Abstract
Light chain shifting (LCS) is a phenomenon that some human antibody producing plasma B cells lost their original immunoglobulin light chain and begin to express new light chains which are different from original one. Each cells after LCS produced only one type of light chain and cell clone producing more than one light chain protein was not ever found. We have demonstrated that LCS is carried out by a secondary light chain gene rearrangement event and LCS-inducible cells also expressed V(D)J rearrangement-relating factors such as recombination activating genes RAG-1, RAG-2 and terminal deoxynucleotidyl transferase, all of which are usually not expressed in the plasma B cells.
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© 1999 Kluwer Academic Publishers
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Haruta, H., Tachibana, H., Yamada, K. (1999). Light Chain Shifting — Characterization of Light Chain Replacement in Human Plasma B Cells. In: Kitagawa, Y., Matsuda, T., Iijima, S. (eds) Animal Cell Technology: Basic & Applied Aspects., vol 1. Springer, Dordrecht. https://doi.org/10.1007/0-306-46865-4_11
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DOI: https://doi.org/10.1007/0-306-46865-4_11
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-5451-2
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