Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes



In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and protects DNA from oxidative damage1). Here we found that ERW scavenges ROS in insulin-responsive L6 myotubes and mouse3T3/L1 adipocytes. Uptake of 1-deoxy-D- glucose (2-DOG) into both L6 cells and 3T3/L1 cells was stimulated by ERW in the presence or absence of insulin. This insulin-like activity of ERW was mediated by the activation of PI-3 kinase, resulting in stimulation of translocation of glucose transporter GLUT4 from microsome to plasma membrane. These results suggest that ERW may be useful to improve insulin-independent type 2 diabetes.


Reactive Oxygen Species Glucose Transporter GLUT4 Intracellular Redox State Telomere Binding Protein Animal Cell Technology 
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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  1. 1.Graduate School of Genetic Resources TechnologyKyushu UniversityFukuokaJapan
  2. 2.Nihon Trim Co. Ltd.OsakaJapan
  3. 3.Water InstituteTokyoJapan
  4. 4.Hita Aqua Green Co. Ltd.HitaJapan

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