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Chemistry and Physics of Primitive Membranes

  • David W. DeamerEmail author
  • Jason P. Dworkin
Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 259)

Abstract

A membrane boundary structure was essential for the advent of cellular life. The membranes of contemporary cells are composed of a mosaic of proteins embedded in a bimolecular layer of phospholipids, each of which requires a complex enzymatic pathway for its synthesis. The earliest forms of life could not have had such a highly evolved pathway in place. Amphiphilic monocarboxylic acids are present in carbonaceous meteorites and can be synthesized under simulated geochemical conditions. Such compounds have physical and chemical properties that allow them to assemble into bilayer membranes and are therefore plausible components of the first cellular membranes.

Artificial cells Encapsulation Lipid vesicles Membranes 

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References

  1. 1.
    Dyson F (1999) The Origins of Life. Princeton University Press, Princeton, NJ Google Scholar
  2. 2.
    Deamer D, Dworkin JP, Sandford SA, Bernstein MP, Allamandola LJ (2002) Astrobiology 2:371–382 CrossRefPubMedGoogle Scholar
  3. 3.
    Segré S, Deamer DW, Lancet D (2001) Orig Life Evol Biosphere 31:119–145 CrossRefPubMedGoogle Scholar
  4. 4.
    Cavalier-Smith T (1987) Cold Spring Harbor Symposia on Quantitative Biology, Vol LII, pp 805–824 Google Scholar
  5. 5.
    Koch AL, Schmidt TM (1991) J Mol Evol 33:297–304 CrossRefPubMedGoogle Scholar
  6. 6.
    Morowitz HJ (1992) Beginnings of Cellular Life. Yale University Press, New Haven, CT Google Scholar
  7. 7.
    Miller SL (1953) Science 117:528–529 PubMedGoogle Scholar
  8. 8.
    Miller SL, Urey HC (1959) Science 130:245–251 PubMedGoogle Scholar
  9. 9.
    Miller SL, Schlesinger G (1984) Orig Life 14:83 CrossRefPubMedGoogle Scholar
  10. 10.
    Nooner DW, Gilbert JM, Gelpi E, Oró J (1976) Geochim Cosmochim Acta 40:915–24 CrossRefGoogle Scholar
  11. 11.
    McCollom TM, Ritter G, Simoneit BRT (1999) Orig Life Evol Biosphere 29:153–166 CrossRefPubMedGoogle Scholar
  12. 12.
    Rushdi AI, Simoneit B (2001) Orig Life Evol Biosphere 31:103–118 CrossRefPubMedGoogle Scholar
  13. 13.
    Kvenvolden KA, Lawless JG, Pering K, Peterson E, Flores J, Ponnamperuma C, Kaplan IR, Moore C (1970) Nature 28:923 CrossRefGoogle Scholar
  14. 14.
    Cronin JR, Pizzarello S, Cruikshank DP (1988) In: Kerridge JF, Matthews MS (eds) Meteorites and the Early Solar System. University of Arizona Press, Tucson, AZ, p 819–857 Google Scholar
  15. 15.
    Sephton MA (2002) Nat Prod Rep 19:292–311 CrossRefPubMedGoogle Scholar
  16. 16.
    Holland HD (1984) The Chemical Evolution of the Atmosphere and Oceans. Princeton University Press, Princeton, NJ Google Scholar
  17. 17.
    Kasting JF, Brown LL (1998) In: Brack A (ed) The Molecular Origins of Life. Cambridge University Press, Cambridge, UK, pp 35–56 Google Scholar
  18. 18.
    Oró J (1961) Nature 190:389–390 Google Scholar
  19. 19.
    Delsemme A (1984) Orig Life 14:51–60 CrossRefGoogle Scholar
  20. 20.
    Anders E (1989) Nature 342:255–257 CrossRefPubMedGoogle Scholar
  21. 21.
    Chyba CF, Sagan C (1992) Nature 355:125–13 CrossRefPubMedGoogle Scholar
  22. 22.
    Maurette M (1998) In: Brack A (ed) The Molecular Origins of Life. Cambridge University Press, Cambridge, UK, pp 147–186 Google Scholar
  23. 23.
    Ehrenfreund P, Charnley SB (2000) Ann Rev Astron Astrophys 38:427–483 CrossRefGoogle Scholar
  24. 24.
    Sandford SA (1996) Meteoritics Planet Sci 31:449–476 Google Scholar
  25. 25.
    Greenberg M, Mendoza-Gomez CX (1993) In: Greenberg M, Mendoza-Gomez CX, Pironella V (eds) The Chemistry of Life's Origins. Kluwer, Dordrecht, pp 1–32 Google Scholar
  26. 26.
    Bernstein MP, Sandford SA, Allamandola, LJ, Chang S, Scharberg MA (1995) Astrophys J 454:327–344 CrossRefGoogle Scholar
  27. 27.
    Ehrenfreund P, d'Hendecourt L, Charnley SB, Ruiterkamp R (2001) J Geophys Res 106:33291–33302 CrossRefGoogle Scholar
  28. 28.
    Muñoz-Caro GM, Meierhenrich WA, Schutte WA, Barbier B, Arcones Segovia A, Rosenbauer W, Thriemann HP, Brack A, Greenberg JM (2002) Nature 416:403–406 CrossRefPubMedGoogle Scholar
  29. 29.
    Bernstein MP, Dworkin JP, Sandford SA, Cooper GW, Allamandola LJ (2002) Nature 416:401 CrossRefPubMedGoogle Scholar
  30. 30.
    Bernstein MP, Dworkin JP, Sandford SA, Allamandola LJ (2001) Meteoritics Planet Sci 36:351–258 Google Scholar
  31. 31.
    Dworkin JP, Deamer DW, Sandford SA, Allamandola LJ (2001) Proc Natl Acad Sci USA 98:815–819 CrossRefPubMedGoogle Scholar
  32. 32.
    Pierazzo E, Chyba C (1999) Meteoritics Planet Sci 32:090–918 Google Scholar
  33. 33.
    Krishnamurthy RV, Epstein S, Cronin JR, Pizzarello S, Yuen GU (1992) Geochim Cosmochim Acta 56:4045–4058 CrossRefPubMedGoogle Scholar
  34. 34.
    Sandford SA, Bernstein MP, Dworkin JP (2001) Meteoritics Planet Sci 36:1117–1133 Google Scholar
  35. 35.
    Love SG, Brownlee, DE (1993) Science 262:550–553 Google Scholar
  36. 36.
    Hargreaves WW, Mulvihill SJ, Deamer DW (1977) Nature 266:78–80 CrossRefPubMedGoogle Scholar
  37. 37.
    Rao M, Eichberg MR, Oró J (1982) J Mol Evol 18:196–202 CrossRefPubMedGoogle Scholar
  38. 38.
    Epps DE, Sherwood E, Eichberg J, Oró J (1978) J Mol Evol 6:279–92 CrossRefGoogle Scholar
  39. 39.
    Ourisson G, Nakatani T (1994) Chem Biol 1:11 CrossRefPubMedGoogle Scholar
  40. 40.
    Conde-Frieboes K, Blochliger E (2001) Biosystems 1:109–114 CrossRefGoogle Scholar
  41. 41.
    Singer SJ, Nicolson GL (1972) Science 175:720–31 PubMedGoogle Scholar
  42. 42.
    Frye LD, Edidin M (1970) J Cell Sci 7:319–35 PubMedGoogle Scholar
  43. 43.
    Oliver A, Deamer DW (1994) Biophys J 66:1364–79 PubMedGoogle Scholar
  44. 44.
    Vlassov A, Khvorova A, Yarus M (2001) Proc Natl Acad Sci USA 98:7706 CrossRefPubMedGoogle Scholar
  45. 45.
    Pohorille A, Schweighofer K, Wilson MA (2005) Astrobiology 1–17 Google Scholar
  46. 46.
    Chakrabarti A, Deamer DW (1994) J Mol Evol 39:1–5 PubMedGoogle Scholar
  47. 47.
    Parsegian A (1969) Nature 221:844–846 PubMedGoogle Scholar
  48. 48.
    Paula S, Volkov AG, Van Hoek AN, Haines TH, Deamer DW (1996) Biophys J 70:339–348 PubMedGoogle Scholar
  49. 49.
    Monnard P-A, Deamer DW (2001) Orig Life Evol Biosphere 31:147–155 CrossRefPubMedGoogle Scholar
  50. 50.
    Walde P, Wick R, Fresta M, Mangone A, Luisi PL (1994) J Am Chem Soc 116:11649–11654 CrossRefGoogle Scholar
  51. 51.
    Hanczyc MM, Fujikawa SM, Szostak JW (2003) Science 302:618–22 CrossRefPubMedGoogle Scholar
  52. 52.
    Hanczyc MM, Szostak JW (2004) Curr Opin Chem Biol 28:660–664 CrossRefGoogle Scholar
  53. 53.
    Shew R, Deamer D (1983) Biochim Biophys Acta 816:1–8 Google Scholar
  54. 54.
    Pick U (1981) Arch Biochem Biophys 212:186 CrossRefPubMedGoogle Scholar
  55. 55.
    Nasseau M, Boublik Y, Meier W, Winterhalter M, Fournier D (2001) Biotech Bioeng 75:615 CrossRefGoogle Scholar
  56. 56.
    Stribling R, Miller SL (1987) Orig Life Evol Biosphere 17:261–73 PubMedGoogle Scholar
  57. 57.
    Cairns-Smith G (1982) Genetic Takeover and the Mineral Origins of Life. Cambridge University Press, Cambridge, UK Google Scholar
  58. 58.
    Hazen RM, Filley TR, Goodfriend GM (2001) Proc Natl Acad Sci USA 98:5487–5490 CrossRefPubMedGoogle Scholar
  59. 59.
    Corliss JB, Baross JA, Hoffman SE (1981) Oceanol Acta. Proceedings of the 26th International Geological Congress, Paris, pp 59–69 Google Scholar
  60. 60.
    Baross JA, Hoffman SE (1985) Orig Life 15:327 CrossRefGoogle Scholar
  61. 61.
    Pace NR (1991) Cell 65:531–533 CrossRefPubMedGoogle Scholar
  62. 62.
    Wächtershäuser G (1988) Syst Appl Microbiol 10:207–210 Google Scholar
  63. 63.
    Wächtershäuser G (1988) Microbiol Rev 52:452–484 PubMedGoogle Scholar
  64. 64.
    Huber C, Wächtershäuser G (1997) Science 276:245 CrossRefPubMedGoogle Scholar
  65. 65.
    Huber C, Wächtershäuser G (1998) Science 281:670–672 CrossRefPubMedGoogle Scholar
  66. 66.
    Martin W, Russell MJ (2003) Phil Trans R Soc Lond B 358:59–83 CrossRefGoogle Scholar
  67. 67.
    Lawless JG, Yuen GU (1979) Nature 282:396–398 CrossRefGoogle Scholar
  68. 68.
    Naraoka H, Shimoyama A, Komiya M, Harada H (1999) Orig Life Evol Biosphere 29:187–201 CrossRefPubMedGoogle Scholar
  69. 69.
    Deamer DW (1985) Nature 317:792–794 CrossRefGoogle Scholar
  70. 70.
    Deamer DW, Pashley RM (1989) Orig Life Evol Biosphere 19:21–33 CrossRefPubMedGoogle Scholar
  71. 71.
    Hargreaves WR, Deamer DW (1978) Biochemistry 17:3759–3768 CrossRefPubMedGoogle Scholar
  72. 72.
    Apel CL, Deamer DW, Mautner M (2002) Biochim Biophys Acta 1559:1 PubMedGoogle Scholar
  73. 73.
    Monnard P-A, Apel CL, Kanavarioti A, Deamer DW (2002) Astrobiology 2:139 CrossRefPubMedGoogle Scholar
  74. 74.
    Johnston WK, Unrau PJ, Lawrence MS, Glasner ME, Bartel DL (2001) Science 292:1319–1325 CrossRefPubMedGoogle Scholar
  75. 75.
    Luisi PL (1996) Adv Chem Phys 92:425–438 Google Scholar
  76. 76.
    Pohorille A, Deamer DW (2002) Trends Biotechnol 20:123 CrossRefPubMedGoogle Scholar
  77. 77.
    Szostak JW, Bartel DP, Luisi PL (2001) Nature 409:387–390 CrossRefPubMedGoogle Scholar
  78. 78.
    Rasmussen S, Chen L, Deamer D, Krakauer DC, Packard NH, Stadelr PF, Bedau MA (2004) Science 303:963–5 CrossRefPubMedGoogle Scholar
  79. 79.
    Chakrabarti A, Breaker RR, Joyce GF, Deamer DW (1994) J Mol Evol 39:555–559 CrossRefPubMedGoogle Scholar
  80. 80.
    Walde P, Goto A, Monnard P-A, Wessicken M, Luisi PL (1994) J Am Chem Soc 116:7541–7547 CrossRefGoogle Scholar
  81. 81.
    Oberholzer T, Wick R, Luisi PL, Biebricker CK (1995) Biochem Biophys Res Commun 207:250 CrossRefPubMedGoogle Scholar
  82. 82.
    Oberholzer T, Albrizio M, Luisi PL (1995) Curr Biol 2:677 Google Scholar
  83. 83.
    Monnard P-A, Deamer DW (2002) Anat Rec 268:196 CrossRefPubMedGoogle Scholar
  84. 84.
    Yu W, Sato K, Wakabayashi M, Nakaishi T, K-Mitamura EP, Shima Y, Urabe I, Yomo T (2001) J Biosci Bioengin 92:590 CrossRefPubMedGoogle Scholar
  85. 85.
    Nomura S, Tsumoto K, Hamada T, Akiyoshi K, Nakatani Y, Yoshikawa K (2003) Chem Biochem 4:1172-1175 Google Scholar
  86. 86.
    Noireaux V, Libchaber A (2004) Proc Natl Acad Sci USA 101:17669–74 CrossRefPubMedGoogle Scholar
  87. 87.
    Ishikawa K, Sato K, Shima Y, Urabe I, Yomo T (2004) FEBS Lett 576:387 CrossRefPubMedGoogle Scholar
  88. 88.
    Beaudry AA, Joyce GF (1992) Science 342:255 Google Scholar
  89. 89.
    Wilson C, Szostak JW (1994) Nature 374:777–782 CrossRefGoogle Scholar

Authors and Affiliations

  1. 1.Department of Biomolecular EngineeringUniversity of CaliforniaSanta Cruz,USA
  2. 2.Laboratory for AstrochemistrySolar System Exploration DivisionGreenbeltUSA

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