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Organolithium in Asymmetric Processes

  • George G. WuEmail author
  • Mingsheng Huang
Chapter
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 6)

Abstract

The development of asymmetric processes has been the focus of industrial research as most of the molecules of pharmaceutical interest contain chiral center(s). Many of the reported processes employ organometallic reagents in their key transformations. This review surveys chemical processes involving organolithium species in their enantioselective steps published in the past decade.

Keywords

Organolithium Asymmetric process Chiral alkylation Chiral imine addition Chiral aldol/Michael addition 

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Authors and Affiliations

  1. 1.Chemical Process Research and DevelopmentSchering-Plough Research InstituteUnionUSA

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