HPI of High-Virulent Yersinia is Found in E. coli Strains Causing Urinary Tract Infection
The E. coli HPI consists of a well vonserved core part, encoding for the yersiniabactin siderophore system (irp/fyuA genes)and for the P4-like integrase (int gene). We could demonstrate that genes as fyuA or irpl and irp2 encoded by the HPI are expressed in E. coli. Moreover, HPI positive E. coli strains were shown to produce the siderophore yersinibactin, indicating the functional integrity of the HPI core in E. coli. Further studies are required to define the impact of the E. coli HPI on virulence and/or fitness.
KeywordstRNA Gene Coli Strain Biosynthetic Gene Cluster Pathogenicity Island Yersinia Enterocolitica
Unable to display preview. Download preview PDF.