Skip to main content

Parasite Strain Diversity and Host Immune Responses

  • Chapter
The Geohelminths: Ascaris, Trichuris and Hookworm

Part of the book series: World Class Parasites ((WCPA,volume 2))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • ALFORD K., OBENDORF D.L., FREDEKING T.M., HAEHLING E. & STEWART G.L. (1998). Comparison of theinflammatory responses of mice infectedwith American and Australian Trichinella pseudospiralis or Trichinella spiralis. International Journal for Parasitology 28, 343–8.

    Article  PubMed  CAS  Google Scholar 

  • ANDERSON T.J., BLOUIN M.S. & BEECH G.N. (1998). Population biology of parasitic nematodes: applications of genetic markers. Advances in Parasitology 41, 219–83.

    Article  PubMed  CAS  Google Scholar 

  • ANDERSON T.J., ROMERO-ABAL M.E. & JAENIKE J. (1995). Mitochondrial DNA and Ascaris microepidemiology: the composition of parasite populations from individual hosts, families and villages. Parasitology 110, 221–9.

    PubMed  Google Scholar 

  • BARRETT F., JACKSON F. & HUNTLEY J.F. (1998). Pathogenicity and immunogenicity of different isolates of Teladorsagia circumcincta. Veterinary Parasitology 76, 95–104.

    Article  PubMed  CAS  Google Scholar 

  • BEHNKE J.M. & WAKELIN D. (1973). The survival of Trichuris muris in wild populations of its natural hosts. Parasitology 67, 157–64.

    PubMed  CAS  Google Scholar 

  • BEHNKE J.M., PAUL V. & RAJASEKARIAH G.R. (1986). The growth and migration of Necator americanus following infection of neonatal hamsters. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 146–9.

    Article  PubMed  CAS  Google Scholar 

  • BELLABY T., ROBINSON K. & WAKELIN D. (1996). Induction of differential T-helper-cell responses in mice infected with variants of the parasitic nematode Trichuris muris. Infection and Immunity 64, 791–5

    PubMed  CAS  Google Scholar 

  • BELLABY T., ROBINSON K., WAKELIN D. & BEHNKE J.M. (1995). Isolates of Trichuris muris vary in their ability to elicit protective immune responses to infection in mice. Parasitology 111, 353–7

    PubMed  Google Scholar 

  • BLACKWELL, N. M. & ELSE, K.J. (2001). B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode parasite Trichuris muris. Infection and Immunity 69, 3860–68.

    Article  PubMed  CAS  Google Scholar 

  • BOLAS-FERNANDEZ F. & WAKELIN D. (1989). Infectivity of Trichinella isolates in mice is determined by host immune responsiveness. Parasitology 99, 83–8.

    PubMed  Google Scholar 

  • BOLAS-FERNANDEZ F., ALBARRAN-GOMEZ E., NAVARRETE I. & MARTINEZ-FERNANDEZ A.R. (1993). Dynamics of porcine humoral responses to experimental infections by Spanish Trichinella isolates: comparison of three larval antigens in ELISA. Journal of Veterinary Medicine Series B 40, 223–9.

    Article  Google Scholar 

  • CURRIE R.M., NEEDHAM C.S., DRAKE L.J., COOPER E.S. & BUNDY D.A. (1998). Antigenic variability in Trichuris trichiura populations. Parasitology 117, 347–53.

    Article  PubMed  CAS  Google Scholar 

  • DEA-AYUELA M.A., MARTINEZ-FERNANDEZA. R. & BOLAS-FERNANDEZ F. (2000). Comparison of IgG3 responses to carbohydrates following mouse infection or immunization with six species of Trichinella. Journal of Helminthology 74, 215–23.

    PubMed  CAS  Google Scholar 

  • DENKERS E.Y., WASSOM D.L. & HAYES C.E. (1990). Characterization of Trichinella spiralis antigens sharing an immunodominant, carbohydrate-associated determinant distinct from phosphorylcholine. Molecular and Biochemical Parasitology 41, 241–50.

    Article  PubMed  CAS  Google Scholar 

  • DICK T.A. & CHADEE K. (1983). Interbreeding and gene flow in the genus Trichinella. Journal of Parasitology 69, 176–80.

    PubMed  CAS  Google Scholar 

  • DOBSON C. & OWEN M. E. (1977). Influence of serial passage on the infectivity and immunogenicity of Nematospiroides dubius in mice. International Journal for Parasitology 7, 463–6.

    Article  PubMed  CAS  Google Scholar 

  • DOBSON C. & TANG J.M. (1991). Genetic variation and host-parasite relations: Nematospiroides dubius in mice. Journal of Parasitology 77, 884–9.

    PubMed  CAS  Google Scholar 

  • DONALDSON L.E., SCHIMTTE E., HUNTLEY J.F., NEWLANDS G.F.J. & GRENCIS R.K. (1996). A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth. International Immunology 8, 559–67.

    PubMed  CAS  Google Scholar 

  • EDWARDS A.J., BURT J.S. & OGILVIE B.M. (1971). The effect of immunity upon some enzymes of the parasitic nematode Nippostrongylus brasiliensis. Parasitology 62, 339–47.

    PubMed  CAS  Google Scholar 

  • ELLIS L.A., REASON A.J., MORRIS H.R., DELL A., IGLESIAS R., UBEIRA F.M. & APPLETON J.A. (1994). Glycans as targets for mononclonal antibodies that protect rats against Trichinella spiralis. Glycobiology 4, 585–92.

    PubMed  CAS  Google Scholar 

  • ELSE K. J. & GRENCIS R.K. (1996). Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris. Infection and Immunity 64 2950–4

    PubMed  CAS  Google Scholar 

  • FRASER E.M. & KENNEDY M.W. (1991). Heterogeneity in the expression of surface-exposed epitopes among larvae of Ascaris lumbricoides. Parasite Immunology 13, 219–25.

    PubMed  CAS  Google Scholar 

  • GARSIDE P., KENNEDY M.W., WAKENLIN D. & LAWRENCE C.E. (2000). Immunopathology of intestinal helminth infection. Parasite Immunology 22, 605–12.

    PubMed  CAS  Google Scholar 

  • GASSER R.B.& NEWTON S.E. (2000). Genomic and genetic research on bursate nematodes: significance, implications and prospects. International Journal for Parasitology 30, 509–34.

    Article  PubMed  CAS  Google Scholar 

  • GEMMILL A.W., VINEY M.E. & READ AF. (2000). The evolutionary ecology of host-specificity: experimental studies with Strongyloides ratti. Parasitology 120, 429–37.

    Article  PubMed  Google Scholar 

  • GOYAL P.K. & WAKELIN D. (1993a). Influence of variation in host strain and parasite isolate on inflammatory and antibody responses to Trichinella spiralis in mice. Parasitology 106, 371–8.

    PubMed  Google Scholar 

  • GOYAL P.K. & WAKELIN D. (1993b). Vaccination against Trichinella spiralis in mice using antigens from different isolates. Parasitology 107, 311–7.

    PubMed  Google Scholar 

  • GOYAL P.K., HERMANEK J. & WAKELIN D. (1994). Lymphocyte proliferation and cytokine production in mice infected with different geographical isolates of Trichinella spiralis. Parasite Immunology 16, 105–10.

    PubMed  CAS  Google Scholar 

  • GRANT W.N & MASCORD L.J. (1996). Beta-tubulin gene polymorphism and benzimidazole resistance in Trichostrongylus colubriformis. International Journal for Parasitology 26, 71–7.

    Article  PubMed  CAS  Google Scholar 

  • GRENCIS R.K. & ENTWISTLE G.M. (1997). Production of an interferon-gamma homologue by an intestinal nematode: functionally significant or interesting artefact? Parasitology 115, S101–6.

    Article  Google Scholar 

  • HALEY J.A. (1966). Biology of the rat nematode Nippostrongylus brasiliensis (Travassos, 1914). III. Characteristics of N. brasiliensis after 30–120 serial passages in the Syrian hamster. Journal of Parasitology 52, 98–108.

    PubMed  CAS  Google Scholar 

  • HALL A. & HOLLAND C. (2000). Geographical variation in Ascaris lumbricoides fecundity and its implications for helminth control. Parasitology Today 16, 540–4.

    Article  PubMed  CAS  Google Scholar 

  • HAWDON J.M., LI T., ZHAN B. & BLOUIN M.S. (2001). Genetic structure of populations of the human hookworm, Necator americanus, in China. Molecular Ecology 10, 1433–7.

    Article  PubMed  CAS  Google Scholar 

  • JARVIS L.M. & PRITCHARD D.I. (1992). An evaluation of the role of carbohydrate epitopes in immunity to Trichinella spiralis. Parasite Immunology 14, 489–501.

    PubMed  CAS  Google Scholar 

  • JASMER D.P. (1995). Trichinella spiralis: subversion of differentiated mammalian skeletal muscle cells. Parasitology Today 11, 185–8.

    Article  Google Scholar 

  • JENKINS D.C.. & PHILLIPSON R.F. (1972). Evidence that the nematode Nippostrongylus brasiliensis can adapt to and overcome the effects of host immunity. International Journal for Parasitology 2, 353–9.

    PubMed  CAS  Google Scholar 

  • JENKINS S.N. & WAKELIN D. (1983). Functional antigens of Trichuris muris released during in vitro maintenance: their immunogenicity and partial purification. Parasitology 86, 73–82.

    PubMed  CAS  Google Scholar 

  • KAPEL C.M. (2001). Sylvatic and domestic Trichinella spp. in wild boars; infectivity, muscle larvae distribution, and antibody response. Journal of Parasitology 87, 309–14.

    PubMed  CAS  Google Scholar 

  • KAPEL C.M. & GAMBLE H.R. (2000). Infectivity, persistence, and antibody response to domestic and sylvatic Trichinella spp. in experimentally infected pigs. International Journal for Parasitology 30, 215–21.

    Article  PubMed  CAS  Google Scholar 

  • KOYAMA K. & ITO Y. (19%). Comparative studies on immune responses to infection in susceptible B10.BR mice infected with different strains of the murine nematode parasite Trichuris muris. Parasite Immunology 18, 257–63

    Google Scholar 

  • KOYAMA K. & ITO Y. (2001). Comparative studies on the levels of serum IgG1 and IgG2a in susceptible B10.BR micein fected with different strains of theintestinal nematode parasite Trichuris muris. Parasitology Research. In press.

    Google Scholar 

  • KURATLI S., HEMPHILL A., LINDH J., SMITH D.F. & CONNOLLY B. (2001). Secretion of the novel Trichinella protein TSJ5 by T. spiralis and T. pseudospiralis muscle larvae. Molecular and Biochemical Parasitology 115, 199–208.

    Article  PubMed  CAS  Google Scholar 

  • KURATLI S., LINDH J., GOTTSTEIN B, SMITH D.F. & CONNOLLY B. (1999). Trichinella spp.: differential expression of two genes in the muscle larva of encapsulating and non-encapsulating species. Experimental Parasitology 93, 153–9.

    Article  PubMed  CAS  Google Scholar 

  • LA ROSA G. & POZIO E. (2000). Molecular investigation of African isolates of Trichinella reveals genetic polymorphism in Trichinella nelsoni. International Journal for Parasitology 30, 663–7.

    PubMed  Google Scholar 

  • LA ROSA G., MARUCCI G., ZARLENGA D.S. & POZIO E. (2001). Trichinella pseudospiralis populations of the Palearctic region and their relationship with populations of the Nearctic and Australian regions International Journal for Parasitology 31, 297–305.

    PubMed  Google Scholar 

  • MAINGI N., SCOTT M.E. & PRICHARD R.K. (1990). Effect of selection pressure for thiabendazole resistance on fitness of Haemonchus contortus in sheep. Parasitology, 100, 327–35.

    PubMed  Google Scholar 

  • MALLET S. & HOSTE H. (1995). Physiology of two strains of Trichostrongylus colubriformis resistant and susceptible to thiabendazole and mucosal response of experimentally infected rabbits. International Journal for Parasitology 25, 23–7.

    Article  PubMed  CAS  Google Scholar 

  • MARTINEZ-FERNANDEZ A.R., ARMAS-SERRA, C. de, GOMEZ-BARRIO A. & BOLAS-FERNANDEZ F. (1988). Single-pair cross hybridization test among Spanish Trichinella isolations. Proceedings of the Seventh International Conference on Trichinellosis 96–101.

    Google Scholar 

  • MURRELL K.D., LICHTENFELS R.J., ZARLENGA D.S. & POZIO E. (2000). The systematics of the genus Trichinella with a key to species. Veterinary Parasitology 93, 293–307.

    Article  PubMed  CAS  Google Scholar 

  • NAGANO I., WU Z., MATSUO A., POZIO E. & TAKAHASHI Y. (1999.) Identification of Trichinella isolates by polymerase chain reaction-restriction fragment length polymorphism of the mitochondrial cytochrome c-oxidase subunit I gene. International Journal of Parasitology 29, 1113–20.

    Article  PubMed  CAS  Google Scholar 

  • NEWTON S.E., MORRISH L.E, MARTIN P.J., MONTAGUE P.E. & ROLPH T.P. (1995). Protection against multiply drug-resistant and geographically distant strains of Haemonchus contortus by vaccination with H11, a gut membrane-derived protective antigen. International Journal for Parasitology 25, 511–21.

    PubMed  CAS  Google Scholar 

  • OGILVIE B.M. (1972). Protective immunity to Nippostrongylus brasiliensis in the rat. II. Adaptation by worms. Immunology 22, 111–8.

    PubMed  CAS  Google Scholar 

  • QUINELL, R.J., BEHNKE, J.M. & KEYMER A. (1991) Host specificity of and cross-immunity between two strains of Heligmosomoides polygyrus. Parasitology, 102, 419–27

    Google Scholar 

  • ROBINSON K., BELLABY T. & WAKELIN D. (1995). High levels of protection induced by a 40-mer synthetic peptide vaccine against the intestinal nematode parasite Trichinella spiralis. Immunology 86, 495–8.

    PubMed  CAS  Google Scholar 

  • SANGSTER N.C. (1999). Anthelmintic resistance: past, present and future. International Journal of Parasitology 29, 115–24.

    Article  PubMed  CAS  Google Scholar 

  • SEN H.G. & SETH D. (1967). Complete development of the human hookworm, Necator americanus in golden hamsters, Mesocricetus auratus. Nature, Land. 214, 609–10.

    Google Scholar 

  • SILBERSTEIN D.S. & DESPOMMIER D.D. (1984). Antigens from Trichinella spiralis that induce a protective response in the mouse. Journal of Immunology 132, 898–904.

    CAS  Google Scholar 

  • SOLOMON, N M.S. & HALEY J.A. (1966). Biology of the rat nematode Nippostrongylus brasiliensis (Travassos, 1914). V. Characteristics of N. brasiliensis after serial passage in the laboratory mouse. Journal of Parasitology 52, 237–41.

    Google Scholar 

  • STEWART G.L. (1989). Biological and immunological characteristics of Trichinella pseudospiralis. Parasitology Today 5, 344–9.

    PubMed  CAS  Google Scholar 

  • STEWART G.L., MANN M.A., UBELAKER J.E., MCCARTHY J.L. & WOOD B.G. (1988). A role for elevated plasma corticosterone in modulation of host response during infection with Trichinella pseudospiralis. Parasite Immunology 10, 139–50.

    PubMed  CAS  Google Scholar 

  • SU Z, & DOBSON C. (1997). Genetic and immunological adaptation of Heligmosomoides polygyrus in mice. International Journal for Parasitology 27, 653–63.

    PubMed  CAS  Google Scholar 

  • TANG J., DOBSON C. & McMANUS D.P. (1995). Antigens in phenotypes of Heligmosomoides polygyrus raised selectively from different strains of mice. International Journal for Parasitology 25, 847–52.

    PubMed  CAS  Google Scholar 

  • WAKELIN D. (1973). The stimulation of immunity to Trichuris muris in mice exposed to low-level infections. Parasitology 66, 181–9.

    Article  PubMed  CAS  Google Scholar 

  • WAKELIN D. & GOYAL P.K. (1996). Trichinella isolates: parasite variability and host responses. International Journal for Parasitology 26, 471–81.

    Article  PubMed  CAS  Google Scholar 

  • WAKELIN D., GOYAL P.K., DEHLAWI M.S. & HERMANEK J. (1994). Immune responses to Trichinella spiralis and T. pseudospiralis in mice. Immunology 81, 475–9.

    PubMed  CAS  Google Scholar 

  • WU Z., NAGANO I. & TAKAHASHI Y. (1998). Differences and similarities between Trichinella spiralis and T. pseudospiralis in morphology of stichocyte granules, peptide maps of excretory and secretory (E-S) products and messenger RNA of stichosomal glycoproteins. Parasitology 116, 61–6.

    Article  PubMed  CAS  Google Scholar 

  • WU Z., NAGANO I., MATSUO A. & TAKAHASHI Y. (2000). The genetic analysis of F1 hybrid larvae between female Trichinella spiralis and male Trichinella britovi. Parasitology International 48, 289–95.

    Article  PubMed  CAS  Google Scholar 

  • WU Z., NAGANO I., POZIO E. & TAKAHASHI Y. (1999). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the identification of Trichinella isolates. Parasitology, 118, 211–8.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Wakelin, D., Bradley, J.E. (2002). Parasite Strain Diversity and Host Immune Responses. In: Holland, C.V., Kennedy, M.W. (eds) The Geohelminths: Ascaris, Trichuris and Hookworm. World Class Parasites, vol 2. Springer, Boston, MA. https://doi.org/10.1007/0-306-47383-6_12

Download citation

  • DOI: https://doi.org/10.1007/0-306-47383-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-7923-7557-9

  • Online ISBN: 978-0-306-47383-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics