Organolithium in Asymmetric Processes
The development of asymmetric processes has been the focus of industrial research as most of the molecules of pharmaceutical interest contain chiral center(s). Many of the reported processes employ organometallic reagents in their key transformations. This review surveys chemical processes involving organolithium species in their enantioselective steps published in the past decade.
KeywordsOrganolithium Asymmetric process Chiral alkylation Chiral imine addition Chiral aldol/Michael addition
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