Vancomycin-resistant Enterococci

  • Esteban C. Nannini
  • Barbara E. Murray
Part of the Emerging Infectious Diseases of the 21st Century book series (EIDC, volume 2)


The incidence of nosocomial infections caused by VRE has consistently increased during the past decade across all types of health-care facilities, especially in the United States. More rigorous infection control measures and reduction in the use of antimicrobials for the treatment of human infections and/or new preventative modalities will likely be necessary to decrease the development of drug resistance in enterococci, as well as in other microorganisms. Restriction of the use of antibiotics as animal growth enhancers in the EU has resulted in decreased transmission of these organisms (and their resistant genes) from animals to humans. This interchange between animals and humans has become even more worrisome after a recent description of an E. faecium outbreak causing severe hemorrhagic disease in pigs and 40 local farmers (12 of them died) in a region of China (Lu et al., 2002). Newer therapeutic agents have been developed and used with relative effectiveness (although without a bactericidal activity) for the treatment of VRE infections, but the propensity of enterococci to develop resistance suggest that VRE will continue to be a therapeutic and infection control challenge for the immediate future.


Antimicrob Agent Vancomycin Resistance National Nosocomial Infection Surveillance Infect Control Hosp Glycopeptide Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Kluwer Academic Publishers 2004

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  • Esteban C. Nannini
  • Barbara E. Murray

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