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Mitochondrial Changes after Acute Alcohol Ingestion

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Mitochondria in Pathogenesis

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Conclusion

Active oxidants produced during ethanol metabolism modulate mitochondrial membrane potential and permeability changes in isolated and cultured hepatocytes. These mitochondrial alterations (loss of ΔΨ;the MPT) are now recognized as a key step in programmed cell death. Our fluorographic investigations demonstrate that acute ethanol-induced oxidative stress can induce mitochondrial permeability change, cyto-chrome c release, caspase activation, and apoptosis in cultured hepatocytes. In addition, our investigations implicate endogenous glutathioneglutathione peroxidase as an impor-tant antioxidant with a cytoprotective machinery in hepatocyte mitochondria exposed to ethanol. Oxidative stress is the consequence of an imbalance between oxidant production and antioxidant defense. Development of new and effective strategies to diminish oxidant production, enhance intracellular and extracellular antioxidant defenses, or both, in the liver offers great promise for preventing and treating liver disease.

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Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, Keio University, Tokyo, 160, Japan

    Hajimi Higuchi & Hiromasa Ishii

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  1. Hajimi Higuchi
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  2. Hiromasa Ishii
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Editors and Affiliations

  1. University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

    John J. Lemasters

  2. Case Western Reserve University, Cleveland, Ohio

    Anna-Liisa Nieminen

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© 2002 Kluwer Academic Publishers

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Higuchi, H., Ishii, H. (2002). Mitochondrial Changes after Acute Alcohol Ingestion. In: Lemasters, J.J., Nieminen, AL. (eds) Mitochondria in Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-46835-2_20

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  • DOI: https://doi.org/10.1007/0-306-46835-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46433-1

  • Online ISBN: 978-0-306-46835-3

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