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Interrelationship Between Virulence Properties of Uropathogenic E. coli and Blood Group Phenotype of Patients with Chronic Urinary Tract Infection

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 485)

Conclusion

The ABO-and Lewis-antigens located at the cells of the epithelial boundary layer of the human organism represent a natural protective mechanism against the invasive efforts of pathogens. However, antigen structures on the uroepithelial cells, such as the glycosphingo-lipids of the P- blood group system, serve as receptors for adhesion. In dependence on this situation, microorganisms are able to express virulence factors at different degrees.

In 53 patients, ABO-, P1-and Lewis-blood group phenotypes as well as the secretor status were investigated in terms of virulence properties of E. coli strains and the degree of bacterial adherence to uroepithelial cells. Pathogenicity was determined in 144 E. coli strains over three years. Patients with PI-antigens (n = 40/76%)had fewer microorganisms with the ability to produce hemolysin and mannose-resistant hemagglutination than persons without P-antigen. This difference was statistically significant (p = 0.05)and greater in patients with blood group B (n = 13/23%), especially in B- secretors (n =9/16%;p <0.0005). E coli strains with K 1-antigen were significantly more often found in patients with Lewis(a+).

The phenotypic expression of virulence properties of E. coli is very likely to be determined by host-specific factors, such as the antigens P1 and B as well as the Lewis-blood group phenotype.

Keywords

Urinary Tract Infection Blood Group Recurrent Urinary Tract Infection Renal Scarring Group Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Kunin, C.M., 1994, Urinary tract infections in femals. Clin. Infect. Dis. 18: 1–12.PubMedGoogle Scholar
  2. 2.
    Svanborg-Eden, C., Hagberg, L., Hanson, L.A., Hult, S., Hult, R., Jodal, U., Leffler, H., Lomberg, H., and Straube, E., 1993, Bacterial adherence—a pathogenic mechanism in urinary tract infections caused in Escherichia coli. Prog. Allergy 33: 175–188.Google Scholar
  3. 3.
    Johnson, J.R., 1991, Virulence factors in Escherichia coli urinary tract infections. Clin. Microbiol. Rev. 4: 80–128.PubMedGoogle Scholar
  4. 4.
    Lurie, S., Sigler, E., and Fenakel, K., 1991, The ABO, Lewis or P blood group phenotypes are not associated with recurrent pelvic inflammatory disease. Gyn. Obstet. Invest. 31: 158–160.Google Scholar
  5. 5.
    Lomberg, H., Cedergren, B., Leffler, H., Nilsson, B., Carlstrom, A.S., and Svanborg-Eden, C., 1986, Influence of blood groups on the availability of receptors for attachment of uropathogenic Escherichia coli. Infect. Immun. 51: 919–926.PubMedGoogle Scholar
  6. 6.
    Lomberg, H., Hanson, L.A., Jacobsson, B., Jodal, U., Leffler, H., and Svanborg-Eden, C., 1983, Correlation of P blood group, vesicoureteral reflux, and bacterial attachment in patients with recurrent pyelonephritis. N. Engl. J. Med. 308: 1189–1192.PubMedCrossRefGoogle Scholar
  7. 7.
    Edwards, R.P., and Ewing, W.H., 1962, Indentification of Enterobacteriaceae. Progress Publishing Co., MinneapolisGoogle Scholar
  8. 8.
    Springer, W., and Goebel, W., 1980, Synthesis and secretion of hemolysin by Escherichia coli. J. Bacteriol. 144: 53–59.PubMedGoogle Scholar
  9. 9.
    Evans, D.J., Evans, D.G., Young, L.S., and Pit, I., 1980, Hemagglutination typing of E. coli: Definition ofserum hemagglutination types. J. Clin. Microbiol. 12: 235–242.PubMedGoogle Scholar
  10. 10.
    Stuart, S.J., Greenwood, K.R., and Luke, R.K.J., 1982, Iron-suppressible production of hydroxamate by E. coli isolates. Infect. Immun. 36: 870–873.PubMedGoogle Scholar
  11. 11.
    Wittig, W., Prager, R., Tietze, E., Seltmann, G., and Tschäpe, H., 1988, Aerobactin-positive Escherichia coli as causative agents of extraintestinal infections among animals. Arch. Exp. Vet. Med. 42: 211–219.Google Scholar
  12. 12.
    Nimmich, W., Naumann, G., Budde, E., and Straube, E., 1980, K-Antigen, Adhärenzfaktor, Dulcitol-Abbau und Hämolysinbildung bei E. coli-R-Stämmen aus Urin. Zentralbl. Bakteriol. Mikrobiol. Hyg. [A] 247: 35–42.Google Scholar
  13. 13.
    Prokop, O., and Göhler, G., 1986, Die menschlichen Blutgruppen. Fischer, 5. Aufl., Jena.Google Scholar
  14. 14.
    Mühldorfer, I,m and Hacker, J., 1999, Pathogenitätscharakteristika potentieller Infektionserreger im Urogenitaltrakt. Nieren-und Hochdruckk. 3: 8–84.Google Scholar
  15. 15.
    Johnson, J.R., 1991, Virulence factors in Escherichia coli urinary tract infection. Clin. Microbiol. Rev. 4: 80–128.PubMedGoogle Scholar
  16. 16.
    Mobley, H.L.T., Island, M.D., and Massad, G., 1994, Virulence determinants of uropathogenic Escherichia coli and Proteus mirabilis. Kidney Int. 47 (Suppl.): 129–136.Google Scholar
  17. 17.
    Mühldorfer, I., and Hacker, J., 1994, Genetic aspects of Escherichia coli virulence. Microb. Pathogen. 16: 171–181.Google Scholar
  18. 18.
    Ludwig, A., and Goebel, W., 1991, Genetic determinants of cytolytic toxins from gram-negative bacteria In Sourcebook of Bacterial Protein Toxins. (J.E. Alouf and J.H. Freer, eds.) Academic Press, London, pp. 117–146.Google Scholar
  19. 19.
    Fünfstück, R., Tschäpe, H., Stein, G., Vollandt, R., and Schneider, S., 1989, Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. Clin. Nephrol. 4: 168–184.Google Scholar
  20. 20.
    Foxman, B., Zhang, L., Palin, K., Tallman, P., and Marrs, C.F., 1995, Bacterial virulence characteristics of Escherichia coli isolates from first-time urinary tract infection. J. Infect. Dis. 171: 1514–1521.PubMedGoogle Scholar
  21. 21.
    Leffler, H., and Svanborg-Eden, C., 1981, Glycolipid receptors for uropathogenic E. coli binding to human erythrocytes and uroepithelial cells. Globoseries glycolipid versus other receptors. Infect. Immun. 34: 920–929.PubMedGoogle Scholar
  22. 22.
    Elo, J., 1991, Mikrobiologische Aspekte in der Pathogenese der Pyelonephritis. In Harnwegsinfektion (G. Stein. and R. Fünfstück, R eds), pmi-Verlag, Frankfut/Main, pp. 11–13.Google Scholar
  23. 23.
    Russo, T.A., Stapleton, A., Wenderoth, S., Hooton, T.M., and Stamm, W.E., 1995, Chromosomal restriction fragment length polymorphism analysis of Escherichia coli strains causing recurrent urinary tract infections in young women. J. Infect. Dis. 172: 440–445.PubMedGoogle Scholar
  24. 24.
    Savoia, D., Millesmo, M., and Fontana, G., 1994, Evaluation of virulence factors and the adhesive capability of Escherichia coli strains. Microbio. 80: 73–81.Google Scholar
  25. 25.
    Stapleton, A., and Stamm, W.E., 1997, Prevention of urinary tract infection. Infect. Dis. Clin. North. Am. 3: 719–733.Google Scholar
  26. 26.
    Hooton, T.M., Roberts, P.L., and Stamm, W.E., 1994, Effects of recent sexual activity and use of a diaphragma on the vaginal microflora. Clin. Infect. Dis. 19: 274–278.PubMedGoogle Scholar
  27. 27.
    Kinane, D.F., Blackwell, C.C., Brettle, R.P., Weir, D.M. Winstanley, F.P., and Elton, R.A., 1982, ABO blood group, secretor state, and susceptibility to recurrent urinary tract infection in women. Br. Med. J. Clin. Res. Ed. 285: (6334), 7–9.PubMedCrossRefGoogle Scholar
  28. 28.
    Sheinfeld,.J., Schaeffer, A.J., and Cordon-Cardo, C., 1989, Association of the Lewis blood-group phenotype with recurrent urinary tract infection in women. N. Engl. J. Med. 320: 773–777.PubMedCrossRefGoogle Scholar
  29. 29.
    Lomberg, H., Hellström, M., Jodal, U., and Svanborg-Eden, C., 1989, Secretor state and renal scarring in girls with recurrent pyelonephritis. FEMS Microbiol. Immunol. 1: 371–376.PubMedGoogle Scholar
  30. 30.
    Plos, K., Connel, H., Jodal, U., Marklund, B-I., Märild, S., Wettergren, B., and Svanborg, C., 1995, Intestinal carriage of P-fimbriated Escherichia coli and the susceptibility to urinary tract infection in yound children. J. Infect. Dis. 171: 625–631.PubMedGoogle Scholar
  31. 31.
    Blackwell, C.C., 1989, The role of ABO blood groups and secretor status in host defences. FEMS Microbiol. Immunol. 1: 341–349.PubMedGoogle Scholar
  32. 32.
    Jacobsohn, N., 1997, Thesis Erreger-Wirt-Beziehung bei chronischer Pyelonephritis unter besonderer Berücksichtigung des ABO-, P-und des Lewis-Blutgruppensystems sowie des Sekretorstatus. University of Jena.Google Scholar
  33. 33.
    Blackwell, C.C., May, S.J., Brettle, R.P., Mac Callum, O.J., and Weir, D.M., 1987, Secretor state and immunglobulin levels among women with recurrent urinary tract infections. J. Clin. Lab. Immunol. 22: 133–137.PubMedGoogle Scholar

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© Kluwer Academic Publishers 2002

Authors and Affiliations

  1. 1.Department of Internal Medicine IVFriedrich-SchillerUniversity of JenaJenaGermany

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