Conclusion
None of MICA microsatellite alleles was significantly increased in Tunisian BD patients. Only HLA-B51 was primarily associated to BD in this population. These data, similar to those found in other ethnics6,9, further support the hypothesis that the amino-acids, common to all HLA-B51 encoding alleles and absent in other HLA-B antigens, probably confer high affinity binding for peptides that may contribute to BD development. However, the possibility that HLA-B contributes to the pathogenesis as an additional or complementary risk factor cannot be excluded.
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References
Mizuki, N., Inoko, H., and Ohno. S., 1997, Pathogenic gene responsible for the predisposition to Behçeťs disease. Intern. Rev. Immunol. 14: 33–48.
Mizuki, N., Ohno, S., Sato, T., et al., 1995, Microsatellite polymorphism located between the TNF and HLA-B genes in Behçeťs disease. Hum. Immunol. 43: 129–135.
Ota, M., Mizuki, N., Katsuyama, Y., et al., 1999, The critical region for Behçet disease in the human major histocompatibilité complex is reduced to a 46-K.b segment centromeric of HLA-B, by association analysis using refined microsatellite mapping. Am. J. Hum. Genet. 64: 1406–1410.
Mizuki, N., Ota, M., Kimura, M., et al., 1997, Triplet repeat polymorphism in the transmembrane region of the MICA gene: a stong association of six GCT repetitions with Behçeťs disease. Proc. Natl. Acad. Sci. 94: 1298–1303.
Yabuki, K., Mizuki, N., Ota, M., et al., 1999, Association of MICA gene and HLA-B*5101 with Behçeťs with disease in Greece. Invest. Opthalmol. Vis. Sci. 40: 1921–1926.
Gonzalez-Escribano, M.F., Rodriguez, M.R., Aguilar, F., et al., 1999, Lack of association of MICA transmembrane region polymorphism and Behçetť disease in Spain. Tissue Antigens 54: 278–281.
Cohen, R., Metzger, S., Nahir, M., et al., 2002, Association of the MIC-A gene and HLA-B51 with Behçeťs disease in Arabs and non-Ashkenazi Jews in Israel. Ann. Rheum. Dis. 61: 157–160.
Salvarani, C., Boiardi, L., Mantovani, V., et al., 2001, Association of MICA alleles and HLA-B51 in Italian patients with Behçeťs disease. J. Rheumatol. 28: 1867–1870.
Wallace, G.R., Verity, D.H., Delamaine, L.J., et al., 1999, MICA-A allele profiles and HLA class I associations in Behçeťs disease. Immunogenetics 49: 613–617.
Bunce, M., Fanning, G.C., and Welsh, K.I., 1995, Comprehensive, serologically equivalent DNA typing for HLA-B by PCR using sequence specific primers (PCR-SSP). Tissue Antigens 45: 81–90.
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Ben Ahmed, M. et al. (2004). MICA Transmembrane Region Polymorphism and HLA B51 in Tunisian Behçeťs Disease Patients. In: Zouboulis, C.C. (eds) Adamantiades-Behçet’s Disease. Advances in Experimental Medicine and Biology, vol 528. Springer, Boston, MA. https://doi.org/10.1007/0-306-48382-3_44
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DOI: https://doi.org/10.1007/0-306-48382-3_44
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