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The Permeability Transition Pore in Myocardial Ischemia and Reperfusion

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Mitochondria in Pathogenesis

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Conclusions

Opening of the permeability transition pore converts mitochondria from organelles whose supply of ATP sustains then in their normal function into organells of death. Conditions during reperfusion after ischemia are optimal for inducing this transition and thus may play a critical role in determining whether the cell recovers. From an understanding of the properties and mechanism of the MPTP, one can devise perfusion protocols that minimize pore opening and improve heart recovery following ischemia. This should lead to better cardioplegia during open-heart surgery. It remains to be established whether the short-term protection of isolated perfused heart, where damage is primarily necrotic, will also be reflected in longer-term recovery, where apoptosis may also play an important role.

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Authors and Affiliations

  1. Department of Biochemistry, Bristol Heart Institute, University of Bristol, British Royal Infirmary, Bristol, BS2 8HW, UK

    Andrew P. Halestrap, Paul M. Kerr & M-Saadah Suleiman

  2. Azerbaijan Medical University, Bakn, Azerbaijan

    Sabzali Javadov

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  1. Andrew P. Halestrap
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  2. Paul M. Kerr
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  3. Sabzali Javadov
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  4. M-Saadah Suleiman
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Editors and Affiliations

  1. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    John J. Lemasters

  2. Case Western Reserve University, Cleveland, Ohio

    Anna-Liisa Nieminen

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Halestrap, A.P., Kerr, P.M., Javadov, S., Suleiman, MS. (2002). The Permeability Transition Pore in Myocardial Ischemia and Reperfusion. In: Lemasters, J.J., Nieminen, AL. (eds) Mitochondria in Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-46835-2_9

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  • DOI: https://doi.org/10.1007/0-306-46835-2_9

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