Control, modulation, and regulation of cell calcium

  • André B. Borle
Part of the Reviews of Physiology, Biochemistry and Pharmacology book series (volume 90)



extracellular ionized calcium concentration


intracellular (cytosolic) ionized calcium concentration




carbonyl-cyanide, m-chlorophenylhydrazone

Cyclic AMP (GMP)

adenosine (guanosine) 3′-5′-monophosphate

Dibutyryl cyclic AMP

dibutyryl adenosine 3′-5′-monophosphate




ethylenediamine tetraacetic acid


ethyleneglycol-bis-(β-aminoethyl ether)-N,N′-tetraacetic acid


endoplasmic reticulum


carbonyl cyanide,p-trifluoromethoxyphenylhydrazone


femtomoles cm−2s−1


N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid


iodoacetic acid


extracellular sodium concentration


intracellular (cystolic) sodium concentration


picomoles cm−2s−1


smooth endoplasmic reticulum


sacroplasmic reticulum


tris (hydroxymethyl)aminomethane




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  1. Adrian RH (1956) The effect of internal and external potassium concentration on the membrane potential of frog muscle. J Physiol (Lond) 133:631–658Google Scholar
  2. Affolter H, Chiesi M, Dabrowska R, Carafoli E (1976) Calcium regulation in heart cells. The interaction of mitochondrial and sarcoplasmic reticulum with troponin-bound calcium. Eur J Biochem 67:389–396Google Scholar
  3. Aguirre J, Pinto JEB, Trifaro JM (1977) Calcium movements during the release of catecholamines from the adrenal medulla: effects of methoxyverapamil and external cations. J Physiol (Lond) 269:371–394Google Scholar
  4. Agus ZS, Gardner LB, Beck LH, Goldberg M (1973) Effect of parathyroid hormone on renal reabsorption of calcium, sodium and phosphate. Am J Physiol 224:1143–1148Google Scholar
  5. Akerman KEO (1978a) Effect of pH and Ca2+ on the retention of Ca2+ by rat liver mitochondria. Arch Biochem Biophys 189:256–252Google Scholar
  6. Akerman KEO (1978b) Changes in membrane potential during calcium ion influx and efflux across the mitochondrial membrane. Biochim Biophys Acta 502:359–366Google Scholar
  7. Akerman KEO, Wikström MKF (1979) (Ca2+ + Mg2+)-stimulated ATPase activity of rabbit myometrium plasma membrane is blocked by oxytocin. FEBS Lett 97:283–287Google Scholar
  8. Allard C, Mathieu R, deLamirande G, Cantero A (1952) Mitochondrial population in mammalian cells. I. Description of a counting technique and preliminary results in rat liver in different physiological and pathological conditions. Cancer Res 12:407–412Google Scholar
  9. Alonso GL, Bazerque PM, Arrigo DM, Tumilasci OR (1971) Adenosine triphosphate-dependent calcium uptake by rat submaxillary gland microsomes. J Gen Physiol 58:340–350Google Scholar
  10. Andersson R, Nilsson K, Wikberg Y, Johansson S, Momhe-Lundholm E, Lundholm L (1975) Cyclic nucleotides and the contraction of smooth muscle. Adv Cyclic Nucleotide Res 5:491–518Google Scholar
  11. Andia-Waltenbaugh AM, Friedmann N (1978) Hormone sensitive calcium uptake by liver microsomes. Biochem Biophys Res Commun 82:603–608Google Scholar
  12. Andia-Waltenbaugh AM, Kimura S, Wood J, Divakaran P, Friedmann N (1978) Effects of glucagon, insulin and cyclic-AMP on mitochondrial calcium uptake in the liver. Life Sci 23:2437–2444Google Scholar
  13. Anghileri LJ (1972) Phospholipids and calcium uptake in experimental tumors. Oncology 28:35–51Google Scholar
  14. Ash GR, Bygrave FL (1977) Ruthenium red as a probe in assessing the potential of mitochondria to control intracellular calcium in liver. FEBS Lett 78:166–168Google Scholar
  15. Ashley CC, Lea TJ (1978) Calcium fluxes in single muscle fibres measured with a glass scintillation probe. J Physiol (Lond) 282:307–331Google Scholar
  16. Ashley CC, Caldwell PC, Lowe AG (1972) The efflux of calcium from single crab and barnacle muscle fibres. J Physiol (Lond) 223:735–755Google Scholar
  17. Assimacopoulos-Jeannet FD, Blackmore PF, Exton JH (1977) Studies on α-adrenergic activation of hepatic glucose output. (Studies on role of Ca++). J Biol Chem 252:2662–2669Google Scholar
  18. Au KS (1979) Observation on the protein activator of erythrocyte membrane (Ca2+-Mg2+) ATPase. Int J Biochem 10:637–643Google Scholar
  19. Aull F (1967) Measurement of the electrical potential difference across the membrane of the Ehrlich mouse ascites cell. J Cell Physiol 69:21–32Google Scholar
  20. Azzone GF, Pozzan T, Massari S, Bragadin M, Dell'Antone P (1977) H+ site ratio and steady state distribution of divalent cations in mitochondria. FEBS Lett 78:21–24Google Scholar
  21. Babcock DF, Chen J-L J, Yip BP, Lardy HA (1979) Evidence for mitochondrial localization of the hormone-responsive pool of Ca++ in isolated hepatocytes. J Biol Chem 254:8117–8120Google Scholar
  22. Badyshtov BA, Seredenin SB (1977) Investigation of the mechanism of action of ouabain and cyclic AMP of the transport of calcium ions by rat heart mitochondria. Bull Exp Biol Med Engl Transl 83:155–158Google Scholar
  23. Baker PF (1972) Transport and metabolism of calcium ions in nerve. Prog Biophys Mol Biol 24:177–223Google Scholar
  24. Baker PF (1976) Regulation of intracellular Ca and Mg in squid axons. Fed Proc 35:2589–2595Google Scholar
  25. Baker PF (1978) The regulation of intracellular calcium in giant axons of Loligo and myxicola. Ann NY Acad Sci 307:250–268Google Scholar
  26. Baker PF, Blaustein MP (1968) Sodium dependent uptake of calcium by crab nerve. Biochim Biophys Acta 150:167–170Google Scholar
  27. Baker PF, Glitsch HG (1973) Does metabolic energy participate directly in the Na+ dependent extension of Ca+2 ions from squid giant axons. J Physiol (Lond) 233:44P–46PGoogle Scholar
  28. Baker PF, Glitsch HG (1975) Voltage-dependent changes in the permeability of nerve membranes to calcium and other divalent ions. Philos Trans R Soc Lond (Biol) 270:389–409Google Scholar
  29. Baker PF, Honerjager P (1978) Influence of carbon dioxide on the level of ionized calcium in squid axon. Nature 273:160–161Google Scholar
  30. Baker PF, McNaughton PA (1976a) Kinetics and energetics of calcium efflux from intact squid giant axons. J Physiol (Lond) 259:103–144Google Scholar
  31. Baker PF, McNaughton PA (1976b) The effect of membrane potential on the calcium transport systems in squid axons. J Physiol (Lond) 260:24–25PGoogle Scholar
  32. Baker PF, McNaughton PA (1977) Selective inhibition of the Ca-dependent Na efflux from intact squid axons by a fall in intracellular pH. J Physiol (Lond) 269:78–79PGoogle Scholar
  33. Baker PF, McNaughton PA (1978) The influence of extracellular calcium binding on the calcium efflux from squid axons. J Physiol (Lond) 276:127–150Google Scholar
  34. Baker PF, Schlaepfer W (1975) Calcium uptake by axoplasm extracted from giant axons of Loligo. J Physiol (Lond) 249)37P–38PGoogle Scholar
  35. Baker PF, Blaustein MP, Hodgkin AL, Steinhardt RA (1969) The influence of calcium on sodium efflux in squid axon. J Physiol (Lond) 200:431–458Google Scholar
  36. Baker PF, Hodgkin AL, Ridgway EB (1971) Depolarization and calcium entry in squid giant axons. J Physiol (Lond) 218:709–755Google Scholar
  37. Barnard T, Afzelius BA (1972) The matrix granules of mitochondria: a review. Subcell Biochem 1:375–389Google Scholar
  38. Barritt GJ, Thorn RFW, Hughes BP (1978) Effects of hormones and N6O27-dibutyrul-adenosine 3′5′-cyclic monophosphate, administered in vivo, on phosphate transport and metabolism in isolated rat liver mitochondria. Biochem J 172:577–585Google Scholar
  39. Baski SN, Kenny AD (1978) Vitamin D metabolism in Japanese quail: gonadal hormones and dietary calcium. Am J Physiol 234:E622–E628Google Scholar
  40. Batra SC (1973a) The role of mitochondrial calcium uptake in contraction and relaxation of the human myometrium. Biochim Biophys Acta 305:428–432Google Scholar
  41. Batra SC (1973b) Effect of some estrogens and progesterone on calcium uptake and calcium release by myometrial mitochondria. Biochem Pharmacol 22:803–809Google Scholar
  42. Batra SC (1974) The effects of drugs on calcium uptake and calcium release by mitochondria and sarcoplasmic reticulum of frog skeletal muscle. Biochem Pharmacol 23:89–101Google Scholar
  43. Batra SC, Bengtsson B (1978) Effects of diethylstilboestrol and ovarian steroids on the contractile responses and calcium movements in rat uterine smooth muscle. J Physiol (Lond) 276:329–342Google Scholar
  44. Batra SC, Daniel EE (1971) ATP-dependent Ca uptake by subcellular fractions of uterine smooth muscle. Comp Biochem Physiol 38A:369–385Google Scholar
  45. Baumrucker CR, Keenan TW (1975) Membranes of mammary glands. X. Adenosine triphosphate dependent calcium accumulation by Golgi apparatus rich fraction from bovine mammary gland. Exp Cell Res 90:253–260Google Scholar
  46. Bayer R, Kalusche D, Kaufman R, Mannhold R (1975) Inotropic and electrophysiological actions of verapamil and D-600 in mammalian myocardium. III. Effects of optical isomers on transmembrane action potentials. Arch Pharmacol 290:81–97Google Scholar
  47. Beckmann A, Jenssen HL, Kalkoff W, Redman K (1970) Das bioelektrische Potential an der zytoplasmatischen Membran der Granulozyten. Experientia 26:186–187Google Scholar
  48. Beigelman DM, Hollander PB (1962) Effect of insulin upon resting electrical potential of adipose tissue. Proc. Soc Exp Biol Med 110:590–595Google Scholar
  49. Bennett HS (1963) Morphological aspects of extracellular polysaccharides. J Histochem Cytochem 11:14–23Google Scholar
  50. Bent-Hansen L, Capito K, Hedeskov CJ (1979) The effect of calcium on somatostatin inhibition of insulin release and cyclic AMP production in mouse pancreatic islets. Biochim Biophys Acta 585:240–249Google Scholar
  51. Bernhardt J, Pauly H (1967) Das Membranpotential von Ehrlich-Aszitestumorzellen. Biophysik 4:101–108Google Scholar
  52. Berridge MJ (1975) The interaction of cyclic nucleotides and calcium in the control of cellular activity. Adv. Cyclic Nucleotide Res 6:1–98Google Scholar
  53. Berridge MJ (1979) Relationship between calcium and the cyclic nucleotides in ion secretion. In: Binder HJ (ed) Mechanisms of intestinal secretion. Alan R Liss, New York, pp 65–82Google Scholar
  54. Berridge MJ, Fain JN (1979) Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine. Biochem J 178:59–69Google Scholar
  55. Berridge MJ, Oschman JC, Wall BJ (1975) Intracellular calcium reservoirs in Calliphora salivary glands. In: Carafoli E, Clementi F, Drabikowski W, Magreth A (eds) Calcium transport in contraction and secretion. North Holland, Amsterdam, pp 131–138Google Scholar
  56. Besley GTN, Snart RN (1971) Effect of vasopressin on the uptake of calcium ions by kidney mitochondria and on the concentration of adenosine 3′–5 cyclic monophosphate in toad bladder. J Physiol (Lond) 125:60P–61PGoogle Scholar
  57. Bhalla RC, Webb RC, Sing D, Brock T (1978) Role of cyclic AMP in rat aortic microsomal phosphorylation and calcium uptake. Am J Physiol 234:H508–H514Google Scholar
  58. Bianchi CP (1968) Cell calcium. Butterworth, LondonGoogle Scholar
  59. Bianchi CP, Lakshminarayanaiah N (1978) Calcium uptake and exchange in leg nerves of the crab Libinia emarginata. J Neurochem 30:27–33Google Scholar
  60. Bianchi CP, Shanes AM (1959) Calcium influx in skeletal muscle at rest, during activity and during potassium contracture. J Gen Physiol 42:803–815Google Scholar
  61. Biddulph DM, Currie MG, Wrenn RW (1979) Effects and interactions of parathyroid hormone and prostaglandins on adenosine 3′5′ monophosphate concentrations in isolated renal tubules. Endocrinology 104:1164–1171Google Scholar
  62. Biddulph DM, Wrenn RW (1977a) Effect of parathyroid hormone on cyclic AMP, cyclic GMP and efflux of calcium in isolated renal tubules. J Cyclic Nucleotide Res 3:129–138Google Scholar
  63. Biddulph DM, Wrenn RW (1977b) Morphology and hormonal responsiveness of renal cortical tubules in vitro. Am J Anat 150:539–558Google Scholar
  64. Biedermann N (1968) Das Verhalten der Membranpotentiale von Leberzellen der Ratte während und nach Gefäßunterbindungen. Acta Biol Med Germ 21:827–833Google Scholar
  65. Binderman I, Duskin D, Harell A, Sachs L, Katchalski E (1974) Formation of bone tissue in culture from isolated bone cells. J Cell Biol 61:427–439Google Scholar
  66. Blackmore PF, Brumley FT, Marks JL, Exton JH (1978) Studies on α-adrenergic activation of hepatic glucose output. Relationship between α-adrenergic stimulation of calcium efflux and activation of phosphorylase in isolated rat liver parenchymal cells. J Biol Chem 253:4851–4858Google Scholar
  67. Blackmore PF, Assimacopoulos-Jeannet FD, Chan TM, Exton JH (1979a) Studies on α-adrenergic activation of hepatic glucose output. Insulin inhibition of α-adrenergic and glucagon actions in normal and calcium-depleted hepatocytes. J Biol Chem 254:2828–2834Google Scholar
  68. Blackmore PF, Dehaye JP, Exton JH (1979b) Studies on α-adrenergic activation of hepatic glucose output. The role of mitochondrial calcium release in α-adrenergic activation of phosphorylase in perfused rat liver. J Biol Chem 254:6945–6950Google Scholar
  69. Blackmore PF, El-Refai MF, Exton JH (1979c) Alpha-adrenergic blockage and inhibiton of A23187 mediated Ca2+ uptake by the calcium antagonist verpamil in rat liver cells. Mol Pharmacol 15:598–606Google Scholar
  70. Blaustein MP (1974) The interrelationship between sodium and calcium fluxes across cell membranes. Rev Physiol Biochem Pharmacol 70:33–82Google Scholar
  71. Blaustein MP (1975) Effects of potassium veratridine and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro. J Physiol (Lond) 247:617–655Google Scholar
  72. Blaustein MP (1976) The ins and outs of calcium transport in squid axons: internal and external ion activation of calcium efflux. Fed Proc 35:2574–2578Google Scholar
  73. Blaustein MP (1977a) Effects of internal and external cations and of ATP on sodium-calcium and calcium-calcium exchange in squid axons. Biophys J 20:79–111Google Scholar
  74. Blaustein MP (1977b) Sodium ions, calcium ions, blood pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol 232:C165–C173Google Scholar
  75. Blaustein MP, Ector AC (1975) Barbiturate inhibition of calcium uptake by depolarized nerve terminals in vitro. Mol Pharmacol 11:369–378Google Scholar
  76. Blaustein MP, Ector AC (1976) Carrier-mediated sodium dependent and calcium dependent calcium efflux from pinched-off presynaptic nerve terminals (synaptosomes) in vitro. Biochim Biophys Acta 419:295–308Google Scholar
  77. Blaustein MP, Hodgkin AL (1969) The effect of cyanide on the efflux of calcium from squid axons. J Physiol (Lond) 200:497–527Google Scholar
  78. Blaustein MP, Oborn CJ (1975) The influence of sodium on calcium fluxes in pinched-off nerve terminals in vitro. J Physiol (Lond) 247:657–686Google Scholar
  79. Blaustein MP, Russell JM (1975) Sodium-calcium exchange and calcium-calcium exchange in internally dialyzed squid giant axons. J Membr Biol 22:285–312Google Scholar
  80. Blaustein MP, Wiesmann WP (1970) Effect of sodium ions on calcium movements in isolated synaptic terminals. Proc Natl. Acad Sci USA 66:664–671Google Scholar
  81. Blaustein MP, Johnson EM, Needleman P (1972) Calcium-dependent norepinephrine release from presynaptic nerve endings in vitro. Proc Natl Acad Sci USA 69:2237–2240Google Scholar
  82. Blaustein MP, Russell JM, DeWeer P (1974) Calcium efflux from internally dialyzed squid axons: the influence of external and internal cations. J Supramol Struct 2:558–581Google Scholar
  83. Blaustein MP, Kendrick NC, Fried RC, Ratzlaff RW (1977) Calcium metabolism of the mammalian presynaptic nerve terminal: lessons from the synaptosome. In: Cowan WM, Ferrendelli JA (eds) Approaches to the cell biology of neurones. Society for Neuroscience Symposia, Society for Neuroscience, Bethesda, pp 172–194Google Scholar
  84. Blaustein MP, Ratzlaff RW, Kendrick NC, Schweitzer ES (1978a) Calcium buffering in presynaptic nerve terminals. I. Evidence for involvement of a nonmitochondrial ATP-dependent sequestration mechanism. J Gen Physiol 72:15–41Google Scholar
  85. Blaustein MP, Ratzlaff RW, Schweitzer ES (1978b) Calcium buffering in presynaptic nerve terminals. II. Kinetic properties of the nonmitochondrial Ca sequestration mechanism. J Gen Physiol 72:43–66Google Scholar
  86. Blaustein MP, Ratzlaff RW, Kendrick NK (1978c) The regulation of intracellular calcium in presynaptic nerve terminals. Ann NY Acad Sci 307:195–211Google Scholar
  87. Blinks JK (1978) Measurement of calcium ion concentration with phosphoproteins. Ann NY Acad Sci 307:71–85Google Scholar
  88. Blinks JR, Pendergast FG, Allen DG (1976) Phosphoproteins on biological calcium indicators. Pharmacol Rev 28:1–93Google Scholar
  89. Blitz AL, Fine RE, Toselli PA (1977) Evidence that coated vesicles isolated from brain are calcium-sequestering organelles resembling sarcoplasmic reticulum. J Cell Biol 75:135–147Google Scholar
  90. Bond GH, Clough DL (1973) A soluble protein activator of (Mg2++Ca2+)-dependent ATPase in human red cell membranes. Biochim Biophys Acta 323:592–599Google Scholar
  91. Bond GH, Green JW (1971) Effects of monovalent cations on the (Mg2++Ca2+)-dependent ATPase of the red cell membrane. Biochim Biophys Acta 241:393–398Google Scholar
  92. Bonucci E, Derenzini M, Marinozzi V (1973) The organic-inorganic relationship in calcified mitochondria. J Cell Biol 59:185–211Google Scholar
  93. Borg J, Mark J, Mandel P (1979) Effects of amino acids on calcium uptake by glial and neuroblastoma cells. J Neurobiol 10:31–40Google Scholar
  94. Borle AB (1968a) Calcium metabolism in HeLa cells and the effects of parathyroid hormone. J Cell Biol 36:567–582Google Scholar
  95. Borle AB (1968b) Effects of purified parathyroid hormone on the calcium metabolism of monkey kidney cells. Endocrinology 83:1316–1322Google Scholar
  96. Borle AB (1968c) Calcium transport in cell culture and the effects of parathyroid hormone. In: Talmage RV, Belanger LF, Clark I (eds) Parathyroid hormone and thyrocalcitonin (calcitonin). Excerpta Medica, New York, pp 258–272Google Scholar
  97. Borle AB (1969a) Kinetic analyses of calcium movements in HeLa cell cultures. I. Calcium influx. J Gen Physiol 53:43–56Google Scholar
  98. Borle AB (1969b) Kinetic analyses of calcium movements in HeLa cell cultures. II. Calcium efflux. J Gen Physiol 53:57–69Google Scholar
  99. Borle AB (1969c) Effects of thyrocalcitonin on calcium transport in kidney cells. Endocrinology 85:194–199Google Scholar
  100. Borle AB (1970a) Kinetic analyses of calcium movements in cell cultures. III. Effect of calcium and parathyroid hormone in kidney cells. J Gen Physiol 55:163–186Google Scholar
  101. Borle AB (1970b) Kinetic analyses of calcium movements in cell cultures. IV. Effects of phosphate and parathyroid hormone in kidney cells. Endocrinology 86:1389–1393Google Scholar
  102. Borle AB (1971a) Effets du phosphate sur les mouvements du calcium en cultures cellulaires. In: Hioco DJ (ed) Phosphate et metabolisme phosphocalcique. Expansion Scientifique, Paris, pp 29–43Google Scholar
  103. Borle AB (1971b) Calcium transport in kidney cells and its regulation. In: Nichols G Jr, Wasserman RH (eds) Cellular mechanisms for calcium transfer and homeostasis. Academic Press, New York, pp 151–174Google Scholar
  104. Borle AB (1972a) Kinetic analyses of calcium movements in cell cultures. V. Intracellular calcium distribution in kidney cells. J Membr Biol 10:45–66Google Scholar
  105. Borle AB (1972b) Parathyroid hormone and cell calcium. In: Talmage RV, Munson PL (eds) Calcium, parathyroid hormone and the calcitonins. Excerpta Medica, Amsterdam, pp 484–491Google Scholar
  106. Borle AB (1973a) Calcium metabolism at the cellular level. Fed Proc 32:1944–1950Google Scholar
  107. Borle AB (1973b) Cyclic AMP regulation of calcium efflux from liver, kidney and heart mitochondria. J Int Res Commun 1:9Google Scholar
  108. Borle AB (1974a) Kinetic studies of calcium movements in intestinal cells: effect of vitamin D deficiency and treatment. J. Membr Biol 16:207–220Google Scholar
  109. Borle AB (1974b) Cyclic AMP stimulation of calcium efflux from kidney, liver and heart mitochondria. J Membr Biol 16:221–236Google Scholar
  110. Borle AB (1975a) Regulation of cellular calcium metabolism and calcium transport by calcitonin. J Membr Biol 21:125–146Google Scholar
  111. Borle AB (1975b) Methods for assessing hormone effects on calcium fluxes in vitro. In: Hardman JG, O'Malley BW (eds) Methods in enzymology, hormone action. Part D: Isolated cells, tissues and organ systems. Academic Press, New York, v 39, pp 513–573Google Scholar
  112. Borle AB (1975c) Regulation of the mitochondrial control of cellular calcium homeostasis and calcium transport by phosphate, parathyroid hormone, calcitononin, vitamin D and cyclic AMP. In: Talmage RV, Owen M, Parsons JA (eds) Calcium regulating hormones. Excerpta Media, Amsterdam, pp 217–228Google Scholar
  113. Borle AB (1975d) Modulation of mitochondrial control of cytoplasmic and calcium activity. In: Carafoli E, Clementi F, Drabikowski W, Magreth A (eds) Calcium transport in contraction and secretion. North Holland, New York, p 77Google Scholar
  114. Borle AB (1976) On the problem of the release of mitochondrial calcium by cyclic AMP. J Membr Biol 29:205–208Google Scholar
  115. Borle AB (1978) On the difficulty of assessing the role of extracellular calcium in cell function. Ann NY Acad Sci 307:431–432Google Scholar
  116. Borle AB (1979) Na-Ca exchange and renal cell Ca homeostasis. Fed Proc 38:1392Google Scholar
  117. Borle AB (1981) Pittfalls of the 45Ca method. Cell Calcium (in press)Google Scholar
  118. Borle AB, Anderson JH (1976) A cybernetic view of cell calcium metabolism. In: Duncan CJ (ed) Calcium in biological systems. Soc Exp Biol Symp, pp 141–160Google Scholar
  119. Borle AB, Briggs FN (1968) Microdetermination of calcium in biological material by automatic fluorometric titration. Anal Chem 40:339–344Google Scholar
  120. Borle AB, Clark I (1981) Effects of phosphate induced hyperparathyroidism and parathyroidectomy on rat kidney calcium in vivo. Am J Physiol (in press)Google Scholar
  121. Borle AB, Loveday J (1968) Effects of temperature, potassium and calcium on the electrical potential difference in HeLa cells. Cancer Res 28:2401–2405Google Scholar
  122. Borle AB, Studer R (1978) Effects of calcium ionophores on the transport and distribution of calcium in isolated cells and in liver and kidney slices. J Membr Biol 38:51–72Google Scholar
  123. Borle AB, Uchikawa T (1978) Effects of parathyroid hormone on the distribution and transport of calcium in cultured kidney cells. Endocrinology 102:1725–1732Google Scholar
  124. Borle AB, Uchikawa T (1979) Effects of adenosine 3′,5′-monophosphate dibutyryl adenosine 3′,5′-monophosphate, aminophylline and imidazole on renal cellular calcium metabolism. Endocrinology 104:122–129Google Scholar
  125. Bornet EP, Entman ML, Van Winkle WB, Schwartz A, Lehotay DC, Levey, GS (1977) Cyclic AMP modulation of calcium accumulation by sarcoplasmic reticulum from fast skeletal musle. Biochim Biophys Acta 468:188–193Google Scholar
  126. Brachet J (1978) The hormonal induction of maturation in amphibian oocytes. Med Biol 56:304–309Google Scholar
  127. Brading AF (1973) Ion distribution and ion movements in smooth muscle. Philos Trans R Soc Lond (Biol) 265:35–46Google Scholar
  128. Brand MD, Chen CH, Lehninger AL (1976) Stoichiometry of the ejection during respiration-dependent accumulation of Ca2+ by rat liver mitochondria. J Biol Chem 251:968–974Google Scholar
  129. Brandt PW (1962) A consideration of the extraneous coats of the plasma membrane. Circulation 26:1075–1091Google Scholar
  130. Brehm P, Eckert R (1978) Calcium entry leads to inactivation of calcium channel in paramecium. Science 202:1203–1206Google Scholar
  131. Brierly GP, Murer E, Bachmann E (1964) Studies on ion transport. III. The accumulation of calcium and inorganic phosphate by heart mitochondria. Arch Biochem Biophys 105:89–102Google Scholar
  132. Brink F (1954) The role of calcium ions in neural processes. Pharmacol Rev 6:243–298Google Scholar
  133. Brinley FJ Jr (1968) Sodium and potassium fluxes in isolated barnacle muscle fibers. J Gen Physiol 51:445–477Google Scholar
  134. Brinley FJ Jr (1976) Calcium and magnesium metabolism in cephalopod axons. Fed Proc 35:2572–2595Google Scholar
  135. Brinley FJ Jr (1978) Calcium buffering in squid axons. Ann Rev. Biophys Bioeng 7:363–392Google Scholar
  136. Brinley FJ Jr, Mullins LJ (1967) Sodium extrusion by internally dialyzed squid axons. J Gen Physiol 50:2303–2331Google Scholar
  137. Brinley FJ Jr, Mullins LJ (1974) Effects of membrane potential on sodium and potassium fluxes in squid axons. Ann NY Acad Sci 242:406–433Google Scholar
  138. Brinley FJ Jr, Scarpa A (1975) Ionized magnesium concentration in axoplasm of dialyzed squid axons. FEBS Lett 50:82–85Google Scholar
  139. Brinley FJ Jr, Spangler SG, Mullins LJ (1975) Calcium and EDTA fluxes in dialyzed squid axons. J Gen Physiol 66:223–250Google Scholar
  140. Brinley FJ Jr, Tiffert T, Scarpa A (1978) Mitochondria and other calcium buffers of squid axon studied in situ. J Gen Physiol 72:101–127Google Scholar
  141. Brinley FJ Jr, Tiffert T, Scarpa A, Mullins LJ (1977) Intracellular buffering capacity in isolated squid axons. J Gen Physiol 70:355–384Google Scholar
  142. Brisson GR, Malaisse WJ (1973) The stimulus-secretion coupling of glucose induced insulin release. XI. Effects of theophylline and epinephrine on 45Ca efflux from perfused islets. Metabolism 22:455–465Google Scholar
  143. Brisson GR, Malaisse-Lagae F, Malaisse WJ (1972) The stimulus secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine 3′,5′-cyclic monophosphate. J Clin Invest 51:232–241Google Scholar
  144. Brömme HJ, Dargel R (1979) Effect of in vivo and in vitro application of glucagon, insulin and epinephrine on Ca++-transport properties of liver mitochondria. Acta Biologica et Medica Germanica 38:1365–1977Google Scholar
  145. Brown HF, McNaughton PA, Noble D, Noble SJ (1975) Adrenergic control of pacemaker currents. Philos Trans R Soc Lond (Biol) 270:527–537Google Scholar
  146. Bruns DE, McDonald JM, Jarett L (1976) Energy-dependent calcium transport in endoplasmic reticulum of adipocytes. J Biol Chem 251:7191–7197Google Scholar
  147. Burgos MH (1960) The role of amorphous cellular coatings in active transport. Anat Rec 137:171Google Scholar
  148. Burnatowska MA, Harris CA, Sutton RAL, Dirks JH (1977) Effect of PTH and cAMP on renal handling of calcium, magnesium and phosphate in the hamster. Am J Physiol 233:F514–F518Google Scholar
  149. Burton J, Godfraind T (1974) Sodium-calcium sites in smooth muscle and their accessibility to lanthanum. J Physiol (Lond) 241:287–298Google Scholar
  150. Busselen P, Carmeliet E (1973) Protagonistic effects of Na and Ca on tension development in cardiac muscle at low extracellular Na concentrations. Nature New Biol 243:57–59Google Scholar
  151. Butlen D, Jard S (1972) Renal handling of 3′,5′-cyclic AMP in the rat. Pfluegers Arch 331:172–190Google Scholar
  152. Bygrave FL (1967) The ionic environment and metabolic control. Nature 214:667–671Google Scholar
  153. Bygrave FL (1976) Mitochondrial calcium transport and the regulation of metabolism by calcium in tumor cells. In: Criss WE, Ono T, Sabine JR (eds) Control mechanisms in cancer. Raven Press, New York, pp 411–423Google Scholar
  154. Bygrave FL (1977) Mitochondrial calcium transport. Curr Top Bioenergetics 6:259–318Google Scholar
  155. Bygrave FL (1978) Mitochondria and the control of intracellular calcium. Biol Rev 53:43–79Google Scholar
  156. Bygrave FL, Ramachandran C, Smith RL (1977) On the mechanism by which inorganic phosphate stimulates mitochondrial calcium transport. FEBS Lett 83:155–158Google Scholar
  157. Bygrave FL, Reed KC, Spencer T (1971a) Cooperative interactions in energy-dependent accumulation of Ca2+ by isolated rat liver mitochondria. Nature New Biol 230:89Google Scholar
  158. Bygrave FL, Reed KC, Spencer T (1971b) Sigmoidal kinetics associated with Ca2+ uptake and related ATPase in rat liver mitochondria. In: Quagliariello E, Papa S, Rossi CS (eds) Energy transduction in respiration and photosynthesis. Adriatica Editrice, Bari, pp 981–988Google Scholar
  159. Bygrave FL, Trauter CJ (1978) The subcellular location, maturation and response to increased plasma glucagon of ruthenium red-insensitive calcium-ion transport in rat liver. Biochem J 174:1021–1030Google Scholar
  160. Caldwell PC (1971) Calcium movement in muscle. In: Podolsky RJ (ed) Contractility of muscle cells and related processes. Prentice Hall, Englewood Cliff, pp 105–114Google Scholar
  161. Calixto JB, Aucélio JG, Turkiewicz A (1979) Relationship between modulation by estradiol, progesterone and calcium upon the pharmacological reactivity of uteri of dogs. Res Commun Chem Pathol Pharmacol 25:447–460Google Scholar
  162. Caputo C, Bolanos P (1978) Effect of external sodium and calcium on calcium efflux in frog striated muscle. J Membr Biol 41:1–14Google Scholar
  163. Caputo CB, Meadows D, Raisz LG (1976) Failure of estrogens and androgens to inhibit bone resorption in tissue culture. Endocrinology 98:1065–1068Google Scholar
  164. Carafoli E (1967) In vivo effect of uncoupling agents on the incorporation of calcium and strontium into mitochondria and other subcellular fractions of rat liver. J Gen Physiol 50:1849–1864Google Scholar
  165. Carafoli E (1976) Mitochondrial calcium transport and calcium binding proteins. In: Packer L, Gomez-Puyou A (eds) Mitochondria, bioenergetics, biogenesis and membrane structure. Academic Press, New York, pp 47–60Google Scholar
  166. Carafoli E, Azzi A (1972) The affinity of mitochondria for calcium. Experientia 27:906–908Google Scholar
  167. Carafoli E, Crompton M (1976) Calcium ions and mitochondria. Soc Exp Biol Symp 30:89–115Google Scholar
  168. Carafoli E, Crompton M (1978a) The regulation of intracellular calcium by mitochondria. Ann NY Acad Sci 307:269–284Google Scholar
  169. Carafoli E, Crompton M (1978b) The regulation of intracellular calcium. Curr Top Membr Transp 10:151–216Google Scholar
  170. Carafoli E, Crompton M, Malmström K, Siegel E, Salzmann M, Chiesi M, Affolter H (1977) Mitochondrial calcium transport and the intracellular calcium homeostasis. In: Semenza G, Carafoli E (eds) Biochemistry of membrane transport. FEBS Symposium No. 42, Springer, Berlin Heidelberg New York, pp 535–551Google Scholar
  171. Carafoli E, Crovetti F (1973) Interactions between prostaglandin E1 and calcium at the level of the mitochondrial membrane. Arch Biochem Biophys 154:40–46Google Scholar
  172. Carafoli E, Gamble RL, Rossi CS, Lehninger AL (1967) Super-stoichiometric ratios between ion movements and electron transport in rat liver mitochondria. J Biol Chem 242:1199–1204Google Scholar
  173. Carafoli E, Lehninger AL (1971) A survey of the interaction of calcium ions with mitochondria from different tissues and species. Biochem J 122:681–690Google Scholar
  174. Carafoli E, Malmström K, Sigel E, Crompton M (1976) The regulation of intracellular calcium. Clin Endocrinology 5:Suppl 49s–59sGoogle Scholar
  175. Carafoli E, Patriarca P, Rossi CS (1961) A comparative study of the role of mitochondria and the sarcoplasmic reticulum in the uptake and release of Ca++ by the rat diaphragm. J Cell Physiol 74:17–30Google Scholar
  176. Carafoli E, Schwarzmann K, Roos I, Crompton M (1978) Protein in mitochondrial calcium transport. In: Blauer G, Sund H (eds) Transport by proteins. de Gruyter, Berlin, pp 171–186Google Scholar
  177. Carafoli E, Tiozzo R (1967) Time course of the distribution of in vivo administered 89Sr in rat liver subcellular fraction. Experientia 23:1017–1020Google Scholar
  178. Carafoli E, Tiozzo R, Lugli G, Crovetti F, Kratzing C (1974) The release of calcium from heart mitochondria by sodium. J Mol Cell Cardiol 6:361–371Google Scholar
  179. Carafoli E, Tiozzo R, Rossi CS, Lugli G (1972) Mitochondrial Ca2+ uptake and heart relaxation. In: Bolis L, Keynes RD, Wilbrandt W (eds) Role of membranes in secretory processes. North Holland, Amsterdam, pp 175–181Google Scholar
  180. Caroni P, Schwerzmann K, Carafoli E (1978) Separate pathways for Ca2+ uptake and release in liver mitochondria. FEBS Lett 96:339–342Google Scholar
  181. Carré M, Ayigbedé O, Miravet L, Rasmussen H (1974) The effect of prednisolone upon the metabolism and action of 25-hydroxy-and 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 71:2996–3000Google Scholar
  182. Carsten GE (1979) Calcium accumulation by human uterine microsomal preparations — effects of progesterone and oxytocin. Am J Obstet Gynecol 133:598–601Google Scholar
  183. Carvalho AP, Leo B (1967) Effects of ATP on the interaction of Ca++, Mg++ and K+ with fragmented sarcoplasmic reticulum isolated from rabbit skeletal muscle. J Gen Physiol 50:1327–1352Google Scholar
  184. Carvalho AP, Sanui H, Pace N (1963) Calcium and magnesium binding properties of cell membrane materials. J Cell Physiol 62:311–317Google Scholar
  185. Case RM, Clausen T (1973) The relationship between calcium exchange and enzyme secretion in the isolated rat pancreas. J Physiol (Lond) 235:75–102Google Scholar
  186. Casteels R, Goffin J, Raeymaekers L, Wuytack F (1973) Calcium pumping in smooth muscle cells of Taenia coli. J Physiol (Lond) 231:19PGoogle Scholar
  187. Casteels R, Kuriyama H (1965) Membrane potential and ionic current in pregnant and nonpregnant rat myometrium. J Physiol (Lond) 177:263–287Google Scholar
  188. Caulfield JB, Schrag PE (1964) Electron microscopic study of renal calcification. Am J Pathol 44:365–381Google Scholar
  189. Cha YN, Shin BC, Lee KS (1971) Active uptake of Ca++ and Ca++-activated Mg++ ATPase in red cell membrane fragments. J Gen Physiol 57:202–215Google Scholar
  190. Chabardès DM, Imbert M, Clique A, Montégut M, Morel F (1975) PTH sensitive adenyl cyclase activity in different segments of the rabbit nephron. Pfluegers Arch 354:229–239Google Scholar
  191. Chambaut AM, Leray-Pecker F, Feldmann G, Hanoune J (1974) Calcium binding properties and ATPase activities of rat plasma membranes. J Gen Physiol 64:104–126Google Scholar
  192. Chambers R (1940) The relation of the extraneous coats to the organization and permeability of cell membranes. Cold Spring Harbor Symp Quant Biol 8:144–153Google Scholar
  193. Chan TM, Blackmore PF, Steiner KE, Exton JH (1979) Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Reciprocal change in α-and β-adrenergic activation of hepatic glycogen phosphorylase and calcium mobilization in adrenalectomized rats. J Biol Chem 254(7):2428–2433Google Scholar
  194. Chance B (1965) The energy-linked reaction of calcium with mitochondria. J Biol Chem 240:2729–2748Google Scholar
  195. Chandler DE, Williams JA (1979) Pancreatic acinar cells: effects of lanthanum ions on amylase release and calcium ion fluxes. J Physiol (Lond) 243:831–846Google Scholar
  196. Charlton RR, Wenner CE (1978) Calcium ion transport by intact Ehrlich ascites tumor cells. Role of respiratory substrates, Pi and temperature. Biochem J 170:537–544Google Scholar
  197. Chase LR, Aurbach GD (1970) The effect of parathyroid hormone on the concentration of adenosine 3′,5′-monophosphate in skeletal tissue in vitro. J Biol Chem 245:1520–1526Google Scholar
  198. Chase LR, Fedak SA, Aurbach GD (1969) Activation of skeletal adenyl cyclase by parathyroid hormone in vitro. Endocrinology 84:761–768Google Scholar
  199. Chausmer AB, Sehrman BS, Wallach S (1972) The effect of parathyroid hormone on hepatic cell transport of calcium. Endocrinology 90:663–672Google Scholar
  200. Chen JLJ, Babcock DF, Lardy HA (1978) Norepinephrine, vasopressin, glucagon and A23187 induce efflux of caclium from an exchangeable pool in isolated rat hepatocytes. Proc Natl Acad Sci USA 75:2234–2238Google Scholar
  201. Cheng SC, Chen SS (1976) Stimulation by cyclic nucleotides of calcium efflux in barnacle muscle fibers. Life Sci 16:1711Google Scholar
  202. Christoffersen GRJ, Simonsen L (1972) Ca2+ sensitive microelectrode — intracellular steady state measurement in nerve cell. Acta Physiol Scand 101:492–494Google Scholar
  203. Christophe JP, Frandsen EK, Conlon TP, Krishna G, Gardner JD (1976) Action of cholecystokinin, cholinergic agents, and A-23187 on accumulation of guanosine 3′-5′-monophosphate in dispersed guinea pig pancreatic acinar cells. J Biol Chem 251:4640–4645Google Scholar
  204. Chudapongse P (1976) Further studies on the effect of phosphoenol pyruvate on respiration dependent calcium transport by rat heart mitochondria. Biochim Biophys Acta 423:196–202Google Scholar
  205. Chudapongse P, Haugaard N (1973) The effect of phosphoenol pyruvate on calcium transport by mitochondria. Biochim Biophys Acta 307:599–606Google Scholar
  206. Cittadini A, Bossi D, Rosi G, Wolf F, Terranova T (1977) Calcium metabolism in Ehrlich ascites tumour cells. Biochim Biophys Acta 469:345–349Google Scholar
  207. Cittadini A, Scarpa A, Chance B (1971) Kinetic evidence for Ca2+ uptake by intact Ehrlich ascites tumor cells. FEBS Lett 18:98–102Google Scholar
  208. Cittadini A, Scarpa A, Chance B (1973) Calcium transport in intact Ehrlich ascites tumor cells. Biochim Biophys Acta 291:246–259Google Scholar
  209. Cittadini A, Van Rossum GDV (1978) Properties of the calcium-extruding mechanism of liver cells. J Physiol (Lond) 281:29–43Google Scholar
  210. Claret-Berthon B, Claret M, Mazet JL (1977) Fluxes and distribution of calcium in rat liver cells: kinetic analysis and identification of pools. J Physiol (Lond) 272:529–552Google Scholar
  211. Clausen T (1977) Calcium, glucose transport and insulin action. In: Semenza G, Carafoli E (eds) Biochemistry of membrane transport. Springer, Berlin Heidelberg New York, pp 481–499Google Scholar
  212. Clausen T, Martin BR (1977) The effect of insulin on the washout of [4 5Ca] calcium from the adipocytes and soleus muscle of the rat. Biochem J 164:251–255Google Scholar
  213. Clemente F, Meldolesi J (1975) Calcium and pancreatic secretonin — dynamics of subcellular pools in resting and stimulated acinar cells. Br J Pharmacol 55:369–379Google Scholar
  214. Cohen JJ, Barac-Nieto M (1973) Renal metabolism of substrates in relation to renal function. In: Orloff J, Berliner RW, Geiger SR (eds) Renal physiology. American Physiological Society, Washington (Handbook of physiology, Sec 8, pp 909–1001)Google Scholar
  215. Cohn DV, Bawdon R, Eller G (1967) The effect of parathyroid hormone in vivo on the accumulation of calcium and phosphate by kidney and kidney mitochondrial function. J Biol Chem 242:1253–1258Google Scholar
  216. Cook GMW, Laico MT, Eylar EH (1965) Biosynthesis of glycoproteins of the Ehrlich ascites carcinoma cell membranes. Proc Natl. Acad Sci USA 54:247–252Google Scholar
  217. Cooke WJ, Robinson JP (1971) Factors influencing calcium movements in rat brain slices. Am J Physiol 221:218–225Google Scholar
  218. Coraboeuf E, Beigelman PM, Breton D (1964) Potentiels électriques du foie de rat in situ. Effets de l'asphyxie. CR Acad Sci (D) (Paris) 25q:2300–2302Google Scholar
  219. Cosmos E (1964) Intracellular distribution of calcium in developing breast muscle of normal and dystrophic chicks. J Cell Biol 23:241–252Google Scholar
  220. Cosmos E, Harris EJ (1961) In vitro studies of the gain and exchange of calcium in frog skeletal muscle. J Gen Physiol 44:1121–1130Google Scholar
  221. Crompton M, Heid I (1978) The cycling of calcium, sodium and protons across the inner membrane of cardiac mitochondria. Eur J Biochem 91:599–608Google Scholar
  222. Crompton M, Sigel E, Salzmann M, Carafoli E (1967a) Kinetic study of the energy-linked influx of Ca2+ into heart mitochondria. Eur J Biochem 69:429–434Google Scholar
  223. Crompton M, Capano M, Carafoli E (1976b) The sodium induced efflux of calcium from heart mitochondria. A possible mechanism for the regulation of mitochondrial calcium. Eur J Biochem 69:453–462Google Scholar
  224. Crompton M, Künzi M, Carafoli E (1977) The calcium-induced and sodium-induced effluxes of calcium from heart mitochondria. Evidence for a sodium calcium carrier. Eur J Biochem 79:549–558Google Scholar
  225. Crompton M, Hediger M, Carafoli E (1978a) The effect of inorganic phosphate on calcium influx into rat heart mitochondria. Biochem Biophys Res Commun 80:540–546Google Scholar
  226. Crompton M, Moser R, Lüdi H, Carafoli E (1978b) The interrelations between the transport of sodium and calcium in mitochondria of various mammalian tissues. Eur J Biochem 82:25–31Google Scholar
  227. Crooks JR, Kyriakides CPM, Simkiss K (1976) Routes of calcium movements across the chick chorioallantois. Q J Exp Physiol 61:265–274Google Scholar
  228. Daniel EE, Janis RA (1975) Calcium regulation in the uterus. Pharmacol Ther (B) 1: 695–729Google Scholar
  229. Davis PW, Vincenzi FF (1971) Ca-ATPase activation and NaK-ATPase inhibition as a function of calcium concentration in human red cell membranes. Life Sci 10:401–406Google Scholar
  230. Dawkins MJR, Judah JD, Rees KR (1959) Factors influencing the survival of liver cells during autolysis. J Path Bact 77:257–275Google Scholar
  231. Dean PM, Matthews EK (1970a) Glucose induced electrical activity in pancreatic islet cells. J Physiol (Lond) 210:255–264Google Scholar
  232. Dean PM, Matthews EK (1970b) Electrical activity in pancreatic islet cells: effect of ions. J Physiol (Lond) 210:265–275Google Scholar
  233. Dean PM, Matthews EK, Sakamoto Y (1975) Pancreatic islet cells: effects of monosaccharides, glycolytic intermediates and metabolic inhibitors on membrane potential and electrical activity. J Physiol (Lond) 246:459–478Google Scholar
  234. Dedman JR, Brinkley BR, Means AR (1979) Regulation of microfilaments and microtubules by calcium and cyclic AMP. Adv Cyclic Nucl Res 11:131–174Google Scholar
  235. Deffner GGJ (1961) The dialysable free organic constituents of squid blood: a comparison with nerve axoplasm. Biochim Biophys Acta 47:378–388Google Scholar
  236. DeMeis L (1969a) Activation Ca2+ uptake by acetylphosphate in muscle microsomes. Biochim Biophys Acta 172:343–344Google Scholar
  237. DeMeis L (1969b) Ca2+ uptake and acetylphosphate of skeletal muscle microsomes. Inhibition by Na+, K+, Li+ and adenosine triphosphate. J Biol Chem 244:3733–3739Google Scholar
  238. DeMeis L (1971) Allosteric inhibition by alkali ions of the Ca2+ uptake and adenosine triphosphatase activity of skeletal muscle microsomes. J Biol Chem 246:4764–4773Google Scholar
  239. DeMeis L, Hasselbach W (1971) Acetylphosphate as substrate for Ca2+ uptake in skeletal muscle microsomes. Inhibition by alkali ions. J Biol Chem 246:4759–4763Google Scholar
  240. DeMeis L, Rubin-Attschul BM, Tillack TW (1970) Comparative data of Ca2+ transport in brain and skeletal muscle microsomes. J Biol Chem 245:1883–1889Google Scholar
  241. Deschodt-Lanckman M, Robberecht P, De Neef P, Lammens M, Christophe J (1976) In vitro action of bombesin and bombesin-like peptides on amylase secretion, calcium efflux, and adenylate cyclase activity in the rat pancreas. J Clin Invest 58:891–898Google Scholar
  242. Deshmukh K, Kline WG, Sawyer BD (1977) Effect of calcitonin and parathyroid hormone on the metabolism of chondrocytes in culture. Biochim Biophys Acta 499:28–35Google Scholar
  243. Deth RC (1978) Effect of lanthanum and reduced temperature on 45Ca efflux from rabbit aorta. Am J Physiol 234:C139–C145Google Scholar
  244. Deth R, Van Breemen C (1977) Agonist induced release of intracellular Ca2+ in the rabbit aorta. J Membr Biol 30:363–380Google Scholar
  245. DeWulf H, Keppens S (1976) Is calcium 2nd messenger in liver for cyclic AMP independent glycogenolytic hormones? Arch Int Physiol Biochim 84:159–160Google Scholar
  246. DiPolo R (1973a) Calcium efflux from internally dialyzed squid giant axons. J Gen Physiol 62:575–589Google Scholar
  247. DiPolo R (1973b) Sodium dependent calcium influx in dialyzed barnacle muscle fiber. Biochim Biophys Acta 298:279–283Google Scholar
  248. DiPolo R (1974) Effect of ATP on the calcium efflux in dialzyed squid giant axon. J Gen Physiol 64:503–517Google Scholar
  249. DiPolo R (1976) The influence of nucleotides on calcium fluxes. Fed Proc 35:2579–2582Google Scholar
  250. DiPolo R (1977) Characterization of the ATP-dependent calcium efflux in dialyzed squid giant axons. J Gen Physiol 69:795–813Google Scholar
  251. DiPolo R (1979) Calcium influx in internally dialyzed squid giant axons. J Gen Physiol 73:91–113Google Scholar
  252. DiPolo R, Caputo C (1977) The effect of ATP on calcium efflux in dialyzed barnacle muscle fibres. Biochim Biophys Acta 470:389–394Google Scholar
  253. DiPolo R, Requena J, Brinley FJ Jr, Mullins LJ, Scarpa A, Tiffert T (1976) Ionized calcium concentration in squid axons. J Gen Physiol 67:433–467Google Scholar
  254. Dorman DM, Barritt GJ, Bygrave FF (1975) Stimulation of hepatic mitochondrial calcium transport by elevated plasma insulin concentration. Biochem J 150:389–395Google Scholar
  255. Douglas WW, Kanno T, Sampson SR (1967a) Effects of acetylcholine and other medullary secretagogues and antagonists on the membrane potential of adrenal chromaffin cells: an analysis employing technique of tissue culture. J Physiol (Lond) 188:107–120Google Scholar
  256. Douglas WW, Kanno T, Sampson SR (1976b) Influence of the ionic environment on the membrane potential of adrenal chromaffin cells and on the deploarizing effect of acetylcholine. J Physiol (Lond) 191:107–121Google Scholar
  257. Drahota Z, Carafoli E, Rossi CS, Gamble RL, Lehninger AL (1965) The steady state maintenance of accumulated Ca++ in rat liver mitochondria. J Biol Chem 240:2712–2720Google Scholar
  258. Droogmans G, Casteels R (1979) Sodium and calcium interactions in vascular smooth muscle cells of the rabbit ear artery. J Gen Physiol 74:57–70Google Scholar
  259. Duffy MJ, Schwarz V (1973) Calcium binding to erythrocyte membrane. Biochim Biophys Acta 330:294–301Google Scholar
  260. Dunnett J, Nayler WG (1979) Effect of pH on calcium accumulation and release by isolated fragments of cardiac and skeletal muscle sarcoplasmic reticulum. Arch Biochem Biophys 198:434–438Google Scholar
  261. Dziak R (1978) Effects of vitamin D3 metabolites on bone cell calcium transport. Calcif Tissue Res 26:65–70Google Scholar
  262. Dziak R, Brand JS (1974a) Calcium transport in isolated bone cells. I. Bone cell isolation procedure. J Cell Physiol 84:75–74Google Scholar
  263. Dziak R, Brand JS (1974b) Calcium transport in isolated bone cells. II. Calcium transport studies. J Cell Physiol 84:85–96Google Scholar
  264. Dziak R, Hausmann E, Chang YW (1979) Effects of lipopolysaccharides and prostaglandins on rat bone cell calcium and cyclic AMP. Arch Oral Biol 24:347–354Google Scholar
  265. Dziak R, Stern PH (1975) Calcium transport in isolated bone cells. III. Effects of parathyroid hormone and cyclic 3′5′ AMP. Endocrinology 97:1281–1287Google Scholar
  266. Ebashi S (1976) Excitation-contraction coupling. Ann Rev Physiol 38:293–313Google Scholar
  267. Eilam Y, Szydel N, Harell A (1980) Effect of calcitonin on transport and intracellular distribution of exchangeable Ca2+ in primary culture of bone cells. Mol Cell Endocrinol 18:215–225Google Scholar
  268. Elder JA, Lehninger AL (1973a) Respiration dependent transport of carbon dioxide into rat liver mitochondria. Biochemistry 12:976–982Google Scholar
  269. Elder JA, Lehninger AL (1973b) Energy linked uptake of Ca2+ supported by carbon dioxide: inhibition by diamox. In: Azzone GF, Ernster L, Papa S, Quagliariello E, Siliprandi N (eds) Mechanisms in bioenergetics. Academic Press, New York, pp 513–526Google Scholar
  270. Entman ML, Levey GS, Epstein SE (1969) Mechanism of action of epinephrine and glucagon on the canine heart. Evidence for increase in sarcotubular calcium stores mediated by cyclic 3′5′ AMP. Circ Res 25:429–438Google Scholar
  271. Eroglu L, Keen P (1977) Active uptake of 45Ca by a microsomal fraction prepared from rat dorsal roots. J Neurochem 29:905–909Google Scholar
  272. Ewe K (1972) Calcium transport in rat small intestine in vitro and in vivo. Arch Pharmacol 273:352–365Google Scholar
  273. Exton JH (1980) Mechanisms involved in α-adrenergic phenomena: role of calcium ions in actions of catecholamines in liver and other tissues. Am J Physiol 238:E3–E12Google Scholar
  274. Exton JH, Park CR (1972) Interaction of insulin and glucagon in the control of liver metabolism. In: Greep RO, Astwood EB (eds) Endocrinology, endocrine pancreas. American Physiological Society, Washington, D.C. (Handbook of physiology, vol I/7, pp 437–455)Google Scholar
  275. Exton JH, Robinson GA, Sutherland EW (1972) Glucagon and cyclic AMP. In: Endocrinology, endocrine pancreas. American Physiological Society, Washington, D.C. (Handbook of physiology, vol I/7, pp 425–436)Google Scholar
  276. Fain JN, Berridge MJ (1979) Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland. Biochem J 178:45–58Google Scholar
  277. Fanburg BL (1968) Calcium transport by skeletal muscle sarcoplasmic reticulum in the hypothyroid rat. J Clin Invest 47:2499–2506Google Scholar
  278. Farber JL, El-Mofty SK, Schanne FAX, Aleo JJ Jr, Serroni A (1977) Intracellular calcium homeostasis in galactosamine-intoxicated rat liver cells. Active sequestration of calcium by microsomes and mitochondria. Arch Biochem Biophys 178:617–624Google Scholar
  279. Feher JJ, Wasserman RH (1979) Intestinal calcium-binding protein and calcium absorption in cortisol-treated chicks: effects of vitamin D3 and 1,25-dihydroxyvitamin D3. Endocrinology 104:547–551Google Scholar
  280. Ferreira HG, Lew VL (1976) Use of ionophore A23187 to measure cytoplasmic Ca buffering and activation of the Ca pump by internal Ca. Nature 259:47–49Google Scholar
  281. Fiskum G, Lehninger AL (1979) Regulated release of calcium from respiring mitochondria by Ca2+/2H+ antiport. J Biol Chem 254, 6236–6239Google Scholar
  282. Foden S, Randle PJ (1978) Calcium metabolism in rat hepatocytes. Biochem J 170:615–625Google Scholar
  283. Foreman JC, Hallett MB, Mongar JL (1977) The relationship between histamine secretion and 45calcium uptake by mast cells. J Physiol (Lond) 271:193–214Google Scholar
  284. Frankel BJ, Imagawa WT, O'Connor MDL, Lundquist I, Kromhout JA, Fanska RE (1978) Glucose stimulated 45calcium efflux from isolated rat pancreatic islets. J Clin Invest 62:525–531Google Scholar
  285. Frankenhauser B, Hodgkin AL (1956) The after effects of impulses in the giant nerve fibres of Loligo. J Physiol (Lond) 131:341–376Google Scholar
  286. Freedman RA, Weiser MM, Isselbacher KJ (1977) Calcium translocation by Golgi and lateral-basal membrane vesicles from rat intestine: decrease in vit-D-deficient rats. Proc Natl Acad Sci USA 74:3612–3616Google Scholar
  287. Freeman DJ, Daniel EE (1973) Calcium movements in vascular smooth muscle and its detection using lanthanum as a tool. Can J Physiol Pharmacol 51:900–913Google Scholar
  288. Friedmann N (1972) Effects of glucagon and cyclic AMP on ion fluxes in the perfused liver. Biochim Biophys Acta 274:214–225Google Scholar
  289. Friedmann N, Divakaran P, Kirkland J, Kimura S, Wood J (1979) Effects of the calcium ionophore A23187 on liver metabolism. J Pharmacol Exp Ther 211:127–132Google Scholar
  290. Friedmann N, Park CR (1968) Early effect of 3′5′ AMP on the fluxes of Ca and potassium in the perfused liver of normal and adrenalectomized rats. Proc Natl Acad Sci USA 61:504–508Google Scholar
  291. Friedmann N, Rasmussen N (1970) Relationship between Ca2+ movement and gluconeogenesis in the perfused liver. Biochim Biophys Acta 222:41–52Google Scholar
  292. Fuchs R, Peterlik M (1979) Vitamin D-induced transepithelial phosphate and calcium transport by chick jejunum: effect of microfilamentous and microtubular inhibitors. FEBS Lett 100:357–359Google Scholar
  293. Gainer H (1968) The role of calcium in excitation-contraction coupling. J Gen Physiol 52:88–110Google Scholar
  294. Galo MG, Bloj B, Farias RN (1975) Kinetic changes of erythrocyte (Mg2+ + Ca2+)-adenosine triphosphatase of rats fed different fat-supplemented diets. J Biol Chem 250:6204–6207Google Scholar
  295. Gardner JD, Conlon TP, Klaeveman HL, Adams TO, Ondetti MA (1975) Action of cholecystokinin and cholinergic agents on calcium transport in isolated pancreatic acinar cells. J Clin Invest 56:366–375Google Scholar
  296. Gardner JD, Hahne WF (1977) Calcium transport in dispersed acinar cells from rat pancreas. Biochim Biophys Acta 471:466–476Google Scholar
  297. Garrison JC, Borland MK, Florio VA, Twible DA (1979) The role of calcium ions as a mediator of the effects of angiotensin II. Catecholamines and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes. J Biol Chem 254:7147–7156Google Scholar
  298. Gasic G, Gasic T (1962) Removal and regeneration of the cell coating in tumour cells. Nature 196:170Google Scholar
  299. Geduldig D, Junge D (1968) Sodium and calcium components of action potentials in the Aplysia giant neurone. J Physiol (Lond) 199:347–365Google Scholar
  300. Gerrard JM, Townsend D, Stoddard S, Witkop CJ, White JG (1977) The influence of prostaglandin G2 on platelet ultrastructure and platelet secretion. Am J Pathol 86(1):99–115Google Scholar
  301. Gerrard JM, Kindom SE, Peterson DA, Peller J, Krautz KE, White J (1979) Lysophosphatidic acid's influence on platelets aggregation and intracellular calcium flux. Am J Pathol 96:423–438Google Scholar
  302. Ghijsen WEJM, Van Os CH (1979) Ca-stimulated ATPase in brush border and basolateral membranes of rat duodenum with high affinity sites for Ca ions. Nature 279:802–803Google Scholar
  303. Giebisch G (1958) Electrical potential measurements on single nephrons of Necturus. J Cell Comp Physiol 51:221–239Google Scholar
  304. Giebisch G (1961) Measurements of electrical potential differences on single nephrons of the perfused Necturus kidney. J Gen Physiol 44:659–678Google Scholar
  305. Gilbert DL, Fenn WD (1957) Calcium equilibrium in muscle. J Gen Physiol 40:393–408Google Scholar
  306. Giles W, Noble SJ (1976) Changes in membrane currents in bullfrog atrium produced by acetylcholine. J Physiol (Lond) 261:103–123Google Scholar
  307. Girardier L, Seydoux J, Clausen T (1968) Membrane potential of brown adipose tissue. A suggested mechanism for the regulation of thermogenesis. J Gen Physiol 52:925–940Google Scholar
  308. Glitsch HG, Reuter H, Scholz H (1970) The effect of the internal sodium concentration on calcium fluxes in isolated guinea-pig auricles. J Physiol (Lond) 209:25–43Google Scholar
  309. Gmaj P, Murer H, Kinne R (1979) Calcium ion transport across plasma membranes isolated from rat kidney cortex. Biochem J 178:549–557Google Scholar
  310. Godfraind T, Kaba A (1972) The role of calcium in the action of drugs on vascular smooth muscle. Arch Int Pharm Therap 196 (Suppl):35–49Google Scholar
  311. Gomez-Puyou A, Tuena de Gomez-Puyou M, Becker G, Lehninger AL (1972) An insoluble Ca2+-binding factor from rat liver mitochondria. Biochem Biophys Res Commun 47:814–819Google Scholar
  312. Gopinath RM, Vincenzi FF (1977) Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+ − Mg2+) ATPase. Biochem Biophys Res Commun 77:1203–1209Google Scholar
  313. Govier WC, Holland WC (1964) Effect of ouabain on tissue calcium and calcium exchange in pacemaker of turtle heart. Am J Physiol 207:195–198Google Scholar
  314. Greenawalt JW, Rossi CS, Lehninger AL (1964) Effect of active accumulation of calcium and phosphate ions on the structure of rat liver mitochondria. J Cell Biol 23:21–38Google Scholar
  315. Greenway DC, Himms-Hagen J (1978) Increased calcium uptake by muscle mitochondria of cold acclimated rats. Am J Physiol 234:C7–C13Google Scholar
  316. Grinstein S, Erlij D (1976) Action of insulin and cell calcium: effect of ionophore A23187. J Membr Biol 29:313–328Google Scholar
  317. Griswold RL, Pace N (1956) The intracellular distribution of metal ions in rat liver. Exptl Cell Res 11:362–367Google Scholar
  318. Grosse D, Lüllman H (1972) Tissue Ca content of intestinal smooth muscles and the Ca++ concentration of the incubation medium. Experientia 28:412–413Google Scholar
  319. Guerrero-Munoz F, Cerreta KW, Guerrero ML, Way EL (1979a) Effect of morphine on synaptosomal Ca++ uptake. J Pharmacol Exper Therap 209:132–135Google Scholar
  320. Guerrero-Munoz F, De Lourdes Guerrero M, Way EL (1979b) Effect of morphine on calcium uptake by lysed synaptosomes. J Pharmacol Exp Ther 211:370–374Google Scholar
  321. Guerrero-Munoz F, DeLourdes Guerrero M, Way EL, Li CH (1979c) Effect of β-endorphin on calcium uptake in the brain. Science 206:89–90Google Scholar
  322. Gunter TE, Puskin JS (1975) The use of electron paramagnetic resonance in studies of free and bound divalent cation: the measurement of membrane potential in mitochondria. Ann NY Acad Sci 264:112–122Google Scholar
  323. Gylfe E, Buitrago A, Berggren PO, Hammarström K, Hellman B (1978) Glucose inhibition of 45Ca efflux from pancreatic islets. Am J Physiol 235:E191–E196Google Scholar
  324. Hagiwara S (1973) Ca spike. Adv Biophys 4:71–102Google Scholar
  325. Hagiwara S, Chichibu S, Naka K (1964) The effects of various ions on resting and spike potentials of barnacles. J Gen Physiol 48:163–179Google Scholar
  326. Hagiwara S, Naka K (1964) The initiation of spike potential in barnacle muscle fibers under low intracellular Ca++. J Gen Physiol 48:141–162Google Scholar
  327. Hagiwara S, Nakajima S (1966) Effects of the intracellular Ca ion concentration upon excitability of the muscle fiber membrane of a barnacle. J Gen Physiol 49:807–818Google Scholar
  328. Hahn TJ, Halstead LR (1979) Cortisol enhancement of PTH-stimulated cyclic AMP accumulation in cultured fetal rat long bone rudiments. Calcif Tissue Int 29:173–175Google Scholar
  329. Hakim A (1973) Effect of human calcitonin on the sarcoplasmic reticulum of the human heart. Naturwissenschaften 60:53Google Scholar
  330. Hales CN, Campbell AK, Luzio JP, Siddle K (1977) Calcium as a mediator of hormone action. Biochem Soc Trans 5:866–871Google Scholar
  331. Hamaguchi Y, Mabuchi I (1978) Measurement of intracellular free calcium concentration in the starfish egg by means of the microinjection of aequorin. Cell Struct Func 3:259–264Google Scholar
  332. Hanahan DJ, Taverna RD, Flynn DD, Echolm JE (1978) The interaction of Ca2+/Mg2+ ATPase activator protein and Ca2+ with human erythrocyte membranes. Biochem Biophys Res Commun 84:1009–1017Google Scholar
  333. Harada E, Laychock SG, Rubin RP (1978) Parathyroid hormone induced stimulation of calcium uptake by renal microsomes. Biochem Biophys Res Commun 84:396–402Google Scholar
  334. Harell A, Binderman I, Gues M (1976) Tissue culture of bone cells: mineral transport, calcification and hormonal effects. Isr J Med Sci 12:115–123Google Scholar
  335. Harell A, Binderman I, Rodan GA (1973) The effect of calcium concentration on calcium uptake by bone cells treated with thyrocalcitonin (TCT) hormone. Endocrinology 92:550–555Google Scholar
  336. Harigaya S, Schwartz A (1969) Rate of calcium binding and uptake in normal animal and failing human cardiac muscle. Membrane vesicles (relaxing system) and mitochondria. Circ Res 25:781–794Google Scholar
  337. Harris EJ (1977) The uptake and release of calcium by heart mitochondria. Biochem J 168:447–456Google Scholar
  338. Harris EJ (1979) Modulation of Ca2+ efflux from heart mitochondria. Biochem J 178:673–680Google Scholar
  339. Harris EJ, Al-Shaikhaly M, Baum H (1979) Stimulation of mitochondrial calcium ion efflux by thiolspecific reagents and by thyroxine. The relationship to adenosine diphosphate retention and to mitochondrial permeability. Biochem J 182:455–464Google Scholar
  340. Harris RH, Ramwell PW, Gilmer PJ (1979) Cellular mechanisms of prostaglandin action. Ann Rev Physiol 41:653–658Google Scholar
  341. Haussler MR, Nagode LA, Rasmussen H (1970) Induction of intestinal brush border alkaline phosphatase by vitamin D and identity with Ca-ATPase. Nature 228:1199–1201Google Scholar
  342. Hayasaki-Kumura N, Takahashi K (1979) Studies on action of somatostatin on growth hormone release in relation to calcium and cyclic AMP. Proc Soc Exp Biol Med 161:312–318Google Scholar
  343. Hazelton BJ, Tupper JT (1979) Calcium transport and exchange in mouse 3T3 and SU40-3T3 cells. J Cell Biol 81:538–542Google Scholar
  344. Heaton GM, Nicholls DG (1976) The calcium conductance of the inner membrane of rat liver mitochondria and the determination of the calcium electrochemical gradient. Biochem J 156:635–646Google Scholar
  345. Heersche JNM, Marcus R, Aurbach GD (1974) Calcitonin and the formation of 3′,5′-AMP in bone and kidney. Endocrinology 94:241–247Google Scholar
  346. Heilbrunn L (1943) An outline of general physiology. Saunders, PhiladelphiaGoogle Scholar
  347. Heilbrunn LV, Wiercinski FJ (1947) The action of various cations on muscle protoplasm. J Cell Physiol 29:15–32Google Scholar
  348. Heisler S, Grondin G (1973) Effect of lanthanum of 45Ca flux and secretion of protein from rat exocrine pancreas. Life Sci 13:783–794Google Scholar
  349. Hellman B, Anderson T (1978) Calcium and pancreatic β-cell function. IV. Evidence that glucose and phosphate stimulate Ca45 incorporation into different intracellular pools (BBA 28582). Biochim Biophys Acta 541:483–491Google Scholar
  350. Hellman B, Sehlin J, Täljedal IB (1971) Calcium uptake by pancreatic β-cells as measured with the aid of 45Ca and mannitol-3H. Am J Physiol 221:1795–1801Google Scholar
  351. Hellman B, Sehlin J, Täljedal IB (1976a) Effects of glucose on 45Ca++ uptake by pancreatic islets as studied with the lanthanum method. J Physiol (Lond) 254:639–656Google Scholar
  352. Hellman B, Sehlin J, Täljedal IB (1976b) Calcium and secretion: distinction between two pools of glucose-sensitive calcium in pancreatic islets. Science 194:1421–1423Google Scholar
  353. Hems DA, Whitton PD (1980) Control of hepatic glycogenolysis. Physiol Rev 60:1–50Google Scholar
  354. Herchuelz A, Couturier E, Malaisse WJ (1980) Regulation of calcium fluxes in pancreatic islets: glucose-induced calcium-calcium exchange. Am J Physiol 238:E96–E103Google Scholar
  355. Herchuelz A, Delcroix C, Malaisse WJ (1979) Regulation of calcium fluxes in pancreatic islets. Quantification of calcium movements. Biochem Med 22:156–164Google Scholar
  356. Herchuelz A, Malaisse WJ (1980) Regulation of calcium fluxes in pancreatic islets: two calcium movements' dissociated response to glucose. Am J Physiol 238:E87–E95Google Scholar
  357. Herrman-Erlee MPM, v.d. Meer JM (1974) The effect of dibutyryl cyclic AMP, amino-phylline, propranolol on PTE-induced bone resorption in vitro. Endocrinology 94:424–434Google Scholar
  358. Hicks MJ, Shigekawa M, Katz AM (1979) Mechanism by which cyclic adenosine 3′,5′ monophosphate-dependent protein kinase stimulates calcium transport in cardiac sarcoplasmic reticulum. Circ Res 44:384–391Google Scholar
  359. Hinds TR, Larsen FL, Vincenzi FF (1978) Plasma membrane Ca2+ transport: stimulation by soluble proteins. Biochem Biophys Res Commun 81:455–461Google Scholar
  360. Hines RN, Wenner CE (1977) The role of Pi in glycolytic inhibition of calcium ion uptake by ELD ascites tumor cells. Biochim Biophys Acta 465:391–399Google Scholar
  361. Hinke JAM (1961) The measurement of sodium and potassium activities in the squid axon by means of cation selective glass microelectrodes. J Physiol (Lond) 156:314–335Google Scholar
  362. Hinnen R, Miyamoto H, Racker E (1979) Ca2+ translocation in Ehrlich ascites tumor cells. J Membr Biol 49:309–324Google Scholar
  363. Hodgkin AL, Keynes RD (1957) Movements of labelled calcium in squid giant axons. J. Physiol (Lond) 138:253–281Google Scholar
  364. Hodgson BJ, Kidwai AM, Daniel EE (1972) Uptake of lanthanum by smooth muscle. Can J Physiol Pharmacol 50:730–733Google Scholar
  365. Höfer M, Kleinzeller A (1963a) Calcium transport in slices of rabbit kidney cortex: the uptake and distribution of calcium. Physiol Bohemoslov 12:405–416Google Scholar
  366. Höfer M, Kleinzeller A (1963b) Calcium transport in slices of rabbit kidney cortex: the steady state compartmentalization of Ca and rate constants of 4 5Ca efflux. Physiol Bohemoslov 12:417–424Google Scholar
  367. Höfer M, Kleinzeller A (1963c) Calcium transport in slices of rabbit kidney cortex: the loss of calcium from Ca-enriched slices. Physiol Bohemoslov 12:425–434Google Scholar
  368. Hogeboom GH, Schneider WC, Striebich MJ (1953) Localization and integration of cellular function. Cancer Res 13:617–632Google Scholar
  369. Hohman W, Schraer H (1966) The intracellular distribution of calcium in the mucosa of the avian shell gland. J Cell Biol 30:317–331Google Scholar
  370. Hope-Gill H, Kissebah A, Tulloch B, Clarke P, Uydelingum N, Fraser TR (1975) The effects of insulin on adipocyte calcium fluxes and the interaction with the effects of dibutyryl cyclic AMP and adrenaline. Horm Metab Res 7:195–196Google Scholar
  371. Hope-Gill HF, Kissebah AH, Clarke P, Vydelingum N, Tulloch B, Fraser TR (1976) Effects of insulin and procaine hydrochloride on glycogen synthetase activation and adipocyte calcium flux — evidence for a role of calcium in insulin activation of glycogen synthetase. Horm Metab Res 8:184–190Google Scholar
  372. Howell SL, Mantague W, Tyhurst M (1975) Calcium distribution in islets of Langerhans: a study of calcium concentrations and calcium accumulation in 3 cell organelles. J Cell Sci 19:395–409Google Scholar
  373. Howell SL, Tyhurst M (1976) 4 5Calcium localization in islets of Langerhans, a study by electron-microscopy autoradiography. J Cell Sci 21:415–422Google Scholar
  374. Hughes BP, Barritt GJ (1978) Effects of glucagon and N6, O2 dibutyryladenosine 3′:5′-cyclic monophosphate on calcium transport in isolated rat liver mitochondria. Biochem J 176:295–304Google Scholar
  375. Hughes BP, Barritt GJ (1979) Interaction between glucocorticoids and glucagon in the hormonal modification of calcium retention by isolated rat liver mitochondria. Biochem J 180:291–295Google Scholar
  376. Hutson SM (1977) Steady state kinetics of energy-dependent Ca2+ uptake in rat liver mitochondria. J Biol Chem 252:4539–4545Google Scholar
  377. Hutson SM, Pfeiffer DR, Lardy HA (1976) Effect of cations and anions on the steady state kinetics of energy-dependent Ca2+ transport in rat liver mitochondria. J Biol Chem 251:5251–5258Google Scholar
  378. Huxley AF, Stämpfli R (1951) Direct determination of membrane resting potential and action potential in single myelinated nerve fibers. J Physiol (Lond) 112:476–495Google Scholar
  379. Huxtable R, Bressler R (1974) The effect of deuterium ion concentration on the properties of sarcoplasmic reticulum. J Membr Biol 17:189–197Google Scholar
  380. Ilundain A, Naftalin RJ (1979) Role of Ca2+-dependent regulator protein in intestinal secretion. Nature 279:446–448Google Scholar
  381. Isaacson A (1969) Caffein-induced contracture and related calcium movements of muscle in hypertonic media. Experientia 25:1263–1265Google Scholar
  382. Isaacson A, Sandow A (1967) Quinine and caffeine effects on 4 5Ca movements in frog sartorius muscle. J Gen Physiol 50:2109–2128Google Scholar
  383. Ishibashi F, Sato T, Onari K, Kawate R (1979) Effect of somatostatin on glucose-induced Ca4 5 uptake in the pancreatic islets. Endocrinol Jpn 26:585–590Google Scholar
  384. Izzard S, Tedeschi H (1973) Characterization of orthophosphate induced active cation transport in isolated liver mitochondria. Arch Biochim Biophys 154:527–539Google Scholar
  385. Jacobus WE, Tiozzo R, Lugli G, Lehninger AL, Carafoli E (1975) Aspects of energy-linked Ca2+ accumulation by rat-heart mitochondria. J Biol Chem 250:7863–7870Google Scholar
  386. Janda S (1969) Mechanism of calcium transport in kidney cortex slices. Physiol Bohemoslov 18:413–423Google Scholar
  387. Jarrett HW, Penniston JT (1977) Partial purification of the (Ca+2 + Mg+2) ATPase activator from human erythrocytes: its similarity to the activator of 3′:5′ cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun 77:1210–1216Google Scholar
  388. Jay AWL, Burton AC (1969) Direct measurement of potential difference across the human red blood cell membrane. Biophys J 9:115–121Google Scholar
  389. Johansson P, Josefsson J (1978) Evidence for a dual effect of intracellular calcium ion on pinocytosis. Acta Physiol Scand 102:71A–72AGoogle Scholar
  390. Judah JD, Ahmed K (1963) Role of phosphoproteins in ion transport: interactions of sodium with calcium and potassium in liver slices. Biochim Biophys Acta 71:34–44Google Scholar
  391. Judah JD, Ahmed K (1964) The biochemistry of sodium transport. Biol Rev 39:160–193Google Scholar
  392. Jundt H, Porzig H, Reuter H, Stucki JW (1975) The effect of substances releasing intracellular calcium ions on sodium-dependent calcium efflux from guinea pig auricles. J Physiol (Lond) 246:229–253Google Scholar
  393. Jundt H, Reuter H (1977) Is sodium-activated calcium efflux from mammalian cardiac muscle dependent on metabolic energy. J Physiol (Lond) 266:78P–79PGoogle Scholar
  394. Juzu HA, Holdsworth ES (1980) New evidence for the role of cyclic AMP in the release of mitochondrial calcium. J Membr Biol 52:185–189Google Scholar
  395. Kakuta S, Suda T, Sasaki S, Kimura N, Nagata N (1975) Effects of parathyroid hormone on the accumulation of cyclic AMP in bone of vitamin D deficient rats. Endocrinology 97:1288–1293Google Scholar
  396. Kalix P (1969) Na-activated calcium efflux in rabbit vagus nerve fibres. Experientia 25:1293–1294Google Scholar
  397. Kalix P (1971) Uptake and release of calcium in rabbit vagus nerve. Pfluegers Arch 326:1–14Google Scholar
  398. Kanagasuntheram P, Randle P (1976) Calcium metabolism and amylase release in rat parotid acinar cells. Biochem J 160:547–564Google Scholar
  399. Käser-Glanzmann R, Jakabova M, George JN, Lüscher EF (1977) Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3′5′-cyclic monophosphate and protein kinase. Biochim Biophys Acta 466:429–440Google Scholar
  400. Kass RS, Tsien RW (1975) Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. J Gen Physiol 66:169–192Google Scholar
  401. Katz AM, Repke DL, Fudyma G, Shigekawa M (1977) Control of calcium efflux from sarcoplasmic reticulum vesicles by external calcium. J Biol Chem 252:4210–4214Google Scholar
  402. Katz B, Miledi R (1967) A study of synaptic transmission in the absence of nerve impulses. J Physiol (Lond) 192:407–436Google Scholar
  403. Katz B, Miledi R (1969) Tetrodotoxin-resistant electric activity in presynaptic terminals. J Physiol (Lond) 203:459–487Google Scholar
  404. Katz S, Remtulla MA (1978) Phosphodiesterase protein activator stimulates calcium transport in cardiac microsomal preparations enriched in sarcoplasmic reticulum. Biochem Biophys Res Commun 83:1373–1379Google Scholar
  405. Katzung BG, Reuter H, Portzig H (1973) Lanthanum inhibits Ca inward current but not Na-Ca exchange in cardiac muscle. Experientia 29:1073–1075Google Scholar
  406. Keppens S, Vendenheede JR, DeWulf H (1977) On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase. Biochim Biophys Acta 496:448–457Google Scholar
  407. Khan AR (1979) Effects of diethylstilbestrol on single fibers of frog skeletal muscle. Acta Physiol Scand 106:69–74Google Scholar
  408. Kahn A, Brachet E (1979) The permeability coefficient of albumin of the isolated rat mesentery — a modification by some mediators of inflammation, cyclic AMP and calcium. Biochim Biophys Acta 588:219–231Google Scholar
  409. Kikuchi M, Wollheim CB, Cuendet GS, Renold AE, Sharp WG (1978) Studies on the dual effects of glucose on 4 5Ca efflux from isolated rat islets. Endocrinology 102:1339–1349Google Scholar
  410. Kikuchi M, Wollheim CB, Seigel EG, Renold AE, Sharp GWG (1979) Biphasic insulin release in rat islets of Langerhans and the role of intracellular Ca++ stores. Endocrinology 105:1013–1019Google Scholar
  411. Kimberg DV, Baerg RD, Gershon E, Graudusius RT (1971) Effect of cortisone treatment on the active transport of calcium by the small intestine. J Clin Invest 50:1309–1321Google Scholar
  412. Kimura S, Rasmussen H (1977) Adrenal glucorticoids, adenine nucleotide translocation, and mitochondrial calcium accumulation. J Biol Chem 252:1217–1225Google Scholar
  413. Kimura T, Chu JW, Mukai R, Ishizuka I, Ymamkawa T (1972) Some properties of a glycoprotein isolated from adrenal cortex mitochondria. Biochem Biophys Res Commun 49:1678–1683Google Scholar
  414. Kinne-Saffran E, Kinne R (1974) Localization of a calcium-stimulated ATPase in the basal-lateral plasma membranes of the proximal tubule of rat kidney cortex. J Membr Biol 17:263–274Google Scholar
  415. Kirchberger MA, Tada M, Repke DL, Katz AM (1972) Cyclic adenosine 3′5′-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomes. J Mol Cell Cardiol 4:673–680Google Scholar
  416. Kissebah AH, Clarke P, Vydelingum N, Hope-Gill H, Tulloch B, Fraser TR (1975) The role of calcium in insulin action. III. Calcium distribution in fat cells; its kinetics and the effects of adrenaline, insulin and procaine-HCl. Eur J Clin Invest 5:339–349Google Scholar
  417. Klaus W, Krebs R (1974) Analysis of the calcium compartments in guinea pig hearts under control conditions and under the influence of ouabain. Arch Pharmacol 283:277–292Google Scholar
  418. Klein CD, Raisz LG (1971) Role of adenosine-3′,5′-monophosphate in the hormonal regulation of bone resorption: studies with cultured fetal bone. Endocrinology 89:818–826Google Scholar
  419. Kohlhardt M, Bauer B, Krause H, Fleckenstein A (1972) Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors. Pflügers Arch 335:309–322Google Scholar
  420. Kohlhart M, Kübler M (1975) The influence of metabolic inhibitors upon the transmembrane slow inward current in the mammalian ventricular myocardium. Arch Pharmacol 290:265–274Google Scholar
  421. Kohlhart M, Mnich Z, Maier G (1977) Alteration of the excitation process of the sinoatrial pacemaker cell in the presence of anoxia and metabolic inhibitors. J Mol Cell Cardiol 9:477–488Google Scholar
  422. Koketsu K, Kitamura R, Tanaka R (1964) Binding of calcium ions to cell membrane isolated from bullfrog skeletal muscle. Am J Physiol 207:509–512Google Scholar
  423. Kondo S, Schulz I (1976a) Calcium ion uptake in isolated pancreas cells induced by secretagogues. Biochim Biophys Acta 419:76–92Google Scholar
  424. Kondo S, Schulz I (1976b) Ca++ fluxes in isolated cells of rat pancreas. Effect of secretagogues and different Ca++ concentrations. J Membr Biol 29:185–203Google Scholar
  425. Kostyuk PG, Krishtal OA (1977a) Separation of sodium and calcium currents in the somatic membrane of mollusc neurones. J Physiol (Lond) 270:545–568Google Scholar
  426. Kostyuk PG, Krishtal OA (1977b) Effects of calcium and calcium-chelating agents on the inward and outward current in the membrane of mollusc neurones. J Physiol (Lond) 270:569–580Google Scholar
  427. Krall JF, Swensen JL, Korenman SG (1976) Hormonal control of uterine contraction characterization of cyclic AMP-dependent membrane properties in the myometrium. Biochim Biophys Acta 448:578–588Google Scholar
  428. Krawitt EL, Kunin AS, Bettejayne FB (1976) Intestinal mitochondrial calcium uptake during adaptation to dietary calcium restriction. Calcif Tissue Res 21:129–133Google Scholar
  429. Krawitt EL, Stubbert PR (1972) The role of intestinal transport proteins in cortisone-mediated suppression of Ca2+ absorption. Biochim Biophys Acta 274:179–188Google Scholar
  430. Kretsinger RH (1979) The informational role of calcium in the cytosol. Adv Cyclic Nucl Res 11:1–26Google Scholar
  431. Kuntzinger H, Amiel C, Roinel N, Morel F (1974) Effects of parathyroidectomy and cyclic AMP on renal transport of phosphate, calcium, and magnesium. Am J Physiol 227:905–911Google Scholar
  432. Kurebe M (1978) Interaction of dibucaine and calcium ion on a calcium pump reconstituted from defined components of intestinal brush border. Mol Pharmacol 14:138–144Google Scholar
  433. Kurebe M (1979) Effect of lipid on the access of ATP and calcium to the delipidated Ca++-ATPase of intestinal brush border membrane. Life Sci 24:275–282Google Scholar
  434. Lacourt A (1971) Action post mortem du pH et de la temperature sur le captage de calcium et l'activité ATPasique du réticulum sarcoplasmique fragmenté du muscle bovin. Ann Biol Anim Bioch Biophys 11:681–694Google Scholar
  435. Lamb JF, Lindsay R (1971) Effect of Na, metabolic inhibitors and ATP on Ca movements in L cells. J Physiol (Lond) 218:691–708Google Scholar
  436. Lamb JF, McCall D (1972) Effect of prolonged ouabain treatment on Na, K, Cl and Ca concentration and fluxes in cultured human cells. J Physiol (Lond) 225(3):599–617Google Scholar
  437. Langer G, Poole-Wilson P (1977) The effect of acidosis and maganese on calcium exchange in the myocardium of the rabbit. J Physiol (Lond) 265:20Google Scholar
  438. Lassen UV, Nielsen AMT, Pape L, Simonsen LO (1971) The membrane potential of Ehrlich ascites tumor cells — microelectrode measurements and their critical evaluation. J Membr Biol 6:269–288Google Scholar
  439. Lassen UV, Sten-Knudsen O (1968) Direct measurements of membrane potential and membrane resistance of human red cells. J Physiol (Lond) 195:681–696Google Scholar
  440. Lazarewicz JW, Kanje M, Sellström A, Hamberger A (1977) Calcium fluxes in cultures and bulk isolated neuronal and glial cells. J Neurochem 29:495–502Google Scholar
  441. Lea TJ, Ashley CC (1978) Increase in free Ca2+ in muscle after exposure to CO2. Nature 275:236–238Google Scholar
  442. Lee KS, Shin BC (1969) Studies on the active transport of Ca++ in human red cells. J Gen Physiol 54:713–729Google Scholar
  443. Lehninger AL (1964) The mitochondrion. Benjamin, New YorkGoogle Scholar
  444. Lehninger AL (1970) Mitochondria and calcium ion transport. Biochem J 119:129–138Google Scholar
  445. Lehninger AL (1974a) Role of phosphate and other proton-donating anions in respiration coupled transport of calcium by mitochondria. Proc Natl Acad Sci USA 71:1520–1524Google Scholar
  446. Lehninger AL (1974b) Ca2+ transport by mitochondria and its possible role in the cardiac contraction-relaxation cycle. Circ Res 35(Suppl III):83–90Google Scholar
  447. Lehninger AL, Rossi CS, Greenwalt JW (1963) Respiration-dependent accumulation of inorganic phosphate and Ca++ by rat liver mitochondria. Biochem Biophys Res Commun 10:444–448Google Scholar
  448. Lehninger AL, Carafoli E, Rossi CS (1967) Energy-linked ion movements in mitochondrial systems. Adv Enzymol 29:259–320Google Scholar
  449. Lehninger AL, Reynafarje B, Vercesi A, Tew WP (1978a) Transport and accumulation of calcium mitochondria. Ann NY Acad Sci 307:160–176Google Scholar
  450. Lehninger AL, Vercesi A, Bababunmi ES (1978b) Regulation of Ca2+ release from mitochondria by the oxidation-reduction state of pyridine nucleotides. Proc Natl Acad Sci USA 75:1690–1694Google Scholar
  451. Lentz RW, Harrison CE Jr, Dewey JD, Barnhorst DA, Danielson GK, Pluth JR (1978) Functional evaluation of cardiac sarcoplasmic reticulum and mitochondria in human pathologic states. J Mol Cell Cardiol 10:3–30Google Scholar
  452. LePeuch CJ, Haiech J, Demaille JG (1979) Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate-dependent and calcium-calmodulin-dependent phosphorylation. Biochemistry 18:5150–5157Google Scholar
  453. Levinson C (1967) Calcium exchange in Ehrlich mouse ascites tumor cells. Biochim Biophys Acta 135:921–926Google Scholar
  454. Levinson C, Blumenson LE (1970) Calcium transport and distribution in Ehrlich mouse ascites tumor cells. J Cell Physiol 75:231–240Google Scholar
  455. Li CL, Shy GM, Wells J (1957) Some properties of mammalian skeletal muscle fibres with particular reference to fibrillation potentials. J Physiol (Lond) 135:522–535Google Scholar
  456. Locke F (1894) Notiz über den Einfluß physiologischer Kochsalzlösung auf die elektrische Erregbarkeit von Muskel und Nerv. Zentralbl für Physiologie 8:166Google Scholar
  457. Lolley RN (1963) The calcium content of isolated cerebral tissues and their steady state exchange of calcium. J Neurochem 10:665–676Google Scholar
  458. Loud AV (1962) A method for the quantitative estimation of cytoplasmic structures. J Cell Biol 15:481–487Google Scholar
  459. Lowe CU, Lehninger AL (1955) Oxidation and phosphorylation in liver mitochondria lacking “polymerized” ribonuclear acid. J Biophys Biochem Cytol 1:89–92Google Scholar
  460. Lowe CU, MacKinney D, Sarkaria D (1955) Effect of cortisone on rat liver mitochondria. J Biophys Biochem Cytol 1:237–244Google Scholar
  461. Lucas M, Schmid G, Kromao R, Löffler G (1978) Calcium metabolism and enzyme secretion in guinea pig pancreas. Uptake, storage and release of calcium in whole cells and mitochondrial and microsomal fractions. Eur J Biochem 85:609–619Google Scholar
  462. Lundberg A (1958) Electrophysiology of salivary glands. Physiol Rev 38:21–40Google Scholar
  463. Lupianez JA, Dileepan KN, Wagle SR (1979) Interrelationship of somatostatin, insulin and calcium in the control of gluconeogenesis in kidney cortex slices. Biochem Biophys Res Commun 90:1153–1158Google Scholar
  464. Luthra MG, Hildebrandt GR, Hanahan DJ (1976a) Studies on an activator of the (Ca++ + Mg++)-ATPase of human ery throcyte membranes. Biochim Biophys Acta 419:164–179Google Scholar
  465. Luthra MG, Hildenbrandt GR, Kim HD, Hanahan DJ (1976b) Observations on the (Ca++ + Mg++)ATPase activator found in various mammalian erythrocytes. Biochim Biophys Acta 419:180–186Google Scholar
  466. Lüttgau HC, Niedergerke R (1958) The antagonism between Ca and Na ions on the frog's heart. J Physiol (Lond) 143:486–505Google Scholar
  467. Lutwak-Mann C, McIntosh JEA (1971) Calcium content and uptake of 45Ca in rabbit blastocysts and their environment. J Reprod Fertil 27:471–475Google Scholar
  468. Luxoro M, Yanez E (1968) Permeability of the giant axon of Dosidicus gigas to calcium ions. J Gen Physiol 51:1115–1225Google Scholar
  469. Lynch TJ, Cheung WY (1979) Human erythrocyte Ca2+-Mg2+-ATPase: mechanisms of stimulation by Ca2+. Arch Biochem Biophys 194:165–170Google Scholar
  470. MacManus JP, Whitfield JF (1970) Inhibition by thyrocalcitonin of the mitogenic action of parathyroid hormone and cyclic adenosine 3′,5′-monophosphate on rat thymocytes. Endocrinology 86:934–939Google Scholar
  471. Malaisse WJ, Herchuelz A, Devis G, Somers G, Boschero AC, Hutton JC, Kawazu S, Sener A (1978) Regulation of calcium fluxes and their regulatory roles in pancreatic islets. Ann NY Acad Sci 307:562–581Google Scholar
  472. Malaisse-Lagae F, Malaisse WJ (1971) Stimulus-secretion coupling of glucose-induced insulin release. III. Uptake of 45calcium by isolated islets of Langerhans. Endocrinology 88:72–80Google Scholar
  473. Malmström K, Carafoli E (1977) The interaction of Ca2+ with mitochondria from human myometrium. Arch Biochem Biophys 182:657–666Google Scholar
  474. Martin BR, Clausen T, Gliemann J (1975) Relationships between the exchange of Ca++ and PO−24 in isolated fat cells. Biochem J 152:121–129Google Scholar
  475. Martin JH, Matthew JL (1970) Mitochondrial granules in chondrocytes osteoblasts and osteocytes. An ultrastructural and microincineration study. Clin Orth op 68:273–278Google Scholar
  476. Martonosi AN (1975) The mechanism of Ca2+ transport in sarcoplasmic reticulum. In: Carafoli E, Clementi F, Drabikowski W, Magreth A (eds) Calcium transport in contraction and secretion. North Holland, Amsterdam, pp 313–327Google Scholar
  477. Martonosi AN, Chyn TL, Schibeci A (1978) The calcium transport of sarcoplasmic reticulum. Ann NY Acad Sci 307:148–156Google Scholar
  478. Matlib A, O'Brien JP (1974) Adenosine 3′:5′-cyclic monophosphate stimulation of calcium efflux. Biochem Soc Trans 2:997–1000Google Scholar
  479. Matsushima Y, Gemba M (1979) Divalent cation transport in kidney slices. I. Properties of calcium transport in slices of rat kidney cortex and the effects of diuretics. Jpn J Pharmacol 29:367–374Google Scholar
  480. Matthews EK (1967) Membrane potential measurement in cells of the adrenal gland. J Physiol (Lond) 189:139–148Google Scholar
  481. Matthews EK (1975) Calcium and stimulus-secretion coupling in pancreatic islet cells. In: Carafoli E, Clementi F, Drabikowski W, Magreth A (eds) Calcium transport in contraction and secretion. North Holland, Amsterdam, pp 203–210Google Scholar
  482. Matthews EK, Petersen OH (1973) Pancreas acinar cells: ionic dependence of the membrane potential and acetylcholine-induced depolarization. J Physiol (Lond) 231:283–295Google Scholar
  483. Matthews EK, Saffran M (1967) Steroid production and membrane potential measurement in cells of the adrenal cortex. J Physiol (Lond) 189:149–161Google Scholar
  484. Matthews EK, Sakamoto Y (1975a) Electrical characteristics of pancreatic islet cells. J Physiol (Lond) 246:421–437Google Scholar
  485. Matthews EK, Sakamoto Y (1975b) Pancreatic islet cells: electrogenic and electrodiffusional control of membrane potential. J Physiol (Lond) 246:439–457Google Scholar
  486. Matthews EK, Petersen OH, Williams JA (1973) Pancreatic acinar cells: acetylcholine-induced membrane depolarization, calcium efflux and amylase release. J Physiol (Lond) 234:689–701Google Scholar
  487. Matthews JL, Martin JH, Sampson HW, Kunin AS, Roan JH (1970) Mitochondrial granules in the normal and rachitic rat epiphysis. Calcif Tissue Res 5:91–99Google Scholar
  488. May RJ, Conlon TP, Erspamer V, Gardner JD (1978) Actions of peptides isolated from amphibian skin on pancreatic acinar cells. Am J Physiol 235:E112–E118Google Scholar
  489. McDonald JM, Bruns DE, Jarett L (1976a) Ability of insulin to increase calcium binding by adipocyte plasma membranes. Proc Natl. Acad Sci USA 73:1542–1546Google Scholar
  490. McDonald JM, Bruns DE, Jarett L (1976b) The ability of insulin to alter the stable calcium pools of isolated adipocyte subcellular fractions. Biochem Biophys Res Commun 71:114–121Google Scholar
  491. McDonald JM, Bruns DE, Jarett L (1978) Ability of insulin to increase calcium uptake by adipocyte endoplasmic reticulum. J Biol Chem 253:3504–3508Google Scholar
  492. McLennan DH, Holland PC (1975) Calcium transport in sarcoplasmic reticulum. Ann Rev Biophys Bioengin 4:377–404Google Scholar
  493. McNaughton PA (1978) Calcium transport in excitable membranes. In: Morad M, Tabatabai M, Smith S (eds) Biophysical aspects of cardiac muscle. Academic Press, New York, pp 107–128Google Scholar
  494. Mears DC (1971) Effects of parathyroid hormone and thyrocalcitonin on the membrane potential of osteoblasts. Endocrinology 88:1021–1028Google Scholar
  495. Meech RW (1974) The sensitivity of Helix aspersa neurones to injected calcium ions. J Physiol (Lond) 237:259–277Google Scholar
  496. Meech RW, Standen NB (1975) Potassium activation in Helix aspersa neurones under voltage clamp: a component mediated by calcium influx. J Physiol (Lond) 249:211–239Google Scholar
  497. Meinertz T, Nawrath H, Scholz H (1973a) Dibutyryl cyclic AMP and adrenaline increase contractile force and 45Ca uptake in mammalian cardiac muscle. Naunyn Schmiedebergs Arch Pharmacol 277:107–112Google Scholar
  498. Meinertz T, Nawrath H, Scholz H (1973b) Stimulatory effects of DB-c-AMP and adrenaline on myocardial contraction and 45Ca exchange. Experiments at reduced calcium concentration and low frequencies of stimulation. Naunyn Schmiedebergs Arch Pharmacol 279:327–338Google Scholar
  499. Mela L (1968) Interaction of La+3 and local anesthetic drugs with mitochondrial Ca+2 and Mn+2 uptake. Arch Biochem Biophys 123:286–293Google Scholar
  500. Mela L (1969) Inhibition and activation of calcium transport in mitochondria. Effect of lanthanides and local anesthetic drugs. Biochemistry 8:2481–2486Google Scholar
  501. Mela L (1977) Mechanism and physiological significance of calcium transport across mammalian mitochondrial membranes. In: Bronner F, Kleinzeller A (eds) Current topics in membranes and transport, vol 9. Academic Press, New York, pp 321–366Google Scholar
  502. Mela L, Chance B (1969) Calcium carrier and the “high affinity calcium binding site” in mitochondria. Biochem Biophys Res Commun 35:556–559Google Scholar
  503. Melson GL, Chase LR, Aurbach GD (1970) Parathyroid hormone sensitive adenyl cyclase in isolated renal tubules. Endocrinology 86:511–518Google Scholar
  504. Miller BE, Nelson DL (1977) Calcium fluxes in isolated acinar cells from rat parotid. Effect of adrenergic and cholinergic stimulation. J Biol Chem 252:3629–3635Google Scholar
  505. Miller DJ, Moiescu DG (1976) The effects of very low external calcium and sodium concentration on cardiac contractile strength and calcium-sodium antagonism. J Physiol (Lond) 259:283–308Google Scholar
  506. Mitchell P (1966) Metabolic flow in the mitochondrial multiphase system: an appraisal of the chemi-osmotic theory of oxydative phosphorylation. In: Tager JM, Papa S, Quagliariello E, Slater EC (eds) Regulation of metabolic processes in mitochondria. Elsevier, Amsterdam, pp 65–85Google Scholar
  507. Mitchell P, Moyle J (1969) Estimation of membrane potential and pH difference across the cristae membrane of rat liver mitochondria. Eur J Biochem 7:471–484Google Scholar
  508. Moore CL (1971) Specific inhibition of mitochondrial Ca++ transport by ruthenium red. Biochem Biophys Res Commun 42:298–305Google Scholar
  509. Moore JW, Cole KS (1960) Resting and action potentials of squid giant axon in vivo. J Gen Physiol 43:961–970Google Scholar
  510. Moore L, Chen T, Knapp HR Jr, Landon EJ (1975) Energy dependent calcium sequestration activity in rat liver microsomes. J Biol Chem 250:4562–4568Google Scholar
  511. Moore L, Fitzpatrick DF, Chen TS, Landon EJ (1974) Calcium pump activity of the renal plasma membrane and renal microsomes. Biochim Biophys Acta 345:405–418Google Scholar
  512. Moore L, Pastan J (1977a) Regulation of intracellular calcium in chick embryo fibroblast: calcium uptake by the microsomal fraction. J Cell Physiol 91:289–296Google Scholar
  513. Moore L, Pastan I (1977b) Energy dependent calcium uptake in cultured mouse fibroblast microsomes. Regulation of the uptake system by cell density. J Biol Chem 252:6304–6309Google Scholar
  514. Moore L, Pastan I (1978) Energy dependent calcium uptake by fibroblast microsomes. Ann NY Acad Sci 307:177–193Google Scholar
  515. Morgenstern M, Noack E, Köhler E (1972) The effects of isoprenaline and tyramine on the 45calcium uptake, the total calcium content and the contraction force of isolated guinea pig atria in dependence on different extracellular hydrogen ion concentrations. Arch Pharmacol 274:125–137Google Scholar
  516. Moriarty CM (1977) Involvement of intracellular calcium in hormone secretion from rat pituitary cells. Mol Cell Endocrinol 6:349–361Google Scholar
  517. Moriarty CM (1980) Kinetic analysis of calcium distribution in rat anterior pituitary slices. Am J Physiol 238:E167–E173Google Scholar
  518. Moyle J, Mitchell P (1977a) Electric charge stoichiometry of calcium translocation in rat liver mitochondria. FEBS Lett 73:131–136Google Scholar
  519. Moyle J, Mitchell P (1977b) The lanthanide-sensitive calcium phosphate porter of rat liver mitochondria. FEBS Lett 77:136–140Google Scholar
  520. Mullins LJ (1976) Steady-state calcium fluxes: membrane versus mitochondrial control of ionized calcium in axoplasm. Fed Proc 35:2583–2588Google Scholar
  521. Mullins LJ (1977) A mechanism for Na/Ca transport. J Gen Physiol 70:681–695Google Scholar
  522. Mullins LJ, Brinley FJ Jr (1975) Sensitivity of calcium efflux from squid axons to changes in membrane potential. J Gen Physiol 65:135–152Google Scholar
  523. Mullins LJ, Requena J (1979) Calcium measurement in the periphery of an axon. J Gen Physiol 74:393–413Google Scholar
  524. Murad F, Brewer HB Jr, Vaughan M (1970) Effect of thyrocalcitonin on adenosine 3′,5′-cyclic phosphate formation by rat kidney and bone. Proc Natl Acad Sci 65:446–453Google Scholar
  525. Nagata N, Rasmussen H (1968) Parathyroid hormone and renal cell metabolism. Biochemistry 7:3728–3733Google Scholar
  526. Nagata N, Rasmussen H (1970) Parathyroid hormone, 3′–5′ AMP, Ca++ and renal gluconeogenesis. Proc Natl Acad Sci USA 65:368–374Google Scholar
  527. Nakamura Y, Schwartz A (1970) Possible control of in tracellular calcium metabolism by [H+]: sarcoplasmic reticulum of skeletal and cardiac muscle. Biochem Biophys Res Commun 41:830–836Google Scholar
  528. Nakamura Y, Schwartz A (1972) The influence of hydrogen ion concentration on calcium binding and release by skeletal muscle sarcoplasmic reticulum. J Gen Physiol 59:22–32Google Scholar
  529. Nanninga LB (1961a) The association constant of the complexes of adenosine triphosphate with magensium, calcium, strontium and barium ions. Biochim Biophys Acta 54:330–338Google Scholar
  530. Nanninga LB (1961b) Calculation of free magnesium, calcium and potassium in muscle. Biochim Biophys Acta 54:338–344Google Scholar
  531. Navickis RJ, Dial OK, Katzenellenbogen BS, Nalbandov AV (1979) Effect of gonadal hormones on calcium-binding protein in chick duodenum. Am J Physiol 237:E409–E417Google Scholar
  532. Nawrath H, TenEick RE, McDonald TF, Trautwein W (1977) On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium. Circ Res 40:408–414Google Scholar
  533. Nayler WG, Merrillees NCR, Chipperfield D, Kurtz JB (1971) Influence of hyperthyroidism on the uptake and binding of calcium by cardiac microsomal fractions and on mitochondrial structures. Cardiovasc Res 5:469–482Google Scholar
  534. Nayler WG, Poole-Wilson PA, Williams A (1979) Hypoxia and calcium. J Mol Cell Cardiol 11:683–706Google Scholar
  535. Nicholls DG (1974) The influence of respiration and ATP hydrolysis on the protonelectrochemical gradient across the inner membrane of rat liver mitochondria as determined by ion distribution. Eur J Biochem 50:305–315Google Scholar
  536. Nicholls DG (1978a) Calcium transport and proton electron chemical potential gradient in mitochondria from guinea pig cerebral cortex and rat heart. Biochem J 170:511–522Google Scholar
  537. Nicholls DG (1978b) The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria. Biochem J 176:463–474Google Scholar
  538. Nichols G Jr, Rogers P (1971) Mechanism for the transfer of calcium into and out of the skeleton. Pediatrics 47:211–228Google Scholar
  539. Niedergerke R (1963) Movements of Ca in beating ventricles of the frog heart. J Physiol (Lond) 167:551–580Google Scholar
  540. Niggli V, Ronner P, Carafoli E, Penniston JT (1979) Effect of calmodulin on the (Ca2+ + Mg2+) ATPase partially purified from erythrocyte membranes. Arch Biochem Biophys 198:124–130Google Scholar
  541. Nishikori K, Maeno H (1979) Close relationship between adenosine 3′,5′-monophosphate-dependent endogenous phosphorylation of a specific protein and stimulation of calcium uptake in rat uterine microsomes. J Biol Chem 254:6099–6106Google Scholar
  542. Nishikori K, Takenaka T, Maeno H (1977) Stimulation of microsomal calcium uptake and protein phosphorylation by adenosine cyclic 3′5′-monophosphate in rat uterus. Mol Pharmacol 13:671–678Google Scholar
  543. Noack EA, Heinen EM (1977) A kinetic study of calcium transport by heart mitochondria. Eur J Biochem 79:245–250Google Scholar
  544. Ogawa Y (1970) Some properties of fragmented frog sarcoplasmic reticulum with particular reference to its response to caffeine. J Biochem (Tokyo) 67:667–683Google Scholar
  545. Ohashi T, Uchida S, Nagai K, Yoshida H (1970) Studies on phosphate hydrolyzing activities in the synaptic membrane. J Biochem (Tokyo) 67:635–641Google Scholar
  546. Ohtsuki I (1969) ATP-dependent Ca uptake of brain microsomes. J Biochem (Tokyo) 66:645–650Google Scholar
  547. Okada Y, Ogawa M, Aoki N, Izutsu K (1973) The effect of K+ on the membrane potential in HeLa cells. Biochim Biophys Acta 291:116–126Google Scholar
  548. Oswald N, Binswanger U (1979) Proximal and distal intestinal calcium transport in vitro as influenced by low calcium diet, uremia, parathyroidectomy and 1,25-dihydroxycholecalciferol treatment in rats. Res Exp Med 175(1):19–30Google Scholar
  549. Otsuka M Ohtsuki I, Ebashi S (1965) ATP dependent Ca binding of brain microsome. J Biochem (Tokyo) 58:188–190Google Scholar
  550. Overton E (1904) Beiträge zur allgemeinen Muskel-und Nervenphysiologie. Pfluegers Arch 105:176–290Google Scholar
  551. Owen JD, Brown HM, Pemberton JP (1977) Neurophysiological applications of a calcium selective microelectrode. Anal Chim Acta 90:241–244Google Scholar
  552. Palek J, Curby WA, Lionetti FJ (1971) Relation of Ca++-activated ATPase to Ca++ linked shrinkage of human red cell ghosts. Am J Physiol 220:1028–1032Google Scholar
  553. Palmer RF, Posey VA (1970) Calcium and adenosine triphosphate binding to renal membranes. J Gen Physiol 55:89–103Google Scholar
  554. Panfili E, Sandri G, Sottocasa GL, Lunazzi G, Liut G, Graziosi G (1976) Specific inhibition of mitochondrial Ca2+ transport by antibodies directed to the Ca2+-binding glycoprotein. Nature 264:185–186Google Scholar
  555. Papworth DG, Patrick G (1970) The kinetics of influx of calcium and strontium into rat intestine in vitro. J Physiol (Lond) 210:999–1020Google Scholar
  556. Parker JC, Barritt GJ (1979) Effects of epinephrine on the subcellular distribution of exchangeable calcium in isolated rat heptaocytes. Proc Aust Biochem Soc 12:52Google Scholar
  557. Parkinson DK, Radde IC (1971) Properties of a Ca2+ and Mg2+-activated ATP hydrolyzing enzyme in rat kidney cortex. Biochim Biophys Acta 242:238–246Google Scholar
  558. Patriarca P, Carafoli E (1968) Study of the intracellular transport of calcium in rat heart. J Cell Physiol 72:29–38Google Scholar
  559. Pau B, Dornand J, Mani JC (1976) Etude critique de l'activité ATPase activée par Ca2+ ou Mg2+ des membranes plasmiques lymphocytaires. Biochimie 58:593–599Google Scholar
  560. Peachy LD (1964) Electron microscopic observations on the accumulation of divalent cations in intramitochondrial granules. J Cell Biol 20:95–108Google Scholar
  561. Peck WA, Carpenter K, Messinger K, DeBra D (1973) Cyclic 3′5′ adenosine monophosphate in isolated bone cells: response to low concentrations of parathyorid hormone. Endocrinology 92:692–697Google Scholar
  562. Perdue JF (1971) The isolation and characterization of plasma membranes from cultured cells. III. The adenosine triphosphate-dependent accumulation of Ca2+ by chick embryo fibroblasts. J Biol Chem 246:6750–6759Google Scholar
  563. Petersen OH, Iwatsuki N (1978) The role of calcium in pancreatic acinar cell stimulus-secretion coupling: an electrophysiological approach. Ann NY Acad Sci 307:599–617Google Scholar
  564. Petith MM, Wilson HD, Schedl HP (1979) Vitamin D dependence of in vivo calcium transport and mucosal calcium binding protein in rat large intestine. Gastroenterology 76:99–104Google Scholar
  565. Peug CF, Price DW, Bhuvaneswaran C, Wadkins CL (1974) Factors that influence phosphoenolpyruvate-induced calcium efflux from rat liver mitochondria. Biochem Biophys Res Commun 56:134–141Google Scholar
  566. Plishker G, Gitelman H (1976) Calcium transport in intact human erythrocytes. J Gen Physiol 68:29–41Google Scholar
  567. Pors-Nielsen S, Petersen OH (1972) Transport of calcium in the perfused submandibular gland of the cat. J Physiol (Lond) 223:685–697Google Scholar
  568. Portzehl H, Caldwell PC, Rüegg JC (1964) The dependence of contraction and relaxation of muscle fibres from the crab Maia squinado on the internal concentrations of free calcium ions. Biochim Biophys Acta 79:581–591Google Scholar
  569. Porzig H (1972) ATP-independent calcium net movements in human red cell ghosts. J Membr Biol 8:237–258Google Scholar
  570. Pozzan T, Bragadin M, Azzone GF (1977) Disequilibrium between steady-state Ca2+ accumulation ratio and membrane potential in mitochondria. Pathway and role of calcium efflux. Biochemistry 16:5618–5625Google Scholar
  571. Price JM, Miller EC, Miller JA (1948) The intracellular distribution of protein, nucleic acids, riboflavin and protein bound aminoazo dye in the liver of rats fed p-dimethylaminoazobenzene. J Biol Chem 173:345–353Google Scholar
  572. Price JM, Miller JA, Miller EC, Weber GM (1949) Studies on the intracellular composition of liver and liver tumor from rats fed 4-dimethylaminoazobenzene. Cancer Res 9:96–102Google Scholar
  573. Prince WT, Berridge MJ (1973) The role of calcium in the action of 5-hydroxytryptamine and cyclic AMP on salivary glands. J Exp Biol 58:367–384Google Scholar
  574. Prince WT, Berridge MJ, Rasmussen H (1972) Role of calcium and adenosine 3′:5′-cyclic monophosphate in controlling fly salivary gland secretion. Proc Natl Acad Sci USA 69:553–557Google Scholar
  575. Puskin JS, Gunter TE, Gunter KK, Russell PR (1976) Evidence for more than one Ca2+ transport mechanism in mitochondria. Biochemistry 15:3834–3842Google Scholar
  576. Quinn PJ, Dawson RMC (1972) The pH dependence of calcium absorption onto anionic phospholipid monolayers. Chem Phys Lipids 8:1–9Google Scholar
  577. Quist EE, Roufogalis BD (1975) Calcium transport in human erythrocytes starvation and reconstitution of high and low affinity (Mg + Ca) ATPase activities in membranes prepared at low ionic strength. Arch Biochem Biophys 168:240–251Google Scholar
  578. Quist EE, Roufogalis BD (1977) Association of (Ca + Mg)-ATPase activity with ATP-dependent Ca uptake in vesicles prepared from human erythrocytes. J Supramol Struct 6:375–381Google Scholar
  579. Raeymaekers L, Wuytack F, Casteels R (1973) Na-Ca exchange in smooth muscle cells of Taenia coli. Arch Int Pharmacodyn 204:196–197Google Scholar
  580. Rahamimoff H, Abramovitz E (1978) Calcium transport and ATPase activity of synaptosomal vesicles from rat brain. FEBS Lett 92:163–167Google Scholar
  581. Raisz LG, Trummel CL, Wener JA, Simmons H (1972) Effect of glucocorticoids on bone resorption in tissue culture. Endocrinology 90:961–967Google Scholar
  582. Rambourg A, Leblond CP (1967) Electron microscope observations on the carbohydrate-rich cell coat present at the surface of cells in the rat. J Cell Biol 32:27–53Google Scholar
  583. Rasmussen H (1966) Mitochondrial ion transport: mechanism and physiological significance. Fed Proc 25:903–911Google Scholar
  584. Rasmussen H (1970) Cell communication, calcium ion, and cyclic adenosine monophosphate. Science 170:404–412Google Scholar
  585. Rasmussen H (1971) Ionic and hormonal control of calcium homeostasis. Am J Med 50:567–588Google Scholar
  586. Rasmussen H, Bordier P (1974) The physiological and cellular basis of metabolic bone disease. Williams & Wilkins, BaltimoreGoogle Scholar
  587. Rasmussen H, Goodman DP (1977) Relationships between calcium and cyclic nucleotides in cell activation. Physiol Rev 57:421–509Google Scholar
  588. Rasmussen H, Jensen P, Lake W, Friedmann N, Goodman DBP (1975a) Cyclic nucleotides and cellular calcium metabolism. Adv Cyclic Nucleotide Res 5:375–394Google Scholar
  589. Rasmussen H, Lake W, Allen JE (1975b) The effect of catecholamines and prostaglandins upon human and rat erythrocytes. Biochim Biophys Acta 411:63–73Google Scholar
  590. Redmann K (1971) Messungen elektrischer Membranpotentiale kultivierter Einzelzellen mittels Mikroelektroden. Acta Biol Med Germ 27:55–68Google Scholar
  591. Redmann K, Stolte C, Lüders D (1967) Membranpotential-Messungen an KB-Zellkulturen. Naturwissenschaften 54:255Google Scholar
  592. Reed KC, Bygrave FL (1974a) The inhibition of mitochondrial calcium transport by lanthanides and ruthenium red. Biochem J 140:143–155Google Scholar
  593. Reed K, Bygrave F (1974b) A reevaluation of energy-independent calcium ion binding by rat liver mitochondria. Biochem J 142:535–566Google Scholar
  594. Reed KC, Bygrave FL (1974c) Accumulation of lanthanum by rat liver mitochondria. Biochem J 138:239–252Google Scholar
  595. Reed KC, Bygrave LF (1975a) Methodology for in vitro studies of Ca2+ transport. Anal Biochem 67:44–54Google Scholar
  596. Reed KC, Bygrave FL (1975b) A kinetic study of mitochondrial calcium transport. Eur. J Biochem 55:497–504Google Scholar
  597. Reed PW (1977) Calcium ionophore activity of prostaglandin endoperoxides and stabilized analogs of prostaglandin H-2. Fed Proc 36:673Google Scholar
  598. Renckens BAM, Schrijen JJ, Swarts HGP, De Pont JJHHM, Bonting SL (1978) Role of calcium in exocrine pancreatic secretion. IV. Calcium movements in isolated acinar cells of rabbit pancreas. Biochim Biophys Acta 544:338–350Google Scholar
  599. Repke DI, Katz AM (1972) Calcium binding and calcium uptake by cardiac microsomes: a kinetic analysis. J Mol Cell Cardiol 4:401–416Google Scholar
  600. Requena J (1978) Calcium efflux from squid axons under constant sodium electrochemical gradient. J Gen Physiol 72:443–470Google Scholar
  601. Requena J, DiPolo R, Brinley FJ, Mullins LJ (1977) The control of ionized calcium in squid axon. J Gen Physiol 70:329–353Google Scholar
  602. Requena J, Mullins LJ (1979) Calcium movements in nerve fibers. Q Rev Biophys 12:371–460Google Scholar
  603. Requena J, Mullins LJ, Brinley FJ Jr (1979) Calcium content and net fluxes in squid giant axons. J Gen Physiol 73:327–342Google Scholar
  604. Reuter H (1967) The dependence of slow inward current in Purkinje fibres on the extracellular calcium concentration. J Physiol (Lond) 192:479–492Google Scholar
  605. Reuter H (1970) Calcium transport in cardiac muscle. In: Bolis L (ed) Permeability and function of biological membranes. North Holland, Amsterdam, pp 342–347Google Scholar
  606. Reuter H (1973) Divalent cations as charge carriers in excitable membranes. Prog Biophys Mol Biol 26:1–43Google Scholar
  607. Reuter H (1974a) Exchange of calcium ions in the mammalian myocardium: mechanisms and physiological significance. Circ Res 34:599–605Google Scholar
  608. Reuter H (1974b) Localization of β-adrenergic receptors and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle. J Physiol (Lond) 242:429–451Google Scholar
  609. Reuter H (1979) Properties of two inward membrane currents in the heart. Annu Rev Physiol 41:413–424Google Scholar
  610. Reuter H, Blaustein MP, Haeusler G (1973) Na-Ca exchange and tension development in arterial smooth muscle. Philos Trans R Soc Lond (Biol) 265:87–94Google Scholar
  611. Reuter H, Scholz H (1977a) A study of the ion selectivity and the kinetic properties of the calcium dependent slow inward current in mammalian cardiac muscle. J Physiol (Lond) 264:17–47Google Scholar
  612. Reuter H, Scholz H (1977b) The regulation of the calcium conductance of cardiac muscle by adrenaline. J Physiol (Lond) 264:49–62Google Scholar
  613. Reuter H, Seitz N (1968) The dependence of calcium efflux from cardiac muscle on temperature and external ion composition. J Physiol (Lond) 195:451–470Google Scholar
  614. Reynafarje B, Lehninger AL (1969) High affinity and low affinity binding of Ca++ by rat liver mitochondria. J Biol Chem 244:584–593Google Scholar
  615. Reynafarje BL, Lehninger AL (1973) Ca2+ transport by mitochondria from L-1210 mouse ascites tumor cells. Proc Natl Acad Sci USA 70:1744–1748Google Scholar
  616. Ringer S (1883) A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J Physiol (Lond) 4:29–49Google Scholar
  617. Rink TJ (1977) The influence of sodium on calcium movement and catecholamine release in thin slices of bovine adrenal medulla. J Physiol (Lond) 266:297–325Google Scholar
  618. Robblee LS, Shepro D, Belamarich FA (1973) Calcium uptake and associated ATPase activity of isolated platelets membranes. J Gen Physiol 61:462–481Google Scholar
  619. Robinson JD, Lust WD (1968) Adenosine triphosphate-dependent calcium accumulation by brain microsomes. Arch Biochem Biophys 125:286–294Google Scholar
  620. Rodan GA, Feinstein MB (1976) Interrelationships between Ca++ and adenylate cyclase in the control of platelet secretion and aggregation. Proc Natl Acad Sci USA 73(6):1829–1833Google Scholar
  621. Rodan S, Rodan G (1974) The effect of parathyroid hormone and thyrocalcitonin on the accumulation of cyclic adenosine 3′,5′-monophosphate in freshly isolated bone cells. J Biol Chem 249:3068–3074Google Scholar
  622. Rodesch F, Bogaert C, Dumont JE (1976) Compartmentalization and movements of calcium in the thyroid. Mol Cell Endocrinol 5:303–313Google Scholar
  623. Rojas E, Taylor RE (1975) Simultaneous measurements of magnesium, calcium and sodium influxes in perfused giant axons under membrane potential control J Physiol (Lond) 252:1–27Google Scholar
  624. Romero P, Whittam R (1971) The control by internal calcium of membrane permeability to sodium and potassium. J Physiol (Lond) 214:481–507Google Scholar
  625. Ronner P, Gazzotti P, Carafoli E (1977) A lipid requirement for the (Ca2+ + Mg2+) activated ATPase of erythrocyte membranes. Arch Biochem Biophys 179:578–583Google Scholar
  626. Roos I, Crompton M, Carafoli E (1978) The effect of phosphoenolpyruvate on the retention of calcium by liver mitochondria. FEBS Lett 94:418–421Google Scholar
  627. Rorive G, Kleinzeller A (1972) The effect of ATP and Ca2+ on the cell volume in isolated kidney tubules. Biochim Biophys Acta 274:226–239Google Scholar
  628. Rose B, Lowenstein WR (1975) Calcium ion distribution in cytoplasm visualized by aequorin. Diffusion in the cytosol is restricted due to energized sequestring. Science 190:1204–1206Google Scholar
  629. Ross DH, Cardenas HL (1979) Nerve cell calcium as a messenger for opiate and endorphin action. In: Loh HH, Ross PH (eds) Neurochemical mechanisms of opiates and endorphins. Raven Press, New York. (Advances in biochemical psychopharmacology, vol 20, pp 301–338)Google Scholar
  630. Rossi C, Azzi A, Azzone GF (1967) Ion transport in liver mitochondria. I Metabolism-independent Ca++ binding and H+ release. J Biol Chem 242:951–957Google Scholar
  631. Rossi CS, Bielawski J, Carafoli E, Lehninger AL (1966) The relationship of the Ca++ efflux rate to the “super-stoichiometry” of respiration-linked Ca++ accumulation by mitochondria. Biochem Biophys Res Commun 22:206–210Google Scholar
  632. Rossi CS, Lehninger A (1974) Stoichiometry of respiratory stimulation, accumulation of Ca++ and phosphate, and oxidative phosphorylation in rat liver mitochondria. J Biol Chem 239:3971–3980Google Scholar
  633. Rossi JPFC, Garrahan PJ, Rega AF (1978) Reversal of the calcium pump in human red cells. J Membr Biol 44:37–46Google Scholar
  634. Rottenberg H (1973) The mechanism of energy-dependent ion transport in mitochondria. J Membr Biol 11:117–137Google Scholar
  635. Rottenberg H, Scarpa A (1974) Calcium uptake and membrane potential in mitochondria. Biochemistry 13:4811–4817Google Scholar
  636. Roulet MJ, Mongo KG, Vassort G, Ventura-Clapier R (1979) The dependence of twitch relaxation and sodium ions and on internal Ca2+ stores in voltage clamped frog atrial fibres. Eur J Physiol 379:259–268Google Scholar
  637. Rubanyi G, Kovach AGB (1979) Effect of ovarian steroid hormones on superficial activator calcium in the rabbit uterus. Acta Physiol Acad Sci Hung 53:71–80Google Scholar
  638. Rubin RP (1974) Calcium and the secretory process. Plenum, New YorkGoogle Scholar
  639. Ruigrok JC, Elbers PF (1972) The effects of calcium acetate on mitochondria in the perfused rat liver. I. Accumulation of Ca++ and concomitant swelling. Cytobiologie 5:51–64Google Scholar
  640. Russell JM, Blaustein MP (1974) Calcium efflux from barnacle muscle fibres: depenon external cations. J Gen Physiol 63:144–167Google Scholar
  641. Russell JM, Blaustein MP (1975) Calcium fluxes in internally dialyzed giant barnacle muscle fibres. J Membr Biol 23:157–179Google Scholar
  642. Sandri G, Panfili E, Sottocasa GL (1976) The calcium-binding glycoprotein and mitochondrial calcium movements. Biochem Biophys Res Commun 68:1272–1279Google Scholar
  643. Sarkadi B, MacIntyre JD, Gardos G (1978) Kinetics of active calcium transport in inside-out red cell membrane vesicles. FEBS Lett 89:78–82Google Scholar
  644. Sarkadi B, Szasz I, Gerlocozy A, Gardos G (1977) Transport parameters and stoichiometry of active calcium ion extrusion in intact human red cells. Biochim Biophys Acta 464:93–107Google Scholar
  645. Sayegh FS, Davis RW, Solomon GC (1974) Mitochondrial role in cellular mineralization. J Dent Res 53:581–587Google Scholar
  646. Scarpa A (1975) Kinetic and energy-coupling of Ca++ transport in mitochondria. In: Carafoli E, Clementi F, Drabikowski W, Magreth A (eds) Calcium transport in contraction and secretion. North Holland, Amsterdam, pp 65–76Google Scholar
  647. Scarpa A, Azzi A (1968) Cation binding to submitochondrial particles. Biochim Biophys Acta 150:473–481Google Scholar
  648. Scarpa A, Azzone G (1970) The mechanism of ion translocation in mitochondria. Eur J Biochem 12:328–335Google Scholar
  649. Scarpa A, Graziotti P (1973) Mechanisms for intracellular calcium regulation in heart. J Gen Physiol 62:756–772Google Scholar
  650. Scarpa A, Malmström K, Chiesi M, Carafoli E (1976) On the problem of the release of mitochondrial calcium by cyclic AMP. J Membr Biol 29:205Google Scholar
  651. Scarpa A, Brinley FJ, Dubyak G (1978a) Antipyrylazo, III, a “middle range” Ca2+ metallochromic indicator. Biochemistry 17:1378–1386Google Scholar
  652. Scarpa A, Brinley FJ, Tiffert T, Dubyak GR (1978b) Metallochromic indicators of ionized calcium. Annal NY Acad Sci 307:86–112Google Scholar
  653. Schanne O, Coraboeuf E (1966) Potential and resistance measurements of rat liver cells in situ. Nature 210:1390–1391Google Scholar
  654. Scharf O (1976) Ca+2 activation of membrane-bound (CA+2+Mg+2)-dependent ATPase from human erythrocytes prepared in the presence or absence of Ca+2. Biochim Biophys Acta 443:206–218Google Scholar
  655. Scharf O, Foder B (1978) Reversible shift between two states of Ca-ATPase in human erythrocytes mediated by Ca+2 and a membrane bound activator. Biochim Biophys Acta 509:67–77Google Scholar
  656. Schatzmann HJ (1966) ATP dependent Ca2+-extrusion from human red cells. Experientia 22:364–365Google Scholar
  657. Schatzmann HJ (1970) Transmembrane calcium movements in released human red cells. In: Cuthbert AW (ed) Calcium and cellular function. Macmillan, London, pp 85–95Google Scholar
  658. Schatzmann HJ (1973) Dependence on calcium concentration and stoichiometry of the calcium pump in human red cells. J Physiol (Lond) 235:551–569Google Scholar
  659. Schatzmann HJ (1975) Active calcium transport and Ca2+-activated ATPase in human red cells. In: Bronner F, Kleinzeller A (eds) Current topics in membranes and transport, vol 6, pp 125–168Google Scholar
  660. Schatzmann HJ (1977) Role of magnesium in the (Ca+2+Mg+2)-stimulated membrane ATPase of human red blood cells. J Membr Biol 35:149–158Google Scholar
  661. Schatzmann HJ, Rossi GL (1971) (Ca2++Mg2+)-activated membrane ATPases in human red cells and their possible relations to cation transport. Biochim Biophys Acta 241:379–392Google Scholar
  662. Schatzmann HJ, Vincenzi FJ (1969) Calcium movements across the membrane of human red cells. J Physiol (Lond) 201:369–395Google Scholar
  663. Schinger Z, Naim E, Lasser M (1970) ATP-dependent calcium uptake by microsomal preparation from rat parotid and submaxillary glands. Biochim Biophys Acta 203:326–334Google Scholar
  664. Schneider WC, Hogeboom GH (1951) Cytochemical studies of mammalian tissues: the isolation of cell components by differential centrifugation: a review. Cancer Res 11:1–22Google Scholar
  665. Schneider WC, Hogeboom GH, Shelton E, Striebich MJ (1953) Enzymatic and chemical studies on the liver and liver mitochondria of rats fed 2-methyl-or 3′-methyl-4-dimethylaminoazobenzene. Cancer Res 13:285–288Google Scholar
  666. Schneyer LH, Schneyer CA (1965) Membrane potentials of salivary gland cells of rat. Am J Physiol 209:1304–1310Google Scholar
  667. Schotland J, Mela L (1977) Role of cyclic nucleotides in the regulation of mitochondrial calcium uptake and efflux kinetics. Biochem Biophys Res Commun 75:920–924Google Scholar
  668. Schraer R, Elder JA, Schraer H (1973) Aspects of mitochondrial function in calcium movement and calcification. Fed Proc 32:1938–1943Google Scholar
  669. Schreurs VVAM, Swarts HGP, De Pont JJHHM, Bontin SL (1976) Role of calcium in exocrine pancreatic secretion. II. Comparison of the effects of carbachol and the ionophore A-23187 on enzyme secretion and calcium movements in rabbit pancreas. Biochim Biophys Acta 419:320–330Google Scholar
  670. Schrier SL, Bensch KG, Johnson M, Junga I (1975) Energized endocytes in human erythrocyte ghosts. J Clin Invest 56:8–22Google Scholar
  671. Schudt C, Gaertner U, Pette D (1976) Insulin action on glucose transport and calcium fluxes in developing muscles cells in vitro. Eur J Biochem 689:103–111Google Scholar
  672. Schulman H, Greengard P (1978) Ca2+-dependent protein phosphorylation system in membranes from various tissues and its activation by “calcium-dependent regulator”. Proc Natl Acad Sci USA 75:5432–5436Google Scholar
  673. Schulz I, Kondo S, Sachs G, Milutinović S (1977) The role of Ca++ in pancreatic enzyme secretion. In: Bonfils S, Fromageot P, Rosselin G (eds) Hormonal receptors in digestive tract physiology. North Holland, Amsterdam, pp 275–288Google Scholar
  674. Schulz I, Stolze HH (1980) The exocrine pancreas: the role of secretagogues, cyclic nucleotides, and calcium in enzyme secretion. Annu Rev Physiol 42:127–156Google Scholar
  675. Schuster SM, Olson MS (1974) Studies of the energy-dependent uptake of divalent metal ions by beef heart mitochondria. J Biol Chem 249:7151–7158Google Scholar
  676. Sehlin J (1976) Calcium uptake by subcellular fractions of pancreatic islets: effects of nucleotides and theophylline. Biochem J 156:63–69Google Scholar
  677. Sekiya T (1962) Studies on the membrane potential of Ehrlich ascites tumor cell. Gann 53:41–57Google Scholar
  678. Selinger Z, Naim E, Lasser M (1970) ATP-dependent calcium uptake by microsomal preparation from rat parotid and submaxillary glands. Biochim Biophys Acta 203:326–334Google Scholar
  679. Silbergeld EK (1977) Na+ regulates release of Ca++ sequestered in synaptosomal mitochondria. Biochem Biophys Res Commun 77:464–469Google Scholar
  680. Simonsen L, Christoffersen GRJ (1979) Intracellular Ca2+ activity in Helix neurons: effects of extracellular Ca2+, H+, Na+ and N3. Comp Biochem Physiol (A) 63:615–618Google Scholar
  681. Singh M (1979) Calcium and cyclic nucleotide interaction in secretion of amylase from rat pancreas in vitro. J Physiol (Lond) 296:159–176Google Scholar
  682. Smith TC, Mikiten TM, Levinson C (1972) The effect of multivalent cations on the membrane potential of the Ehrlich ascites tumor cell. J Cell Physiol 79:117–126Google Scholar
  683. Soderling TR, Hickenbottom JP (1970) Inactivation of glycogen synthetase and activation of phosphorylase b kinase by the same cyclic 3′-5′-AMP dependent kinase. Fed Proc 29:601Google Scholar
  684. Solaro RJ (1972) Cardiac contractility: a problem in calcium conservation. Doctoral Thesis, Univ Pittsburgh School of MedicineGoogle Scholar
  685. Solaro RJ, Briggs FN (1974) Estimating the function capabilities of sarcoplasmic reticulum in cardiac muscle — calcium binding. Circ Res 34:531–540Google Scholar
  686. Sordahl LA (1974) Effect of magnesium, ruthenium red and the antibiotic ionophore A23187 on initial rates of calcium uptake by heart mitochondria. Arch Biochem Biophys 167:104–115Google Scholar
  687. Sorensen MM, DeMeis L (1977) Effects of anions, pH and magnesium on calcium accumulation and release by sarcoplasmic reticulum. Biochim Biophys Acta 465:210–223Google Scholar
  688. Sottocasa GL, Sandri G, Panfili E, de Bernard B (1971) A glycoprotein located in the membrane space of rat liver mitochondria. FEBS Lett 17:100–105Google Scholar
  689. Sottocasa GL, Sandri G, Panfili E, de Bernard B, Gazzotti P, Vasington FD, Carafoli E (1972) Isolation of a soluble Ca2+ binding glycoprotein from ox liver mitochondria. Biochem Biophys Res Commun 47:808–813Google Scholar
  690. Spencer T, Bygrave FL (1973) The role of mitochondria in modifying the cellular ionic environment: studies of the kinetic accumulation of calcium by rat liver mitochondria. Bioenergetics 4:347–362Google Scholar
  691. Sperelakis N (1962) Ca4 5 and Sr8 9 movements with contraction of depolarized smooth muscle. Am J Physiol 203:860–866Google Scholar
  692. Sperelakis N, Schneider JA (1976) A metabolic control mechanism for calcium ion influx that may protect the ventricular myocardial cell. Am J Cardiol 37:1079–1085Google Scholar
  693. Stahl WL, Swanson PD (1969) Uptake of calcium by subcellular fractions isolated from ouabain treated cerebral tissues. J Neurochem 16:1553–1563Google Scholar
  694. Stahl WL, Swanson PD (1971) Movements of calcium and other cations in isolated cerebral tissues. J Neurochem 18:415–427Google Scholar
  695. Stahl WL, Swanson PD (1972) Calcium movements in brain slices in low sodium or calcium media. J Neurochem 19:2395–2407Google Scholar
  696. Stallcup WB (1979) Sodium and calcium fluxes in a clonal nerve cell line. J Physiol (Lond) 286:525–540Google Scholar
  697. Steiner M, Tateishi T (1974) Distribution and transport of calcium in human platelets. Biochim Biophys Acta 367:232–246Google Scholar
  698. Steinhardt R, Zucker R, Schatten G (1977) Intracellular calcium release at fertilization in the sea urchin egg. Dev Biol 58:185–196Google Scholar
  699. Stern PH (1969) Inhibition by steroids of parathyroid hormone-induced 4 5Ca release from embryonic rat bone in vitro. J Pharmacol Exp Ther 168:211–217Google Scholar
  700. Stinnakre J, Tauc L (1973) Calcium influx in active Aplysia neurones detected by injected aequorin. Nature (New Biol) 242:113–115Google Scholar
  701. Streter FA (1969) Temperature, pH and seasonal dependence of Ca-uptake and ATPase activity of white and red muscle microsomes. Arch Biochem Biophys 134:25–33Google Scholar
  702. Striebich MJ, Shelton E, Schneider WC (1953) Quantitative morphological studies on the livers and liver homogenates of rats fed 2-methyl-or 3'methyl-4-dimethylaminoazobenzene. Cancer Res 13:279–284Google Scholar
  703. Strittmatter WJ, Hirata F, Axelrod J (1979) Increased Ca2+-ATPase activity associated with methylation of phospholipids in human erythrocytes. Biochem Biophys Res Commun 88:147–153Google Scholar
  704. Struyvenberg A, Morrison R, Relman A (1968) Acid-base balance of separated canine renal tubule cells. Am J Physiol 214:1155–1162Google Scholar
  705. Stucki JW, Ineichen EA (1974) Energy dissipation by calcium recycling and the efficiency of calcium transport in rat liver mitochondria. Eur J Biochem 48:365–375Google Scholar
  706. Studer RK (1978) The influence of hydrogen ion on calcium metabolism of renal cell. Ph.D. Thesis, University of PittsburghGoogle Scholar
  707. Studer RK, Borle AB (1979) Effect of pH on the calcium metabolism of isolated rat kidney cells. J Membr Biol 48:325–341Google Scholar
  708. Studer RK, Borle AB (1980) The effect of hydrogen ion on the kinetics of calcium transport by rat kidney mitochondria. Arch Biochem Biophys 203:707–718Google Scholar
  709. Sugden MC, Christie MR, Ashcroft SJH (1979) Presence and possible role of calcium-dependent regulator (calmodulin) in rat islets of Langerhans. FEBS Lett 105:95–100Google Scholar
  710. Suko J (1971) Alterations of Ca2+ uptake and Ca2+-activated ATPase of cardiac sarcoplasmic reticulum in hyper-and hypothyroidism. Biochim Biophys Acta 252:324–327Google Scholar
  711. Sulakhe PV, Drummond GI, Ng DC (1973) Calcium binding by skeletal muscle sarcolemma. J Biol Chem 248:4150–4157Google Scholar
  712. Sullivan WJ (1968) Electrical potential differences across distal renal tubules of Amphiuma. Am J Physiol 214:1096–1103Google Scholar
  713. Sutfin LV, Holtrop ME, Oglivie RE (1971) Microanalysis of individual mitochondrial granules with diameters less than 1000 angstroms. Science 174:947–949Google Scholar
  714. Swanson PD, Anderson L, Stahl WL (1974) Uptake of calcium ions by synaptosomes from rat brain. Biochim Biophys Acta 356:174–183Google Scholar
  715. Swift MR, Todaro GJ (1968) Membrane potential of human fibroblast strains in culture. J Cell Physiol 71:61–64Google Scholar
  716. Szasz I, Sarkodi B, Gardos G (1977) Mechanism of Ca2+-dependent selective rapid K+-transport induced by propranolol in red cells. J Membr Biol 35:75–93Google Scholar
  717. Szasz I, Sakardi B, Gardos G (1978) Mechanisms for passive calcium transport in human red cells. Acta Biochim Biophys Acta Sci Hung 13:239–242Google Scholar
  718. Tada M, Kirchberger MA, Repke DI, Katz AM (1974) The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3′5′-monophosphate-dependent protein kinase. J Biol Chem 249:6174–6180Google Scholar
  719. Tada M, Yamamoto T, Tonomura Y (1978) Molecular mechanism of active calcium transport by sarcoplasmic reticulum. Physiol Rev 58:1–79Google Scholar
  720. Tashmukhamedov BA, Gagelgans AI, Mamatkulov K, Makhmodova EM (1972) Inhibition of Ca2+ transport in mitochondria by selective blockade of membrane mucopolysaccharides by hexamine cobaltichloride. FEBS Lett 28:239–242Google Scholar
  721. Ten Eick R, Nawrath H, McDonald TF, Trautwein W (1976) On the mechanism of the negative inotropic effect of acetylcholine. Pfluegers Arch 361:207–213Google Scholar
  722. Terepka AF, Stewart ME, Merkel U (1969) Transport functions of the chick chorioallantoic membrane. II. Active calcium transport in vitro. Exp Cell Res 58:107–117Google Scholar
  723. Thiers RE, Villee BL (1957) Distribution of metals in subcellular fractions of rat liver. J Biol Chem 226:911–920Google Scholar
  724. Thiers RE, Reynolds ES, Villee BL (1960) The effect of carbon tetrachloride poisoning on subcellular metal distribution in rat liver. J Biol Chem 235:2130–2133Google Scholar
  725. Thorens S (1979) Ca2+-ATPase and Ca uptake without requirement for Mg2+ in membrane fractions of vascular smooth muscle. FEBS Lett 98:177–180Google Scholar
  726. Thorens S, Haeusler G (1978) Effects of adenosine 3′:5′-monophosphate and guanosine 3′:5′-monophosphate on calcium uptake and phosphorylation in membrane fractions of vascular smooth muscle. Biochim Biophys Acta 512:415–428Google Scholar
  727. Thorne RFW, Bygrave FL (1975) Kinetic evidence for calcium-ion and phosphate-ion transport systems in mitochondria from Ehrlich ascites tumour cells. FEBS Lett 56:185–188Google Scholar
  728. Ting A, Lee JW, Vidaver GA (1979) Calcium transport by pigeon erythrocyte membrane vesicles. Biochim Biophys Acta 555:239–248Google Scholar
  729. Tobias JM, Agin DP, Pawlowski R (1962) The excitable system in the cell surface. Circulation 26:1145–1150Google Scholar
  730. Tower DB (1968) Ouabain and the distribution of calcium and magnesium in cerebral tissues in vitro. Exp Brain Res 6:273–283Google Scholar
  731. Trautwein W (1975) Membrane currents in cardiac muscle fibers. Physiol Rev 53:793–835Google Scholar
  732. Trotta EE, DeMeis L (1975) ATP-dependent calcium accumulation in brain microsomes. Enhancement by phosphate and oxalate. Biochim Biophys Acta 394:239–247Google Scholar
  733. Tsien RW (1977) Cyclic AMP and contractile activity in heart. Adv Cyclic Nucl Res 8:364–420Google Scholar
  734. Tsokos J, Sans R, Bloom S (1977) Ca2+ uptake by hyperpermeable mouse heart cells: effects of inhibitors of mitochondrial function. Life Sci 20:1913–1922Google Scholar
  735. Tsumura Y, Kagawa S, Yoshika K, Koboyashi K, Matsuoka A (1979) Insulin release and metabolism of calcium, adenine and adenine 3′-5′ cyclic monophosphate. Endoorinol Jpn 26:359–370Google Scholar
  736. Tupper JT, Zorgniotti F (1977) Calcium content and distribution as a function of growth and transformation in the mouse 3T3 cell. J Cell Biol 75:12–22Google Scholar
  737. Uchikawa T, Borle AB (1978a) Kinetic analysis of calcium desaturation curves from isolated kidney cells. Am J Physiol 234:R29–R33Google Scholar
  738. Uchikawa T, Borle AB (1978b) Studies of calcium-45 desaturation from kidney slices in flow-through chambers. Am J Physiol 234:R34–R38Google Scholar
  739. Umbreit W, Burris RH, Stauffer JF (1964) Manometric techniques, 4th ed. Burgess, Minneapolis, pp 132Google Scholar
  740. Vaes (1968) Parathyroid hormone-like action of N6-2′-0-dibutyryladenosine-3′,5′ (cyclic) monophosphate on bone explant in tissue culture. Nature 219:939–940Google Scholar
  741. Vallieres J, Scarpa A, Somlyo AP (1975) Subcellular fractions of smooth muscle. Isolation, substrate utilization and calcium transport by main pulmonary artery and mesenteric vein mitochondria. Arch Biochem Biophys 120:659–669Google Scholar
  742. Van Breemen C, Aaronson P, Loutzenhiser R (1978) Sodium calcium interactions in mammalian smooth muscle. Pharmacol Rev 30:167–208Google Scholar
  743. Van Breemen C, Daniel EE, Van Breemen D (1966) Calcium distribution and exchange in the rat uterus. J Gen Physiol 49:1265–1297Google Scholar
  744. Van Breemen C, Farinas BR, Casteels R, Gerba B, Wuytack F, Deth R (1973) Factors controlling cytoplasmic Ca2+ concentration. Philos Trans R Soc Lond (Biol) 265:57–71Google Scholar
  745. Van Breemen C, Farinas BR, Gerba P, McNaughton ED (1972) Excitation-contraction coupling in rabbit aorta studied by the lanthanum method for measuring cellular calcium influx. Circ Res 30:44–54Google Scholar
  746. Van Breemen C, McNaughton E (1970) The separation of cell membrane calcium transport from extracellular calcium exchange in vascular smooth muscle. Biochem Biophys Res Commun 39:567–574Google Scholar
  747. Van Breemen C, Hwang O, Siegel B (1977) The lanthanum method. In: Casteels R, Goodfraind T, Rüegg JC (eds) Excitation-contraction coupling in smooth muscle. Elsevier/North Holland, Amsterdam, pp 243–252Google Scholar
  748. Van Rossum GDV (1970) Net movements of calcium and magnesium in slices of rat liver. J Gen Physiol 55:18–32Google Scholar
  749. Van Rossum GVD, Gosalvez M, Galeotti T, Morris HP (1971) Net movements of monovalent and bivalent cations and their relation to energy metabolism in slices of hepatoma 3924A and of a mammary tumour. Biochim Biophys Acta 245:263–276Google Scholar
  750. Vasington FD, Gazzotti P, Tiozzo R, Carafoli E (1972) The effect of ruthenium red on Ca2+ transport and respiration in rat liver mitochondria. Biochim Biophys Acta 256:43–54Google Scholar
  751. Vasington FD, Greenawalt JW (1964) Ca++ and Pi uptake by non-phosphorylating mitochondrial preparations. Biochem Biophys Res Commun 15:133–138Google Scholar
  752. Vassalle M (1979) Electrogenesis of the plateau and pacemaker potential. Annu Rev Physiol 41:425–440Google Scholar
  753. Vassort G, Rougier O, Garnier D, Sanviat MP, Coraboeuf E, Gardouil YM (1969) Effects of adrenalin on membrane inward currents during the cardiac action potential. Pfluegers Arch 309:70–81Google Scholar
  754. Vaughan-Williams EM (1959) The effect of changes in extracellular potassium concentration on the intracellular potentials of isolated rabbit atria. J Physiol (Lond) 146:411–427Google Scholar
  755. Veloso D, Guynn RW, Oskarsson M, Veech I (1973) The concentration of free and bound magnesium in rat tissues. J Biol Chem 248:4811–4819Google Scholar
  756. Vincenzi FF (1971) A calcium pump in red cell membranes. In: Nichols G Jr, Wasserman RH (eds) Cellular mechanisms for calcium transfer and homeostasis. Academic Press, New York, pp 135Google Scholar
  757. Vincenzi FF (1979) Calmodulin in the regulation of intracellular calcium. Proc West Pharmacol Soc 22:289–294Google Scholar
  758. Vincenzi FF, Farrance ML (1977) Interaction between cytoplasmic (Ca2+ — Mg2+) ATPase activator and erythrocyte membrane. J Supramol Struc 7:301–306Google Scholar
  759. Vinogradov A, Scarpa A (1973) The initial velocities of calcium uptake by rat liver mitochondria. J Biol Chem 248:5527–5531Google Scholar
  760. Visscher MB, Lee YCP (1972) Calcium ions and the cardiotonic action of glucagon. Proc Natl Acad Sci 69:463–465Google Scholar
  761. Wallach S, Chausmer AB, Sherman BS (1971) Hormonal effects on calcium transport in liver. Clin Orthop 78:40–46Google Scholar
  762. Wallach S, Reizenstein DL, Bellavia JV (1966) The cellular transport of calcium in rat liver. J Gen Physiol 49:743–762Google Scholar
  763. Walling MW, Kimberg DV, Wasserman RH, Feinberg RR (1976) Duodenal active transport of calcium and phosphate in vitamin D-deficient rats; effects of nephrectomy, cestrum diurnum and 1α-25-dihydroxyvitamin D3. Endocrinology 98:1130–1134Google Scholar
  764. Walling MW, Rothman SS (1969) Phosphate independent, carrier-mediated active transport of calcium by rat intestine. Am J Physiol 217:1144–1148Google Scholar
  765. Walling MW, Rothman SS (1970) Apparent increase in carrier affinity for intestinal calcium transport following dietary calcium restriction. J Biol Chem 245:5007–5011Google Scholar
  766. Walsh DA, Krebs EG, Reimann EM, Brostrom MA, Corbin JD, Hickenbottom JP, Soderling TR, Perkins JP (1970) The receptor protein for cyclic AMP in the control of glycogenolysis. In: Greengard P, Costs E (eds) Role of cyclic AMP in cell function. Raven Press, New York, pp 265–285Google Scholar
  767. Walsh DA, Perkins JP, Krebs EG (1968) An adenosine 3′,5′-monophosphate-dependent protein kinase from rabbit skeletal muscle. J Biol Chem 243:3763–3774Google Scholar
  768. Wang JH, Waisman DM (1979) Calmodulin and its role in the second-messenger system. Curr Top Cell Regul 15:47–107Google Scholar
  769. Watlington CO, Burke PK Estep HL (1968) Calcium flux in isolated frog skin; the effect of parathyroid substance. Proc Soc Exp Biol Med 128:853–856Google Scholar
  770. Watson EL, Siegel IA (1978) Factors affecting calcium accumulation and release in canine submandibular salivary microsomes. Arch Oral Biol 23:323–328Google Scholar
  771. Webb RC, Bhalla RC (1976) Calcium sequestration by subcellular fractions isolated from vascular smooth muscle: effect of cyclic nucleotides and prostaglandins. J Mol Cell Cardiol 8:145–147Google Scholar
  772. Weber AM (1966) Energized calcium transport and relaxing factor. Curr Top Bioenerg 1:203–254Google Scholar
  773. Weber A, Herz R, Reiss I (1966) Study of the kinetics of calcium transport by isolated fragmented sarcoplasmic reticulum. Biochem Z 345:329–369Google Scholar
  774. Weibel ER, Stäubli W, Gnägi HR, Hess FA (1969) Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods and normal morphometric data for rat liver. J Cell Biol 42:68–91Google Scholar
  775. Weinbach EC, Von Brand T (1965) The isolation and composition of dense granules from Ca++-loaded mitochondria. Biochem Biophys Res Commun 19:133–137Google Scholar
  776. Weiner ML, Lee KS (1972) Active calcium ion uptake by inside-out and right-side-out vesicles of red blood cell membranes. J Gen Physiol 59:462–475Google Scholar
  777. Weiss GB, Goodman FR (1969) Effects of lanthanum on contraction, calcium distribution and 45Ca movements in intestinal smooth muscle. J Pharmacol Exp Ther 169:46–55Google Scholar
  778. Weller M, Laing W (1979) The effect of cyclic nucleotides and protein phosphorylation on calcium permeability and binding in the sarcoplasmic reticulum. Biochim Biophys Acta 551:406–419Google Scholar
  779. Wendt IR, Langer GA (1977) The sodium-calcium relationship in mammalian myocardium: effect of sodium deficient perfusion on calcium fluxes. J Mol Cell Cardiol 9:551–564Google Scholar
  780. Wester PO (1965) Concentration of 17 elements in subcellular fractions of beef heart tissue determined by neutron activation. Biochim Biophys Acta 109:268–283Google Scholar
  781. Whitfield JF, MacManus JP, Gilland DJ (1971) Inhibition by thyrocalcitonin (calcitonin) of the cyclic AMP-mediated stimulation of thymocyte proliferation by epinephrine. Horm Metab Res 3:348–351Google Scholar
  782. Whitney RB, Sutherland RM (1972) Enhanced uptake of calcium by transforming lymphocytes. Cell Immunol 5:137–147Google Scholar
  783. Whitney RB, Sutherland RM (1973) Characteristics of calcium accumulation by lymphocytes and alterations in the process induced by phytohemagglutinin. J Cell Physiol 82:9–20Google Scholar
  784. Whittembury G, Windhager E (1961) Electrical potential difference measurements in perfused single proximal tubule of Necturus kidney. J Gen Physiol 44:679–687Google Scholar
  785. Wikström M, Ahonen P, Luukkainen T (1975) The role of mitochondria in uterine contraction. FEBS Lett 56:120–123Google Scholar
  786. Williams AJ, Barrie SE (1978) Temperature effects on the kinetics of calcium transport by cardiac mitochondria. Biochem Biophys Res Commun 84:89–94Google Scholar
  787. Williams JA (1966) Effect of external K+ concentration on transmembrane potentials of rabbit thyroid cells. Am J Physiol 211:1171–1174Google Scholar
  788. Williams JA (1970) Origin of transmembrane potentials in non-excitable cells. J Theor Biol 28:287–296Google Scholar
  789. Winegrad S, Shanes AM (1962) Calcium flux and contractility in guinea pig atria. J Gen Physiol 45:371–394Google Scholar
  790. Wolf HU (1970) Purification of the Ca2+ dependent ATPase of human erythrocyte membranes. Biochim Biophys Acta 219:521–524Google Scholar
  791. Wolf HU (1972) Studies on a Ca2+ dependent ATPase of human erythrocyte membranes. Effects of Ca2+ and H+. Biochim Biophys Acta 266:361–375Google Scholar
  792. Wollheim CB, Kikuchi M, Renold AE (1978) The roles of intracellular and extracellular Ca++ in glucose-stimulated biphasic insulin release by rat islets. J Clin Invest 62:451–458Google Scholar
  793. Wong GL, Luben RA, Cohn DV (1977) 1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells. Science 197:663–665Google Scholar
  794. Wood JM, Schwartz A (1978) Effects of ouabain on calcium-45 flux in guinea pig cardiac tissue. J Mol Cell Cardiol 10:137–144Google Scholar
  795. Woodbury DM, Woodbury JW (1963) Correlation of micro-electrode potential recordings with histology of rat and guinea pig thyroid glands. J Physiol (Lond) 169:553–567Google Scholar
  796. Worsfold W, Peter JB (1970) Kinetics of calcium transport by fragmented sarcoplasmic reticulum. J Biol Chem 245:5545–5552Google Scholar
  797. Wrenn RW, Biddulph DM (1979a) Parathyroid hormone-induced calcium efflux from isolated renal cortical tubules — evidence for cyclic AMP mediation. Mol Cell Endocrinol 15:29–40Google Scholar
  798. Wrenn RW, Biddulph DM (1979b) Correlation between cyclic AMP levels and calcium efflux in isolated renal cortical tubules. J Cyclic Nucleotide Res 5:239–250Google Scholar
  799. Wright FS (1971) Increasing magnitude of electrical potential along the renal tubule. Am J Physiol 220:624–638Google Scholar
  800. Yamaguchi M, Takei Y, Yamamoto T (1975) Effect of thyrocalcitonin on calcium concentration in liver of intact and thyroparathyroidectomized rats. Endocrinology 96:1004–1008Google Scholar
  801. Yamaguchi M (1979) Effect of calcitonin on Ca-ATPase activity of plasma membrane in liver of rats. Endocrinol Jpn 26:605–609Google Scholar
  802. Yamazaki RK (1975) Glucagon stimulation of mitochondrial respiration. J Biol Chem 250:7924–7930Google Scholar
  803. Yasamura S (1976) Effect of adrenal steroids on bone resorption in rat. Am J Physiol 230:90–93Google Scholar
  804. Yeung WK, Weisman G, Vidaver GA (1979) active Ca2+ transport by vesicle reconstituted from Triton X-100-solubilized pigeon erythrocyte membrane. Biochim Biophys Acta 555:249–288Google Scholar
  805. Yonaga T, Morimoto S (1979) A calcitonin-like action of prostaglandin E-1. Prostaglandins 17:801–820Google Scholar
  806. Zadunaisky JA, Lande MA (1972) Calcium content and exchange in amphibian skin and its isolated epithelium. Am J Physiol 222:1309–1315Google Scholar
  807. Zadunaisky JA, Gennaro JF Jr, Bashirelahi N, Hilton M (1968) Intracellular redistribution of sodium and calcium during stimulation of sodium transport in epithelial cells. J Gen Physiol 51:290–302Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • André B. Borle
    • 1
  1. 1.Department of PhysiologyUniversity of Pittsburgh, School of MedicinePittsburghUSA

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