Skip to main content

Conclusion

Information is the king and knowledge is the queen in this post-genomics era. He who can mine the useful information from the messy raw data and turn it into knowledge is God. The software that helps the mining process is Michael the Archangel who leads the victorious battle against the complex biological problems. If you want to win the battle, start working with your angel now!

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Becker KG. (2001). The sharing of cDNA microarray data. Nat Rev Neurosci. 2:438–440.

    Article  PubMed  CAS  Google Scholar 

  • Brazma A., Vilo J. (2000) Gene expression data analysis. FEBS Lett. 480:17–24.

    Article  PubMed  CAS  Google Scholar 

  • Brazma A., Hingamp P., Quackenbush J., Sherlock G., Spellman P., Stoeckert C., Aach J., Ansorge W., Ball C.A., Causton H.C., Gaasterland T., Glenisson P., Holstege F.C., Kim I.F., Markowitz V., Matese J.C., Parkinson H., Robinson A., Sarkans U., Schulze-Kremer S., Stewart J., Taylor R., Vilo J., Vingron M. (2001) Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 29:365–371.

    Article  PubMed  CAS  Google Scholar 

  • D’haeseleer P., Liang S., Somogyi R. (2000). Genetic network inference: from co-expression clustering to reverse engineering. Bioinformatics. 16:707–726.

    Google Scholar 

  • de Jong H. (2002). Modeling and simulation of genetic regulatory systems: a literature review. J Comput Biol. 9:67–103.

    PubMed  Google Scholar 

  • Eisen M.B., Spellman P.T., Brown P.O., Botstein D. (1998). Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 95:14863–14868.

    Article  PubMed  CAS  Google Scholar 

  • Fiehn 0. (2002). Metabolomics—the link between genotypes and phenotypes. Mol Biol. 48:155–171.

    CAS  Google Scholar 

  • Gardiner-Garden M., Littlejohn T.G. (2001), A comparison of microarray databases. Brief Bioinform. 2:143–158.

    PubMed  CAS  Google Scholar 

  • Geschwind D.H. (2001). Sharing gene expression data: an array of options. Nat Rev Neurosci. 2:435–438.

    Article  PubMed  CAS  Google Scholar 

  • Grosu P., Townsend J.P., Hartl D.L., Cavalieri D. (2002). Pathway Processor: a tool for integrating whole-genome expression results into metabolic networks. Genome Res. 12:1121–1126.

    Article  PubMed  CAS  Google Scholar 

  • Hebestreit H.F. (2001). Proteomics: an holistic analysis of nature’s proteins. Curr Opin Pharmacol. 2001; 1:513–520.

    PubMed  CAS  Google Scholar 

  • Horvath S., Baur M.P. (2000). Future directions of research in statistical genetics. Stat Med. 19:3337–3343.

    Article  PubMed  CAS  Google Scholar 

  • Hughes T.R., Marton M.J., Jones A.R., Roberts C.J., Stoughton R., Armour C.D., Bennett H.A., Coffey E., Dai H., He Y.D., Kidd M.J., King A.M., Meyer M.R., Slade D., Lum P.Y., Stepaniants S.B., Shoemaker D.D., Gachotte D., Chakraburtty K., Simon J., Bard M., Friend S.H. (2000). Functional discovery via a compendium of expression profiles. Cell. 102:109–26.

    Article  PubMed  CAS  Google Scholar 

  • Jain A.N., Tokuyasu T.A., Snijders A.M., Segraves R., Albertson D.G., Pinkel D. (2002). Fully automatic quantification of microarray image data. Genome Res. 12:325–332.

    Article  PubMed  CAS  Google Scholar 

  • Jagota A. (2001). Microarray Data Analysis and Visualization. Bioinformatics by the Bay Press.

    Google Scholar 

  • Knuden S. (2002). A Biologist’s Guide to Analysis of DNA Microarray Data. New York: John Wiley & Sons, 2002.

    Google Scholar 

  • Krause A., Olson M. (2000). The Basics of S and S-Plus. New York: Springer Verlag.

    Google Scholar 

  • Leung Y.F., Lam D.S.C., Pang C.P. (2001). In silico biology: observation, modeling, hypothesis and verification. Trends Genet. 17:622–623.

    Article  PubMed  CAS  Google Scholar 

  • Leung Y.F. (2002). Microarray data analysis for dummies... and experts too? Trends Biochem Sci. in press.

    Google Scholar 

  • Leung Y.F., Pang C.P. (2002). Eye on bioinformatics — dissecting complex disease trait in silico. Applied Bioinform., in press.

    Google Scholar 

  • Leung Y.F., Tam P.O.S., Lee W.S., Yam G.H.F., Chua J.K.H., Lam D.S.C., Pang C.P. (2002). The dual role of dexamethasone on anti-inflammation and outflow resistance in human trabecular meshwork. Submitted.

    Google Scholar 

  • Lönnstedt I., Speed T.P. (2002). Replicated Microarray Data. Stat Sinica 12:31–46.

    Google Scholar 

  • Miles M.F. (2001). Microarrays: lost in a storm of data? Nat Rev Neurosci. 2:441–443.

    Article  PubMed  CAS  Google Scholar 

  • Nadon R., Shoemaker J. (2002). Statistical issues with microarrays: processing and analysis. Trends Genet. 18:265–271.

    Article  PubMed  CAS  Google Scholar 

  • Phelps T.J., Palumbo A.V., Beliaev A.S. (2002). Metabolomics and microarrays for improved understanding of phenotypic characteristics controlled by both genomics and environmental constraints. Curr Opin Biotechnol. 13:20–24.

    Article  PubMed  CAS  Google Scholar 

  • Quackenbush J. (2001). Computational genetics computational analysis of microarray data. Nat Rev Genet. 2:418–427.

    Article  PubMed  CAS  Google Scholar 

  • Roberts C.J., Nelson B., Marton M.J., Stoughton R., Meyer M.R., Bennett H.A., He Y.D., Dai H., Walker W.L., Hughes T.R., Tyers M., Boone C., Friend S.H. (2000). Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 287:873–880.

    PubMed  CAS  Google Scholar 

  • Roth F.P., Hughes J.D., Estep P.W., Church G.M. (1998). Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation. Nat Biotechnol. 16:939–945.

    Article  PubMed  CAS  Google Scholar 

  • Schoeberl B., Eichler-Jonsson C., Gilles E.D., Muller G. (2002). Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors. Nat Biotechnol. 20:370–375.

    Article  PubMed  Google Scholar 

  • Selvin S. (1998). Modern Applied Biostatistical Methods: Using S-Plus. New York: Oxford University Press.

    Google Scholar 

  • Sherlock G. (2001). Analysis of large-scale gene expression data. Brief Bioinform. 2:350–362.

    PubMed  CAS  Google Scholar 

  • Stewart J.E., Mangalam H., Zhou J. (2001). Open Source Software meets gene expression. Brief Bioinform. 2:319–328.

    PubMed  CAS  Google Scholar 

  • Tavazoie S., Hughes J.D., Campbell M.J., Cho R.J., Church G.M. (1999). Systematic determination of genetic network architecture. Nat Genet. 22:281–285.

    PubMed  CAS  Google Scholar 

  • Tomiuk S., Hofmann K. (2001). Microarray probe selection strategies. Brief Bioinform. 2:329–340.

    PubMed  CAS  Google Scholar 

  • Venables WN, Ripley BD. (1999). Modern Applied Statistics With S-Plus. New York: Springer Verlag.

    Google Scholar 

  • Wu T.D. (2001). Analysing gene expression data from DNA microarrays to identify candidate genes. J Pathol 195:53–65.

    Article  PubMed  CAS  Google Scholar 

  • Yang Y.H., Buckley M.J., Speed T.P. (2001). Analysis of cDNA microarray images. Brief Bioinform 2:341–349.

    PubMed  CAS  Google Scholar 

  • Yang Y.H., Dudoit S., Luu P., Lin D.M., Peng V., Ngai J., Speed T.P. (2002). Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30:E15.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Kluwer Academic Publishers

About this chapter

Cite this chapter

Leung, Y.F., Chiu Lam, D.S., Pang1, C.P. (2003). Microarray Software Review. In: Berrar, D.P., Dubitzky, W., Granzow, M. (eds) A Practical Approach to Microarray Data Analysis. Springer, Boston, MA. https://doi.org/10.1007/0-306-47815-3_19

Download citation

  • DOI: https://doi.org/10.1007/0-306-47815-3_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4020-7260-4

  • Online ISBN: 978-0-306-47815-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics