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Heterochromatin-Associated Protein 1, HP1Hsα, in Breast Cancer Invasion and Metastasis

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Cancer Metastasis — Related Genes

Part of the book series: Cancer Metastasis — Biology and Treatment ((CMBT,volume 3))

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Abstract

Heterochromatin has repressive effects on euchromatic gene expression. The mechanisms contributing to gene silencing are not known, however silencing has been shown to be modulated in part by heterochromatin-associated protein 1, HP1Hsα. We have identified a reduction in HP1Hsα expression in invasive/metastatic human breast cancer cell lines and in tumor cells from distant metastases. Furthermore, HP1Hsα transfected invasive/metastatic breast cancer cells show a reduction in the invasive phenotype indicating that HP1Hsα is involved in modulating specific biological activities in the metastatic cascade. Here, we discuss the role of heterochromatin and HP1Hsα expression in breast cancer invasion and metastasis with regard to gene silencing, chromatin packaging, and nuclear architecture. In addition, we introduce working models for mechanisms of HP1Hsα function that will be addressed with future studies.

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  1. Department of Anatomy & Cell Biology, Holden Cancer Center at the University of Iowa, College of Medicine, Iowa City, Iowa, 52242-1109, USA

    Dawn A. Kirschmann & Mary J.C. Hendrix

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  1. Dawn A. Kirschmann
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  1. Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Pennsylvania, USA

    Danny R. Welch

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Kirschmann, D.A., Hendrix, M.J. (2002). Heterochromatin-Associated Protein 1, HP1Hsα, in Breast Cancer Invasion and Metastasis. In: Welch, D.R. (eds) Cancer Metastasis — Related Genes. Cancer Metastasis — Biology and Treatment, vol 3. Springer, Dordrecht. https://doi.org/10.1007/0-306-47821-8_9

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  • DOI: https://doi.org/10.1007/0-306-47821-8_9

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