Abstract
Helminths or worms are multicellular organisms living as endoparasites within the human body. Most of these organisms treat human body as definitive host so that parasitic adult-worm stage resides in the intestine. The manifestation of infection varies depending on organ involvement, from skin, intestines to the brain, worm burden, and the species involved. Many infections could be chronic with severe disabilities. The clinically relevant organisms are broadly divided as trematodes (flatworms), cestodes (tapeworms), and nematodes (roundworms). They occur worldwide, though common in tropical countries. The parasitic helminthiasis form significant number among neglected tropical diseases (NTDs). The chemotherapy against helminths is distinct in the sense that these drugs target multicellular organisms unlike bacteria or protozoa. The important group of drugs includes benzimidazoles, macrocyclic lactones, imidazothiazoles, and piperazine derivatives. Albendazole is the mainstay drug for most of the nematodes, except, filariasis, Strongyloides, and Onchocerca infection. Praziquantel is the mainstay drug for most of the trematodes and cestodes, except, Fasciola and Echinococcus. Diethylcarbamazine is used in filariasis. Ivermectin has a significant impact on disease burden of Onchocerca and Strongyloides. Triclabendazole is used in Fasciola and albendazole in Echinococcus.
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Bibliography
Azam A, Peerzada MN, Ahmad K (2015) Parasitic diarrheal disease: drug development and targets. Front Microbiol 6:1183
Chen WJ (2016) Honoring antiparasitics: the 2015 Nobel prize in physiology or medicine. Biom J 39(2):93–97
Gandhi P, Schmitt EK, Chen CW, Samantray S, Venishetty VK, Hughes D (2019) Triclabendazole in the treatment of human fascioliasis: a review. Trans R Soc Trop Med Hyg 113(12):797–804
International Agency for Research on Cancer (IARC) (2012) Biological agents. A review of human carcinogens. IARC monographs on the evaluation of carcinogenic risks to humans. World Health Organization. Int Agency Res Cancer 100B:1–441
Jourdan PM, Lamberton PHL, Fenwick A, Addiss DG (2018) Soil-transmitted helminth infections. Lancet 391(10117):252–265
Kamgno J, Nguipdop-Djomo P, Gounoue R, Téjiokem M, Kuesel AC (2016) Effect of two or six doses 800 mg of Albendazole every two months on Loa loa Microfilaraemia: a double blind, randomized, placebo-controlled trial. PLoS Negl Trop Dis 10(3):e0004492
Martin RJ (1997) Modes of action of anthelmintic drugs. Vet J 154:11–34
Robertson AP, Puttachary S, Buxton SK, Martin RJ (2015) Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum. PLoS Negl Trop Dis 9(2):e0003495
Rugel AR, Guzman MA, Taylor AB et al (2020) Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum? Int J Parasitol Drugs Drug Resist 13:8–15
Shakya A, Bhat HR, Ghosh SK (2018) Update on nitazoxanide: a multifunctional chemotherapeutic agent. Curr Drug Discov Technol 15:201–213
Vale N, Gouveia MJ, Gärtner F (2020) Current and novel therapies against helminthic infections: the potential of antioxidants combined with drugs. Biomol Ther 10(3):E350
WHO (2017) Guideline: preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups. World Health Organization, Geneva. Licence: CC BY-NC-SA 3.0 IGO
WHO (n.d.-a) Foodborne trematode infections [Internet]. World Health Organization. https://www.who.int/foodborne_trematode_infections/infections_more/en/. Accessed 25 Apr 2020
WHO (n.d.-b) World Health Assembly adopts resolution on neglected tropical diseases [Internet]. World Health Organization. http://www.who.int/neglected_diseases/WHA_66_seventh_day_resolution_adopted/en/. Accessed 19 Apr 2020
WHO (n.d.-c) World Health Organization [Internet]. http://www.who.int/neglected_diseases/diseases/en/. Accessed 25 Apr 2020
Wolstenholme AJ (2011) Ion channels and receptor as targets for the control of parasitic nematodes. Int J Parasitol Drugs Drug Resist 1(1):2–13
Zeeshan M, Alam MT, Vinayak S, Bora H, Tyagi RK, Alam MS et al (2012) Genetic variation in the Plasmodium falciparum circumsporozoite protein in India and its relevance to RTS,S malaria vaccine. PLoS One 7:e43430
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Srinivasamurthy, S.K., Bairy, L.K. (2021). Chemotherapy of Helminthiasis. In: Paul, A., Anandabaskar, N., Mathaiyan, J., Raj, G.M. (eds) Introduction to Basics of Pharmacology and Toxicology. Springer, Singapore. https://doi.org/10.1007/978-981-33-6009-9_61
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DOI: https://doi.org/10.1007/978-981-33-6009-9_61
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