Molecular cloning in heterologous systems

  • Karl Esser
  • Christine Lang-Hinrichs
Conference paper
Part of the Advances in Biochemical Engineering/Biotechnology book series (ABE, volume 26)

Abstract

During the last years the knowledge accumulated by fundamental research of DNA recombination in vitro became more relevant to biotechnology.

One of the main advantages of this so-called genetic engineering is the possibility to recombine genetic material from organisms which cannot be hybridized by means of the classical techniques of chromosomal recombination.

After a brief survey of the historical background of DNA transformation, the principal requirements of transforming DNA molecules are outlined, and widely used DNA vehicles are compiled.

Strategies and limits of molecular cloning are commented prior to the discussion of the main host organisms for foreign DNA.

In this review we have tried to select from the enormous number of results those which are of biotechnological relevance at present and those which may have future perspective in applied research.

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References

  1. 1.
    Esser, K., Kuenen, R.: Genetics of fungi, Berlin Heidelberg New York: Springer 1967Google Scholar
  2. 2.
    Whitehouse, H. L. K.: Towards an understanding of the mechanism of heredity, London: E. Arnold 1973Google Scholar
  3. 3.
    Stahl, F. W.: Genetic recombination, San Francisco: W. H. Freeman and Company 1979Google Scholar
  4. 4.
    Ball, C.: Genetic modification in filamentous fungi, in: Fungal Biotechnology. (Smith, J. E., Berry, D. R., Kristiansen, B. eds.), p. 43, The British Mycological Soc. Symp. Series No. 3, London: Academic Press 1980Google Scholar
  5. 5.
    Esser, K.: Impact of basic research on the practical application of fungal processes, in: Developments in Industrial Microbiology, Vol. 22, p. 19, Arlington (Virginia): Soc. for Industrial Microbiology 1981Google Scholar
  6. 6.
    Minuth, W., Esser, K.: unpublished dataGoogle Scholar
  7. 7.
    Ephrussi, B., Weiss, M.: Proc. Nat. Acad. Sci. US 53, 1040 (1965)Google Scholar
  8. 8.
    Webber, H. J.: Science 18, 501 (1903)Google Scholar
  9. 9.
    Rieger, R., Michaelis, A., Green, M. M.: Glossary of genetics and cytogenetics, Berlin-Heidelberg-New York: Springer 1976Google Scholar
  10. 10.
    Cohen, S. N. et al.: Proc. Nat. Acad. Sci. US 70, 3240 (1973)Google Scholar
  11. 11.
    Ehrlich, S. D. et al.: Proc. Nat. Acad. Sci. 73, 4145 (1976)Google Scholar
  12. 12.
    Cohen, S. N. et al.: Macro-and microevolution of bacterial plasmids, in: Microbiology. (Schlesinger, D. ed.), p. 217, Washington, D.C.: Amer. Soc. of Microbiology 1978Google Scholar
  13. 13.
    Struhl, K. et al.: Proc. Nat. Acad. Sci. US 76, 1035 (1979)Google Scholar
  14. 14.
    Primrose, S. B., Ehrlich, S. D.: Plasmid 6, 193 (1981)Google Scholar
  15. 15.
    Collins, J.: Current Topics Microbiol. Immunol. 78, 121 (1976)Google Scholar
  16. 16.
    Curtiss, R.: Ann. Rev. Microbiol. 30, 507 (1976)Google Scholar
  17. 17.
    Klingmüller, W.: Genmanipulation und Gentherapie, Berlin Heidelberg New York: Springer 1976Google Scholar
  18. 18.
    Bukhari, A. I., Shapiro, J. A., Adhya, S. L.: DNA insertion elements, plasmids and episomes, Cold Spring Harbor Lab. 1977Google Scholar
  19. 19.
    Sinsheimer, R. L.: Ann. Rev. Biochem. 46, 415 (1977)Google Scholar
  20. 20.
    Colowick, S. P., Kaplan, N. D. (eds.): Methods in enzymology, Vol. 68, New York-London: Academic Press 1979Google Scholar
  21. 21.
    Klingmüller, W.: Naturwiss. 66, 182 (1979)Google Scholar
  22. 22.
    Hollenberg, C. P.: Progr. Botan. 42, 171 (1980)Google Scholar
  23. 23.
    Old, R. W., Primore, S. B.: Principles of gene manipulation. Studies in microbiology, Vol. 2, Oxford: Blackwell Scientific Publications 1980Google Scholar
  24. 24.
    Cocking, E. C. et al.: Nature 293, 265 (1981)Google Scholar
  25. 25.
    Esser, K., Stahl, U.: Hybridization, in: Biotechnology. (Rehm, H. J., Reed, G. eds.), p. 305, Weinheim: Verlag Chemie 1981Google Scholar
  26. 26.
    Griffith, F.: J. Hyg. 27, 113 (1928)Google Scholar
  27. 27.
    Avery, O. T., MacLeod, C. M., McCarthy, M.: J. Exptl. Med. 79, 137 (1944)Google Scholar
  28. 28.
    Spizizen, J.: Proc. Nat. Acad. Sci. US 44, 1072 (1958)Google Scholar
  29. 29.
    Ravin, A. W.: Adv. Genet. 10, 61 (1961)Google Scholar
  30. 30.
    Benoit, J. et al.: C.R. Acad. Sci. (Paris) 244, 2320 (1957)Google Scholar
  31. 31.
    Fox, A. S., Yoon, S. B.: Genetics 53, 897 (1966)Google Scholar
  32. 32.
    Hess, D.: Z. Pflanzenphysiol. 60, 348 (1969)Google Scholar
  33. 33.
    Benoit, J. et al.: Trans. N.Y. Acad. Sci. 22, 494 (1960)Google Scholar
  34. 34.
    Mishra, N. C., Tatum, E. L.: Proc. Nat. Acad. Sci. US 70, 3875 (1973)Google Scholar
  35. 35.
    Mishra, N. C., Szabo, G., Tatum, E. L.: Nucleic-acid induced genetic changes in Neurospora, in: The role of RNA in Reproduction and Development. (Niu, M. C., and Segal, S. J. eds.), North-Holland Publ. Co. 1973Google Scholar
  36. 36.
    Arber, W., Dussoix, D.: J. Molec. Biol. 5, 18 (1962)Google Scholar
  37. 37.
    Dussoix, D., Arber, W.: J. Molec. Biol. 5, 37 (1962)Google Scholar
  38. 38.
    Jackson, D. A., Symonds, R. H., Berg, P.: Proc. Nat. Acad. Sci. US 69, 2904 (1972)Google Scholar
  39. 39.
    Southern, E. M.: J. Molec. Biol. 98, 503 (1975)Google Scholar
  40. 40.
    Esser, K., Blaich, R.: Adv. Genet. 17, 107 (1973)Google Scholar
  41. 41.
    Dubnau, D. et al.: Molecular cloning in Bacillus subtilis, in: Genetic Engineering, Vol. 2 (Setlow, J. K., Hollaender, A. eds.), p. 115, New York-London: Plenum Press 1980Google Scholar
  42. 42.
    Novick, R. P. et al.: Bacteriol. Rev. 40, 168 (1976)Google Scholar
  43. 43.
    Jacob, F., Brenner, S., Cuzin, F.: Cold Spring Harbor Symp. Quant. Biol. 28, 329 (1963)Google Scholar
  44. 44.
    Lederberg, J.: Physiol. Rev. 32, 403 (1952)Google Scholar
  45. 45.
    Hershey, A. D. (ed.): The bacteriophaga lambda, New York: Cold Spring Harbor Laboratory 1971Google Scholar
  46. 46.
    Das, G. C., Niyogi, S. K.: Progr. Nucl. Acid Res. Molec. Biol. 25, 187 (1981)Google Scholar
  47. 47.
    Hartley, J. L., Donelson, J. E.: Nature 286, 860 (1980)Google Scholar
  48. 48.
    Hollenberg, C. P.. Borst, P., Van Bruggen, E. F. J.: Biochim. Biophys. Acta 209, 1 (1970)Google Scholar
  49. 49.
    Beggs, J.: Nature 275, 104 (1978)Google Scholar
  50. 50.
    Livingston, D. M., Kupfer, D. M.: J. Molec. Biol. 116, 249 (1977)Google Scholar
  51. 51.
    Taketo, M., Jazwinski, S. M., Edelman, G. M.: Proc. Nat. Acad. Sci. US 77, 3144 (1980)Google Scholar
  52. 52.
    Stahl, U. et al.: Molec. gen. Genet. 162, 341 (1978)Google Scholar
  53. 53.
    Sinclair, J. H. et al.: Science 156, 1234 (1967)Google Scholar
  54. 54.
    Del Giudice, L. et al.: Molec. gen. Genet. 172, 165 (1979)Google Scholar
  55. 55.
    Del Giudice, L. et al.: Molec. gen. Genet. 181, 306 (1981)Google Scholar
  56. 56.
    Locker, J., Lewin, A., Rabinowitz, M.: Plasmid 2, 155 (1979)Google Scholar
  57. 57.
    Mannella, C. A., Goewert, R. R., Lambowitz, A. M.: Cell 18, 1197 (1979)Google Scholar
  58. 58.
    De Vries, H. et al.: Current Genet. 3, 205 (1981)Google Scholar
  59. 59.
    Lazarus, C. M. et al.: Eur. J. Biochem. 106, 633 (1980)Google Scholar
  60. 60.
    Pring, D. R. et al.: Proc. Nat. Acad. Sci. US 74, 2904 (1977)Google Scholar
  61. 61.
    Kemble, R. J., Bedbrooke, J. R.: Nature 284, 565 (1980)Google Scholar
  62. 62.
    Collins, R. A. et al.: Cell 24, 443 (1981)Google Scholar
  63. 63.
    Stinchcomb, D. T., Struhl, K., Davis, R. W.: Nature 282, 39 (1979)Google Scholar
  64. 64.
    Beach, D., Piper, M., Shall, S.: Nature 284, 185 (1980)Google Scholar
  65. 65.
    Stahl, U. et al.: Proc. Nat. Acad. Sci. US 79, 3641 (1982)Google Scholar
  66. 66.
    Tiollais, P., Rambach, A.: La Recherche 8, 821 (1977)Google Scholar
  67. 67.
    Cohen, S. N. et al.: Proc. Nat. Acad. Sci. US 70, 3240 (1973)Google Scholar
  68. 68.
    Hershfield, V. et al.: Proc. Nat. Acad. Sci. US 71, 3455 (1974)Google Scholar
  69. 69.
    Rodriguez, R. L. et al.: Construction and characterization of cloning vehicles, in: ICN-UCLA Symp. Molec. Cell Biol., Vol. V, (Nierlich, D. P., Rutter, W. J., Fox, C. F. eds.), New York: Academic Press 1976Google Scholar
  70. 70.
    Bolivar, F. et al.: Gene 2, 75 (1977)Google Scholar
  71. 71.
    Bolivar, F. et al.: Gene 2, 95 (1977)Google Scholar
  72. 72.
    Bolivar, F.: Gene 4, 121 (1978)Google Scholar
  73. 73.
    Chang, A. C. Y., Cohen, S. N.: J. Bacteriol. 134, 1141 (1978)Google Scholar
  74. 74.
    Tiemeier, D., Enquist, L., Leder, P.: Nature 263, 526 (1976)Google Scholar
  75. 75.
    Messing, J. et al.: Nucl. Acids Res. 9, 309 (1981)Google Scholar
  76. 76.
    Hohn, B., Collins, J.: Gene 11, 291 (1980)Google Scholar
  77. 77.
    Bernhard, K., Schrempf, H., Goebel, W.: J. Bacteriol. 133, 897 (1978)Google Scholar
  78. 78.
    Ehrlich, S. D.: Proc. Nat. Acad. Sci. US 74, 1680 (1977)Google Scholar
  79. 79.
    Gryczan, T. J., Contente, S., Dubnau, D.: J. Bacteriol. 134, 318 (1978)Google Scholar
  80. 80.
    Weisblum, B. et al.: J. Bacteriol. 137, 635 (1979)Google Scholar
  81. 81.
    Kreft, J., Bernhard, K., Goebel, W.: Molec. gen. Genet. 162, 59 (1978)Google Scholar
  82. 82.
    Chang, S., Cohen, S. N.: Molec. gen. Genet. 168, 111 (1979)Google Scholar
  83. 83.
    Duncan, C. H., Wilson, G. A., Young, F. E.: Proc. Nat. Acad. Sci. US 75, 3664 (1978)Google Scholar
  84. 84.
    Hollenberg, C. P.: The expression of bacterial resistance genes in the yeast Saccharomyces cerevisiae, in: Plasmids of Medical, Environmental and Commercial Importance. (Timmis, K. N., Pühler, A. eds.), p. 481, Amsterdam-New York-Oxford: Elsevier/North-Holland Medical Press 1979Google Scholar
  85. 85.
    Kingsman, A. J. et al.: Gene 7, 141 (1979)Google Scholar
  86. 86.
    Broach, J. R., Strathern, J. N., Hicks, J. B.: Gene 8, 121 (1979)Google Scholar
  87. 87.
    McKnight, S. L., Croce, C., Kingsbury, R.: Carnegie Institute Year Book 78, 56 (1979)Google Scholar
  88. 88.
    Stahl, U. et al.: Molec. gen. Genet. 178, 639 (1980)Google Scholar
  89. 89.
    Kück, U., Stahl, U., Esser, K.: Current Genet. 3, 151 (1981)Google Scholar
  90. 90.
    Murray, N. E., Murray, K.: Nature 251, 476 (1974)Google Scholar
  91. 91.
    Williams, B. G., Blattner, F. R.: Bacteriophage lambda vectors for DNA cloning, in: Genetic Engineering, Principles and Methods (Setlow, J. K., Hollaender, A. eds.), p. 201, New York-London: Plenum Press 1980Google Scholar
  92. 92.
    Hohn, B.: J. Molec. Biol. 98, 93 (1975)Google Scholar
  93. 93.
    Collins, J., Hohn, B.: Proc. Nat. Acad. Sci. US 75, 4242 (1978)Google Scholar
  94. 94.
    Messing, J. et al.: Proc. Nat. Acad. Sci. US 74, 3642 (1977)Google Scholar
  95. 95.
    Air, G. M.: Crit. Rev. Biochem. 6, 1 (1979)Google Scholar
  96. 96.
    Watson, J.: Molecular biology of the gene, Menlo Park, Benjamin Inc. 1975Google Scholar
  97. 97.
    Breathnach, R., Mandel, J. L., Chambon, P.: Nature 270, 314 (1977)Google Scholar
  98. 98.
    Gilbert, W.: Nature 271, 501 (1978)Google Scholar
  99. 99.
    Gallwitz, D., Sures, I.: Proc. Nat. Acad. Sci. US 77, 2546 (1980)Google Scholar
  100. 100.
    Durica, D. S., Schloss, J. A., Crain, W. R. jr.: Proc. Nat. Acad. Sci. US 77, 5683 (1980)Google Scholar
  101. 101.
    Fyrberg, E. A., Kindle, K. L., Davidson, N.: Cell 19, 365 (1980)Google Scholar
  102. 102.
    Goldberg, D. A.: Proc. Nat. Acad. Sci. US 77, 5794 (1980)Google Scholar
  103. 103.
    Young, R. A., Hagenbüchle, O., Schibler, U.: Cell 23, 451 (1981)Google Scholar
  104. 104.
    Slonimski, P. P. et al.: Mosaic organization and expression of the mitochondrical DNA region controlling cytochrome c reductase and oxidase. III. A model of structure and function, in: Biochemistry and Genetics of Yeast: Pure and Applied Aspects. (Bacila, M., Horecker, L., Stoppani, A. O. M. eds.), p. 391, New York: Academic Press 1978Google Scholar
  105. 105.
    Nunberg, J. H. et al.: Cell 19, 355 (1980)Google Scholar
  106. 106.
    Tsujimoto, Y., Suzuki, Y.: Cell 16, 425 (1979)Google Scholar
  107. 107.
    Jeffreys, A. J., Flavell, R. A.: Cell 12, 1097 (1977)Google Scholar
  108. 108.
    Tilghman, S. M. et al.: Proc. Nat. Acad. Sci. US 75, 725 (1978)Google Scholar
  109. 109.
    Mears, J. G. et al.: Cell 15, 15 (1978)Google Scholar
  110. 110.
    Tonegawa, S. et al.: Proc. Nat. Acad. Sci. US 75, 1485 (1978)Google Scholar
  111. 111.
    Lomedico, P. et al.: Cell 18, 545 (1979)Google Scholar
  112. 112.
    Bell, G. I. et al.: Nature 284, 26 (1980)Google Scholar
  113. 113.
    Sullivan, D. et al.: Nature 289, 516 (1981)Google Scholar
  114. 114.
    Nguyen-Hun, M. C. et al.: Proc. Nat. Acad. Sci. US 76, 76 (1979)Google Scholar
  115. 115.
    Catterall, J. F. et al.: Nature 278, 323 (1979)Google Scholar
  116. 116.
    Sun, S. M., Slightom, J. L., Slightom, T. C.: Nature 289, 37 (1981)Google Scholar
  117. 117.
    Ryffel, G. U. et al.: Cell 19, 53 (1980)Google Scholar
  118. 118.
    Nevins, R. J., Darnell, J. E.: Cell 15, 1477 (1978)Google Scholar
  119. 119.
    Efstratiadis, A. et al.: Cell 7, 279 (1976)Google Scholar
  120. 120.
    Higuchi, R. et al.: Proc. Nat. Acad. Sci. US 73, 3146 (1976)Google Scholar
  121. 121.
    Goodman, H. M., MacDonald, R. J.: Cloning of hormone genes from a mixture of cDNA molecules, in: Methods in Enzymology. (Wu, R. ed.), Vol. 68, p. 75, New York: Academic Press 1979Google Scholar
  122. 122.
    Cosloy, S. D., Oishi, M.: Proc. Nat. Acad. Sci. US 70, 84 (1973)Google Scholar
  123. 123.
    Pribnow, D.: Proc. Nat. Acad. Sci. US 72, 784 (1975)Google Scholar
  124. 124.
    Schaller, H., Gray, C., Herrmann, K.: Proc. Nat. Acad. Sci. US 72, 737 (1975)Google Scholar
  125. 125.
    Gannon, F. et al.: Nature 278, 428 (1979)Google Scholar
  126. 126.
    Flavell, R. A.: Nature 285, 356 (1980)Google Scholar
  127. 127.
    Grosschedle, R., Birnstiel, M. L.: Proc. Nat. Acad. Sci. US 77, 1432 (1980)Google Scholar
  128. 128.
    Benoist, C., Chambon, P.: Nature 290, 304 (1981)Google Scholar
  129. 129.
    Itakura, K. et al.: Science 198, 1056 (1977)Google Scholar
  130. 130.
    Shine, J., Dalgarno, L.: Proc. Nat. Acad. Sci. US 71, 1342 (1974)Google Scholar
  131. 131.
    Rottman, F., Shatkin, A. J., Perry, R. P.: Cell 3, 197 (1974)Google Scholar
  132. 132.
    Shatkin, A. J.: Cell 9, 645 (1976)Google Scholar
  133. 133.
    Sippel, A. E. et al.: Proc. Nat. Acad. Sci. US 71, 4635 (1974)Google Scholar
  134. 134.
    Marbaix, G. et al.: Proc. Nat. Acad. Sci. US 72, 3065 (1975)Google Scholar
  135. 135.
    Hautala, J. A. et al.: Proc. Nat. Acad. Sci. US 76, 5774 (1979)Google Scholar
  136. 136.
    Villa-Komaroff, L. et al.: Proc. Nat. Acad. Sci. US 75, 3727 (1978)Google Scholar
  137. 137.
    Backman, K., Ptashne, M.: Cell 13, 65 (1978)Google Scholar
  138. 138.
    Chang, A. C. Y. et al.: Nature 275, 617 (1978)Google Scholar
  139. 139.
    Goeddel, D. V. et al.: Proc. Nat. Acad. Sci. US 76, 106 (1979)Google Scholar
  140. 140.
    Itakura, K., Riggs, A. D.: Science 209, 1401 (1980)Google Scholar
  141. 141.
    Köster, H.: Drug Research 30, 548 (1980)Google Scholar
  142. 142.
    Barrell, B. G., Bankier, A. T., Drouin, J.: Nature 282, 189 (1979)Google Scholar
  143. 143.
    Struhl, K., Davis, R. W.: Proc. Nat. Acad. Sci. US 74, 5255 (1977)Google Scholar
  144. 144.
    Skalka, A., Shapiro, L.: Gene 1, 65 (1976)Google Scholar
  145. 145.
    Shine, J. et al.: Nature 285, 456 (1980)Google Scholar
  146. 146.
    Hitzeman, R. A., Clarke, L., Carbon, J.: J. Biol. Chem. 255, 12073 (1980)Google Scholar
  147. 147.
    Goebel, W. et al.: Replication and gene expression of extrachromosomal replicons in unnatural bacterial hosts, in: Genetic Engineering. (Boyer, H. W., Nicosia, S. eds.), p. 47, Amsterdam-New York-Oxford: Elsevier Biomedical Press 1978Google Scholar
  148. 148.
    Dobson, M. J., Futcher, A. B., Cox, B. S.: Current Genet. 2, 201 (1980)Google Scholar
  149. 149.
    Hinnen, A., Hicks, J. B., Fink, G. R.: Proc. Nat. Acad. Sci. US 75, 1929 (1978)Google Scholar
  150. 150.
    Noack, D. et al.: Molec. gen. Genet. 184, 121 (1981)Google Scholar
  151. 151.
    Sena, E. P. et al.: J. Bacteriol. 123, 497 (1975)Google Scholar
  152. 152.
    Sherratt, D. J.: Cell 3, 189 (1974)Google Scholar
  153. 153.
    Makler, I., Halvorson, H. O.: J. Bacteriol. 131, 374 (1977)Google Scholar
  154. 154.
    Chi, N. W., Ehrlich, S. D., Lederberg, J.: J. Bacteriol. 133, 816 (1978)Google Scholar
  155. 155.
    Brammar, W. J., Muir, S., McMorris, A.: Molec. gen. Genet. 178, 217 (1980)Google Scholar
  156. 156.
    Ehrlich, S. D.: Proc. Nat. Acad. Sci. US 75, 1433 (1978)Google Scholar
  157. 157.
    Ehrlich, S. D., Sgaramella, V.: Trends Biochem. Sci. 3, 259 (1978)Google Scholar
  158. 158.
    Ratzkin, B., Carbon, J.: Proc. Nat. Acad. Sci. US 74, 487 (1977)Google Scholar
  159. 159.
    Carbon, J. et al.: Brookhaven Symp. Biol. 29, 277 (1977)Google Scholar
  160. 160.
    Clarke, L., Carbon, J.: Nature 287, 504 (1980)Google Scholar
  161. 161.
    Hsiao, C., Carbon, J.: Proc. Nat. Acad. Sci. US 76, 3829 (1979)Google Scholar
  162. 162.
    Citron, B. A., Feiss, M., Donelson, J. E.: Gene 6, 251 (1979)Google Scholar
  163. 163.
    Crabeel, M. et al.: Arch. Int. Physiol. Biochim. 88, B21 (1980)Google Scholar
  164. 164.
    Guerry-Kopecko, P., Wickner, R. B.: J. Bacteriol. 143, 1530 (1980)Google Scholar
  165. 165.
    Vapnek, D. et al.: Proc. Nat. Acad. Sci. US 74, 3508 (1977)Google Scholar
  166. 166.
    Kit, S. et al.: Proc. Nat. Acad. Sci. US 78, 582 (1981)Google Scholar
  167. 167.
    Goeddel, D. V. et al.: Nature 281, 544 (1979)Google Scholar
  168. 168.
    Nagata, S. et al.: Nature 284, 316 (1980)Google Scholar
  169. 169.
    Ratzkin, B. et al.: Proc. Nat. Acad. Sci. US 78, 3313 (1981)Google Scholar
  170. 170.
    Küpper, H. et al.: Nature 289, 555 (1981)Google Scholar
  171. 171.
    Burrell, C. J. et al.: Nature 279, 43 (1979)Google Scholar
  172. 172.
    Wetzel, R. et al.: Biochemistry 19, 6069 (1980)Google Scholar
  173. 173.
    Edge, M.D. et al.: Nature 292, 756 (1981)Google Scholar
  174. 174.
    Guarente, L. et al.: Cell 20, 543 (1980)Google Scholar
  175. 175.
    Stewart, W. E. II: The interferon system, Berlin Heidelberg New York: Springer 1979Google Scholar
  176. 176.
    Newmark, P.: Nature 291, 105 (1981)Google Scholar
  177. 177.
    Sun, M.: Science 212, 141 (1981)Google Scholar
  178. 178.
    Cantell, K., Hirvonen, S.: Tex. Rep. Biol. Med. 35, 138 (1977)Google Scholar
  179. 179.
    Derynck, R. et al.: Nature 287, 193 (1980)Google Scholar
  180. 180.
    Stewart, W. E. II et al.: Gene 11, 181 (1980)Google Scholar
  181. 181.
    Barlow, E. H. et al.: Production of plasminogen activator by tissue culture techniques, in: Proteases and Biological Control. (Reich, E., Rifkin, D. B., Shaw, E. eds.), p. 325, New York: Cold Spring Harbor Laboratories 1975Google Scholar
  182. 182.
    Langbeheim, H., Arnon, R., Sela, M.: Proc. Nat. Acad. Sci. US 73, 4636 (1976)Google Scholar
  183. 183.
    Kleid, D. G. et al.: Science 214, 1125 (1981)Google Scholar
  184. 184.
    Olson, K. C. et al.: Nature 293, 408 (1981)Google Scholar
  185. 185.
    Vale, W., Rivier, C., Brown, M.: Ann. Rev. Physiol. 39, 473 (1977)Google Scholar
  186. 186.
    Foley, K. M. et al.: Proc. Nat. Acad. Sci. US 76, 5377 (1979)Google Scholar
  187. 187.
    Goldstein, A. L. et al.: Proc. Nat. Acad. Sci. US 74, 725 (1977)Google Scholar
  188. 188.
    Young, F. E., Wilson, G. A.: Genetics of Bacillus subtilis and other gram-positive sporulating bacilli, in: Spores V. (Halvorson, H. O., Hanson, R., Campbell, L. L. eds.), p. 77, Washington, D.C.: Amer. Soc. for Microbiology 1972Google Scholar
  189. 189.
    Ehrlich, S. D. et al.: Bacillus subtilis as a host for DNA cloning, in: Genetic Engineering. (Boyer, H., Nicosia, S. eds.), p. 25, Amsterdam-New York-Oxford: Elsevier Biomedical Press 1978Google Scholar
  190. 190.
    Priest, F. G.: Bacteriol. Rev. 41, 711 (1977)Google Scholar
  191. 191.
    De Vos, D. M. et al.: Molec. gen. Genet. 181, 424 (1981)Google Scholar
  192. 192.
    Canosi, U., Iglesias, A., Trautner, T.: Molec. gen. Genet. 181, 434 (1981)Google Scholar
  193. 193.
    Rubin, E. M., Wilson, G. A., Young, F. E.: Gene 10, 227 (1980)Google Scholar
  194. 194.
    Hardy, K., Stahl, S., Küpper, H.: Nature 293, 481 (1981)Google Scholar
  195. 195.
    Schottel, J. L., Bibb, M. J., Cohen, S. N.: J. Bacteriol. 146, 360 (1981)Google Scholar
  196. 196.
    Kleeberger, A., Klingmüller, W.: Molec. gen. Genet. 180, 621 (1980)Google Scholar
  197. 197.
    Klingmüller, W., Kleeberger, A.: Ber. Deutsch. Bot. Ges. Bd. 94, 85 (1981)Google Scholar
  198. 198.
    Hiltner, L.: Brache, Arb. Deut. Landw. Ges. 98, 59 (1904)Google Scholar
  199. 199.
    Anderson, K. et al.: Trends Biochem. Sci. 5, 35 (1980)Google Scholar
  200. 200.
    Burns, R. C., Hardy, R. W.: Nitrogen fixation in bacteria and higher plants, Berlin-Heidelberg-New York: Springer 1975Google Scholar
  201. 201.
    Klingmüller, W.: Naturwiss. 66, 182 (1979)Google Scholar
  202. 202.
    Streicher, S., Gurney, E., Valentine, R. V.: Proc. Nat. Acad. Sci. US 68, 1174 (1971)Google Scholar
  203. 203.
    Cannon, F. C. et al.: Proc. Nat. Acad. Sci. US 74, 2963 (1977)Google Scholar
  204. 204.
    Pühler, A., Burkhard, H. J., Klipp, W.: Molec. gen. Genet. 176, 17 (1979)Google Scholar
  205. 205.
    Riedel, G. et al.: The nitrogen fixation (nif) operon of Klebsiella pneumoniae: Cloning nifgenes and the isolation of nif control mutants, in: Miami Winter Symp. Vol. 13 (Scott, W. A., Werner, R. eds.), p. 115, New York-San Francisco-London: Academic Press 1977Google Scholar
  206. 206.
    Buchanan-Wollaston, V. et al.: Nature 294, 776 (1981)Google Scholar
  207. 207.
    Klingmüller, W.: personal communicationGoogle Scholar
  208. 208.
    Chakrabarty, A. M.: Ann. Rev. Genet. 10, 7 (1976)Google Scholar
  209. 209.
    Berdy, J.: Adv. Appl. Microbiol. 18, 309 (1974)Google Scholar
  210. 210.
    Bagdasarian, M. et al.: Gene 16, 237 (1981)Google Scholar
  211. 211.
    Bibb, M., Schottel, J. L., Cohen, S. N.: Nature 284, 526 (1980)Google Scholar
  212. 212.
    Thompson, J. C., Ward, J. M., Hopwood, D. A.: Nature 286, 525 (1980)Google Scholar
  213. 213.
    Suarez, J. E., Chater, K. F.: Nature 286, 527 (1980)Google Scholar
  214. 214.
    Petes, T. D.: Ann. Rev. Biochem. 49, 845 (1980)Google Scholar
  215. 215.
    Guérineau, M.: Plasmid DNA in yeast; in: Viruses and Plasmids in Fungi. (Lemke, P. A. ed.), p. 540, New York-Basel: Marcel Dekker 1979Google Scholar
  216. 216.
    Panthier, J. et al.: Current Genet. 2, 109 (1980)Google Scholar
  217. 217.
    Jimenez, A., Davies, J.: Nature 287, 869 (1980)Google Scholar
  218. 218.
    Dickson, R. C.: Gene 10, 347 (1980)Google Scholar
  219. 219.
    Henikoff, S. et al.: Nature 289, 33 (1981)Google Scholar
  220. 220.
    Hitzeman, R. A. et al.: Nature 293, 717 (1981)Google Scholar
  221. 221.
    Mercereau-Puijalon, O. et al.: Gene 11, 163 (1980)Google Scholar
  222. 222.
    Ferreira, N. P., Mitchell, D. J., Thomson, J. A.: Transformation of Saccharomycopsis lipolytica by chimaeric plasmid DNA, in: Symp. on Yeast Genetics and Molecular Biology, p. 30, Louvain: 1980Google Scholar
  223. 223.
    Beach, D., Nurse, P.: Nature 290, 140 (1981)Google Scholar
  224. 224.
    Gerbaud, C. et al.: Gene 5, 233 (1979)Google Scholar
  225. 225.
    McNeil, J. B., Storms, R. K., Friesen, J. D.: Current Genet. 2, 17 (1980)Google Scholar
  226. 226.
    Beggs, J. D. et al.: Nature 283, 835 (1980)Google Scholar
  227. 227.
    Case, M. E. et al.: Proc. Nat. Acad. Sci. US 76, 5259 (1979)Google Scholar
  228. 228.
    Schweizer, M. et al.: Gene 14, 23 (1981)Google Scholar
  229. 229.
    Tudzynski, P., Stahl, U., Esser, K.: Current Genet. 2, 181 (1980)Google Scholar
  230. 230.
    De Cleene, M., De Ley, J.: Bot. Rev. 42, 389 (1976)Google Scholar
  231. 231.
    Watson, B. et al.: J. Bacteriol. 123, 255 (1975)Google Scholar
  232. 232.
    Chilton, M. D. et al.: Cell 11, 263 (1977)Google Scholar
  233. 233.
    Bomhoff, G. et al.: Molec. gen. Genet. 145, 177 (1976)Google Scholar
  234. 234.
    Schell, J. et al.: Proc. Roy. Soc. (London) Ser. B 204, 251 (1979)Google Scholar
  235. 235.
    Depicker, A., Van Montagu, M., Schell, J.: Nature 275, 150 (1978)Google Scholar
  236. 236.
    Schell, J., Van Montagu, M.: New insight into the molecular genetics of fungi and plants, in: Recombinant DNA and Genetic Experimentation. (Morgan, J., Wheelan, W. J. eds.), p. 91, Oxford-New York: Pergamon Press 1979Google Scholar
  237. 237.
    Rörsch, A., Schilperoort, R. A.: Agrobacterium tumefaciens plasmids: potential vectors for genetic engineering of plants, in: Genetic Engineering. (Boyer, H. W., Nicosia, S. eds.), p. 189, Amsterdam-New York-Oxford: Elsevier Biomedical Press 1978Google Scholar
  238. 238.
    Otten, L. et al.: Molec. gen. Genet. 183, 209 (1981)Google Scholar
  239. 239.
    Wullems, G. J. et al.: Proc. Nat. Acad. Sci. US 78, 4344 (1981)Google Scholar
  240. 240.
    Ooms, G. et al.: Gene 14, 33 (1981)Google Scholar
  241. 241.
    Marton, L. et al.: Nature 277, 129 (1979)Google Scholar
  242. 242.
    Hernalsteens, J. et al.: Nature 287, 654 (1980)Google Scholar
  243. 243.
    Shepherd, R. J.: Ann. Rev. Plant Physiol. 30, 405 (1979)Google Scholar
  244. 244.
    Haber, S.: Nature 289, 324 (1981)Google Scholar
  245. 245.
    Howell, S. H., Walker, L. L., Walden, R. M.: Nature 293, 483 (1981)Google Scholar
  246. 246.
    Gronenborn, B. et al.: Nature 294, 773 (1981)Google Scholar
  247. 247.
    Flavell, R. A.: Trends Biochem. Sci. 5, 313 (1980)Google Scholar
  248. 248.
    Spier, R. E.: Adv. Chem. Eng. 14, 119 (1980)Google Scholar
  249. 249.
    Gordon, J. W. et al.: Proc. Nat. Acad. Sci. US 77, 7380 (1980)Google Scholar
  250. 250.
    Capechi, M. R.: Cell 22, 479 (1980)Google Scholar
  251. 251.
    Anderson, W. F. et al.: Proc. Nat. Acad. Sci. US 77, 5399 (1980)Google Scholar
  252. 252.
    Maitland, N. J., McDougall, J. K.: Cell 11, 233 (1977)Google Scholar
  253. 253.
    Wigler, M. et al.: Cell 16, 777 (1979)Google Scholar
  254. 254.
    Fiers, W. et al.: Nature 273, 113 (1978)Google Scholar
  255. 255.
    Hamer, D. H.: DNA cloning in mammalian cells with SV40 vectors, in: Genetic Engineering, Principles and Methods, Vol. 2. (Setlow, J. K., Hollaender, A. eds.), p. 83, New York-London: Plenum Press 1980Google Scholar
  256. 256.
    Hamer, D. H. et al.: J. Molec. Biol. 112, 155 (1977)Google Scholar
  257. 257.
    Mulligan, R. C., Howard, B. H., Berg, P.: Nature 277, 108 (1979)Google Scholar
  258. 258.
    Mulligan, R. C., Berg, P.: Science 209, 1422 (1980)Google Scholar
  259. 259.
    Wong, T., Nicolau, C., Hofschneider, P. H.: Gene 10, 87 (1980)Google Scholar
  260. 260.
    O'Hare, K., Benoist, C., Breathnach, R.: Proc. Nat. Acad. Sci. US 78, 1527 (1981)Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Karl Esser
    • 1
  • Christine Lang-Hinrichs
    • 1
  1. 1.Lehrstuhl für Allgemeine BotanikRuhr-UniversitätBochum 1Germany

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