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Micrometastasis pp 127–138Cite as

Prognostic Value of Minimal Residual Disease in Esophageal Cancer

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Part of the Cancer Metastasis - Biology and Treatment book series (CMBT,volume 5)

Abstract

A substantial proportion of patients (40% to 50%) with supposedly localized esophageal cancer who had undergone curative surgical treatment with complete tumour removal suffer from a metastatic tumour relapse within 24 months after surgery. A reason for such an early tumour relapse in these patients might be a minimal tumour cell dissemination (minimal residual disease, MRD) present at the time of operation, which cannot be detected by clinical and routine histopathological tumour staging procedures. Over the past 10 years, more sensitive immunohisto-/-cytochemical and nucleic acid based assays have been developed that are based on the detection of epithelial cell-or tumour-associated marker proteins and are able to detect single tumour cells or small tumour cell clusters present in lymph nodes classified as tumour-free by conventional histopathologic analysis, bone marrow or blood. Here we present an overview of recent studies concerning the prevalence and prognostic value of occult tumour cells in lymph nodes and bone marrow of patients with esophageal cancer identified by antibody or nucleic acid based assays.

Keywords

  • Esophageal Cancer
  • Esophageal Squamous Cell Carcinoma
  • Reverse Transcriptase Polymerase Chain Reaction
  • Esophageal Carcinoma
  • Negative Lymph Node

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Authors and Affiliations

  1. Department of General and Thoracic Surgery, Universitätsklinikum Eppendorf, Martinistrasse 52, D-20246, Hamburg, Germany

    Peter Scheuemann, Stefan B. Hosch & Jacob R. Izbicki

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  1. Peter Scheuemann
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  2. Stefan B. Hosch
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  3. Jacob R. Izbicki
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Editor information

Editors and Affiliations

  1. Institute of Tumour Biology, University Hospital Hamburg-Eppendorf, Germany

    Klaus Pantel (Director) (Director)

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Scheuemann, P., Hosch, S.B., Izbicki, J.R. (2003). Prognostic Value of Minimal Residual Disease in Esophageal Cancer. In: Pantel, K. (eds) Micrometastasis. Cancer Metastasis - Biology and Treatment, vol 5. Springer, Dordrecht. https://doi.org/10.1007/0-306-48355-6_7

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  • DOI: https://doi.org/10.1007/0-306-48355-6_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1155-9

  • Online ISBN: 978-0-306-48355-4

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