Genetics of Scars and Keloids

  • Chao-Kai Hsu
  • Hsing-San Yang
  • John A. McGrathEmail author


Clinical, epidemiological, and experimental data suggest that genetics plays a role in the pathogenesis of keloids. In this chapter, we review the contribution of genetics to the pathobiology of keloids, including assessment of keloid-related syndromes, genetic linkage analyses, genome-wide association studies, individual fibrosis-related genes, and ongoing insights from genomic medicine. Collectively, the evidence improves understanding of the molecular basis of keloid formation, and indicates possible new strategies for prevention, diagnosis, and treatment.


Keloid Scars Genetics Keloid-related syndromes Linkage analysis Genome-wide association study Single-nucleotide polymorphisms 


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Copyright information

© Springer Nature Singapore Pte Ltd. 2020

Authors and Affiliations

  • Chao-Kai Hsu
    • 1
    • 2
  • Hsing-San Yang
    • 1
  • John A. McGrath
    • 3
    Email author
  1. 1.Department of DermatologyNational Cheng Kung University Hospital, College of Medicine, National Cheng Kung UniversityTainanTaiwan
  2. 2.International Center for Wound Repair and Regeneration (iWRR)National Cheng Kung UniversityTainanTaiwan
  3. 3.St John’s Institute of Dermatology, School of Basic and Medical Biosciences, King’s College London, Guy’s HospitalLondonUK

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