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Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases pp 59–67Cite as

Genetic Factors Involved in Central Nervous System/Immune Interactions

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 493))

Abstract

Analysis of several inbred rat strains has led us to hypothesize that HPA axis abnormalities may contribute, in part, to susceptibility to both autoimmune disease and addiction. In this article we review the evidence for this hypothesis and describe our ongoing efforts to genetically characterize these traits. We have mapped the locations of 23 loci that regulate autoimmune disease in rats, and are currently constructing QTL congenic lines in which a genomic region from the resistant strain is transferred to the susceptible strain or vice versa. These QTL congenic lines will be valuable to test whether genes encoding autoimmune regulation also control neuroendocrine traits. Further genetic dissection and identification of the underlying genes will be necessary to infer a mechanistic link between autoimmune and neuroendocrine traits.

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Author information

Authors and Affiliations

  1. Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, 20892

    Dr. Ronald L. Wilder & Dr. Elaine F. Remmers

  2. Research Service, Veteran Affairs Medical Center, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, 84132

    Dr. Marie M. Griffiths & Dr. Grant W. Cannon

  3. Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892

    Dr. Rachel Caspi

  4. Columbia University College of Physicians and Surgeons, New York, NY, 10032

    Dr. Percio S. Gulko

Authors
  1. Dr. Ronald L. Wilder
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  2. Dr. Marie M. Griffiths
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  3. Dr. Grant W. Cannon
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  4. Dr. Rachel Caspi
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  5. Dr. Percio S. Gulko
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  6. Dr. Elaine F. Remmers
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Editors and Affiliations

  1. College of Medicine, University of South Florida, Tampa, Florida

    Herman Friedman  & Thomas W. Klein  & 

  2. Georgia Mental Health Institute, Emory University, Atlanta, Georgia

    John J. Madden

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© 2002 Kluwer Academic Publishers

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Wilder, R.L., Griffiths, M.M., Cannon, G.W., Caspi, R., Gulko, P.S., Remmers, E.F. (2002). Genetic Factors Involved in Central Nervous System/Immune Interactions. In: Friedman, H., Klein, T.W., Madden, J.J. (eds) Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases. Advances in Experimental Medicine and Biology, vol 493. Springer, Boston, MA. https://doi.org/10.1007/0-306-47611-8_7

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  • DOI: https://doi.org/10.1007/0-306-47611-8_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46466-9

  • Online ISBN: 978-0-306-47611-2

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