Legionnaires’ Disease

  • Joseph F. Plouffe


Urinary Antigen Cruise Ship Pontiac Fever Buffer Charcoal Yeast Extract Agar Hospital Water System 
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  1. Bahl, S. Wali, J. P., Handa, R., Rattan. A, Aggarwal, P., & Kindo, A. J. (1997) Legionella as a lower respiratory pathogen in north India. Indian J. Chest Dis. Allied Sci.. 39, 81–86.PubMedGoogle Scholar
  2. Baty, V., Hoen, B., Schuhmacher, H., Amiel, C., Reyrolle, M., Garin, H., & Canton, P. (1997). Legionella jordanis pneumonia unresponsive to fluoroquinolones in a non-immuno-compromised host. Scand. J. Infect. Dis., 29, 319–320.PubMedCrossRefGoogle Scholar
  3. Benson, R. F., & Fields, B. S. (1998). Classification of the genus Legionella. Semin. Respir. Infect., 13, 90–99.PubMedGoogle Scholar
  4. Berbari, E. F, Cockerill, F. R. III, & Steckelberg, J. M. (1997). Infective endocarditis due to unusual or fastidious micro-organisms. Mayo Clinic Proc., 72, 532–542.CrossRefGoogle Scholar
  5. Bopp, C. A., Sumner, J. W., Morris, G. K., & Wells, J. C. (1981). Isolation of Legionella spp. from environmental water samples by low-pH treatment and use of a selective medium, J. Clin. Microbiol., 13. 714–719.PubMedGoogle Scholar
  6. Brenner, D.J., Feeley, J. C., & Weaver, R. F. (1984). Re: Family VII, Legionellaceae, in: Bergey’s Manual of Systematic Bacteriology, vol. 1 (N. R. Krieg & J. G. Holt, eds.). Baltimore, MD: Williams & Wilkins, pp. 279–288.Google Scholar
  7. Brieland, J., McClain, M., Heath, L., Chrisp, C., Huffnagle, G., DeGendre, M., Hurley, M., Fantone, J., & Engleberg, C. (1996). Comoculation with Hartmannella vermiformis enhances replicative Legionella pneumophila lung infection in a murine model of Legionnaires’ disease. Infect. Immun., 64, 2449–2456.PubMedGoogle Scholar
  8. Buesching, W.L. Brust, R.A., & Ayers, L.W. (1983). Enhanced primary isolation of Legionella pneumophila from clinical specimens by low-pH treatment. J. Clin. Microbiol., 17, 1153–1155.PubMedGoogle Scholar
  9. Butler, J. C., Benson, R. F., Drozanski, W. J., Rowbotham, T. J., Bialkowska, I., Lipman, H. B., Fields, B. S., File, T. M., Plouffe, J. E., & the CBPIS Group. (1995). Pneumonia associated with Legionella like amoebal pathogens: characteristics and clinical manifestations. 35th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy, September 17–20, San Francisco.Google Scholar
  10. Centers for Disease Control and Prevention. (1997a). Legionnaires disease associated with a whirlpool spa display— Virginia. MMWR, 46. 83–86.Google Scholar
  11. Centers for Disease Control and Prevention. (1997b). Sustained transmission of nosocomial Legionnaires disease—Arizona, 1997. MMWR, 46, 416–421.Google Scholar
  12. Chang, F. Y., Jacobs, S. L., Colodny, S. M., Stout, J. E., & Yu, V. L. (1996b). Nosocomial Legionnaires’ disease caused by Legionella pneumophila serogroup 5: laboratory and epidemiologic implications. J. Infect. Dis., 174, 1116–1119.PubMedGoogle Scholar
  13. Chang, F. Y., Stout, J. E., & Yu, V. L. (1996a). Assessment of enzyme immunoassay versus radioimmunoassay for detection of Legionella pneumophila serogroup 1 antigen in frozen urine specimens, J. Clin. Microbiol., 34, 2628–2629.PubMedGoogle Scholar
  14. Chen, T. T., Schapiro, J. M., & Loutit, J. (1996). Prosthetic valve endocarditis due to Legionella pneumophila, J. Cardiovasc. Surg., 37, 631–633.Google Scholar
  15. Chiba, Y., Okamoto, H., Nagatomo, A., Kunikane, H., & Watanabe, K. (1998). Legionnaires’ disease diagnosed by bronchoalveolar lavage. Intern. Med., 37, 153–156.PubMedGoogle Scholar
  16. College of American Pathologists (1989). College of American Pathologists Survey Program: Bacteriology survey, specimen D-12, final critique, 1989. Skokie, IL.Google Scholar
  17. Cunha, B. A. (1998). Severe community acquired pneumonia. Crit. Care Clin. North Am., 14, 105–118.Google Scholar
  18. Domingo, P., Rodriguez, P., Lopez-Contreras, J., Rebasa, P., Mota, S., & Matias-Guiu, X. (1996). Spontaneous rupture of the spleen associated with pneumonia. Eur. J. Clin. Microbiol. Infect. Dis., 15, 733–736.PubMedCrossRefGoogle Scholar
  19. Drozanski, W. J. (1991). Sarcobium lyticum gen. nov., sp. nov., an obligate intracellular bacterial parasite of small free-living amoebae. Int. J. Syst. Bacteriol., 41, 82–97.CrossRefGoogle Scholar
  20. Ebiary, M., Sarmiento, X., Torres, A., Nogue, S., Mesalles, E., Bodi, M., & Almirall, J. (1997). Prognostic factors of severe Legionella pneumonia requiring admission to ICU. Am. J. Respir. Crit. Care Med., 156, 1467–1472.PubMedGoogle Scholar
  21. Edelstein, P. H., & Cetron, M. S. (1999). Editorial response: sea, wind, and pneumonia. Clin. Infect. Dis., 28, 39–41.PubMedGoogle Scholar
  22. Edelstein, P. H., Edelstein, M. A., Lehr, K. H., & Ren, J. (1996a). In-vitro activity of levofloxacin against clinical isolates of Legionella spp, its pharmacokinetics in guinea pigs, and use in experimental Legionella pneumophila pneumonia. J. Antimicrobial. Chemother., 37, 117–126.Google Scholar
  23. Edelstein, P. H., Edelstein, M. A., Ren, J., Polzer, R., & Gladue, R. P. (1996b). Activity of trovafloxacin (CP-99,219) against Legionella isolates: in vitro activity, intracellular accumulation and killing in macrophages, and pharmacokinetics and treatment of guinea pigs with L. pneumophila pneumonia. Antimicrob. Agents Chemother., 40, 314–319.PubMedGoogle Scholar
  24. Eisenberg, V. H., Eidelman, L. A., Arbel, R., & Ezra, Y. (1997). Legionnaire’s disease during pregnancy: a case presentation and review of the literature. Eur. J. Obstet. Gyn. Reprod. Biol., 72, 15–18.Google Scholar
  25. Ernst, A., Gordon, F. D., Hayek, J., Silvestri, R. C., & Koziel, H. (1998). Lung abscess complicating Legionella micdadei pneumonia in an adult liver transplant recipient: case report and review. Transplantation, 65, 130–134.PubMedGoogle Scholar
  26. Fabbi, M., Pastoris, M. C., Scanziani, E., Magnino, S., & Di Matteo, L. (1998). Epidemiological and environmental investigations of Legionella pneumophila infection in cattle and case report of fatal pneumonia in a calf. J. Clin. Microbiol., 36, 1942–1947.PubMedGoogle Scholar
  27. Fiore, A. E., Nuorti, J. P., Levine, O. S., Marx, A., Weltman, A. C., Yeager, S., Benson, R. F., Pruckler, J., Edelstein, P. H., Greer, P., Zaki, S. R., Fields, B. S., & Butler, J. C. (1998). Epidemic Legionnaires’ disease two decades later: old sources, new diagnostic methods. Clin. Infect. Dis., 26, 426–433.PubMedGoogle Scholar
  28. Fraser, D. W., Tsai, T. R., Orenstein, W., Parkin, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., McDade, J. E., Shepard, C. C., & Brachman, P. S. (1977). Legionnaires’ disease: description of an epidemic of pneumonia. N. Engl. J. Med., 297, 1189–1197.PubMedCrossRefGoogle Scholar
  29. Garcia-de-Lomas, J., Millas, E., Lazaro, M. A., Bermejo, M., Gimeno, C., Navarro, D., & Sanchez, S. (1998). A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs. Eur. J. Clin. Microbiol. Infect. Dis., 17, 420–423.PubMedCrossRefGoogle Scholar
  30. Gardumo, R. A., Quinn, F. D., & Hoffman, P. S. (1998). HeLa cells as a model to study the invasiveness and biology of Legionella pneumophila. Can. J. Microbiol., 44, 430–440.Google Scholar
  31. Girod, J. C., Reichman, R. C., Winn, W. C. Jr., Klaucke, D. N., Vogt, R. L., & Dolin, R. (1982). Pneumonic and non-pneumonic forms of legionellosis. The result of a common-source exposure to L. pneumophila. Arch. Intern. Med., 142, 545–547.PubMedCrossRefGoogle Scholar
  32. Goetz, A. M., Stout, J. E., Jacobs, S. L., Fisher, M. A., Ponzer, R. E., Drenning, S., & Yu, V. L. (1998). Nosocomial Legionnaires’ disease discovered in community hospitals following cultures of the water system: seek and ye shall find. Am. J. Infect. Control, 26, 8–11.PubMedGoogle Scholar
  33. Green, M., Wald, E. R., Dashefsky, B., Barbadora, K., & Wadowsky, R. M. (1996). Field inversion gel electrophoretic analysis of Legionella pneumophila strains associated with nosocomial legionellosis in children. J. Clin. Microbiol., 34, 175–176.PubMedGoogle Scholar
  34. Hackman, B. A., Plouffe, J. F., Benson, R. F., Fields, B. S., & Breiman, R. F. (1996). Comparison of Binax Legionella Urinary Antigen EIA kit with Binax RIA Urinary Antigen kit for detection of Legionella pneumophila serogroup 1 antigen. J. Clin. Microbiol., 34, 1579–1580.PubMedGoogle Scholar
  35. Harrington, R. D., Woolfrey, A. E., Bowden, R., McDowell, M. G., & Hackman, R. C. (1996). Legionellosis in a bone marrow transplant center. Bone Marrow Transplant., 18, 361–368.PubMedGoogle Scholar
  36. Harris, A., Lally, M., & Albrecht, M. (1998). Legionella bozemanii pneumonia in three patients with AIDS. Clin. Infect. Dis., 27, 97–99.PubMedGoogle Scholar
  37. Heath, C. H., Grove, D. L, & Looke, D. F. (1996). Delay in appropriate therapy of Legionella pneumonia associated with increased mortality. Eur. J. Clin. Microbiol. Infect. Dis., 15, 286–290.PubMedCrossRefGoogle Scholar
  38. Heller, R., Holler, C., Sussmuth, R., & Gundermann, K. O. (1998). Effect of salt concentration and temperature on survival of Legionella pneumophila. Lett. Appl. Microbiol., 26, 64–68.PubMedCrossRefGoogle Scholar
  39. Ingram, J. G., & Plouffe, J. F. (1994). Community acquired pneumonia: new pathogens, new therapy. Intern. Med., 15, 41–59.Google Scholar
  40. Ivanyi, B., Hamilton-Dutoit, S. J., Hansen, H. E., & Olsen, S. (1996). Acute tubulointerstitial nephritis: phenotype of infiltrating cells and prognostic impact of tubulitis. Virchows Archiv., 428, 5–12.PubMedGoogle Scholar
  41. Jack, C. I., Smith, T., Jones, R., Ibreck, R., Malster, M. G., & Lye, M. (1996). Legionnaires’ disease—a potential hazard of rationalisation. Br. J. Clin. Pract., 50, 106–107.PubMedGoogle Scholar
  42. Jernigan, D. B., Hofmann, J., Cetron, M. S., Genese, C. A., Nuorti, J. P., Fields, B. S., Benson, R. F., Carter, R. J., Edelstein, P. H., Guerrero, I. C., Paul, S. M., Lipman, H. B., & Breiman, R. (1996). Outbreak of Legionnaires’ disease among cruise ship passengers exposed to a contaminated whirlpool spa. Lancet, 347, 494–499.PubMedCrossRefGoogle Scholar
  43. Johnson, K. M., & Huseby, J. S. (1997). Lung abscess caused by Legionella micdadei. Chest, 111, 252–253.PubMedGoogle Scholar
  44. Joseph, C., Morgan, D., Birtles, R., Pelaz, C., Martin-Bourgon, C., Black, M., Garcia-Sanchez, I., Griffin, M., Bornstein, N., & Bartlett, C. (1996). An international investigation of an outbreak of Legionnaires’ disease among UK and French tourists. Eur. J. Epidemiol, 12, 215–219.PubMedCrossRefGoogle Scholar
  45. Joseph, C. A., Harrison, T. G., Ilijic-Car, D., & Bartlett, C. L. (1997). Legionnaires’ disease in residents of England and Wales: 1996. Commun. Dis. Rep. CDR Rev., 7, R153–R159.PubMedGoogle Scholar
  46. Kazandjian, D., Chiew, R., & Gilbert, G. L. (1997). Rapid diagnosis of Legionella pneumophilla serogroup 1 infection with the binax enzyme immunoassay urinary antigen test. J. Clin. Microbiol, 35, 954–956.PubMedGoogle Scholar
  47. Keller, D. W., Lipman, H. B., Marston, B. J., Plouffe, J. F., File, T. M., & Breiman, R. F. (1995). Clinical diagnosis of Legionnaires’ disease (LD) using a multivariate model. 35th Annual Meeting of the Interscience Conference on Antimicrobial Agents and Chemotherapy, September 17–20, San Francisco, CA.Google Scholar
  48. Keller, D. W., Hajjeh, R., DeMaria, A., Fields, B. S., Pruckler, J. M., Benson, R. S., Kludt, P. E., Lett, S. M., Mermel, L. A., Giorgio, C., & Breiman, R. F. (1996). Community outbreak of Legionnaires’ disease: an investigation confirming the potential for cooling towers to transmit Legionella species. Clin. Infect. Dis., 22, 257–261.PubMedGoogle Scholar
  49. Kirby, B. D., Snyder, R. M., Meyer, R. D., & Finegold, S. M. (1980). Legionnaires’ disease: report of 65 nosocomially acquired cases and a review of the literature. Medicine, 59, 188–205.PubMedGoogle Scholar
  50. Konecny, P., & Bell, A. J. (1996). Positive serology to Legionella longbeachae in patients with adult respiratory distress syndrome. Anaesth. Intens. Care, 24, 678–681.Google Scholar
  51. Kool, J. L., Carpenter, J. C., & Fields, B. S. (1999). Effect of monochloramine disinfection of municipal drinking water on risk of nosocomial Legionnaires’ disease. Lancet, 353, 272–277.PubMedCrossRefGoogle Scholar
  52. Korman, T. M., Fuller, A., Ibrahim, J., Kaye, D., & Bergin, P. (1998). Fatal Legionella longeachae infection following heart transplantation. Eur. J. Clin. Microbiol. Infect. Dis., 17, 53–55.PubMedCrossRefGoogle Scholar
  53. Levy, I., & Rubin, L. G. (1998). Legionella pneumonia in neonates: a literature review. J. Perinatol., 18, 287–290.PubMedGoogle Scholar
  54. Lieberman, D., Porath, A., Schlaeffer, F., Lieberman, D., & Boldur, I. (1996). Legionella species community-acquired pneumonia. A review of 56 hospitalized adult patients. Chest, 109, 1243–1249.PubMedGoogle Scholar
  55. Liu, Z., Stout, J. E., Boldin, M., Rugh, J., Diven, W. F., & Yu, V. L. (1998). Intermittent use of copper-silver ionization for Legionella control in water distribution systems: a potential option in buildings housing individuals at low risk of infection. Clin. Infect. Dis., 26, 138–140.PubMedGoogle Scholar
  56. LoPresti, F., Riffard, S., Neyret, C., Celard, M., Vandenesch, F., & Etienne, J. (1998). First isolation in Europe of Legionella feeleii from two cases of pneumonia. Eur. J. Clin. Microbiol. Infect. Dis., 17, 64–66.Google Scholar
  57. Lüttichau, H. R., Vinther, C., Uldum, S. A., Moller, J., Faber, M., & Jensen, J. S. (1998). An outbreak of Pontiac fever among children following use of a whirlpool. Clin. Infect. Dis., 26, 1374–1378.PubMedGoogle Scholar
  58. Marco, F., Biedenbach, D. J., & Jones, R. N. (1997). Anti-Legionella activity of trovafloxacin compared with seven other antimicrobial agents including an intermethod evaluation. Diagn. Microbiol. Infect. Dis., 29, 55–57.PubMedCrossRefGoogle Scholar
  59. McDade, J. E., Shepard, C. C., Fraser, D. W., Tsai, T. R., Redus, M. A., & Dowdle, W. R. (1977). Legionnaires’ disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N. Engl. J. Med., 297, 1197–1203.PubMedCrossRefGoogle Scholar
  60. McNally, C., Hackman, B., Fields, B., & Plouffe, J. (1998). Importance of Legionella species as etiologies in community acquired pneumonia (CAP). 98th General Meeting of the American Society for Microbiology, May 17–21, Atlanta, Georgia.Google Scholar
  61. Muder, R. R., Yu, V. L., & Woo, A. H. (1986). Mode of transmission of Legionella pneumophila. A critical review. Arch. Intern. Med., 146, 1607–1612.PubMedCrossRefGoogle Scholar
  62. Murdoch, D. R., Walford, E. J., Jennings, L. C., Light, G. J., Schousboe, M. I., Chereshsky, A. Y., Chambers, S. T., & Town, G. I. (1996). Use of the polymerase chain reaction to detect Legionella DNA in urine and serum samples from patients with pneumonia. Clin. Infect. Dis., 23, 475–480.PubMedGoogle Scholar
  63. Musso, D., & Raoult, D. (1997). Serological cross-reactions between Coxiella burnetii and Legionella micdadei. Clin. Diagn. Lab. Immun., 4, 208–212.Google Scholar
  64. Ostergaard, L., Huniche, B., & Andersen, P. L. (1996). Relative bradycardia in infectious diseases. J. Infect., 33, 185–191.PubMedCrossRefGoogle Scholar
  65. Pai, P., Kumar, S., Bell, G. M., & Ahmad, R. (1996). Rapidly progressive crescentic glomerulonephritis and Legionnaires’ disease. Clin. Nephrol., 45, 209–210.PubMedGoogle Scholar
  66. Pankhurst, C. L., Johnson, N. W., & Woods, R. G. (1998). Microbial contamination of dental unit waterlines: the scientific argument. Int. Dent. J., 48, 359–368.PubMedGoogle Scholar
  67. Pastoris, M. C., Monaco, R. L., Goldoni, P., Mentore, B., Balestra, G., Ciceroni, L., & Visca, P. (1999). Legionnaires’ disease on a cruise ship lined to the water supply system, clinical and public health implications. Clin. Infect. Dis., 28, 33–39.Google Scholar
  68. Pechere, J. C., & Gootz, T. D. (1998). Bacteriological activity of trovafloxacin, a new quinolone, against respiratory tract pathogens. Eur. J. Clin. Microbiol. Infect. Dis., 17, 405–412.PubMedGoogle Scholar
  69. Pedro-Botet, M. L., Sabria-Leal, M., Sopena, N., Manterola, J. M., Morera, J., Blavia, R., Padilla, E., Matas, L., & Gimeno, J. M. (1998). Role of immunosuppression in the evolution of Legionnaires’ disease. Clin. Infect. Dis., 26. 14–19.PubMedGoogle Scholar
  70. Plouffe, J. F., File, T. M., Breiman, K. F., Hackman, B. A., Salstrom, S. J., Marston, B. J., Fields, B. S., & CBPIS Study Group. (1995). Reevalualion of the definition of Legionnaires’ disease: use of the urinary antigen assay. Clin. Infect. Dis., 20, 1286–1291.PubMedGoogle Scholar
  71. Porath, A., Schlaeffer, F., & Lieberman, D. (1997). The epidemiology of community-acquired pneumonia among hospi-Uihed adults. J. Infect., 34, 41–48PubMedCrossRefGoogle Scholar
  72. Ramirez., J. A., Ahkee, S., Tolentino, A., Miller, R. D., & Summersgill, J. T. (1996). Diagnosis of Legionella pneumophila, Mycoplasma pneumoniae, or Chlamydia pneumoniae lower respiratory infection using the polymerase chain reaction on a single throat swab specimen. Diagn. Microbiol. Infect. Dis., 24, 7–14.PubMedCrossRefGoogle Scholar
  73. Ramon, D. F., Ruiz de Porras, L., Elizalde, G., & Abella, M. (1997). Description and study of the etiology of a community outbreak of atypical pneumonia in L’Espluga de Francoli, Tarragona. Medicina Clinca, 108, 490–494.Google Scholar
  74. Rowbotham, T. J. (1993). Legionella-like amoebal pathogens, in: Legionella: Current State and Emerging Perspectives (J. M. Barbaree, R. F. Breiman, & A. P. Dufour, eds.). Washington, DC: American Society for Microbiology, pp. 137–140.Google Scholar
  75. Schrock, J., Hackman, B. A., & Plouffe, J. F. (1997). Susceptibility of ninety-eight clinical isolates of Legionella to macrolides and quinolones using the E test. Diagn. Microbiol. Infect. Dis., 28, 221–223.PubMedCrossRefGoogle Scholar
  76. Schulin, T., Wennersten, C. B., Ferraro, M. J., Moellering, R. C. Jr., & Eliopoulos, G. M. (1998). Susceptibilities of Legionella spp. to newer antimicrobials in vitro. Antimicrob. Agents Chemother., 42, 1520–1523.PubMedGoogle Scholar
  77. Sommese, L., Scarfogliero, P., Vitiello, M., Catalanotti, P., & Galdiero, E. (1996). Presence of Legionella spp. in thermal springs of the Campania region of south Italy. New Microbiologica, 19, 315–320.PubMedGoogle Scholar
  78. Sopena, N., Sabria-Leal, M., Pedro-Botet, M. L., Padilla, E., Dominguez, J., Morera, J., & Tudela, P. (1998). Comparative study of the clinical presentation of Legionella pneumonia and other community-acquired pneumonias. Chest. 113, 1195–1200.PubMedGoogle Scholar
  79. Stout, J. E., Arnold, B., & Yu, V. L. (1998a). Activity of azithromycin, clarithromycin, roxithromycin, dirithromyein. quinupristin/dalfopristin and erythromycin against Legionella species by intracellular susceptibility testing in HL-60 cells. J. Antimicrob. Chemother., 41, 289–291.PubMedCrossRefGoogle Scholar
  80. Stout, J. E., Yu-sen, E. L., Goetz, A. M., & Muder, R. R. (1998b). Controlling Legionella in hospital water systems: experience with the superheat-and-flush method and copper-silver ionization. Infect. Control Hosp. Epidemiol., 19, 911–914.PubMedGoogle Scholar
  81. Straus, W. L., Plouffe, J. F., File, T. M. Jr., Lipman, H. B., Hackman, B. H., Salstrom, S. J., Benson, R. F., & Breiman, R. F. (1996). Risk factors for domestic acquisition of legionnaires disease. Ohio Legionnaires Disease Group. Arch. Intern. Med., 156, 1685–1692.PubMedCrossRefGoogle Scholar
  82. Tang, P. W., & Toma, S. (1986). Broad-spectrum enzyme-linked immunosorbent assay for detection of Legionella soluble antigens. J. Clin. Microbiol, 24, 556–558.PubMedGoogle Scholar
  83. Tewari, K., Wold, S. M., & Asrat, T. (1977). Septic shock in pregnancy associated with Legionella pneumonia: case report. Am. J. Obstet. Gynecol., 176, 706–707.Google Scholar
  84. Tolentino, A., Ahkee, S., & Ramirez, J. (1996). Hot tub legionellosis. J. Kentucky Med. Assoc., 94, 393–394.Google Scholar
  85. Torres, A., Dorca, J., Zalacain, R., Bello, S., El-Ebiary, M., Molinos, L., Arevalo, M., Blanquer, J., Celis, R., Iriberri, M., Prats, E., Fernandez, R., Irigaray, R., & Serra, J. (1996). Community-acquired pneumonia in chronic obstructive pulmonary disease: a Spanish multicenter study. Am. J. Respir. Crit. Care Med., 154, 1456–1461.PubMedGoogle Scholar
  86. Verhaeverbeke, I., Van der Niepen, P., Sennesael, J., Van den Houte, K., Lauwers, S., & Verbeelen, D. (1995). Legionnaires’ disease and acute renal insufficiency: report of a case and review of the literature. Acta Clinica Belgica, 50, 363–367.PubMedGoogle Scholar
  87. Walz, A., Nichterlein, T., & Hof., H. (1997). Excellent activity of newer quinolones on Legionella pneumophila in J774 macrophages. Zentralblatt Bakteriol., 285, 431–439.Google Scholar
  88. Weir, S. C., Fischer, S. H., Stock, F, & Gill, V. J. (199X). Detection of Legionella by PCR in respiratory specimens using a commercially available kit. Am. J. Clin. Pathol., 110, 295–300.Google Scholar
  89. Whitney, C. G., Hofmann, J., Pruckler, J. M., Benson, R. F, Fields, B. S., Bandyopadhyay, U., Donnally, E. F., Giorgio-Almonte, C., Mermel, L. A., Boland, S., Matyas, B. T., & Breiman, R. F. (1997). The role of arbitrarily primed PCR in identifying the source of an outbreak of Legionnaires’ disease. J. Clin. Microbiol., 35, 1800–1804.PubMedGoogle Scholar
  90. Yu, V. L. (1998). Resolving the controversy on environmental cultures for Legionella: a modest proposal. Infect. Control Hosp. Epidemiol., 19, 893–897.PubMedGoogle Scholar
  91. Yu-sen, E. L., Stout, J. E., Yu, V. L., & Vidic, R. D. (1998). Disinfection of water distribution systems for Legionella. Semin. Respir. Infect., 13, 147–159.Google Scholar

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© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Joseph F. Plouffe
    • 1
  1. 1.Internal MedicineThe Ohio State University Medical CenterColumbus

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