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Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention pp 195–213Cite as

Tight Junctions, a Critical Structure in the Control of Cancer Invasion and Metastasis

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Part of the book series: Cancer Metastasis — Biology and Treatment ((CMBT,volume 1))

Abstract

Tight junction is the apical most structure in epithelium as well as in the endothelium. Its main function is to control the paracellular diffusion of ions and certain molecules. Although the structure has been known for decades, the molecular composition of the tight junction has only been recognised in the past decade. Molecules making up tight junctions include the transmembrane proteins occludin, claudin and paracellin, and cytoplasmic proteins, MAGUK family members. The structure has now been demonstrated as also having a role in the control of cancer cell penetration of the endothelium and in the development of cancer.

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  1. Wen G. Jiang
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  2. Tracey Martin
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  3. Iraj Llaffafian
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  4. Robert E. Mansel
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  1. University of Wales College of Medicine, UK

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Jiang, W.G., Martin, T., Llaffafian, I., Mansel, R.E. (2000). Tight Junctions, a Critical Structure in the Control of Cancer Invasion and Metastasis. In: Jiang, W.G., Mansel, R.E. (eds) Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention. Cancer Metastasis — Biology and Treatment, vol 1. Springer, Dordrecht. https://doi.org/10.1007/0-306-48388-2_7

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