Apoptosis and cell culture technology

  • Mohamed Al-Rubeai
Chapter
Part of the Advances in Biochemical Engineering Biotechnology book series (ABE, volume 59)

Abstract

The importance of apoptosis in cell culture has now been widely recognised. Recent work has shown that this process is widely manifested during the in vitro cultivation of commercially important mammalian cell lines.

In this review I summarise what is now known of the characteristics, significance and regulatory mechanisms of apoptosis. As the process of cell proliferation and cell death are now considered intimately related, particular attention is paid to highlight the progress and opportunities in the field of cell culture engineering. The strategies that have been undertaken to prevent the induction of apoptosis in cell culture and those which have been suggested as possibilities to improve culture productivity through the apoptosis route are discussed with given examples.

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References

  1. 1.
    Handa-Corrigan A, Emery AN, Spier RE (1989) Enzyme Microb. Technol. 11: 230CrossRefGoogle Scholar
  2. 2.
    Kioukia N, Nienow AW, Emery AN, Al-Rubeai M (1992) Trans IChemE 70: 143Google Scholar
  3. 3.
    Kunas KT, Papoutsakis ET (1990) Biotechnol Bioeng 36: 476CrossRefGoogle Scholar
  4. 4.
    Al-Rubeai M, Oh SKW, Musaheb R, Emery AN (1990) Biotechnol Lett 12: 323CrossRefGoogle Scholar
  5. 5.
    Emery AN, Jan DC-H, Al-Rubeai M (1995) Appl Microbiol Biotechnol 43: 1028CrossRefGoogle Scholar
  6. 6.
    Bailey JE (1991) Science 252: 1668CrossRefGoogle Scholar
  7. 7.
    Kearns MJ (1990) Bio/Technol 8: 409CrossRefGoogle Scholar
  8. 8.
    Curling EM, Hayter PM, Baines AJ, Bull AT, Gull K, Strange PG, Jenkins N (1990) Biochem J 272: 333Google Scholar
  9. 9.
    Freshney RI (1989) Animal cell culture, a practical approach, IRL Press, OxfordGoogle Scholar
  10. 10.
    Heichman KA, Roberts JM (1994) Cell 79: 557CrossRefGoogle Scholar
  11. 11.
    King RW, Jackson PK, Kirschner MW (1994) Cell 79: 563CrossRefGoogle Scholar
  12. 12.
    Nurse P (1994) Cell 79: 547CrossRefGoogle Scholar
  13. 13.
    Sherr CJ (1994) Cell 79: 551CrossRefGoogle Scholar
  14. 14.
    Murray A (1994) Current opinion in cell biology 6: 872CrossRefGoogle Scholar
  15. 15.
    Sherr CJ, Roberts JM (1995) Gene & Development 9: 1149Google Scholar
  16. 16.
    Al-Rubeai M, Emery AN, Chalder S, Jan DC (1992) Cytotech 9: 85CrossRefGoogle Scholar
  17. 17.
    Ashwell JD, Cunningham RE, Noguchi PD, Hernandez D (1987) J Exp Med 165: 173CrossRefGoogle Scholar
  18. 18.
    Cotter TG, Lennon SV, Glynn JM, Green DR (1992) Cancer Res 52: 997Google Scholar
  19. 19.
    Buja LM, Eigenbrodt ML, Eigenbrodt EH (1993) Arch Pathol Lab Med 117: 1208Google Scholar
  20. 20.
    Manjo G, Joris I (1995) American J Pathol 146: 1Google Scholar
  21. 21.
    Singh RP, Al-Rubeai M, Gregory CD, Emery AN (1994) Biotechnol Bioeng 44: 720CrossRefGoogle Scholar
  22. 22.
    Milner AE, Wang H, Gregory CD (1966) In: Al-Rubeai M, Emery AN (eds) Flow Cytometry Applications in Cell Culture, Marcel Dekker, New YorkGoogle Scholar
  23. 23.
    Darzynkiewicz Z, Li X, Gong J (1994) In: Darzynkiewicz Z, Robinson JP, Crissman HA (eds) Methods in Cell Biology, Vol 41 Flow Cytometry, 2nd edition, Academic PressGoogle Scholar
  24. 24.
    Studzinski GP (1995) Cell growth and apoptosis: A practical approach, IRL PressGoogle Scholar
  25. 25.
    Evan GI, Harrington E, McCarthy N, Gilbert C, Benedict MA, Nunez G (1995) In: Thomas NSB (ed) Apoptosis and cell cycle control in cancer, BIOS, OxfordGoogle Scholar
  26. 26.
    Bursch W, Paffe S, Putz B, Barthel G, Schlte-Hermann R (1990) Carcinogenesis 11: 847Google Scholar
  27. 27.
    DelVecchio M, Leoncini L, Buerki K, Kraft R, Megha T, Barbini R, Tosi P, Cottier H (1991) Int J Cancer 47: 38Google Scholar
  28. 28.
    Moser B (1995) Microscopy and Analysis 50: 21Google Scholar
  29. 29.
    Al-Rubeai M, Mills D, Emery AN (1990) Cytotechnol 4: 13CrossRefGoogle Scholar
  30. 30.
    Falcieri E, Gobbi P, Zamai L, Vitale M (1994) Scanning Microscopy 8: 653Google Scholar
  31. 31.
    Oberhammer F, Fritsch G, Pavelka M, Froschl G, Tiefenbacher R, Purchio T, Schulte-Hermann R (1992) Toxicol Lett 64–65: 701.CrossRefGoogle Scholar
  32. 32.
    Cohn GM, Sun X-M, Snowden RT, Dinsdale D, Skilleter DN (1992) Biochem J 286: 331Google Scholar
  33. 33.
    Walker R (1995) In: CHI Conference on Commercial Prospects of Apoptotic Research, Cambridge, MA, May 1–3Google Scholar
  34. 34.
    Al-Rubeai M, Emery AN (1993) Bio/Technol 11: 572CrossRefGoogle Scholar
  35. 35.
    Dive C, Gregory CD, Phipps DJ, Evans DL, Milner AE, Wyllie AH (1992) Biochimica et Biophysica Acta 1133: 275CrossRefGoogle Scholar
  36. 36.
    Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) J Cell Biol 119: 493CrossRefGoogle Scholar
  37. 37.
    Gorczyca W, Bruno S, Darzynkiewicz RJ, Gong J, Darzynkiewicz Z (1992) Int J Onclogy 1: 639Google Scholar
  38. 38.
    Gold R, Schmied M, Rothe G, Zischler H, Breitschopt H, Wekerle H, Lassman H (1993) J Histochem Cytochem 41: 1023Google Scholar
  39. 39.
    Li X, Traganos F, Melamed MR, Darzynkiewicz Z (1995) Cytometry 20: 172CrossRefGoogle Scholar
  40. 40.
    Cohen JJ (1991) Adv Immunol 50: 55CrossRefGoogle Scholar
  41. 41.
    Wyllie AH (1980) Nature 284, 555CrossRefGoogle Scholar
  42. 42.
    Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S (1991) Cell 66: 233CrossRefGoogle Scholar
  43. 43.
    Collins MKL, Marvel J, Malde P, Lopez-Rivas A (1992) J Exp Med 176: 10430CrossRefGoogle Scholar
  44. 44.
    Schwartzman RA, Cidlowski A (1993) Endocrine Rev 14: 133CrossRefGoogle Scholar
  45. 45.
    Iwata M (1995) In: Kroemer G, Martinez AC (eds) Apoptosis in Immunology, Springer Berlin Heidelberg New YorkGoogle Scholar
  46. 46.
    McConkey DJ, Orrenius S, Jondal M (1990) Immunol Today 11: 120CrossRefGoogle Scholar
  47. 47.
    Bellomo G, Perotti M, Taddei F, Finardi G, Nicotera P, Orrenius S (1992) Cancer Res. 52: 1342Google Scholar
  48. 48.
    McConkey DJ, Orrenius S (1995) In: Kroemer G, Martinez AC (eds) Apoptosis in Immunology, Springer, Berlin Heidelberg New YorkGoogle Scholar
  49. 49.
    Lennon SV, Kilfeather SJ, Hallet MB, Campbell AK, Cotter TG (1991) Clin Exp Immunol 87: 465CrossRefGoogle Scholar
  50. 50.
    Fesus L, Davies PJA, Piacentini M (1991) Eur J Cell Biol 56: 170Google Scholar
  51. 51.
    Owen-Schaub LB, Yonehara S, Crump III WL, Grimm E (1992) Cell Immunol. 140: 197CrossRefGoogle Scholar
  52. 52.
    Klas C, Debatin KM, Jonker RR, Krammer PH (1993) Int Immunol 5: 625Google Scholar
  53. 53.
    Nagata S, Golstein P (1995) Science 267: 1449CrossRefGoogle Scholar
  54. 54.
    Yoshino T, Kondo E, Cao L et al. (1994) Blood 83: 1856Google Scholar
  55. 55.
    Cohen JJ, Dukle RC (1984) J Immunol 132: 38Google Scholar
  56. 56.
    Wyllie AH, Morris RG, Smith AL, Dunlop DJ (1984) J Pathol 142: 67CrossRefGoogle Scholar
  57. 57.
    Sellins KS, Cohen JJ (1987) J Immunol 139: 3199Google Scholar
  58. 58.
    Shi Y, Szalay MG, Paskar L, Boyer M, Singh B, Green DR (1990) J Immunol 144: 3326Google Scholar
  59. 59.
    Crompton T (1991) Growth Factors 4: 109Google Scholar
  60. 60.
    Takano YS, Harmon BV, Kerr JFR (1991) J Pathol 163: 329CrossRefGoogle Scholar
  61. 61.
    Brach MA, de Vos S, Gruss HJ, Hermann F (1992) Blood 80: 2920Google Scholar
  62. 62.
    Carson D, Ribeiro JM (1993) The Lancet 341: 150CrossRefGoogle Scholar
  63. 63.
    Cotter TG, Al-Rubeai M (1995) TIBTECH 13: 1251Google Scholar
  64. 64.
    Raff MC (1992) Nature 356: 397CrossRefGoogle Scholar
  65. 65.
    Kurita T, Namiki H (1994) J Cellular Physiology 161: 63CrossRefGoogle Scholar
  66. 66.
    Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC (1992) Cell 69: 119CrossRefGoogle Scholar
  67. 67.
    Mercille S, Massie B (1994) Biotechnol Bioeng 44: 1140CrossRefGoogle Scholar
  68. 68.
    Steller H (1995) Science 267: 1445CrossRefGoogle Scholar
  69. 69.
    Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993) Cell 75: 653CrossRefGoogle Scholar
  70. 70.
    Wang L, Miura M, Bergeron L, Zhu H, Yuan J (1994) Cell 78: 739CrossRefGoogle Scholar
  71. 71.
    Yuan J (1995) Current Opinion in Cell Biology 7: 211CrossRefGoogle Scholar
  72. 72.
    Lane DP (1993) Nature 362: 786CrossRefGoogle Scholar
  73. 73.
    El-Deiry WS (1995) In: Thomas NSB (ed) Apoptosis and cell cycle control in cancer, BIOS, OxfordGoogle Scholar
  74. 74.
    Shi Y, Glynn JM, Guilbert L, Cotter TG, Bissonette R, Green DR (1992) Science 257: 212CrossRefGoogle Scholar
  75. 75.
    Vaux DL, Cory S, Adams JM (1988) Nature 335: 440CrossRefGoogle Scholar
  76. 76.
    McDonnell TJ, Korsmeyer SJ (1991) Nature 349: 254CrossRefGoogle Scholar
  77. 77.
    Hockenbery D, Nunez G, Millman C, Schreiber RD, Korsmeyer SJ (1990) Nature 348: 334CrossRefGoogle Scholar
  78. 78.
    Gregory CD (1992) Rev Med Virol 2: 205Google Scholar
  79. 79.
    Ferandez-Sarabia M, Bischoff J (1993) Nature 366: 274CrossRefGoogle Scholar
  80. 80.
    Halder S, Negrini M, Monne M, Sabbioni S, Croce CM (1994) Cancer Res 54: 2095Google Scholar
  81. 81.
    Reed JC (1994) J Cell Biol 124: 1CrossRefGoogle Scholar
  82. 82.
    Oltvai ZN, Korsmeyer SJ (1994) Cell 79: 189CrossRefGoogle Scholar
  83. 83.
    Halder S, Jena N, Cross R, Sedar AW, Wachsberger PR, Beatty C, Croce CM (1994) Cell Death and Differentiation 1: 109Google Scholar
  84. 84.
    Chen-Levy S, Cleary MS (1990) J Biol Chem 265: 4929Google Scholar
  85. 85.
    Hockenbery D, Oltvai Z, Yin X, Milliman C, Korsmeyer S (1993) Cell 75: 241CrossRefGoogle Scholar
  86. 86.
    Kane D, Safafian T, Anton R, Hahn H, Gralla E, Valentine J, Ord T, Bredesen D (1993) Science 262: 1274CrossRefGoogle Scholar
  87. 87.
    Muschel R, Bernhard E, Garza L, Mckenna E, Koch C (1995) Cancer Res 55: 995Google Scholar
  88. 88.
    Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y (1995) Nature 374: 811CrossRefGoogle Scholar
  89. 89.
    Jacobson MD, Raff MC (1995) Nature 374: 814CrossRefGoogle Scholar
  90. 90.
    Franek F, Dolnikova J (1991) Febs Letters 248: 285CrossRefGoogle Scholar
  91. 91.
    Franek F, Vomanstek T, Dolnikova J (1992) Cytotechnol 8: 55Google Scholar
  92. 92.
    Solis-Recendez MG, Perani A, D'Habit B, Stacey GN, Maugras M (1995) J Biotechol 38: 117CrossRefGoogle Scholar
  93. 93.
    Mercille S, Massie B (1994) Biotechnol Bioeng 44: 1140CrossRefGoogle Scholar
  94. 94.
    Al-Rubeai M, Singh RP, Goldman MH, Emery AN (1995) Biotechnol Bioeng 45: 463CrossRefGoogle Scholar
  95. 95.
    Franek F (1995) Biotechnol Bioeng 45: 86CrossRefGoogle Scholar
  96. 96.
    Racher AJ, Looby D, Griffiths JB (1990) J Biotechnol 15: 129CrossRefGoogle Scholar
  97. 97.
    Mercille S, Massie B (1994) Cytotechnol 15: 117CrossRefGoogle Scholar
  98. 98.
    Singh RP, Emery AN, Al-Rubeai M (1996) Biotechnol Bioeng 52: 166CrossRefGoogle Scholar
  99. 99.
    Itoh Y, Ueda H, Suzuki E (1995) Biotechnol Bioeng 48: 118CrossRefGoogle Scholar
  100. 100.
    Murray K, Ang C-E, Gull K, Hickman JA, Dickson AJ (1995) In: Abstract, Society for General Microbiology meeting, University of Bath, April 3–6Google Scholar
  101. 101.
    Mercille S, Gervais C, Paquette D, Tardif AB, Martin L, Massie B (1995) In: Cytotechnology 17 (Abstrct, Cell Culture Engineering V meeting, San Diego)Google Scholar
  102. 102.
    Jeurissen SHM, Wagenaar F, Pol JMA, van der Eb AJ, Noteborn MHM (992) J Virol 66: 7383Google Scholar
  103. 103.
    Gougeon M, Montagnier L (1993) Science 260: 1269CrossRefGoogle Scholar
  104. 104.
    Hinshaw VS, Olsen CW, Dybdahl-Sissoko N, Evans D (1994) J Viorol 68: 3667Google Scholar
  105. 105.
    Chem RJ, Fechheimer M, Miller LK (1991) Science 254: 1388CrossRefGoogle Scholar
  106. 106.
    Crook NE, Clem RJ, Miller LK (1993) J Virol 67: 2168Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Mohamed Al-Rubeai
    • 1
  1. 1.Centre for Biochemical Engineering, School of Chemical EngineeringUniversity of BirminghamBirminghamUK

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