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Yersinia Outer Protein E, YopE

A Versatile Type III Effector Molecule for Cytosolic Targeting of Heterologous Antigens by Attenuated Salmonella

  • Chapter
The Genus Yersinia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 529))

Abstract

Many Gram-negative pathogens evade the host’s immune response by utilizing a specialized protein secretion machinery, known as type III secretion system (TTSS). Virulence factors such as the Yersinia outer protein E (YopE) are delivered directly into the cytosol of target cells in a TTSS-dependent fashion. This unique translocation mechanism can be used by attenuated Salmonella carrier vaccines for the delivery of heterologous antigens fused to YopE into the MHC class I-restricted antigen processing pathway. In orally immunized mice, this novel vaccination strategy results in the induction of pronounced peptide-specific cytotoxic CD8 T cell responses.

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Author information

Authors and Affiliations

  1. Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universität München, Pettenkoferstrasse 9a, 80336, München, Germany

    Holger Rüssmann

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  1. Holger Rüssmann
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Editors and Affiliations

  1. University of Helsinki, Helsinki, Finland

    Mikael Skurnik

  2. Hospital Son Dureta, Palma Mallorca, Spain

    José Antonio Bengoechea

  3. National Public Health Institute, Turku, Finland

    Kaisa Granfors

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© 2004 Kluwer Academic Publishers

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Rüssmann, H. (2004). Yersinia Outer Protein E, YopE. In: Skurnik, M., Bengoechea, J.A., Granfors, K. (eds) The Genus Yersinia. Advances in Experimental Medicine and Biology, vol 529. Springer, Boston, MA. https://doi.org/10.1007/0-306-48416-1_81

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  • DOI: https://doi.org/10.1007/0-306-48416-1_81

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47759-1

  • Online ISBN: 978-0-306-48416-2

  • eBook Packages: Springer Book Archive

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