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The Biology and Pathology of Innate Immunity Mechanisms pp 147–161Cite as

Similarities and Dissimilarities Between Humans and Mice Looking at Adhesion Molecules Defects

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 479))

5. Conclusion

The careful investigation of the LAD syndromes in man and the adhesion molecule-deficient mice has dramatically increased our understanding of the physiology and the cell and molecular biology of leukocyte emigration. These experiments have also generated new questions for future studies. Clearly, William Harvey’ observation of over three hundred years ago holds true even today:

“Nature is nowhere accustomed more openly to display her secret mysteries than in cases where she shows traces other workings apart from the beaten path; nor is there any better way to advance the proper practice ofmedicine than to give our minds to discovery of the usual law ofnature by careful investigation of cases ofrarer forms of disease.” (I657).

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Author information

Authors and Affiliations

  1. Department of Pediatrics and Immunology, Rambam Medical Center, B. Rappaport School of Medicine, Technion, Haifa, Israel

    Amos Etzioni

  2. Physiology Program, Harvard School of Public Health, Boston, MA, USA, 021 15

    Claire M. Doerschuk

  3. Division of Hematology, University of Washington, Seattle, USA, 98195

    John M. Harlan

Authors
  1. Amos Etzioni
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  2. Claire M. Doerschuk
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  3. John M. Harlan
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Editor information

Editors and Affiliations

  1. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Yona Keisari  & Itzhak Ofek  & 

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© 2002 Kluwer Academic Publishers

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Etzioni, A., Doerschuk, C.M., Harlan, J.M. (2002). Similarities and Dissimilarities Between Humans and Mice Looking at Adhesion Molecules Defects. In: Keisari, Y., Ofek, I. (eds) The Biology and Pathology of Innate Immunity Mechanisms. Advances in Experimental Medicine and Biology, vol 479. Springer, Boston, MA. https://doi.org/10.1007/0-306-46831-X_13

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  • DOI: https://doi.org/10.1007/0-306-46831-X_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-46409-6

  • Online ISBN: 978-0-306-46831-5

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