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Micrometastasis pp 117–125Cite as

Early Disseminated Tumour Cells in Operable Non-Small Cell Lung Cancer

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Part of the Cancer Metastasis - Biology and Treatment book series (CMBT,volume 5)

Abstract

Metastasis to lymph nodes or distant organs is a well-known feature of poor prognosis in potentially resectable non-small cell lung cancer (NSCLC). However, a significant number of lymph node negative patients die early of metastatic disease. Therefore, it has to be assumed that in some patients an early tumour cell dissemination has occurred which is clearly underestimated by current staging procedures. Recently, it has been shown, that an early dissemination of individual carcinoma cells to regional lymph nodes or bone marrow can be detected by using sensitive immunocytochemical techniques with monoclonal antibodies against epithelium-specific proteins. The incidence of immunohistochemically positive patients varies between 30% and 70% depending on the type of primary tumour, the immunohistochemical staining procedure used and especially on the primary monoclonal antibody. The detection of disseminated tumour cells in lymph nodes or bone marrow by immunocytochemistry is associated with a poorer prognosis in lung cancer. In conclusion, the immunohistochemical detection of early disseminated tumour cells in lymph nodes or bone marrow can help to obtain a more exact identification of patients with an unfavorable prognosis. Whether the identified patients will gain from an adjuvant therapy needs to be evaluated in further studies.

Keywords

  • NSCLC Patient
  • Tumour Cell Dissemination
  • International Breast Cancer Study Group
  • Bone Marrow Status
  • Immunohistochemical Staining Procedure

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Pantel K, Riethmüller G. Micrometastasis detection and treatment with monoclonal antibodies. Curr Top Microbiol Immunol. 1996;213:1–18.

    PubMed  CAS  Google Scholar 

  2. Mountain CF. Revisions in the international system for staging lung cancer. Chest. 1997;111:1710–17.

    PubMed  CAS  Google Scholar 

  3. Passlick B, Pantel K. Prognostic factors in stage I non-small cell lung cancer. Zentralbl Chir. 1996;121:851–60.

    PubMed  CAS  Google Scholar 

  4. Chen ZL, Perez S, Holmes CE, Wang HJ, Coulson WF, Wen DR, Cochran AJ. Frequency and distribution of occult micrometastases in lymph nodes of patients with non-small cell lung cancer. J Natl Cancer Inst. 1993;85:493–8.

    PubMed  CAS  Google Scholar 

  5. Maruyama R, Sugio K, Mitsodomi T, Saitoh G, Ishida T, Sugimachi K. Relationship between early recurrence and micrometastases in the lymph nodes of patients with stage I non-small cell lung cancer. J Thorac Cardiovas Surg. 1997;114:535–43.

    CAS  Google Scholar 

  6. Passlick B, Izbicki JR, Kubuschok B, Nathrath W, Thetter O, Pichlmeier U, Schweiberer L, Riethmüller G, Pantel K. Immunohistochemical assessment of individual tumour cells in lymph nodes of patients with non-small cell lung cancer. J Clin Oncol. 1994;12:1827–32.

    PubMed  CAS  Google Scholar 

  7. Cote RJ, Beattie EJ, Chaiwun B, Shi SR, Harvey J, Chen SC, Sherrod AE, Groshen S, Taylor CR. Detection of occult bone marrow micrometastases in patients with operable lung carcinoma. Ann Surg. 1995;222:415–25.

    CrossRef  PubMed  CAS  Google Scholar 

  8. Ohgami A, Mitsodomi T, Sugio K, Tsuda T, Oyama T, Nishida K, Osaki T, Yasumoto K. Micrometastatic tumour cells in the bone marrow of patients with non-small cell lung cancer. Ann Thorac Surg. 1997;64:363–7.

    CrossRef  PubMed  CAS  Google Scholar 

  9. Pantel K, Izbicki JR, Passlick B, Angstwurm M, Häussinger K, Thetter O, Riethmüller G. Frequency and prognostic significance of isolated tumour cells detected in bone marrow of non-small cell lung cancer patients without overt metastases. Lancet. 1996;347:649–53.

    CrossRef  PubMed  CAS  Google Scholar 

  10. Pantel K, Dickmanns A, Zippelius F, Klein Ch, Hoechtelen-Vollmar B, Schlimok G, Weckermann D, Oberneder R, Shi J, Fanning E et al. Establishment of carcinoma cell lines from bone marrow of patients with minimal residual cancer: a novel source of tumor cell vaccines. J Natl Cancer Inst. 1995;87:1162–8.

    PubMed  CAS  Google Scholar 

  11. International Breast Cancer Study Group. Prognostic significance of occult axillary lymph node micrometastases from breast cancers. Lancet. 1990;335:1565–8.

    Google Scholar 

  12. Dowlatshahi K, Fan M, Snider HC, Habib FA. Lymph node micrometastases from breast carcinoma: reviewing the dilemma. Cancer. 1997;80:1188–97.

    CrossRef  PubMed  CAS  Google Scholar 

  13. Pantel K, Braun S, Passlick B, Schlimok G. Minimal residual epithelial cancer: diagnostic approaches and prognostic relevance. Prog Hstochem Cytochem. 1996;30:1–46.

    CAS  Google Scholar 

  14. Domagala W, Bedner E, Chosia M, Weber K, Osborn M. Keratin-positive reticulum cells in fine needle aspirates and touch imprints of hyperplastic lymph nodes. Acta Cytol. 1991;36:241–5.

    Google Scholar 

  15. Doglioni C, DellľOrto P, Zanetti G, Iuzzolino P, Coggi G, Viale G. Cytokeratin-immunoreactive cells of human lymph nodes and spleen in normal and pathological conditions. Virchows Archiv A Pathol Anat. 1990;416:479–90.

    CrossRef  CAS  Google Scholar 

  16. Momburg F, Moldenhauer G, Hämmerling GJ, Möller P. Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues. Cancer Res. 1987;47:2883–91.

    PubMed  CAS  Google Scholar 

  17. Latza U, Niedobitek G, Schwarting R, Nekarda H, Stein H. Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelia. J Clin Pathol. 1990;43:213–19.

    PubMed  CAS  Google Scholar 

  18. Debus E, Moll R, Franke WW, Weber K, Osborn M. Immunohistochemical distinction of human carcinomas by cytokeratin typing with monoclonal antibodies. Am J Pathol. 1984;114:121–30.

    PubMed  CAS  Google Scholar 

  19. Pantel K, Izbicki JR, Angstwurm M, Braun S, Passlick B, Karg O, Thetter O, Riethmüller G. Immunocytological detection of bone marrow micrometastasis in operable non-small cell lung cancer. Cancer Res. 1993;53:1027–31.

    PubMed  CAS  Google Scholar 

  20. Harrison WJ. The total cellularity of the bone marrow in man. J Clin Pathol. 1962 15:254–9.

    PubMed  CAS  Google Scholar 

  21. Hermanek P. pTNM and residual tumor classifications: problems of assessment and prognostic significance. World J Surg. 1995;19:184–90.

    PubMed  CAS  Google Scholar 

  22. Pantel K, Schlimok G, Braun S, Kutter D, Lindemann F, Schaller G, Funke I, Izbicki JR, Riethmüller G. Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. J Natl Cancer Inst. 1993;85:1419–24.

    PubMed  CAS  Google Scholar 

  23. Passlick B, Sienel W, Seen-Hilber R, Wückel W, Thetter O, Pantel K. The 17-1A antigen is expressed on primary, metastatic and disseminated non-small cell lung carcinoma cells. Int J Cancer. 2000;87:548–52.

    CrossRef  PubMed  CAS  Google Scholar 

  24. Kubuschok B, Passlick B, Izbicki JR, Thetter O, Pantel K. Disseminated tumor cells in lymph nodes as a determinant for survival in surgically resected non-small cell lung cancer. J Clin Oncol. 1999;17:19–24.

    PubMed  CAS  Google Scholar 

  25. Passlick B, Kubuschok B, Izbicki JR, Thetter O, Pantel K. Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer. Ann Thorac Surg. 1999;68:2053–8.

    CrossRef  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgery, Division of Thoracic Surgery, University of Munich, Germany

    Bernward Passlick

Authors
  1. Bernward Passlick
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Editors and Affiliations

  1. Institute of Tumour Biology, University Hospital Hamburg-Eppendorf, Germany

    Klaus Pantel (Director) (Director)

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© 2003 Kluwer Academic Publishers

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Passlick, B. (2003). Early Disseminated Tumour Cells in Operable Non-Small Cell Lung Cancer. In: Pantel, K. (eds) Micrometastasis. Cancer Metastasis - Biology and Treatment, vol 5. Springer, Dordrecht. https://doi.org/10.1007/0-306-48355-6_6

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  • DOI: https://doi.org/10.1007/0-306-48355-6_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-1155-9

  • Online ISBN: 978-0-306-48355-4

  • eBook Packages: Springer Book Archive

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