Summary Points
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Late age at first birth, early age at menarche, late age at menopause, and nulliparity are each associated with an increase in breast cancer risk.
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Nulliparity increases the risk of ovarian cancer, while tubal ligation has been found to decrease risk.
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Although less well studied, nulliparity and late age at menopause appear to increase the risk of endometrial cancer.
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Suggested Further Reading
Harris JR, Lippman ME, Veronsei U, Willett WC (1992) Breast cancer. N Engl J Med (3 parts) 327: 319–328, 390–398, 473–480.
Willett WC, Rockhill B, Hankinson SE, Hunter D, Colditz GA (1999) Non-genetic factors in the causation of breast cancer. In: Harris JR, Lippman ME, Morrow M, Osborne CK, eds. Diseases of the Breast, 2nd ed. Philadelphia, PA (USA): Lippincott-Raven Press.
Whittemore AS, Harris R, Itnyre J, and the Collaborative Ovarian Cancer Group (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. IV. The pathogenesis of epithelial ovarian cancer. Am J Epidemiol 136: 1212–1220.
Parazzini F, La Vecchia C, Bociolone L, Franceschi S (1991) The epidemiology of endometrial cancer. Gynecol Oncol 41: 1–16.
Brinton LA (1992) Epidemiology of cervical cancer — overview. In: Muñoz N, Bosch FX, Shah KV, Meheus A, eds. The Epidemiology of Cervical Cancer and Human Papillomavirus. Scientific Publication No. 119. Lyon, France: International Agency for Research on Cancer, pp. 3–23.
Potter JD, Slattery ML, Bostick RM, Gapstur SM (1993) Colon cancer: a review of the epidemiology. Epidemiol Rev 15: 499–545.
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Missmer, S.A., Hankinson, S.E. (2000). Reproductive Factors and Cancer Risk. In: Colditz, G.A., Hunter, D. (eds) Cancer Prevention: The Causes and Prevention of Cancer. Cancer Prevention-Cancer Causes, vol 1. Springer, Dordrecht. https://doi.org/10.1007/0-306-47523-5_8
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DOI: https://doi.org/10.1007/0-306-47523-5_8
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