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IRC-SET 2018 pp 401-412 | Cite as

Structural Biomimetic Scaffold Modifications for Bones

  • Xin Yi Ariel Ho
  • Hui Yu Cherie Lee
  • Jing Wen Nicole SzeEmail author
  • Tee Wei Teo
Conference paper

Abstract

Over the years, biomimetic scaffolds have been commonly used in the process of tissue regeneration for treatment of bone defects. Even though current biomimetic scaffolds are easily accessible, they lack mechanical strength for ideal applications. This research aims to improve on current designs to create new three-dimensional biomimetic scaffolds for bones. Different biomimetic scaffolds were designed and 3D-printed and was tested for mechanical strength conducting a tensile strength test on the scaffolds. The tests show that the scaffold with hexagonal pores proved to be the most effective scaffold due to its geometrical properties which allows it to withstand more pressure. This was concluded according to the spread of pressure along the scaffold that is dependent on the amount of pressure exerted, and the identification of first fracture which affects the line of breakage across the entire scaffold. This research is able to better help extend the field of tissue engineering and the applicability of 3D biomimetic bone scaffolds for clinical usage.

Keywords

Tissue regeneration Bone defects Mechanical strength Biomimetic 3D scaffolds 

Notes

Acknowledgements

Special thanks to Mr Teo Tee Wei from National Junior College for his patient guidance throughout the research process of this project. It is also greatly appreciated with gratitude towards National Junior College for the provision of the opportunity to engage in scientific research.

References

  1. 1.
    Kheirallah, M., & Almeshaly, H. (2016). Bone graft substitutes for bone defect regeneration. A collective review. International Journal of Dentistry and Oral Science, 3(5), 247–257.Google Scholar
  2. 2.
    Albert, A., Leemrijse, T., Druez, V., Delloye, C., & Cornu, O. (2006). Are bone autografts still necessary in 2006? A three-year retrospective study of bone grafting. Acta Orthopaedica Belgica, 72(6), 734.PubMedGoogle Scholar
  3. 3.
    O’brien, F. J. (2011). Biomaterials & scaffolds for tissue engineering. Materials Today, 14(3), 88–95.CrossRefGoogle Scholar
  4. 4.
    Torkzadeh, R. A. (2010). Accidents happen but who’s going to pay the bills?: A consumers guide to the california personal injury and wrongful death system. Cork: BookBaby.Google Scholar
  5. 5.
    Bhatnagar, R. S., & Li, S. (2004, September). Biomimetic scaffolds for tissue engineering. In: 26th Annual International Conference of the IEEE (Vol. 2, pp. 5021–5023). IEMBS’04. Engineering in Medicine and Biology Society, 2004. IEEE.Google Scholar
  6. 6.
    Yang, S., Leong, K. F., Du, Z., & Chua, C. K. (2001). The design of scaffolds for use in tissue engineering. Part I. Traditional factors. Tissue Engineering, 7(6), 679–689.CrossRefGoogle Scholar
  7. 7.
    3D Printing Systems Australia. (2017). Retrieved January 31, 2017, from http://3dprintingsystems.com/products/filament/.
  8. 8.
    Chan, B. P., & Leong, K. W. (2008). Scaffolding in tissue engineering: General approaches and tissue-specific considerations. European Spine Journal, 17(4), 467–479.CrossRefGoogle Scholar
  9. 9.
    Ju, J., Summers, J. D., Ziegert, J., & Fadel, G. (2010, January). Compliant hexagonal meso-structures having both high shear strength and high shear strain. In: Proceedings of the ASME International Design Engineering Technical Conferences, Montreal, Quebec, Canada.Google Scholar
  10. 10.
    Egan, P., Ferguson, S., & Shea, K. (2017). Design of hierarchical 3D printed scaffolds considering mechanical and biological factors for bone tissue engineering. Journal of Mechanical Design, 139.  https://doi.org/10.1115/1.4036396.
  11. 11.
    Miranda, P., Pajares, A., Saiz, E., Tomsia, A. P., & Guiberteau, F. (2007). Fracture modes under uniaxial compression in hydroxyapatite scaffolds fabricated by robocasting. Journal of Biomedical Materials Research, Part A, 83(3), 646–655.CrossRefGoogle Scholar
  12. 12.
    Tozzi, G., De Mori, A., Oliveira, A., & Roldo, M. (2016). Composite hydrogels for bone regeneration. Materials, 9(4), 267.CrossRefGoogle Scholar

Copyright information

© Springer Nature Singapore Pte Ltd. 2019

Authors and Affiliations

  • Xin Yi Ariel Ho
    • 1
  • Hui Yu Cherie Lee
    • 1
  • Jing Wen Nicole Sze
    • 1
    Email author
  • Tee Wei Teo
    • 1
  1. 1.National Junior CollegeSingaporeSingapore

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