Growth, Survival and Migration: The Trk to Cancer

  • Joshua B. Rubin
  • Rosalind A. Segal
Part of the Cancer Treatment and Research book series (CTAR, volume 115)


Trk signaling is of widespread importance during development as it regulates the differentiation, survival and migration of multiple cell types. Similar fanctions for Trks can be found in a wide variety of cancers. These activities not only determine the biology of these cancers but also offer a potentially unique target for the control of cancer cell growth and motility through the inhibition of the Trk kinase.


Nerve Growth Factor Papillary Thyroid Cancer Human Neuroblastoma Cell Neurotrophin Receptor Nerve Growth Factor Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Joshua B. Rubin
    • 1
    • 2
  • Rosalind A. Segal
    • 1
    • 2
  1. 1.Department of Pediatric Oncology Dana Farber Cancer InstituteHarvard Medical SchoolBoston
  2. 2.Department of NeurobiologyHarvard Medical SchoolBoston

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