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Structure and Function of Aminopeptidase N

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 477)

Keywords

Secondary Structure Prediction Human Seminal Plasma Zinc Ligand TGEV Infection Human Coronavirus 229E 
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References

  1. Bauer, K., 1994, Purification and characterisation of the thyrotropin-releasing-hormone degrading ectoenzyme. Eur. J. Biochem. 224: 387–396.CrossRefPubMedGoogle Scholar
  2. Chen, H., Kinzer, C.A., and Paul, W.E., 1996, p161, a murine membrane protein expressed on mast cells and some macrophages, is mouse CD13/aminopeptidase N. J. Immunol. 157: 2593–2600.PubMedGoogle Scholar
  3. Danielsen, E.M., Cowell, G.M., Norén, O., Sjöström, H., and Dorling, P.R., 1983, Biosynthesis of intestinal microvillar proteins. The effect of swainsonine on post-translational processing of aminopeptidase N. Biochem. J. 216: 325–331.PubMedGoogle Scholar
  4. Danielsen, E.M., 1995, Involvement of detergent-insoluble complexes in the intracellular transport of intestinal brush border enzymes. Biochem. 34: 1596–1605.Google Scholar
  5. Delmas, B., Gelfi, I, L’Haridon, R., Vogel, L.K., Sjöström, H., Norén, O., and Laude, H., 1992, Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV. Nature 357: 411–419.CrossRefGoogle Scholar
  6. Delmas, B., Gelfi, J., Kut, E., Sjöström, H., Norén, O., and Laude, H., 1994, Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymicsite. J. Virol. 68: 5216–5224.PubMedGoogle Scholar
  7. Gilbert, W., 1987, The exon theory of genes. Cold Spring Harbor Symposia Quant. Biol. 52: 901–905.Google Scholar
  8. Hansen, G.H., Delmas, B., Besnardeau, L., Vogel, L.K., Laude, H., Sjöström, H., and Norén, O., 1998, The coronavirus transmissible gastroenteritis virus causes infection after receptor-mediated endocytosis and acid-dependent fusion with an intracellular compartment J. Virol. 72: 527–534.PubMedGoogle Scholar
  9. Hesp, J.R., and Hooper, N.M., 1997, Proteolytic fragmentation reveals the oligomeric and domain structure of porcine aminopeptidase A. Biochem. 36: 3000–3007.Google Scholar
  10. Hooper, N.M., 1994, Families of metalloproteases. FEBS Lett. 354: 1–6.CrossRefPubMedGoogle Scholar
  11. Huang, K., Takahara, S., Kinouchi, T., Takeyama, M., Ishida, T., Ueyama, H., Nishi, K., and Ohkubo, I., 1997, Alanyl aminopeptidase from human seminal plasma: purification, characterization, and immunohistochemical localization in the male genitaltract. J. Biochem. 122: 779–787.PubMedGoogle Scholar
  12. Hussain, M.M., Tranum-Jensen, J., Norén, O., Sjöström, H., and Christiansen, K., 1981, Reconstitution of purified amphiphilic pig intestinal aminopeptidase. Mode of membrane insertion and morphology. Biochem. J. 199: 179–186.PubMedGoogle Scholar
  13. Keller, S.R., Scott, H.M., Mastick, C.C., Aebersold, R., and Lienhard, G.E., 1995, Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J. Biol. Chem. 270: 23612–23618.CrossRefPubMedGoogle Scholar
  14. Kolb, A.F., Hegyi, A., and Siddell, S.G., 1997, Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N. J. Gen. Virol. 78: 2795–2802.PubMedGoogle Scholar
  15. Lerche, C., Vogel, L.K., Shapiro, L.H., Norén, O., and Sjöström, H., 1996, Human aminopeptidase N is encoded by 20 exons. Mammalian Genome 7: 712–713.CrossRefPubMedGoogle Scholar
  16. Look, A.T., Ashmun, R.A., Shapiro, L.H., and Peiper, S.C., 1989, Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N. J. Clin. Invest. 83: 1299–1307.PubMedGoogle Scholar
  17. Luciani, N., Marie-Claire, C., Ruffet, E., Beaumont, A., Roques, B.P., and Fournié-Zaluski, M.-C., 1998, Characterisation of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC3.4.11.2): Insights into its mechanism of action. Biochem. 37: 686–692.Google Scholar
  18. Malfroy, B., Kado-Fong, H., Gros, C., Giros, B., Schwartz J.-C., and Helmiss, R., 1989, Molecular cloning and amino acid sequence of rat kidney aminopeptidase M: a member of a super family of zinc-metallohydrolases. Biochem. Biophys. Res. Comm. 161: 236–241.CrossRefPubMedGoogle Scholar
  19. Midorikawa, T., Abe, R., Yamagata, Y., Nakajima, E., and Ichishima, E., 1998, Isolation and characterization of cDNA encoding chicken egg yolk aminopeptidase Ey. Comp. Biochem. Phys. Part B 119: 513–520.Google Scholar
  20. Norén, K., Hansen, G.H., Clausen, H., Norén, O., Sjöström, H., and Vogel, L.K., 1997, Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity. Exp. Cell Res. 231: 112–118.CrossRefPubMedGoogle Scholar
  21. Norén. O., Sjöström, H., and Olsen, J., 1997, Aminopeptidase N. In Cell-surface peptidases in health and disease (A.J. Kenny, and C.M. Boustead, eds.), BIOS Scientific Publishers, Oxford, pp. 175–191.Google Scholar
  22. Olsen, J., Cowell, G.M., Kønigshøfer, E., Danielsen, E.M., Møller, J., Laustsen, L., Hansen, O.C., Welinder, K.G., Engberg, J., Hunziker, W., Spiess, M., Sjöström, H., and Norén, O., 1988, Complete amino acid sequence of human intestinal aminpeptidase N as deduced from cloned cDNA. FEBS Lett. 238: 307–314.CrossRefPubMedGoogle Scholar
  23. Rawlings, N.D., and Barrett, A.J., 1999, MEROPS: the peptidase database. Nucl. Acids Res. 27: 325–331.CrossRefPubMedGoogle Scholar
  24. Rost, N., Sander, C., and Schneider, R., 1994, PHD — an automatic mail server for protein secondary prediction. Comput. Appl. Biosci. 10: 53–60.PubMedGoogle Scholar
  25. Sjöström, H., Norén, O., Jeppesen, L., Staun, M., Svensson, B., and Christiansen, L., 1978, Purification of different amphiphilic forms of a microvillus aminopeptidase from pig small intestine using immunoadsorbent chromatography. Eur. J. Biochem. 88: 503–511.PubMedGoogle Scholar
  26. Sjöström, H., and Norén, O., 1982, Changes of the quaternary structure of microvillus aminopeptidase in the membrane. Eur. J. Biochem. 122: 245–250.PubMedGoogle Scholar
  27. Sjöström, H., Norén, O., Danielsen, E.M., and Skovbjerg, H., 1983, Structure of microvillar enzymes in different phases of their life cycles. In Brush border membranes, Ciba Foundation Symposium 95, Pitman, London, pp 50–69.Google Scholar
  28. Stoltzfus, A., Spencer, D.F., Zuker, M., Logsdon, J.M., and Doolittle, W.F., 1994, Testing the exon theory of genes: the evidence from protein structure. Science 265: 202–207.PubMedGoogle Scholar
  29. Tatu, U., and Helenius, A., 1997, Interactions between newly synthesized glycoproteins, calnexin and a network of resident chaperons in the endoplasmic reticulum. J. Cell Biol. 136: 555–565.CrossRefPubMedGoogle Scholar
  30. Tresnan, D.B., Levis, R., and Holmes, K.V., 1996, Feline aminopeptidase N serves as a receptor for feline, canine, porcine and human coronaviruses in serogroup I. J. Virol. 70: 8669–8674.PubMedGoogle Scholar
  31. Watanabe, Y., Iwaki-Egawa, S., Mizukoshi, H., and Fujimoto, Y., 1995, Identification of an alanine aminopeptidase in human maternal serum as a membrane-bound aminopeptidase N. Biol. Chem. Hoppe Seyler 376: 397–400.PubMedGoogle Scholar
  32. Watanabe, Y., Ito, K., Iwaki-Egawa, S., Yamaguchi, R., and Fujimoto, Y., 1998, Aminopeptidase N in sera of healthy subjects is a different N-terminal processed derivative from the one obtained from maternal serum. Mol. Gen. Metab. 63: 289–294.Google Scholar
  33. Watt, V.M., and Yip, C.C., 1989, Amino acid sequence deduced from a rat kidney cDNA suggests it encodes Zn-peptidase aminopeptidase N. J. Biol. Chem. 264: 5480–5487.PubMedGoogle Scholar
  34. Yang, X.F., Milhiet, P.E., Gaudoux, F., Crine, P., and Boileau, G., 1993, Complete sequence of rabbit kidney aminopeptidase N and mRNA localization in rabbit kidney by in situ hybridization. Biochem. Cell. Biol. 71: 278–287.PubMedGoogle Scholar
  35. Yeager, C.L., Ashmun, R.A., Williams, R.K., Cardellichio, C.B., Shapiro, L.H., Look, A.T., and Holmes, K. V., 1992, Human aminopeptidase N is a receptor for human coronavinis 229E. Nature 357: 420–422.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  1. 1.Departmentof Medical Biochemistry and GeneticsBiochemistry Laboratory C, The Panum InstituteCopenhagenDenmark

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