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Pathogenesis of Legionella pneumophila Infection

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Opportunistic Intracellular Bacteria and Immunity

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Conclusions

We have attempted to present new information on the biology of the legionellae. Most new developments have focused on the events that follow host cell entry and lead to intracellular replication in macrophages or macrophage-like cell lines. However, we have also presented recent findings addressing the early events of invasion of nonphagocytic cells by L.pneumophila and the unusual role that the heat-shock protein Hsp60 may play in these early events. Readers may have grasped the wealth of potential knowledge that could be extracted from using the legionellae to model the pathogenesis and evolution of intracellular bacterial pathogens. In particular, the study of the recently discovered developmental cycle of L.pneumophila offers unique opportunities,as developmental cycles have been basically described only for obligate intracellular pathogens.

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Authors and Affiliations

  1. Departments of Microbiology, Immunology, and Medicine, Division of Infectious Diseases, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada

    Paul S. Hoffman

  2. Departments of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada

    Rafael Garduno

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© 2002 Kluwer Academic Publishers

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Hoffman, P.S., Garduno, R. (2002). Pathogenesis of Legionella pneumophila Infection. In: Opportunistic Intracellular Bacteria and Immunity. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/0-306-46809-3_8

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  • DOI: https://doi.org/10.1007/0-306-46809-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-45894-1

  • Online ISBN: 978-0-306-46809-4

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