Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ahonen, M., Baker, A.H., and Kähäri, V.-M., 1998, Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells. Cancer Res.58:2310–2315.
Airola, K., Johansson, N., Kariniemi, A.-L., Kähäri, V.-M., and Saarialho-Kere, U., 1997, Human collagenase-3 is expressed in malignant squamous epithelium of the skin. J. Invest. Dermatol.109:225–231.
Airola, K., Ahonen, M., Johansson, N., Heikkilä, P., Kere, J., Kähäri, V.-M., and Saarialho-Kere, U.K., 1998, Human TIMP-3 is expressed during fetal development, hair growth cycle and cancer progression. J. Histochem. Cytochem.46:437–448.
Albini, A., Melchiori, A., Santi, L., Liotta, L.A., Brown, P.D., and Stetler-Stevenson, W.G., 1991, Tumor cell invasion inhibited by T1MP-2. J. Natl. Cancer Inst.83:775–779.
Amour, A., Slocombe, P.M., Webster, A., Butler, M., Knight, C.G., Smith, B.J., Stephens, P.E., Shelley, C., Hutton, M., Knauper, V., Docherty, A.J., and Murphy, G., 1998, TNF-α converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett.435:39–44.
Alonso, D.F., Skilton, G., DeLorenzo, M.S., Scursoni, A.M., Yoshiji, H., and Gomez, D.E., 1998, Histopathological findings in a highly invasive mouse mammary carcinoma transfected with human tissue inhibitor of metalloproteinases-1. Oncology Reports.5:1083–1087.
Bafetti, L.M., Young, T.N., Itoh, Y., and Stack, M.S., 1998, Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells. J. Biol. Chem.273:143–149.
Baker, A.H., Zaltsman, A.B., George, S.J., and Newby, A.C., 1998, Divergent effects of tissue inhibitor of metalloproteinase-1,-2 or-3 overexpression on rat vascular smooth muscle cell invasion, proliferation and death in vitro: TIMP-3 promotes apoptosis. J. Clin. Invest.101:1478–1487.
Baker, A.H., George, S.J., Zaltsman, A.B., Murphy, G., and Newby, A.C., 1999, Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3. Br. J. Cancer, in press.
Basset, P., Okada, A., Chenard, M.P., Kannan, R., Stoll, I., Anglard, P., Bellocq, J.P., and Rio, M.C., 1997, Matrix metalloproteinases as stromal effectors of human carcinoma progression: therapeutic implications. Matrix Biol15:535–541.
Bian, J., Wang, Y., Smith, M.R., Kim, H., Jacobs, C., Jackman, J., Kung, H.F., Colburn, N.H., and Sun, Y., 1996, Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3. Carcinogenesis17:1805–1811.
Birkedal-Hansen, H., Moore, W.G.I., Bodden, M.K., Windsor, L.J., Birkedal-Hansen, B., De Carlo, A., and Engler, J.A., 1993, Matrix metalloproteinases: A review. Crit. Rev. Oral Biol. Med.4:197–250.
Bode, W., Reinemer, P., Huber, R., Kleine, T., Schnierer, S., and Tschesche, H., 1994, The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J.13:1263–1269.
Bond, M., Fabunmi, R.P., Baker, A.H., and Newby, A.C., 1998, Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-κB. FEBS Lett.435:29–34.
Brooks, P.C., Stromblad, S., Sanders, L.C., von Schalscha, T.L., Stetler-Stevenson, W.G., Quigley, J.P., and Cheresch, D.A., 1996, Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin 480-1 Cell85:683–693.
Brown, P.D., 1998, Synthetic inhibitors of matrix metalloproteinases. In: Matrix metalloproteinases. W.C. Parks, and R.P. Mecham, eds. Academic Press, San Diego. 243–261.
Butler, G.S., Butler, M.J., Atkinson, S.J., Will, H., Tamura, T., van Westrum, S.S., Crabbe, T., Clements, J., d’Ortho, M.P., and Murphy, G., 1998, The TIMP2 membrane type 1 metalloproteinase “receptor” regulates the concentration and efficient activation of progelatinase A. A kinetic study. J. Biol. Chem.273:871–880.
Declerck, Y.A., Yean, T.D., Chan, D., Shimada, H., and Langley, K.E., 1991, Inhibition Of Tumor Invasion Of Smooth-Muscle Cell-Layers By Recombinant Human Metalloproteinase Inhibitor. Cancer Res.51:2151–2157.
DeClerck, Y.A., Perez, N., Shimada, H., Boone, T.C., Langley, K.E., and Taylor, S.M., 1992, Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases. Cancer Res.52:701–708.
d’Ortho, M.P., Will, H., Atkinson, S., Butler, G., Messent, A., Gavrilovic, J., Smith, B., Timpl, R., Zardi, L., and Murphy, G., 1997, Membrane type matrix metalloproteinases 1 and 2 exhibit broadspectrum proteolytic capacities comparable to many matrix metalloproteinases. Eur. J. Biochem.250: 751–757.
Dunsmore, S.E., Saarialho-Kere, U.K., Roby, J.D., Wilson, C.L., Matrisian, L.M., Welgus, H.G., and Parks, W.C., 1998 Matrilysin expression and function in airway epithelium. J. Clin. Invest.102:1321–1331.
Freije, J.M.P., Díez-Itza, I., Balbín, M., Sánchez, L.M., Blasco, R., Tolivia, J., López, and Otín, C., 1994, Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J. Biol. Chem.269:16766–16773.
Guedez, L., Courtemanch, L., and StetlerStevenson, M., 1998, Tissue inhibitor of metalloproteinase (TIMP)-1 induces differentiation and an antiapoptotic phenotype in germinal center B Cells. Blood.92:1342–1349.
Heppner, K.J., Matrisian, L.M., Jensen, R.A., and Rodgers, W.H., 1996, Expression of most matrix metallo-proteinases family members in breast cancer represents a tumor-induced host response. Am. J. Pathol.149:273–282.
Howard, E.W., Bullen, E.C., and Banda, M.J., 1991, Preferential inhibition of 72-and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2. J. Biol. Chem.266:13070–13075.
Imren, S., Kohn, D.B., Shimada, H., Blavier, L., and DeClerck, Y.A., 1996, Overexpression of tissue inhibitor of metalloproteinases-2 retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion. Cancer Res.56:2891–2895.
Itoh, T., Tanioka, M., Yoshida, H., Yoshioka, T., Nishimoto, H., and Itohara, S., 1998, Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res.58:1048–1051.
Johansson, N., Airola, K., Grenman, R., Kariniemi, A.-L., Saarialho-Kere, U., and Kähäri, V.-M., 1997, Expression of collagenase-3 (matrix metalloproteinase-l 3) in squamous cell carcinomas of the head and neck. Am. J. Pathol.151:499–508.
Johansson, N., Vaalamo, M., Grénman, S., Hietanen, S., Klemi, P., Saarialho-Kere, U., and Kähäri V.-M., 1999 Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous carcinomas. Am. J. Pathol., in press.
Johnsen, M., Lund, L.R., Romer, J., Almholt, K., and Dano, K., 1998, Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation. Curr. Opin. Cell. Biol.10:667–671.
Kähäri, V.-M., and Saarialho-Kere, U., 1997, Matrix metalloproteinases in skin. Exp. Dermatol.6:199–213.
Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., Yoshino, K., Okumra, K., and Yagita, H., 1995, Metalloproteinase-Mediated Release Of Human Fas Ligand. J. Exp. Med.182:1777–1783.
Kruger, A., SanchezSweatman, O.H., Martin, D.C., Fata, J.E., Ho, A.T., Orr, F.W., Ruther, U., and Khokha, R., 1998,. Host TIMP-1 Overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line. Oncogene.16:2419–2423.
Koop, S., Khokha, R., Schimdt, E.E., MacDonald, I.C., Morris, V.L., Chambers, A.F., and Groom, A.C., 1994, Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth. Cancer Res.54:4791–4797.
Llano, E., Pendas, A.M., Kääuper, V., Sorsa, T., Ding, Y., Santavirta, S., Ceponis, A., and López-Otin, C., 1997, Identification and characterization of human enamelysin. Biochemistry36:15101–15108.
MacDougall, J.R., and Matrisian, L.M., 1995, Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis. Cancer Metastasis Rev.14:351–362.
MacDougall, J.R., Bani, M.R., Lin, Y., Rak, J., and Kerbel, R.S., 1995, The 92-kDa gelatinase B is expressed by advanced stage melanoma cells: suppression by somatic cell hybridization with early stage melanoma cells. Cancer Res.55:4174–4181.
Martin, D.C., Ruther, U., Sanchez-Sweatman, O.H., Orr, F.W., and Khokha, R., 1996, Inhibition of SV40 T antigen-induced hepatocellular carcinoma in TIMP-1 transgenic mice. Oncogene13:569–576.
Masson, R., Lefebvre, O., Noel, A., Fahime, M.E., Chenard, M.P., Wendling, C., Kebers, F., LeMeur, M., Dierich, A., Foidart, J.M., Basset, P., and Rio, M.C., 1998, In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J. Cell Biol.140: 1535–41.
Matsuzawa, K., Fukuyama, K., Hubbard, S.L., Dirks, P.B., and Rutka, J.T., 1996, Transfection of an invasive human astrocytoma cell line with a TIMP-1 cDNA: Modulation of astrocytoma invasive potential. J Neuropath. Exp. Neural. 55:88–96.
Montgomery, A.M., De Clerck, Y.A., Langley, K.E., Reisfeld, R.A., and Mueller, B.M., 1993, Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways. Cancer Res.53:693–700.
Montgomery, A.M., Mueller, B.M., Reisfeld, R.A., Taylor, S.M., and DeClerck, Y.A., 1994, Effect of tissue inhibitor of the matrix metalloproteinases-2 expression on the growth and spontaneous metastasis of a human melanoma cell line. Cancer Res.54:5467–5473.
Muller, D., Wolf, C., Abecassis, J., Millon, R., Engelmann, A., Bronner, G., Rouyer, N., Rio, M.C., Eber, M., Methlin, G., Chambon, P., and Basset, P., 1993, Increased stromelysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas. Cancer Res.53:165–169.
Murray, G.I., Duncan, M.E., O’Neil, P., Melvin, W.T., and Fothergill, J.E., 1996, Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat. Med.2:461–462.
Murray, G.I., Duncan, M.E., O’Neil, P., McKay, J.A., Melvin, W.T., and Fothergill, J.E., 1998, Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J. Pathol.185:256–261.
Murphy, G., Willenbrock, F., Ward, R.V., Cockett, M.I., Eaton, D., and Docherty, A.J.P., 1992, The Cterminal domain of 72kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases. Biochem. J.283: 637–641.
Nuovo, G.J., MacConnell, P.B., Simsir, A., Valea, F., and French, D.L., 1995, Correlation of the in situ detection of polymerase chain reaction amplified metalloproteinase complementary cDNAs and their inhibitors with prognosis in cervical carcinoma. Cancer Res.55:267–275.
Oku, T., Ata, N., Yonezawa, K., Tokai, H., Fujii, H., Shinagawa, A., Ohuchi, E., and Saiki, I., 1997, Antimetastatic and antitumor effect of a recombinant human tissue inhibitor of metalloproteinases-2 in murine melanoma models. Biol. Pharm. Bull.20:843–849.
Pei, D., Majmudar, G., and Weiss, S.J., 1994. Hydrolytic inactivation of a breast carcinoma cell-derived serpin byhuman stromelysin-3. J. Biol. Chem.269:25849–25855.
Pendas, A.M., Knüuper, V., Puente, X.S., Llano, E., Mattei, M.G., Apte, S., Murphy, G., and López-Olín, C., 1997 Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal localization and tissue distribution. J. Biol. Chem.272:4281–4286.
Ray, J.M., and Stetler-Stevenson, W.G., 1995, Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J.14:908–917.
Saarialho-Kere, U.K., Crouch, E.C., and Parks, W.C., 1995, Matrix metalloproteinase matrilysin is constitutively expressed in adult human exocrine epithelium. J. Invest. Dermatol.105:190–196.
Shapiro, S.D., 1998, Matrix metalloproteinase degradation of extracellular matrix: biological consequences. Curr. Opin. Cell. Biol.10:602–608.
Shima, I., Sasapuri, Y., Kusukawa, J., Fujita, H., Kakegava, T., and Morimatsu, M., 1992, Production of matrix metalloproteinase-2 and metalloproteinase-3 related to malignant behavior of esophageal carcinoma. A clinicopathological study. Cancer70:2747–2753.
Shindoh, M., Higashino, F., Kaya, M., Yasuda, M., Funaoka, K., Hanzawa, M., Hida, K., Kongo, T., Amemiya, A., Yoshida, K., and Fujinaga, K., 1996 Correlated expression of matrix metalloproteinases and ets family transcription factor E1A-F in invasive oral squamous-cell-carcinoma-derived cell lines. Am. J. Pathol.148:693–700.
Smith, M.R., Kung, H.F., Durum, S.K., Colburn, N.H., and Sun, Y., 1997, TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells. Cytokine.9:770–780.
Tsuchiya, Y., Sato, H., Endo, Y., Okada, Y., Mai, M., Sasaki, T., and Seiki, M., 1993, Tissue Inhibitor Of Metalloproteinase-1 Is a Negative Regulator Of the Metastatic Ability Of a Human Gastric-Cancer Cell-Line, Kkls, In the Chick-Embryo. Cancer Res.53:1397–1402.
Uría, A., Ståhle-Bäckdahl, M., Seiki, M. Fueyo, A., and Lípez-Otín, C., 1997, Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions. Cancer Res.57:4882–888.
Uría, J.A., Balbin, M., López, J.M., Alvarez, J., Vizoso, F., Takigawa, M., and López-Otín, C., 1998, Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor. Am. J. Pathol.153:91–101.
Valente, P., Fassina, G., Melchiori, A., Masiello, L., Cilli, M., Vacca, A., Onisto, M., Santi, L., Stetler-Stenvenson, W.G., and Albini, A., 1998, TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis. Int. J. Cancer75:246–253.
Väisänen, A., Tuominen, H., Kallioinen, M., and Turpeenniemi-Hujanen, T., 1996, Matrix metalloproteinase-2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value. J. Pathol.180:283–289.
van Wart, H.E., and Birkedal-Hansen, H., 1990, The cystein switch: A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase family. Proc. Natl. Acad. Sci. USA87:5578–5582.
Visscher, D.W., Hoyhtya, M., Ottosen, S.K., Liang, CM., Sarkar, F.H., Crissman, J.D., and Fridman, R., 1994, Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence. Int. J. Cancer59:339–344.
Wang, M., Liu, Y.E., Greene, J., Sheng, S., Fuchs, A., Rosen, E.M., and Shi, Y.E., 1997, Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4. Oncogene14:2767–2774.
Watanabe, M., Takahashi, Y., Ohta, T., Mai, M., Sasaki, T., and Seiki, M., 1996, Inhibition of metastasis in human gastric cancer cells transfected with Tissue inhibitor of metalloproteinase 1 gene in nude mice. Cancer.77:1676–1680.
Wernert, N., Raes, M.B., Lassalle, P., Dehouck, M.P., Gosselin, B., Vandenbunder, B., and Stehelin, D., 1992, c-ets1 proto-oncogene is a transcription factor expressed inendothelial cells during tumor vascularization and other forms of angiogenesis in humans. Am. J. Pathol.140:119–127.
Wernert, N., Gilles, F., Fafeur, V., Bouali, F., Raes, M.B., Pyke, C., Dupressoir, T., Seitz, G., Vandenbunder, B., and Stehelin, D., 1994, Stromal expression of c-Ets1 transcription factor correlates with tumor invasion. Cancer Res.54:5683–5688.
Westermarck, J., Seth, A., and Kähäri, V.-M., 1997. Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors. Oncogene14:2651–2660.
Willenbrock, F., and Murphy, G., 1994, Structure-function relationships in the tissue inhibitors of metallo-proteinases. Am. J. Respir. Crit. Care Med.150:S165–S170.
Wilson, C.L., Heppner, K.J., Labosky, P.A., Hogan, B.L., and Matrisian, L.M., 1997, Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc. Natl. Acad. Sci. USA94:1402–1407.
Woolley, D.E., and Grafton, C.A., 1980, Collagenase immunolocalization studies of cutaneous secondary melanomas. Br. J. Cancer42:260–265.
Yoneda, T., Sasaki, A., Dunstan, C., Williams, P.J., Bauss, F., De Clerck, Y.A., and Mundy, G.R., 1997, Inhibition of osteolytic bone metastasis of breast cancer by combinedtreatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J. Clin. Invest.99:2509–2517.
Yoshiji, H., Gomez, D.E., and Thorgeirsson, U.P, 1996, Enhanced RNA expression of tissue inhibitor of metalloprotenases-1 (TIMP-1) in human breast cancer. Int. J. Cancer69:131–134.
Zucker, S., Drews, M., Conner, C., Foda, H.D., DeClerck, Y.A., Langley, K.E., Bahou, W.F., Docherty, A.J., and Cao, J., 1998, Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP). J. Biol. Chem.273:1216–1222.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Kluwer Academic Publishers
About this chapter
Cite this chapter
Baker, A.H., Ahonen, M., Kähäri, VM. (2002). Potential Applications of Tissue Inhibitor of Metalloproteinase (TIMP) Overexpression For Cancer Gene Therapy. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_41
Download citation
DOI: https://doi.org/10.1007/0-306-46817-4_41
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-306-46191-0
Online ISBN: 978-0-306-46817-9
eBook Packages: Springer Book Archive