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Growth, Survival and Migration: The Trk to Cancer

  • Chapter
Signal Transduction in Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 115))

Conclusions

Trk signaling is of widespread importance during development as it regulates the differentiation, survival and migration of multiple cell types. Similar fanctions for Trks can be found in a wide variety of cancers. These activities not only determine the biology of these cancers but also offer a potentially unique target for the control of cancer cell growth and motility through the inhibition of the Trk kinase.

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Authors and Affiliations

  1. Department of Pediatric Oncology Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts

    Joshua B. Rubin & Rosalind A. Segal

  2. Department of Neurobiology, Harvard Medical School, Boston, Massachusetts

    Joshua B. Rubin & Rosalind A. Segal

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  1. Joshua B. Rubin
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  1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Frank MD, PhD

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Rubin, J.B., Segal, R.A. (2004). Growth, Survival and Migration: The Trk to Cancer. In: Frank, D.A. (eds) Signal Transduction in Cancer. Cancer Treatment and Research, vol 115. Springer, Boston, MA. https://doi.org/10.1007/0-306-48158-8_1

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