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Cancer Gene Therapy pp 335–346Cite as

Dendritic Cell-based Immunization for Cancer Therapy

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References

  • Alijagic, S., Moller, P., Artuc, M., Jurgovsky, K., Czarnetzki P.M., and Schadendorf, D., 1995, Dendritic cells generated from peripheral blood transfected with human tyrosinase induce specific T cell activation, Eur. J. Immunol.25:3100–3107.

    PubMed  CAS  Google Scholar 

  • Alters, S.E., Gadea, J.R., Sorich, M., O’Donoghue, G., Talib, S., and Philip, R., 1998, Dendritic cells pulsed with CEA peptide induce CEA-specific CTL with restricted TCR repertoire, J. Immunother.21:17–26.

    PubMed  CAS  Google Scholar 

  • Anichini, A., Mortarini, R., Maccalli, C., Squarcina, P., Fleischhauer, K., Mascheroni, L., and Parmiani, G., 1996, Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma, J. Immunol.156:208–217.

    PubMed  CAS  Google Scholar 

  • Asley, D.M., Faiola, B., Nair, S. Hale, L.P., Bigner, D., and Gilboa, E., 1997, Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors, J. Exp. Med.7:1177–1182.

    Google Scholar 

  • Austyn, J., 1996, New insights into the mobilization and phagocytic activity of dendritic cells, J. Exp. Med.183:1287–1292.

    PubMed  CAS  Google Scholar 

  • Azizi, E., Bunana, C., Goldberg, L., and Kripke, M.L., 1987, Perturbations of epidermal Langerhans cells in basal cell carcinoma, Am. J. Dermatopath.9:465–473.

    PubMed  CAS  Google Scholar 

  • Bannerji, R., Arroyo, C.D., Cordon-Cardo, C., and Gilboa, E., 1994, The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity, J. Immunol.152:2324–2332.

    PubMed  CAS  Google Scholar 

  • Barnd, D.L., Lan, M.S., Metzgar, R.S., and Finn, O.J., 1989, Specific MHC-unrestricted recognition of tumor associated mucins by human cytotoxic cells, Proc. Natl. Acad. Sci. USA86:7159–63.

    PubMed  CAS  Google Scholar 

  • Becker, Y, 1993, Dendritic cell activity against primary tumors: an overview, In Vivo7:187–191.

    PubMed  CAS  Google Scholar 

  • Becker, Y., 1992, Anticancer role of dendritic cells (DC) in human and experimental cancers-areview, Anti-cancer Res.12:511–520.

    CAS  Google Scholar 

  • Bender, A., Sapp, M., Schuler, G., Steinman, R.M., and Bhardwaj, N., 1996, Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood, J. Immunol. Methods196:121–135.

    PubMed  CAS  Google Scholar 

  • Boczkowski, D., Nair, S., Snyder, D., and Gilboa, E., 1996, Dendritic cells pulsed with RNA are potent antigen presenting cells in vitro and in vivo, J. Exp. Med.184:465–472.

    PubMed  CAS  Google Scholar 

  • Bos, J.L., 1989, ras Oncogenes in human cancer: a review, Cancer Res.49:4682.

    PubMed  CAS  Google Scholar 

  • Bulbul, M.A., Huben, R.P., and Murpy, G.P., 1989, Interferon-β treatment of metastatic prostate cancer, J. Surg. Oncol.33:231–233.

    Google Scholar 

  • Caux, C., Vandervliet, B., Massacrier, C., Dezutter-Dambuyant, C., de Saint-Vis, B., Jacquet, C., Yoneda, K., Imamura, S., Schmitt, D., and Banchereau, J., 1996, CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNFα, J. Exp. Med.184:695–706.

    PubMed  CAS  Google Scholar 

  • Cavanagh, L.L., Saal, R.J., Grimmett, K.L., and Thomas, R., 1998, Proliferation in monocyte-derived den-dritic cell cultures is caused by progenitor cells capable of myeloid differentiation, Blood92:1598–1607.

    PubMed  CAS  Google Scholar 

  • Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A., and Alber, G., 1996, Ligation of CD40 on dendritic cells triggers production of high level of interleukin-12 and enhances T cell stimulator capacity: T-T help via APC activation, J. Exp. Med.184:747–752.

    PubMed  CAS  Google Scholar 

  • Celluzzi, C.M., Mayordomo, J.I., Storkus, W.J., Lotze, M.T., and Falo, J.L.D., 1996, Peptide-pulsed dendritic cells induce antigen-specific, CTL-mediated protective tumor immunity, J. Exp. Med.183:283–287.

    PubMed  CAS  Google Scholar 

  • Coulie, P.G., Somville, M., Lehmann, F., Hainaut, P., Brasseur, F., Devos, R., and Boon, T., 1992, Precursor frequency analysis of human cytolytic T lymphocytes directed against autologous melanoma cells, Int. J. Cancer50:289–297.

    PubMed  CAS  Google Scholar 

  • Disis, M.L, and Cheever, M.A., 1997, HER-2/neu protein: A target for antigen-specific immunotherapy of human cancer, Adv. Cancer Res.71:343–371.

    PubMed  CAS  Google Scholar 

  • Darrow, T., Slingluff, C., and Seigler, H, 1989, The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens, J. Immunol.42:3329–3335.

    Google Scholar 

  • Disis, M.L., Calenoff, E., McLaughlin, G., Murphy, A.E., Chen, W., Groner, B., Jeschke, M., Lydon, N., McGlynn, E., Livingston, R.B., and Cheever, M., 1994, Existent T cell and antibody immunity to HER-2/neu protein in patients with breast cancer, Cancer Res.54:1620.

    Google Scholar 

  • Fisk, B., Blevins, T.L., Wharton, J.T., and Loannides, C.G., 1995, Identification of an immunodominant peptide of HER-2/neu proto-oncogene recognized by ovarian tumorspecific cytotoxic T lymphocyte lines, J. Exp. Med.181:2109–2117.

    PubMed  CAS  Google Scholar 

  • Flamand, V., Sornasse, T., Thielemans, K., Demanet, C., Bakkus, M., Bazin, H., Tielemans, F., Leo, O., Urbain, J., and Moser, M., 1994, Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo, Eur. J. Immunol.24:605–610.

    PubMed  CAS  Google Scholar 

  • Gabrilovich, D.I., Ciernik, I.F., and Carbone, D.P., 1996, Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts, Cell. Immunol.170:101–110.

    PubMed  CAS  Google Scholar 

  • Gabrilovich, D.I., Nadaf, S., Corak, J., Berzofsky, J.A., and Carbone, D.P., 1996, Dendritic cells in antitumor immune responses. II Dendritic cells grown from bone marrow precursors, but not mature DC from tumor bearing mice, are effective antigen carriers in the therapy of established tumors, Cell. Immunol.170:111–119.

    PubMed  CAS  Google Scholar 

  • Galy, A., Travis, M., Cen, D., and Chen, B., 1995, Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset, Immunity3:459–73.

    PubMed  CAS  Google Scholar 

  • Gong, J, Chen, D., Kashiwaba, M., and Kufe, D., 1997, Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells, Nature Med.3:558–61.

    PubMed  CAS  Google Scholar 

  • Grouard, G., Durand, I., Filgueira, L., Banchereau, J., and Liu, Y.J., 1996, Dendritic cells capable of stimulating T cells in germinal centers, Nature384:364–367.

    PubMed  CAS  Google Scholar 

  • Grouard, G., Rissoan, M.C., Filgueira, L., Durand, I. Banchereau, J., and Liu, Y.J., 1997, The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand, J. Exp. Med.185:1101–1111.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Halbert, C., Demers, G.W., and Galloway, D.A., 1991, The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells, J. Viral.65:473–478.

    CAS  Google Scholar 

  • Hinkel, A., Gitlitz, B., Mulders, P., Moldawer, N., Tso, C., Kaboo, R., Belldegrun, A., and Figlin, R., 1998, Dendritic cell therapy for metastatic renal cell carcinoma-A translational phase I clinical trial, Proc. Am. Soc. Clin. Oncol.17:432a.

    Google Scholar 

  • Hock, B.D., Starling, G.C., Daniel, P.B., and Hart, D.N.J., 1994, CMRF-44, a novel monoclonal antibody to an activation antigen expressed by the allostimulatory cells within peripheral blood, including dendritic cells, Immunol.83:573–581.

    CAS  Google Scholar 

  • Hsu, F.J., Benike, C., Fagnoni, F., Liles, T.M., Czerwinski, D., Taidi, B., Engleman, E.G., and Levy, R., 1996, Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nature Med.2:52–58.

    PubMed  CAS  Google Scholar 

  • Huang, A.Y.C., Golumbek, P., Ahmadzedah, M., Jaffee, E., Pardoll, D., and Levitsky, H., 1994, Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens, Science264:961–965.

    PubMed  CAS  Google Scholar 

  • Inaba, K., Young, J.W., and Steinman, R.M., 1987, Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells, J Exp Med.166:182–194.

    PubMed  CAS  Google Scholar 

  • Kawakami, Y., Eliyahu, S., Delgado, C.H., Robbins, P.F., Rivoltini, L., Topalian, S.L., Miki, T., and Rosenberg, S.A., 1994, Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor, Proc. Natl. Acad Sci. USA91:3515–3519.

    PubMed  CAS  Google Scholar 

  • Knight, S.C., Farrant, J., Bryant, A., Edwards, A.J., Burman, S., Lever, A., Clarke, J., and Webster, A.D., 1986, Non-adherent, low-density cells from human peripheral blood contain dendritic cells and monocytes, both with veiled morphology, Immunol.57:595–603.

    CAS  Google Scholar 

  • Liu, Y.J., Grouard, G., De Boutteillier, O., and Banchereau, J., 1996, Follicular dendritic cells and germinal centers. Int. Rev. Cytol.166:139–179.

    PubMed  CAS  Google Scholar 

  • Macatonia, S.E., Taylor, P.M., Knight, S.C., and Askonas, B.A., 1988, Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro, J. Exp. Med.169:1255–1264.

    Google Scholar 

  • Maraskovsky, E., Brasel, K., Teepe, M., Roux, E.R., Lyman, S.D., Shortman, K., and McKenna, H.J., 1996, Dramatic increase in the number of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified, J. Exp. Med.184:1953–1962.

    PubMed  CAS  Google Scholar 

  • Matzinger, P., 1994, Tolerance, danger, and the extended family, Ann. Rev. Immunol.12:991–1045.

    CAS  Google Scholar 

  • Mayordomo, J.I., Zorina, T., Storkus, W.J., Zitvogel, L., Celluzzi, C., Falo, L.D., Melief, C.J., Ildstad, S.T., Kast, W.M., Deleo, A.B., and Lotze, M.T., 1995, Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity, Nature Med.12:1297–1302.

    Google Scholar 

  • Mazzocchi, A., Belli, F., Mascheroni, L., Vegetti, C., Parmiani, G., and Anichini, A., 1994, Frequency of cyto-toxic T lymphocyte precursors (CTLp) interacting with autologous tumor via the T-cell receptor: limiting dilution analysis of specific CTLp in peripheral blood and tumor invaded lymph nodes of melanoma patients, Int. J. Cancer.58:330–339.

    PubMed  CAS  Google Scholar 

  • McKinney, E.C., and Streilein, E.W., 1989, On the extraordinary capacity of allogeneic epidermal langerhans cells to prime cytotoxic T cells in vivo, J. Immunol143:1560–1564.

    PubMed  CAS  Google Scholar 

  • Mehta-Damani, A., Markowicz, S., and Engleman, E.G., 1994, Generation of antigen-specific CD8+ CTLs from naive precursors, J. Immunol.153:996–1003.

    PubMed  CAS  Google Scholar 

  • Morse, M.A., Zhou, L.-J., Tedder, T.F., Lyerly, H.K., and Smith, C., 1997, Generation of dendritic cells in vitro from peripheral blood mononuclear cells with GM-CSF, IL-4, and TNF-a for use in cancer immunotherapy, Ann. Surg.226:6–16.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Morse, M.A., Lyerly, H.K., Gilboa, E., Thomas, E., and Nair, S.K, 1998, The role of CD40-ligand in induction of dendritic cell maturation, Cancer Res. (In Press).

    Google Scholar 

  • Mortarini, R., Anichini, A., Di Nicola, M., Siena, S., Bregni, M., Belli, F., Molla, A., Gianni, A.M., and Parmiani, G., 1997, Autologous dendritic cells derived from CD34+ progenitors and from monocytes are not functionally equivalent antigen-presenting cells in the induction of Melan-A/Mart-127–35-specific CTLs from peripheral blood lymphocytes of melanoma patients with low frequency of CTL precursors, Cancer Res.57:5534–5541.

    PubMed  CAS  Google Scholar 

  • Mukherji, B., Chakraborty, N.G., Yamasaki, S., Okino, T., Yamase, H., Sporn, J.R., Kurtzman, S.K., Ergin, M.T., Ozols, J., and Meehan, J., 1995, Induction of antigen-specific cytolytic T cells in situ in human melanoma by immunization with synthetic peptide-pulsed autologous antigen presenting cells, Proc. Natl. Acad. Sci. USA92:8078–8082.

    PubMed  CAS  Google Scholar 

  • Murphy, G., Tjoa, B., Ragde, H., Kenny, G., and Boynton, A., 1996, Phase I clinical trial: T-cell therapy for prostate cancer using autologous dendritic cells pulsed with HLA-A0201-specific peptides from prostate-specific membrane antigen, The Prostate29:371–380.

    PubMed  CAS  Google Scholar 

  • Nair, S., Zhou, F, Reddy, R., Huang, L., and Rouse, B.T., 1992, Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte responses in vitro, J. Exp. Med.175:609–612.

    PubMed  CAS  Google Scholar 

  • Nair, S., Babu, J.S., Dunham, R.G., Kanda, P., Burke, R.L., and Rouse, B.T., 1993, Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells, J. Virol.67:4062–4069.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Nair, S.K., Bocczowski, D., Morse, M.A., Cumming, R.I., Lyerly, H.K., and Gilboa, E., 1998, Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA, Nature Biotech.16:1–8.

    Google Scholar 

  • Nair, S.K., Snyder, YD., Rouse, B.T., and Gilboa, E., 1997, Regression of tumors in mice vaccinated with professional antigen-presenting cells pulsed with tumor extracts, Int. J. Cancer70:706–715.

    PubMed  CAS  Google Scholar 

  • Nestle, F.O., Alijagic, S., Gilliet, M., Sun, Y, Grabbe, S., Dummer, R., Burg, G., and Schadendorf, D., 1998, Vaccination of melanoma patients with peptide-or tumor lysate-pulsed dendritic cells, Nature Med.4:328–332.

    PubMed  CAS  Google Scholar 

  • Ossevoort, M.A., Feltkamp, M.C.W., Van Veen, K.J.H., Melief, C.J., and Kast, W.M., 1995, Dendritic cells as carriers for a cytotoxic T-lymphocyte epitope-based peptide vaccine in protection against a human papillomavirus type 16-induced tumor, J. Immunother.18:86–94.

    CAS  Google Scholar 

  • Paglia, P., Chiodoni, C., Rodolfo, M., and Colombo, M.P., 1996, Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo, J. Exp. Med.183:317–322.

    PubMed  CAS  Google Scholar 

  • Porgador, A., Snyder, D., and Gilboa, E., 1996, Induction of antitumor immunity using bone marrow-generated dendritic cells, J. Immunol.156:2918–2926.

    PubMed  CAS  Google Scholar 

  • Porgador, A., and Gilboa, E., 1995, Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes, J. Exp. Med.182:255–260.

    PubMed  CAS  Google Scholar 

  • Reichardt, V., Okada, C., Benike, C., Long, G., Engleman, E., Blume, K., and Levy, R., 1996, Idiotypic vaccination using dendritic cells for multiple myeloma patients after autologous peripheral blood stem cell transplantation, Blood88:481 (Abstract).

    Google Scholar 

  • Reid, C.D.L., Stackpoole, A., Meager, A., and Tikerpae, J., 1992, Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow, J. Immunol.149:2681–2688.

    PubMed  CAS  Google Scholar 

  • Reeves, M.E., Royal, R.E., Lam, J.S., Rosenberg, S.A., and Hwu, P., 1996, Retroviral transduction of human dendritic cells with a tumor-associated antigen gene, Cancer Res.56:5672–5677.

    PubMed  CAS  Google Scholar 

  • Robinson, M.R., Rigby, C.C., Pugh, C.B., and Dumonde, D.C., 1977, Adjuvant immunotherapy with BCG in carcinoma of the prostate, Br. J. Urol.49:221–226.

    PubMed  CAS  Google Scholar 

  • Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P.O., Steinman, R.M., and Schuler, G., 1994, Proliferating dendritic cell progenitors in human blood, J. Exp. Med.180:83–93.

    PubMed  CAS  Google Scholar 

  • Romani, N., Reider, D., Heuer, M., Ebner, S., Kampgen, E., Eibl, B., Niederwieser, D., and Schuler, G., 1996, Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability, J. Immunol. Methods (1996) 196:137–151.

    PubMed  CAS  Google Scholar 

  • Rosenberg, S.A., Lotze, M.T., Muul, L.M., Chang, A.E., Avis, F.P., Leitman, S., Linehan, W.M., Robertson, C.N., Lee, R.E., and Rubin, J.T., 1987, A progress report on the treatment of 157 patients with advanced cancer using lymphokine activated killer cells and interleukin-2 or high-dose interleukin-2 alone, N. Engl. J. Med.316(15):889–897.

    PubMed  CAS  Google Scholar 

  • Rosenberg, S.A., Lotze, M.T., Yang, J.C., Aebersold, P.M., Linehan, W.M., Seipp, C.A., and White, D.E., 1989, Experience with the use of high-dose interleukin-2 in the treatment of 652 patients with cancer, Ann. Surg.210:474–485.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Rouse, R.J.D., Nair, S.K., Lydy, S.L., Bowen, J.C., and Rouse, B.T., 1994, Induction in vitro of primary cytotoxic T-lymphocytes responses with DNA encoding herpes simplex virus proteins, J. Virol.68:5685–5689.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Santiago-Schwarz, F., Belilos, E., Diamond, B., and Carsons, S.E., 1992, TNF in combination with GM-CSF enhances the differentiation of neonatal cord blood stem cells into dendritic cells and macrophages, J. Leuk. Biol.52:274–281.

    CAS  Google Scholar 

  • Saunders, D., Lucas, K., Ismaili, J., Wu, L., Maraskovsky, E., Dunn, A., and Shortman, K., 1996, Dendritic cell development in culture from thymic precursor cells in the absence of granulocyte/macrophage colony-stimulating factor, J. Exp. Med.184:2185–2196.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Siena, S., Di Nicola, M., Bregni, M., Mortarini, R., Anichini, A., Lombardi, L., Ravagnani, F., Parmiani, G., and Gianni, A.M., 1995, Massive ex vivo generation of functional dendritic cells from mobilized CD34+ blood progenitors for anti-cancer therapy, Exp. Hematol.23:1463–1471.

    PubMed  CAS  Google Scholar 

  • Song, W., Kong, H.L., Carpenter, H., Torii, H., Granstein, R., Rafii, S., Moore, M.A.S., and Crystal, R.G., 1997, Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity, J. Exp. Med.186:1247–1256.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Specht, J.M., Wang, G., Do, M.T., Lam, J.S., Royal, R.E., Reeves, M.E., Rosenberg, S.A., and Hwu, P., 1997, Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases, J. Exp. Med., 186:1213–1221.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Steinman, R.M., and Swanson, J., 1995, The endocytic activity of dendritic cells, J. Exp. Med.182:283–88.

    PubMed  CAS  Google Scholar 

  • Steinman, R.M., 1991, The dendritic cell system and its role in immunogenicity, Ann. Rev. Immunol.9:271–296.

    CAS  Google Scholar 

  • Strobl, H., Scheinecker, C., Riedl, E., Csmarits, B., Bello-Fernandez, C., Pickl, W.F., Majdic, O., and Knapp, W., 1998, Identification of CD68+lin-peripheral blood cells with dendritic precursor characteristics, J. Immunol.161:740–748.

    PubMed  CAS  Google Scholar 

  • Suss, G., and Shortman, K., 1996, A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis, J. Exp. Med.183:1789–1796.

    PubMed  CAS  Google Scholar 

  • Szabolcs, P., Moore, M.A., and Young, J.W, 1995, Expansion of immunostimulatory dendritic cells among the myeloid progeny of human CD34+ bone marrow precursors cultured with c-kit ligand, granulocyte-macrophage colony-stimulating factor, and TNF-α, J. Immunol.154:5851–5861.

    PubMed  CAS  Google Scholar 

  • Szabolcs, P., Avigan, D., Gezelter, S., Ciocon, D.H., Moore, M.A., Steinman, R.M., and Young, J.W., 1996, Dendritic cells and macrophages can mature independently from a human bone marrow-derived, postcolony forming unit intermediate, Blood87:4520–4530.

    PubMed  CAS  Google Scholar 

  • Tazi, A., Bouchonnet, F., Grandsaigne. M., Boumsell, L., Hance, A.J., and Soler, P., 1993, Evidence that granulocyte-macrophage-colony stimulating factor regulates the distribution and differentiated state of dendritic cells/Langerhans cells in human lung and lung cancers, J. Clin. Invest.91:566–576.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Takahashi, H., Nakagaway, Y., Yokomuro, K., and Berzofsky, J.A., 1993, Induction of CD8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells, Int. Immunol.5:849–857.

    PubMed  CAS  Google Scholar 

  • Tarte, K., Lu, Z.Y., Fiol, G., Legouffe. E., Rossi, J.F., and Klein, B., 1997, Generation of virtually pure and potentially proliferating dendritic cells from non-CD34 apheresis cells from patients with multiple myeloma, Blood90:3482–3495.

    PubMed  CAS  Google Scholar 

  • Thomas, R., Davis, L., and Lipsky, P., 1993, Isolation and characterization of human peripheral blood dendritic cells, J. Immunol.150:821–834.

    PubMed  CAS  Google Scholar 

  • Thompson, J.A., Gruner, T.F., and Zimmermann, W., 1991, Carcinoembryonic antigen gene family: molecular biology and clinical prospectives, J. Clin. Lab. Anal.5:344–366.

    PubMed  CAS  Google Scholar 

  • Tsang, K.Y, Zaremba, S., Nieroda, C.A., Zhu, M.Z., Hamilton, J.M., and Schlom, J., 1995, Generation of human cytotoxic T cells specific for human carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA vaccine, J. Natl. Cancer Inst.87:982–990.

    PubMed  CAS  Google Scholar 

  • Valone, F.H., Small, E.J., Whisenant, S., Peshwa, M., Strang, G., Laus, R., Ruegg, C., and van Schooten, W., 1998. Immunotherapy of hormone refractory prostate cancer with antigen-pulsed dedritic cells: A Phase I/II study, Proc. Am. Soc. Clin. Oncol.17:346a.

    Google Scholar 

  • Van den Eynde, B., Hainut, P., Herin, M., Knuth, A., Lemoine, C., Weynants, P., van der Bruggen. P.C., Fauchet, R., and Boon, T., 1989, Presence on a human melanoma of multiple antigens recognized by autologous CTL, Int. J. Cancer44:634–640.

    PubMed  Google Scholar 

  • Van der Bruggen, P.C., Traversari, C., Chomez, P., Lurquin, C., De Plaen, E., Van den Eynde, B., Knuth, A., and Boon, T., 1991, A gene encoding an antigen recognized by cytotoxic T lymphocytes on a human melanoma, Science254:1643–1647.

    PubMed  Google Scholar 

  • Van Pel, A., and Boon. T, 1982, Protection against a nonimmunogenic mouse leukemia by an immunogenic variant obtained by mutagenesis, Proc. Natl. Acad. Sci. USA79:4718–4722.

    PubMed  Google Scholar 

  • Van Voorhis, W.C., Hair, L.S., Steinman, R.M., and Kaplan, G., 1982, Human dendritic cells: Enrichment and characterization from peripheral blood, J. Exp. Med155:1172–1187.

    PubMed  PubMed Central  Google Scholar 

  • Vremee, D., Zorbas, M., Scollay, R., Saunders, D., Ardavin, C., Wu, L., and Shortman, K., 1992, The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells, J. Exp. Med176:47–58.

    Google Scholar 

  • Williams, L.A., Egner, W., and Hart, D.N.J., 1994, Isolation and function of human dendritic cells, Int. Rev. Cytol.153:41–103.

    PubMed  CAS  Google Scholar 

  • Wong, C., Morse, M.A., and Nair, S.K., 1998, Induction of primary, human antigen-specific cytotoxic T lymphocytes in vitro using dendritic cells pulsed with peptides, J. Immunother. 21:32–40.

    PubMed  CAS  Google Scholar 

  • Young, J.W., and Steinman, R.M., 1990, Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells, J. Exp. Med.171:1315–1332.

    PubMed  CAS  Google Scholar 

  • Young, J.W., and Steinman, R.M., 1988, Accessory cell requirements for the mixed-leukocyte reaction and polyclonal mitogens, as studied with a new technique for enriching blood dendritic cells, Cell. Immunol.111:167–182.

    PubMed  CAS  Google Scholar 

  • Zhou, L.-J., and Tedder, T.F., 1995, Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily, J. Immunol.154:3821–3835.

    PubMed  CAS  Google Scholar 

  • Zhou, L.-J., and Tedder, T.F., 1996, CD14+ Blood monocytes can differentiate into functionally mature CD83+ dendritic cells, Proc. Natl. Acad Sci. USA93:2588–2592.

    PubMed  CAS  Google Scholar 

  • Zitvogel, L., Mayordomo, J.I., Tjandrawan, T., DeLeo, A.B., Clarke, M.R., Lotze, M.T., and Storkus, W.J., 1996, Therapy of murine tumors with tumor peptide pulsed dendritic cells: dependence on T cells, B7 costimulation, and Thl-asssociated cytokines, J. Exp. Med.183:87–97.

    PubMed  CAS  Google Scholar 

  • Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D. Ricciardi-Castagnoli, P., Raposo, G., and Amigorena, S., 1998, Eradication of established murine tumors using a novel cell-free vaccine; dendritic cell-derived exosomes, Nature Med.4:594–600.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, Duke University Medical Center, Box 2606, Durham, North Carolina, 27710, USA

    Michael A. Morse

  2. Department of Surgery, Duke University Medical Center, Box 2606, Durham, North Carolina, 27710, USA

    H. Kim Lyerly

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  1. Michael A. Morse
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  2. H. Kim Lyerly
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Editors and Affiliations

  1. Imperial College School of Medicine, Hammersmith Hospital, London, UK

    Nagy A. Habib

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© 2002 Kluwer Academic Publishers

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Morse, M.A., Kim Lyerly, H. (2002). Dendritic Cell-based Immunization for Cancer Therapy. In: Habib, N.A. (eds) Cancer Gene Therapy. Advances in Experimental Medicine and Biology, vol 465. Springer, New York, NY. https://doi.org/10.1007/0-306-46817-4_28

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  • DOI: https://doi.org/10.1007/0-306-46817-4_28

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  • Print ISBN: 978-0-306-46191-0

  • Online ISBN: 978-0-306-46817-9

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