Conclusions
A variety of studies demonstrate a central role for ASM and ceramide in several forms of apoptosis. Ceramide seems to regulate the activity of certain proteins and, thus, may function, in some circumstances, as a second messenger. In addition, the concept of raft modification by ceramide provides a comprehensive model for cellular effects of ceramide, and perhaps a biophysical explanation for the diverse functions of this lipid.
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Gulbins, E., Kolesnick, R. (2004). Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis. In: Quinn, P.J., Kagan, V.E. (eds) Phospholipid Metabolism in Apoptosis. Subcellular Biochemistry, vol 36. Springer, Boston, MA. https://doi.org/10.1007/0-306-47931-1_12
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