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Radiation-Induced Bioradicals

Physical, Chemical and Biological Aspects

  • Chapter
Physics and Chemistry Basis of Biotechnology

Part of the book series: Focus on Biotechnology ((FOBI,volume 7))

Abstract

This chapter is part one of a review in which the production and application of radiation-induced bioradicals is discussed. Bioradicals play a pivotal role in the complex chain of processes starting with the absorption of radiation in biological materials and ending with the radiation-induced biological after-effects. The general aspects of the four consecutive stages (physical, physicochemical, chemical and biological) are discussed from an interdisciplinary point of view. The close relationship between radiation dose and track structure, induced DNA damage and cell survival or killing is treated in detail. The repair mechanisms that cells employ, to insure DNA stability following irradiation, are described. Because of their great biomedical importance tumour suppressor genes involved in radiation-induced DNA repair and in checkpoint activation will be treated briefly, together with the molecular genetics of radiosensitivity. Part two of this review will deal with modern theoretical methods and experimental instrumentation for quantitative studies in this research field. Also an extensive overview of the applications of radiation-induced bioradicals will be given. A comprehensive list of references allows further exploration of this research field, characterised in the last decade by a substantial advance, both in fundamental knowledge and in range of applications.

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Authors and Affiliations

  1. Laboratoly of Subatomic and Radiation Physics, Radiation Physics group, Ghent University, Proeftuinstraat 86, B-9000, Ghent, Belgium

    Win Mondelaers (Member of Ibitech) & Philippe Lahorte (Member of Ibitech)

  2. Division of Nuclear Medicine, Ghent University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium

    Philippe Lahorte (Member of Ibitech)

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  1. Win Mondelaers
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Editors and Affiliations

  1. Interdisciplinaire Research Center, Katholieke Universiteit Leuven, Kortrijk, Belgium

    Marcel De Cuyper

  2. National Institutes of Health, Bethesda, MD, USA

    Jeff W. M. Bulte

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Mondelaers, W., Lahorte, P. (2001). Radiation-Induced Bioradicals. In: De Cuyper, M., Bulte, J.W.M. (eds) Physics and Chemistry Basis of Biotechnology. Focus on Biotechnology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/0-306-46891-3_10

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