10.3. Summary
In this chapter the relationship between initial velocity as well as its operational parameters and the energy transitions associated with the conversion of each intermediate to every downstream transition state with which it is connected by reversible steps has been derived. In addition the conceptual and mathematical model was developed for the effect of changes in the magnitude of these energy transitions on the initial velocity, and its operational parameters. In the following chapters the effects of changes in specific environmental conditions will be related to the initial velocity by virtue of the changes in the energy of specific chemical transitions. In this way the effect of changes in environmental conditions on the kinetic parameters can be at least partially interpreted in terms of the chemical mechanism.
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10.4. References
Albery, J. and Knowles, J.R. “Evolution of Enzyme Function and the Development of Catalytic Efficiency,” Biochemistry, 15, 5631–40 (1976).
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© 2004 Kluwer Academic Publishers
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(2004). The Thermodynamics of Initial Velocity. In: Enzyme Kinetics and Mechanisms. Springer, Dordrecht. https://doi.org/10.1007/0-306-48025-5_10
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DOI: https://doi.org/10.1007/0-306-48025-5_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-4020-0728-6
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