Chapter

Animal Cell Technology: Products from Cells, Cells as Products

pp 425-427

Electrolyzed and Natural Reduced Water Exhibit Insulin-Like Activity on Glucose Uptake into Muscle Cells and Adipocytes

  • M. OdaAffiliated withGraduate School of Genetic Resources Technology, Kyushu University
  • , K. KusumotoAffiliated withGraduate School of Genetic Resources Technology, Kyushu University
  • , K. TeruyaAffiliated withGraduate School of Genetic Resources Technology, Kyushu University
  • , T. HaraAffiliated withGraduate School of Genetic Resources Technology, Kyushu University
  • , T. MakiAffiliated withGraduate School of Genetic Resources Technology, Kyushu University
  • , S. KabayamaAffiliated withGraduate School of Genetic Resources Technology, Kyushu University
  • , Y. KatakuraAffiliated withNihon Trim Co. Ltd.
  • , K. OtsuboAffiliated withNihon Trim Co. Ltd.
  • , S. MorisawaAffiliated withNihon Trim Co. Ltd.
    • , H. HayashiAffiliated withWater Institute
    • , Y. IshiiAffiliated withHita Aqua Green Co. Ltd.
    • , S. ShirahataAffiliated withGraduate School of Genetic Resources Technology, Kyushu University

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Abstract

In the type 2 diabetes, it has become clear that reactive oxygen species (ROS) cause reduction of glucose uptake by inhibiting the insulin-signaling pathway in muscle cells and adipocytes. We demonstrated that electrolyzed-reduced water (ERW) scavenges ROS and protects DNA from oxidative damage1). Here we found that ERW scavenges ROS in insulin-responsive L6 myotubes and mouse3T3/L1 adipocytes. Uptake of 1-deoxy-D- glucose (2-DOG) into both L6 cells and 3T3/L1 cells was stimulated by ERW in the presence or absence of insulin. This insulin-like activity of ERW was mediated by the activation of PI-3 kinase, resulting in stimulation of translocation of glucose transporter GLUT4 from microsome to plasma membrane. These results suggest that ERW may be useful to improve insulin-independent type 2 diabetes.