Rockey  performed the first successful total pancreatectomy (TP) for pancreatic adenocarcinoma in 1943, which resulted in early perioperative mortality because of a bile duct fistula. The procedure was considered as a “radical operation” for the surgical treatment of pancreatic cancer. However, performing TP for pancreatic neoplasms has not been shown to bring any survival benefit over the less aggressive techniques of resection . The short- and long-term morbidity and mortality related to apancreatic state continue to be of concern today . Therefore, TP cannot be considered as the standard procedure for the surgical treatment of pancreatic cancer.
- 6.Schmidt CM, Glant J, Winter JM, Kennard J, Dixon J, Zhao Q, Howard TJ, Madura JA, Nakeeb A, Pitt HA, Cameron JL, Yeo CJ, Lillemoe KD. Total pancreatectomy (R0 resection) improves survival over subtotal pancreatectomy in isolated neck margin positive pancreatic adenocarcinoma. Surgery. 2007;142:572–8. discussion 578–580.CrossRefGoogle Scholar
- 12.Watanabe Y, Ohtsuka T, Matsunaga T, Kimura H, Tamura K, Ideno N, Aso T, Miyasaka Y, Ueda J, Takahata S, Igarashi H, Inoguchi T, Ito T, Tanaka M. Long-term outcomes after total pancreatectomy: special reference to survivors’ living conditions and quality of life. World J Surg. 2015;39:1231–9.CrossRefGoogle Scholar