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Multidrug-resistant Tuberculosis (MDRTB)

  • Chapter
Reemergence of Established Pathogens in the 21st Century

Part of the book series: Emerging Infectious Diseases of the 21st Century ((EIDC,volume 2))

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Summary

From a U.S. perspective, the problem of MDRTB has been greatly ameliorated through the use of standardized four-drug regimens in the initial phase of treatment, rapid DST, directly observed therapy, and improved infection control practices. The importation of MDRTB cases from countries with high levels of drug resistance, however, will continue to challenge TB control efforts in the United States. In other areas of the world, the rapid emergence of MDRTB represents an even greater challenge to such efforts, and will require the influx of significant resources and expertise to meet this challenge. Given that the best treatment of MDRTB is its prevention, the expansion of DOTS to prevent the production of MDRTB and the careful expansion of DOTS-Plus to treat existing cases and prevent further transmission of MDR M. tuberculosis are critical. In addition, as the HIV epidemic reaches areas in which the prevalence of TB and antituberculosis drug resistance are high, a concerted effort to treat these coexisting diseases will be essential to mitigate the convergence of factors that led to the large outbreaks of MDRTB that occurred in the United States in the early 1990s.

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Authors
  1. Philip Spradling
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  2. Renee Ridzon
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Editors and Affiliations

  1. St. Michael’s Hospital, University of Toronto Head of Infectious Diseases, Canada

    I. W. Fong

  2. St. Michael’s Hospital, University of Toronto, Toronto, Ontario, Canada

    I. W. Fong

  3. The Public Health Research Institute, Newark, New Jersey

    Karl Drlica

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© 2004 Kluwer Academic Publishers

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Spradling, P., Ridzon, R. (2004). Multidrug-resistant Tuberculosis (MDRTB). In: Fong, I.W., Drlica, K. (eds) Reemergence of Established Pathogens in the 21st Century. Emerging Infectious Diseases of the 21st Century, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-306-48411-0_7

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  • DOI: https://doi.org/10.1007/0-306-48411-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-47500-9

  • Online ISBN: 978-0-306-48411-7

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