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Role of Proteases in the Pathophysiology of Neurodegenerative Diseases pp 47–61Cite as

Papain-like Cysteine Proteases and Their Implications in Neurodegenerative Diseases

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Summary

It is apparent that most studies assessing the role of cysteine lysosomal proteases in various processes of neurodegeneration pertain to cathepsin L and cathepsin B the classical and most well characterized members of the family. With the advent of animal models for a number of neurodegenerative disorders, and the availability of high throughput analyses of gene expression it is now possible to begin assessing which members of this family of proteases participate in the establishing of various neuropathological states.

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Authors and Affiliations

  1. Department of Genetics, Mount Sinai School of Medicine, New York, NY, 10029

    Dieter Brömme

  2. Department of Psychiatry, New York University Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, 10962

    Suzana Petanceska

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  1. Dieter Brömme
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  1. Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York

    Abel Lajtha

  2. Medical University of South Carolina, Charleston, South Carolina

    Naren L. Banik

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Brömme, D., Petanceska, S. (2002). Papain-like Cysteine Proteases and Their Implications in Neurodegenerative Diseases. In: Lajtha, A., Banik, N.L. (eds) Role of Proteases in the Pathophysiology of Neurodegenerative Diseases. Springer, Boston, MA. https://doi.org/10.1007/0-306-46847-6_4

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  • DOI: https://doi.org/10.1007/0-306-46847-6_4

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