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HPI of High-Virulent Yersinia is Found in E. coli Strains Causing Urinary Tract Infection

Structural, Functional Aspects, and Distribution
  • Sören Schubert
  • Johanna L. Sorsa
  • Sonja Cuenca
  • Daniela Fischer
  • Christoph A. Jacobi
  • Jürgen Heesemann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 485)

Conclusion

The E. coli HPI consists of a well vonserved core part, encoding for the yersiniabactin siderophore system (irp/fyuA genes)and for the P4-like integrase (int gene). We could demonstrate that genes as fyuA or irpl and irp2 encoded by the HPI are expressed in E. coli. Moreover, HPI positive E. coli strains were shown to produce the siderophore yersinibactin, indicating the functional integrity of the HPI core in E. coli. Further studies are required to define the impact of the E. coli HPI on virulence and/or fitness.

Keywords

tRNA Gene Coli Strain Biosynthetic Gene Cluster Pathogenicity Island Yersinia Enterocolitica 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Sören Schubert
    • 1
  • Johanna L. Sorsa
    • 1
  • Sonja Cuenca
    • 1
  • Daniela Fischer
    • 1
  • Christoph A. Jacobi
    • 1
  • Jürgen Heesemann
    • 1
  1. 1.Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie der LMUMünchenGermany

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