethanol self-administration in adulthood, and, in addition, increase craving-like behavior and the potential for alcohol relapse. With suitable animal models, a better understanding of the mechanisms underlying adolescent alcohol drinking and its long-range consequences can be attained.

Keywords

Ventral Tegmental Area Alcohol Drinking Conditioned Taste Aversion Acoustic Startle Response Ethanol Drinking 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers 2005

Authors and Affiliations

  • William J. McBride
    • 1
  • Richard L. Bell
    • 1
  • Zachary A. Rodd
    • 1
  • Wendy N. Strother
    • 1
  • James M. Murphy
    • 1
  1. 1.Institute of Psychiatric ResearchIndiana University School of MedicineIndianapolis

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