Skip to main content

Mitochondrial Implication in Cell Death

  • Chapter

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adachi, S., Cross, A. R., Babior, B. M., and Gottlieb, R. A., 1997, Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during Fas-mediated apoptosis, J. Biol. Chem. 272: 21878–21882.

    CAS  PubMed  Google Scholar 

  • Amarante-Mendes, G. P., Kim, C. N., Liu, L., Huang, Y., and Perkins, C. L., 1998, Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspase-3, Blood 5:1700–1705.

    Google Scholar 

  • Antonsson, B., Conti, R, Ciavatta, A., Montessuit, S., and Lewis, S., 1997, Inhibition of Bax channel-forming activity by Bcl-2, Science 277: 370–372.

    Article  CAS  PubMed  Google Scholar 

  • Bernardi, P., and Petronilli, V, 1996, The permeability transition pore as a mitochondrial calcium release channel: A critical appraisal, J. Bioenerg. Biomembr. 28: 129–136.

    Article  Google Scholar 

  • Beutner, G., Rück, A., Riede, B., Welte, W., and Brdiczka, D., 1996, Complexes between kinases, mitochondrial porin, and adenylate translocator in rat brain resemble the permeability transition pore, FEBS Lett. 396: 189–195.

    Article  CAS  PubMed  Google Scholar 

  • Beutner, G., Rück, A., Riede, B., and Brdiczka, D., 1998, Complexes between porin, hexokinase, mitochondrial creatine kinase, and adenylate translocator display properties of the permeability transition pore: Implication for regulation of the permeability transition by the kinases, Biochim. Biophys. Acta 1368: 7–18.

    CAS  PubMed  Google Scholar 

  • Bojes, H. K., Datta, K., Xu, J., Chin, A. S. P., Nunez, G., and Kehrer, J. P., 1997, Bcl-XL overexpression attenuates glutathione depletion in FL5.12 cells following interleukin-3 withdrawal, Biochem. J. 325: 315–319.

    CAS  PubMed  Google Scholar 

  • Bossy-Wetzel, E., Newmeyer, D. D., and Green, D. D., 1998, Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial depolarization, EMBO J. 17: 37–49.

    Article  CAS  PubMed  Google Scholar 

  • Boveris A., and Chance, B., 1973, The mitochondial generation of hydrogen peroxide, Biochem. J. 134: 707–716.

    CAS  PubMed  Google Scholar 

  • Brustovetsky, N., and Klingenberg, M., 1996, Mitochondrial ADP/ATP carrier can be reversibly converted into a large channel by Ca2-Biochemistry 35: 8483–8488.

    Article  CAS  PubMed  Google Scholar 

  • Cassarino, D. S., Swerdlow, R. H., Parks, J. K., Parker, W. D., and Bennett, J. P, 1998, Cyclosporine, a increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer’s disease cybrids, Biochem. Biophys. Res. Commun. 248: 168–173.

    Article  CAS  PubMed  Google Scholar 

  • Castedo, M., Hirsch, T. Susin, S. A. Zamzami, N. Marchetti, P. Macho, A., and Kroemer, G., 1996. Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. J. Immunol. 157: 512–521.

    CAS  PubMed  Google Scholar 

  • Chinnaiyan, A. M., Chaudhary, D., O’Rourke, K., Koonin, K., and Dixit, V. M., 1997a, Role of CED-4 in the activation of CED-3, Nature 388: 728–729.

    Article  CAS  PubMed  Google Scholar 

  • Chinnaiyan, A. M., O’Rourke, K., Lane, B. R., and Dixit, V. M., 1997b, Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death, Science 275: 1122–1126.

    Article  CAS  PubMed  Google Scholar 

  • Clapham, D. E., 1998, At last, the structure of an ion-selective channel, Nature Struct. Biol. 5: 342–344.

    Article  CAS  PubMed  Google Scholar 

  • Collins, M. K. L., Forlong, I. J., Malde, P., Ascaso, R., Oliver, J., and Rivas, A. L., 1996, An apoptotic endonuclease activated either by decreasing pH or by increasing calcium, J. Cell Sci. 109: 2393–2399.

    CAS  PubMed  Google Scholar 

  • Cosulich, S. C., Worrall, V., Hedge, P. J., Green, S., and Clarke, P. R., 1998, Regulation of apoptosis by BH3 domains in a cell-free system. Curr. Biol. 7: 913–920.

    Google Scholar 

  • Decaudin, D., Geley, S., Hirsdch, T., Castedo, M., and Marchetti, P., 1997, Bcl-2 and Bel-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents, Cancer Res. 57: 62–69.

    CAS  PubMed  Google Scholar 

  • Deckwerth, T. L., and Johnson, E. M., 1993, Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor, J. Cell Biol. 123: 1207–1222.

    Article  CAS  PubMed  Google Scholar 

  • Deshmuth, M., and Johnson, E. M., 1998, Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome c, Neuron 21: 695–705.

    Google Scholar 

  • Du, Y., Dodel, R. C., Bales, K. R., Jemmerson, E., Hamilton-Byrd, S. M., and Paul, J., 1998, Alpha2-macroglobulin attenuates beta-amyloid peptide 1–40 fibril formation and associated neurotoxicity of cultured fetal rat cortical neurons, Neurochemistry 69: 1382–1388.

    Google Scholar 

  • Dubrez, L., Eymin, B., Sordet, O., Droin, N., Turhan, A. G., and Solary, E., 1998, BCR-Abl delays apoptosis upstream of caspase-3 activation, Blood 91: 2415–2422.

    CAS  PubMed  Google Scholar 

  • Dumont, M. E., Cardillo, T. S., Hayes, M. K., and Sherman, F., 1991, Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Sacchammyces cerevisiae, Mol. Cell. Biol. 11: 5487–5496.

    CAS  PubMed  Google Scholar 

  • Enari, M., Hase, A., and Nagata, S., 1995, Apoptosis by a cytosolic extract from Fas-activated cells, EMBO J. 14: 5201–5208.

    CAS  PubMed  Google Scholar 

  • Enari, M., Talanian, R. V, Wong, W. W., and Nagata, S., 1996, Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis, Nature 380: 723–726.

    Article  CAS  PubMed  Google Scholar 

  • Eskes, R., Antosson, B., Osen-Sand, A., Montesuit, S., and Richter, C., 1998, Bax-induced cytochrome c release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions, J. Cell Biol. 143: 217–224.

    Article  CAS  PubMed  Google Scholar 

  • Frade, J. M., and Michaelidis, T. M., 1997, Origin of eucaryotic programmed cell death: A consequence of the aerobic metabolism, BioEssays 19: 827–832.

    Article  CAS  PubMed  Google Scholar 

  • Fridovic, I., 1978, The biology of oxygen radicals, Science 201: 875–880.

    Google Scholar 

  • Fujimura, M., Morita-Fugimura, Y, Murakani, K., Kawase, M., and Chan, P. H., 1998, Cytosolic redistribution of cytochrome c after transient focal ischemia in rats, J. Cereb. Blood Flow Metab. 18: 1239–1247.

    CAS  PubMed  Google Scholar 

  • Gleichmann, M., Beinroth, S., Reed, J. C., Krajewski, S., and Schultz, J. B., 1998, Potassium deprivation-induced apoptosis of cerebellar granule neurons: Cytochrome c release in the absence of altered expression of Bcl-2 family proteins. Cell Physiol. Biochem. 8: 194–201.

    Article  CAS  PubMed  Google Scholar 

  • Goossens, V, Grooten, J., De Vos, K., and Fiers, W., 1995, Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity, Proc. Natl. Acad. Sci. USA 92: 8115–8119.

    CAS  PubMed  Google Scholar 

  • Granville, D. J., Carthy, C. M., Jiang, H., Shore, G. C., McManus, B. M., and Hunt, D. W., 1998, Rapid cytochrome c release, activation of caspases 3, 6, 7, and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy, FEBS Lett. 437: 5–10.

    Article  CAS  PubMed  Google Scholar 

  • Green, D. R., 1998, Apoptotic pathways: The road to ruin, Cell 94: 695–698.

    Article  CAS  PubMed  Google Scholar 

  • Greenlund, L. J. S., Deckwert, T. L., and Johnson, E. M., 1995, Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed cell death, Neuron 14: 303–315.

    Article  CAS  PubMed  Google Scholar 

  • Gudz, T. I., Tsemg, K. Y., and Hoppel, C. L., 1997, Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide, J. Biol. Chem. 272: 24154–24158.

    Article  CAS  PubMed  Google Scholar 

  • Guénal, I., Sidoti-de Fraisse, C., Gaumer, S., and Mignotte, B., 1997, Bcl-2 and HSP27 act at different levels to suppress programmed cell death, Oncogene 15: 347–360.

    Article  PubMed  Google Scholar 

  • Hartley, A., Stone, J. M., Heron, C., Cooper, J. M., and Schapira, A. H. V, 1994, Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson disease, J. Neurochem. 63: 1987–1990.

    CAS  PubMed  Google Scholar 

  • Henkart, P. A., and Grinstein, S., 1996, Apoptosis: Mitochondria resurrected? J. Exp. Med. 183: 1293–1295.

    Article  CAS  PubMed  Google Scholar 

  • Henze, K., Nadr, A., Wettem, M., Cerff, R., and Martin, W., 1995, A nuclear gene of eubacterial origin in Euglena gracilis reflects cryptic endosymbioses during protist evolution, Proc. Natl. Acad. Sci. USA 92: 9122–9126.

    CAS  PubMed  Google Scholar 

  • Higuchi, M., Aggarwal, B. B., and Yeh, E. T. H., 1997, Activation of CCP32-like protease in tumor necrosis factor-induced apoptosis is dependent on mitochondrial function, J. Clin. Invest. 99: 1751–1758.

    CAS  PubMed  Google Scholar 

  • Hoffmann, K., Bucher, P., and Tschopp, J., 1997, The CARD domain: A new apoptotic signaling motif, Trends Biochem. Sci. 22: 155–156.

    Google Scholar 

  • Ichas, F., Jouaville, L., and Mazat, J. P., 1997, Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals, Cell 89: 1145–1153.

    Article  CAS  PubMed  Google Scholar 

  • Jacobson, M. D., 1996, Reactive oxygen species and programmed cell death, Trends Biochem. Sci. 21: 83–86.

    Article  CAS  PubMed  Google Scholar 

  • Jacobson, M. D., and Raff, M. C., 1995, Programmed cell death and Bcl-2 protection in very low oxygen, Nature 374: 814–816.

    Article  CAS  PubMed  Google Scholar 

  • Jones, D. P., McConkey, D. J., Nicotera, P., and Orrenius, S., 1989, Calcium-activated DNA fragmentation in rat liver nuclei, J. Biol. Chem. 264: 6398–6403.

    CAS  PubMed  Google Scholar 

  • Jones, D. P., and Lash, L. H., 1993, Criteria for Assessing Normal and Abnormal Mitochondrial Functions, Vol. 2, Academic, San Diego, pp. 1–7.

    Google Scholar 

  • Kane, D. J., Sarafian, T. A., Anton, R., Hahn, H., and Gralla, E. B., 1993, Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species, Science 262: 1274–1277.

    CAS  PubMed  Google Scholar 

  • Kerr, J. F. R., Wyllie, A. H., and Currie, A. R., 1972, Apoptosis: A basic biological phenomenon with wideranging implications in tissue kinetics, Br J. Cancer 26: 239–257.

    CAS  PubMed  Google Scholar 

  • Kharbanda, S., Pandey, P., Schofield, L., Israels, S., and Roncinske, R., 1997, Role of Bcl-XL as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis, Proc. Natl. Acad. Sci. USA 94: 6939–6942.

    Article  CAS  PubMed  Google Scholar 

  • Kiberstis, P. A., 1999, Mitochondria make their comeback. Science 83: 1475.

    Google Scholar 

  • Kim, C. N., Wang, X., Huang, Y., Liu, L., Fang, G., and Bhalla, K., 1997, Overexpression of Bcl-XL inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis, Cancer Res. 57: 3115–3120.

    CAS  PubMed  Google Scholar 

  • Kinnaly, K.. W., Lohret, T. A., Campo, M. L., and Mannella, C. A., 1996, Perspectives on the mitochondrial multiple conductance channel, J. Bioenerg. Biomenbr. 28: 115–123.

    Google Scholar 

  • Kluck, R. M., Bossy-Wetzel, E., Green, D. R., and Newmeyer, D. D., 1997a, The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275: 1132–1136.

    Article  CAS  PubMed  Google Scholar 

  • Kluck, R. M., Martin, S. J., Hoffman, B. M., Zhou, J. S., Green, D. R., and Newmeyer, D. D., 1997b, Cytochrome c activation of CPP32-like proteolysis plays a critical role in Xenopus cell-free apoptosis system, EMBO J. 16: 4639–4649.

    Article  CAS  PubMed  Google Scholar 

  • Korsmeyer, S. J., 1992, Bcl-2: A repressor of lymphocyte death, Immunol. Today 13: 285–288.

    Article  CAS  PubMed  Google Scholar 

  • Krippner, A., Matsuno-Yagi, A., Gottlieb, R. A., and Babior, B. M., 1996, Loss of function of cytochrome c in Jurkat cells undergoing Fas-mediated apoptosis, J. Biol. Chem. 271: 21629–21636.

    CAS  PubMed  Google Scholar 

  • Kroemer, G., 1997a, Mitochondrial implication in apoptosis: Toward an endosymbiont hypothesis of apoptosis evolution, Cell Death Diff. 4: 443–456.

    CAS  Google Scholar 

  • Kroemer, G., 1997b, The proto-oncogene Bcl-2 and its role in regulating apoptosis: The mechanism of action of Bcl-2 clues for therapeutic interventions, Nature Medicine 3: 614–620.

    Article  CAS  PubMed  Google Scholar 

  • Kroemer, G., Petit, P. X., Zamzami, N., Vayssière, J.-L., and Mignotte, B., 1995, The biochemistry of apoptosis, FASEB J. 9: 1277–1287.

    CAS  PubMed  Google Scholar 

  • Kroemer, G., Zamzami, N., and Susin, S. A., 1997, Mitochondrial control of apoptosis, Immunol. Today 18: 44–51.

    Article  CAS  PubMed  Google Scholar 

  • Kumar, S., and Harvey, N. L., 1995, Role of multiple cellular proteases in the execution of programmed cell death, FEBS Lett. 375: 169–173.

    Article  CAS  PubMed  Google Scholar 

  • Kupsch, E. M, Knepper, B., Kuroki, T., Heuer, I., and Meyer, T. F., 1993, Variable opacity (Opa) outer membrane proteins account for the cell trophisms displayed by Neisseria gonorrhoeae for human leukocytes and epithelial cells, EMBO J. 12: 641–650.

    CAS  PubMed  Google Scholar 

  • Kurihara, H., Torigoe, S., Omura, M., Saito, K., Kurihara, M., and Matsubara, S., 1998, DNA fragmentation induced by a cytoplasmic extract from irradiated cells, Radiat. Res. 150: 269–274.

    CAS  PubMed  Google Scholar 

  • Kuwana, T., Smith, J. J., Muzio, M., Dixit, V, Newmeyer, D. D., and Kornbluth, S., 1998, Apoptosis induction by caspase-8 is amplified through the mitochondrial release of cytochrome c, J. Biol. Chem. 273: 16589–16594.

    Article  CAS  PubMed  Google Scholar 

  • Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G., and Earnshaw, W. C., 1993, Nuclear events of apoptosis in vitro in cell-free mitotic extracts: A model system for analysis of the active phase of apoptosis, J, Cell. Biol. 123: 7–22.

    Article  CAS  Google Scholar 

  • Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C., 1994, Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE, Nature 371: 346–347.

    Article  CAS  PubMed  Google Scholar 

  • Lazebnik, Y. A., Takahashi, A., Poirier, G. G., Kaufman, S. H., and Earnshaw, W. C., 1995, Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells, J. Cell Sci. S19: 41–49.

    Google Scholar 

  • Lennon, S. V, Martin, S. J., and Cotter, T. G., 1991, Dose-dependent induction of apoptosis in human tumor cell lines by widely diverging stimuli, Cell Prolif. 24: 203–214.

    CAS  PubMed  Google Scholar 

  • Leoni, L. M., Chao, Q., Cottam, H. B., Rosenbach, M., and Carrera, C. J., 1998, Induction of an apoptotic program in cell-free extract by 2-chloro-2′-deoxyadenosine 5′triphosphate and cytochrome c Proc. Natl. Acad. Sci. USA 95: 9567–9571.

    Article  CAS  PubMed  Google Scholar 

  • Lin, K. T., Xue, J. Y, and Wong, P. Y, 1997, Reactive oxygen species participate in peroxinitrite-induced apoptosis in HL-60 cells, Biochem. Biophys. Res. Commun. 230: 115–119.

    Article  CAS  PubMed  Google Scholar 

  • Liu, X., Kim, C. N., Yang, J., Jemmerson, R., and Wang, X., 1996, Induction of apoptic program in cell-free extracts: Requirement for dATP and cytochrome c Cell 86: 147–157.

    CAS  PubMed  Google Scholar 

  • Liu, X., Zou, H., Slaughter, C., and Wang, X., 1997, DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis, Cell 89: 175–184.

    CAS  PubMed  Google Scholar 

  • Mancini, M., Nicholson, D. W., Roy, S., Thornberry, N. A., and Peterson, E. P., 1998, The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling, J. Cell Biol. 140: 1485–1495.

    Article  CAS  PubMed  Google Scholar 

  • Manon, S., B. C., and Guùrin, M., 1997, Release of cytochrome c and decrease of cytochrome c oxidase in Baxexpressing yeast cells, and prevention of these effects by coexpression of Bcl-XL, FEBS Lett. 415: 29–32.

    Article  CAS  PubMed  Google Scholar 

  • Marchetti, P., Susin, S. A., Decaudin, D., Gamen, S., and Castedo, M., 1996a, Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA, Cancer Res. 56: 2033–2038.

    CAS  PubMed  Google Scholar 

  • Marchetti, P., Zamzami, N., Susin, S. A., Petit, P. X., and Kroemer, G., 1996b, Apoptosis of cells lacking mitochondrial DNA, Apoptosis 1: 119–125.

    CAS  Google Scholar 

  • Marchetti, P., Decaudin, D., Macho, A., Zamzami, N., and Hirsch, T., 1997, Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function, Eur. J. Immunol. 27: 289–296.

    CAS  PubMed  Google Scholar 

  • Margulis, L., 1996, Archaeal-eubacterial mergers in the origin of Eukarya: Phylogenetic classification of life, Proc. Natl. Acad. Sci. USA 93: 1071–1076.

    Article  CAS  PubMed  Google Scholar 

  • Martin, S. J., and Cotter, T. G., 1991, Ultraviolet B irradiation of human leukemia HL-60 cells in vitro induces apoptosis, Int. J. Radiat. Biol. 59: 1001.

    CAS  PubMed  Google Scholar 

  • Martin, S. J., and Green, D. R., 1995, Protease activation during apoptosis: Death by a thousand cuts? Cell 82: 349–352.

    Article  CAS  PubMed  Google Scholar 

  • Martin, S. J., Newmeyer, D. D., Mathisa, S., Farschon, D. M., and Wang, H. G., 1995, Cell-free reconstitution of Fas-, UV radiation-and ceramide-induced apoptosis, EMBO J. 14: 5191–5200.

    CAS  PubMed  Google Scholar 

  • Marzo, L, Brenner, C., Zamzami, N., Jurgensmeier, J. M., and Susin, S. A., 1998a, Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis, Science 281: 2027–2031.

    Article  CAS  PubMed  Google Scholar 

  • Marzo, I., Brenner, C., Zamzami, N., Susin, S. A., and Beutner, G., 1998b, The permeability transition pore complex: A target for apoptosis regulation by caspases and Bcl-2, J. Exp. Med. 187: 1261–1271.

    Article  CAS  PubMed  Google Scholar 

  • Marzo, I., Susin, S. A., Petit, P. X., Ravagnan, L., and Brenner, C., 1998c, Caspases disrupt mitochondrial membrane barrier function, FEBS Lett. 427: 198–202.

    Article  CAS  PubMed  Google Scholar 

  • Mayer, M., and Noble, M., 1994, N-acetyl-L-cystein is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro, Proc. Natl. Acad. Sci. USA 91: 7496–7500.

    CAS  PubMed  Google Scholar 

  • Mayer, A., Neupert, W., and Lill, R., 1995a, Mitochondrial protein import: Reversible binding of the presequence at the trans side of the outer membrane drives partial translocation and unfolding, Cell 80: 127–137.

    Article  CAS  PubMed  Google Scholar 

  • Mayer, A., Neupert, W., and Lill, R., 1995b, Translocation of apopcytochrome c across the outer membrane of mitochondria, J. Biol. Chem. 270: 12390–12397.

    CAS  PubMed  Google Scholar 

  • McConkey, D. J., 1996, Calcium-dependent, interleukin 1 beta-converting enzyme inhibitor-insensitive degradation of lamin B-l and DNA fragmentation in isolated thymocyte nuclei, J. Biol. Chem. 271: 22398–22406.

    CAS  PubMed  Google Scholar 

  • McEnery, M. W., Snowman, A. M, Trifiletti, R. R. and Snyder, S. H., 1992, Isolation of the mitochondrial benzodiazepine receptor. Association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. USA 89: 3170–3174.

    CAS  PubMed  Google Scholar 

  • Mehlen, P., Schulze-Osthoff, K., and Arrigo, A.-P., 1996, Small stress proteins as novel regulators of apoptosis: Heat shock protein 27 blocks Fas/Apo-1 and staurosporine-induced cell death, J. Biol. Chem. 271: 16510–16514.

    CAS  PubMed  Google Scholar 

  • Metivier, D., Dallaporta, B., Zamzami, N., Larochette, N., and Susin, S. A., 1998, Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-l-triggered apoptosis of Jurkat lymphoma cells: Comparison of seven mitochondrion-specific fluorochromes, Immunol. Lett., in press.

    Google Scholar 

  • Mignotte, B., Larcher, J. C., Zheng, D. Q., Esnault, C., Coulaud, D., and Feuteun, J., 1990, SV40 induced cellular immortalization: Phenotypic changes associated with the loss of proliferative capacity in a conditionally immortalized cell line, Oncogene 5: 1529–1533.

    CAS  PubMed  Google Scholar 

  • Minn, A. J., Velez, P., Schnedel, S. L., Liang, H., and Muchmore, S. W., 1997, Bcl-XL forms an ion channel in synthtic lipid membranes, Nature 385: 353–357.

    Article  CAS  PubMed  Google Scholar 

  • Mirkovic, N., Voehringer, D. W, Story, M. D., McConkey, D. J., McDonnell, T. J., and Meyn, R. E., 1997, Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols, Oncogene 15: 1461–1470.

    Article  CAS  PubMed  Google Scholar 

  • Muchmore, S. W., Sattler, M., Liang, H., Meadows, R. P., and Harlan, J. E., 1996, X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature 381: 335–341.

    Article  CAS  PubMed  Google Scholar 

  • Muzio, M., Salvesen, G. S., and Dixit, V M., 1997, FL1CE induced apoptosis in a cell-free system: Cleavage of caspase zymogens, J. Biol Chem. 272: 2952–2956.

    CAS  PubMed  Google Scholar 

  • Neame, S. J., Rubin, L. L., and Philpott, K. L., 1998, Blocking cytochrome c activity within intact neurons inhibits apoptosis, J. Cell Biol. 142: 1583–1593.

    Article  CAS  PubMed  Google Scholar 

  • Newmeyer, D. D., Farschon, D. M., and Reed, J. C., 1994, Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria. Cell 79: 353–364.

    Article  CAS  PubMed  Google Scholar 

  • Nicholson, D. W., and Thornberry, N. A.. 1997, Caspases: Killer proteases, Trends Biachem. Sci. 22: 299–306.

    CAS  Google Scholar 

  • Nieminen, A.-L., Dawson, T. L., Gores, G. J., Kawanishi, T., Herman, B., and Lemasters, J. J., 1990, Protection by acidotic pH and fructose against lethal injury to rat hepatocytes from mitochondrial inhibitors, ionophores, and oxidant chemicals, Biochem. Biophys. Res. Commun. 167: 600–606.

    Article  CAS  PubMed  Google Scholar 

  • O’Donnell, V B., Spycher, S., and Azzi, A., 1995, Involvement of oxidants and oxidant-generating enzymes in tumor necrosis factor γ-mediated apoptosis: Role for lipoxygenase pathway but not mitochondrial respiratory chain, Biochem. J. 310: 133–141.

    CAS  PubMed  Google Scholar 

  • O’Ciorman, E., Beutner, G., Dolder, M., Koretsky, A. P., Brdiczka, D., and Walliman, T., 1997, The role of creatine kinase in inhibition of mitochondrial permeability transition, FEBS Lett. 414: 253–257.

    Google Scholar 

  • Oltvai, Z. N., and Korsmeyer, S. J., 1994, Checkpoints of dueling dimers foil death wishes, Cell 79: 189–192.

    Article  CAS  PubMed  Google Scholar 

  • Pastorino, J. G., Simbula, G., Gilfor, E., Hoek, J. B., and Farber, J. L., 1994. Protoporphyrin IX, an endogenous ligand of the peripheral benzodiazepine receptor, potentiates induction of the mitochondrial permeability transition and the killing of cultured hepatocytes by rotenone. J Biol Chem 269: 31041–31046.

    CAS  PubMed  Google Scholar 

  • Petit, P. X., Lecoeur, H., Zorn, E., Dauguet, C., Mignotte, B., and Gougeon, M. L., 1995, Alterations of mitochondrialstructure and function are early events of dexamethasone-induced thymocyte apoptosis, J. Cell. Biol. 130: 157–167.

    Article  CAS  PubMed  Google Scholar 

  • Petit, P. X., Susin, S. A., Zamzami, N., Mignotte, B., and Kroemer, G., 1996, Mitochondria and programmed cell death: Back to the future. FEBS Lett. 396: 7–14.

    Article  CAS  PubMed  Google Scholar 

  • Petit, P. X., Zamzami, N., Sidoti-de Fraisse, C., Vayssiere, J. L., and Mignotte, B., 1997, Implication of mitochondria in apoptosis, Mol. Cell. Biochem. 174: 185–188.

    Article  CAS  PubMed  Google Scholar 

  • Petit, P. X., Goubern, M., Diolez, P., Susin, S. A., and Zamzami, N. G. K., 1998, Disruption of the outer mitochondrial membrane as a result of largeamplitude swelling: The impact of irreversible permeability transition, WHS Lett. 426: 11–116.

    Google Scholar 

  • Pinkus, R., Weiner, L. M., Daniel, V, 1996. Role of oxidants and antioxidants in the induction of AP-1, and glutathion S-transferase gene expression, J. Biol. Chem. 271: 13422–13429.

    CAS  PubMed  Google Scholar 

  • Quillet-Mary, A., Jaffrezou, J. P., Mansat, V., Bordier, C., Naval, J., and Laurent, G., 1997, Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis, J. Biol. Chem. 272: 21388–21395.

    Article  CAS  PubMed  Google Scholar 

  • Ratan, R. R., Murphy, T. H., and Baraban, J. M., 1994, Oxidative stress induces apoptosis in embryonic cortical neurons. J. Neurochem. 62: 376–379.

    CAS  PubMed  Google Scholar 

  • Reed, J. C., 1997, Cytochrome c: Can’t live without it, Cell 91: 559–562.

    Article  CAS  PubMed  Google Scholar 

  • Reed, J. C., Jurgensmeier, J. M., and Matsuyama, S., 1998, Bcl-2 family proteins and mitochondria, Biochim. Biophys. Acta 1366: 127–137.

    CAS  PubMed  Google Scholar 

  • Richter, C., Schweizer, M., Cossariza, A., and Franceschi, C., 1996, Control of apoptosis by ATO levels, FEBS Lett. 378: 107–110.

    Article  CAS  PubMed  Google Scholar 

  • Rottenberg, H., and Wu, S., 1998, Quantitative assay by flow cytometry of the mitochondrial membrane potential in intact cells, Biochim. Biophys. Acta 1404: 393–404.

    CAS  PubMed  Google Scholar 

  • Rudel, T., Schmid, A., Benz, R., Kolb, H. A., Lang, F., and Meyer, T. F., 1996, Modulation of Neisseria porin (poR) by cytosolic ATP/GTP of target cells: Parallels between pathogen accomodation and mitochondria endosymbiosis, Cell 85: 391–402.

    Article  CAS  PubMed  Google Scholar 

  • Sandstrom, P. A., and Buttke, T. M., 1993, Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium, Proc. Natl. Acad. Sci. USA 90: 4708–712.

    CAS  PubMed  Google Scholar 

  • Sato, N., Iwata, S., Nakamura, K., Hori, T., Mori, K.., and Yodoi, J., 1995, Thiol-mediated redox regulation of apoptosis: Possible roles of cellular thiols other than glutathione in T cell apoptosis, J. Immunol. 154: 3194–3203.

    CAS  PubMed  Google Scholar 

  • Schendel, S. L., Xie, Z., Montal, M. O., Matsuyama, S., Montal, M., and Reed, J. C., 1997, Channel formation by antiapoptotic protein Bcl-2, Proc. Natl Acad. Sci. USA 94: 5113–5118.

    Article  CAS  PubMed  Google Scholar 

  • Schlesinger, P. H., Gross, A., Yin, X. M., Yamamoto, K., and Saito, M., 1997, Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2z, Proc. Natl. Acad. Sci. USA 94: 11357–11362.

    Article  CAS  PubMed  Google Scholar 

  • Schulze-Osthoff, K., Bakker, A. C., Vanhaesbroeck, B., Beyaert, R., Jacob, W. A., and Fiers, W., 1992, Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions: Evidence for the involvement of mitochondrial radical generation, J. Biol. Chem. 267: 5317–5323.

    CAS  PubMed  Google Scholar 

  • Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V, Haegeman, G., and Fiers, W., 1993, Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF, EMBO J. 12: 3095–3104.

    CAS  PubMed  Google Scholar 

  • Shimizu, S., Eguchi, Y, Kosaka, H., Kamiike, W., Matsuda, H., and Tsujimoto, Y, 1995, Prevention of hypoxia-induced cell death by Bcl-2 and Bel-XL, Nature 374: 811–813.

    Article  CAS  PubMed  Google Scholar 

  • Stridh, H., Kimland, M., Jones, D. P., Orrenius, S., and Hampton, M. B., 1998, Cytochrome c release and caspase activation in hydrogen peroxide-and tributyltin-induced apoptosis, FEBS Lett. 429: 351–355.

    Article  CAS  PubMed  Google Scholar 

  • Susin, S. A., Zamzami, N., Castedo, M., Hirsch, T., and Marchetti, P., 1996, Bcl-2 inhibits the mitochondrial release of an apoptogenic protease, J. Exp. Med. 184: 1331–1342.

    Article  CAS  PubMed  Google Scholar 

  • Susin, S. A., Zamzami, N., Castedo, M., Daugas, E., and Wang, H.-G., 1997a, The central executioner of apoptosis: Multiple connections between proteases activation and mitochondria in Fas/APO-1/CD95-and ceramide-induced apoptosis, J. Exp. Med. 186: 25–37.

    Article  CAS  PubMed  Google Scholar 

  • Susin, S. A., Zamzami, N., Larochette, N., Dallaporta, B., and Marzo, I., 1997b, A cytofluorometric assay of nuclear apoptosis in a cell-free system: Application to ceramide-induced apoptosis, Exp. Cell Res. 236: 397–403.

    Article  CAS  PubMed  Google Scholar 

  • Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., and Brenner, C., 1998, Mitochondrial release of caspase-2 and caspase-9 during the apoptotic process, J. Exp. Med. 189: 381–394.

    Google Scholar 

  • Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., and Snow, E. B., 1999, Molecular characterization of mitochondrial apoptosis-inducing factor, Nature 397: 441–445.

    CAS  PubMed  Google Scholar 

  • Taylor, F. R. J., 1974, Implications and extensions of the serial endosymbiosis theory of the origin of eukaryotes, Taxon 23: 229–258.

    Google Scholar 

  • Thompson, C. B., 1995, Apoptosis in the pathogenesis and treatment of disease, Science 267: 1456–1462.

    CAS  PubMed  Google Scholar 

  • Tudor, J. J., and Karp, M. A., 1994, Translocation of an outer membrane protein into prey cytoplasmic membranes of Bdellovibrio bacteriavirus, J. Bacterial. 172: 4002–4007.

    Google Scholar 

  • Uckun, F. M., Tuel-Ahlgren, L., Song, C. W., Waddick, K., and Myers, D. E., 1992, Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death, Proc. Natl. Acad. Sci. USA 89: 9005–9009.

    CAS  PubMed  Google Scholar 

  • Van den Dobbelsteen, D. J., Nobel, C. S. I., Schlegel, J., Cotgreave, I. A., Orrenius, S., and Slater, A. F. G., 1996, Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody, J. Biol. Chem. 271: 15240–15427.

    Google Scholar 

  • Van der Heiden, M. G., Chandel, N. S., Williamson, E. K., Schumacher, P. J., and Thompson, C. B., 1997, Bcl-XL regulates the membrane potential and volume homeostasis of mitochondria, Cell 91: 627–637.

    Google Scholar 

  • Vayssière, J.-L., Petit, P. X., Risler, Y., and Mignotte, B., 1994, Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40, Proc. Natl. Acad. Sci. USA 91: 11752–11756.

    PubMed  Google Scholar 

  • Weel, J. F. L., and va Putten, J. P. M., 1991, Fate of the major outer membrane protein P.IA in early and late events of gonococcal infection of epithelial cells, Res. Microbiol. 142: 985–993.

    Article  CAS  PubMed  Google Scholar 

  • Wolvetang, E. J., Johnson, K. L., Krauer, K., Ralph, S. J., and Linnane, A. W., 1994, Mitochondrial respiratory chain inhibitors induce apoptosis, FEBS Lett. 339: 40–44.

    Article  CAS  PubMed  Google Scholar 

  • Wong, A., and Cortopassi, G., 1997, MtDNA mutations confer cellular sensitivity to oxidant stress that is partially rescued by calcium depletion and cyclosporine A, Biochem. Biophys. Res. Commun. 239: 139–145.

    Article  CAS  PubMed  Google Scholar 

  • Wong, G. H. W., Elwell, J. H., Oberley, L. W., and Goeddel, D. V, 1989, Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor, Cell 58: 923–931.

    Article  CAS  PubMed  Google Scholar 

  • Yang, J., Liu, X., Bhalla, K.., Kim, C. N., and Ibrado, A. M., 1997, Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked, Science 275: 1129–1132.

    Article  CAS  PubMed  Google Scholar 

  • Zamzami, N., Marchetti, P., Castedo, M., Decaudin, D., and Macho, A., 1995a, Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death, J. Exp. Med. 182: 367–377.

    Article  CAS  PubMed  Google Scholar 

  • Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., and Vayssière, J.-L., 1995b, Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo, J. Exp. Med. 181: 1661–1672.

    Article  CAS  PubMed  Google Scholar 

  • Zamzami, N., Susin, S. A., Marchetti, P., Hirsch, T., and Gómez-Monterrey, I., 1996, Mitochondrial control of nuclear apoptosis, J. Exp. Med. 183: 1533–1544.

    Article  CAS  PubMed  Google Scholar 

  • Zhong, L.-T., Sarafinn, T., Kane, D. J., Charles, A. C., and Mah, S. P., 1993, Bcl-2 inhibits death of central neural cells induced by multiple agents, Proc. Natl. Acad. Sci. USA 90: 4533–4537.

    CAS  PubMed  Google Scholar 

  • Zoratti, M., and Szabò, I., 1995, The mitochondrial permeability transition, Biochim. Biophys. Acta-Rev. Biomembr. 1241: 139–176.

    Google Scholar 

  • Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X., 1997, Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3, Cell 90: 405–413.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Kluwer Academic Publishers

About this chapter

Cite this chapter

Petit, P.X. (2002). Mitochondrial Implication in Cell Death. In: Lemasters, J.J., Nieminen, AL. (eds) Mitochondria in Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-46835-2_11

Download citation

  • DOI: https://doi.org/10.1007/0-306-46835-2_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46433-1

  • Online ISBN: 978-0-306-46835-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics