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Identifying the Mechanisms of Trypanotolerance in Cattle

Chapter
Part of the World Class Parasites book series (WCPA, volume 1)

Abstract

Some West African cattle breeds such as N’Dama have survived in tsetse-infected areas for thousands of years and are productive under trypanosome challenge, a trait known as trypanotolerance. Elucidation of the mechanisms of trypanotolerance could lead to new options for disease control. This review describes responses in trypanotolerant and trypanosusceptible breeds of cattle, and compares them with responses in mouse models. It focuses on the roles of haemopoietic tissue, T lymphocytes and antibodies in resistance to trpanosomiasis.

Key words

N’Dama trypanotolerance T. congolense T. vivax parasitemia anemia chimera T cell depletion 

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  1. 1.International Livestock Research InstituteNairobiKenya
  2. 2.Department of PediatricsJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.I.W.T.BrusselsBelgium

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